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Rare Metals 2021年第5期40卷 1099-1109页

作者： Bao-Shan He jia-wen li School of Food Science and Technology Henan University of TechnologyZhengzhou 450001China

CoSe_(2) nanosheet materials with a wrinkled sheet structure and large surface area were synthesized via a simple hydrothermal *** polyethyleneimine(PEI)was used to functionalize wrinkled CoSe_(2)(w-CoSe_(2))to make gold nanocubes(AuNCs)uniformly anchored onto the surface of PEI-w-CoSe_(2) via Au-N *** its application in electrochemical immunosensors for the detection of dipropyl phthalate(DPrP)was *** obtained material was characterized by the Fourier transform infrared spectroscopy(FTIR),transmission electron microscope(TEM),energydispersive spectroscopy(EDS),X-ray diffraction(XRD)and Raman *** effective surface area and conductivity of the electrode were enhanced by the introduction of AuNCs/PEI-w-CoSe_(2) *** voltammetry(CV),differential pulse voltammetry(DPV)and electrochemical impedance spectroscopy(EIS)were used to characterize the performance of *** DPrP binds to antibodies via the antigen-antibody interaction,[Fe(CN)6]3-/4-was used as a signal probe to monitor the change of oxidation current of different DPrP *** optimal conditions,the electrochemical responses of the prepared immunosensor were linear when the DPrP concentrations ranged from 1×10^(-11) to 1×10^(-5) mol·L-1,with a detection limit of 1.39×10^(-12) mol·L^(-1).The coefficient of determination(R2)is 0.995,indicating that the degree of fitting is ***,the constructed immunosensor exhibited acceptable reproducibility,selectivity,and ***,it may be found that the composite material has good application prospects in the electrochemical sensors field.

关键词： CoSe_(2)nanosheets Polyethyleneimine Gold nanocubes Dipropyl phthalate

A novel blind deconvolution algorithm using single frequency bin

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第8期8卷 1271-1276页

作者： ZHANG Gui-bao li jia-wen li Cong-xin National Die ＆ Mold CAD Engineering Research Center Shanghai Jiao Tong University Shanghai 200030 China

Former frequency-domain blind devolution algorithms need to consider a large number of frequency bins and recover the sources in different orders and with different amplitudes in each frequency bin,so they suffer from permutation and amplitude indeterminacy troubles. Based on sliding discrete Fourier transform,the presented deconvolution algorithm can directly recover time-domain sources from frequency-domain convolutive model using single frequency bin. It only needs to execute blind sepa-ration of instantaneous mixture once there are no permutation and amplitude indeterminacy troubles. Compared with former algorithms,the algorithm greatly reduces the computation cost as only one frequency bin is considered. Its good and robust per-formance is demonstrated by simulations when the signal-to-noise-ratio is high.

关键词： Blind deconvolution Single frequency bin Convolutive mixture

Significant Histologic Changes Are Not Rare in Treatment-naive Hepatitis B Patients with Normal Alanine Aminotransferase Level:A Meta-analysis

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 615-625页

作者： Chi Zhang jia-wen li Zhao Wu Hong Zhao Gui-Qiang Wang Department of Infectious Disease Center for Liver DiseasePeking University First HospitalXicheng DistrictBeijingChina The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases Zhejiang UniversityHangzhouZhejiangChina Peking University International Hospital BeijingChina

Background and Aims:Chronic hepatitis B is the main cause of liver ***,the most neglected group has been treatment-naive chronic hepatitis B patients with normal alanine aminotransferase(ALT).People have tended to subjectively assume that the liver lesions of these patients are not serious and do not need antiviral ***,the truth is not as optimistic as we *** aimed in this study to analyze the proportion of significant inflammation or fibrosis in aforementioned ***:Medline,Embase,and Cochrane library were searched up to January 10th 2020,to identify studies of these patients with liver *** double arcsine method was used with a random-effect model to combine the proportion of significant inflammation or *** heterogeneity was explored by subgroup analysis and *** of interests included the proportion of significant inflammation or fibrosis and *** secondary outcome was to find the risk factors of significant histological ***:Nineteen eligible studies,with 2,771 participants,were *** pooled proportion of significant inflammation or fibrosis was 35%[95%confidence interval(CI):27 to 43]and 30%(95%CI:25 to 36),*** pooled proportion of cirrhosis was 3%[95%CI:1 to 5,(12 studies;1,755 participants)].In subgroup analysis,old age[***(<40 years-old),44%vs.26%,p=0.012]was significantly associated with higher fibrosis stage as well as cirrhosis[***(<40 years-old),4.8%vs.1.8%,p<0.001].Conclusions:About 1/3 of the treatment-naive chronic hepatitis B patients with normal ALT show significant histological changes,and some even have cirrhosis.

关键词： Significant histologic changes Chronic hepatitis B Normal ALT Meta-analysis

Cytochrome P450 family 17 subfamily A member 1 mutation causes severe pseudohermaphroditism: A case report

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World Journal of Clinical Cases 2022年第11期10卷 3553-3560页

作者： Yu Gong Fang Qin wen-jia li Le-Yu li Ping He Xing-jian Zhou Department of Endocrine and Metabolism Xiangyang No.1 People's HospitalHubei University of MedicineXiangyang 441000Hubei ProvinceChina

BACKGROUND 17α-Hydroxylase deficiency(17-OHD)is a rare form of congenital adrenal hyperplasia,characterized by hypertension,hypokalemia,and gonadal ***,due to the lack of a comprehensive understanding of this disease,it is prone to misdiagnosis and missed diagnosis,and there is no complete *** SUMMARY We report a female patient with *** patient was admitted to the Department of Neurology of our hospital due to limb *** treatment,it was found that the patient’s condition was difficult to correct except for hypokalemia,and her blood pressure was difficult to control with various antihypertensive *** was then transferred to our department for further *** physical examination,the patient's gonadal development was found to be abnormal,and chromosome analysis demonstrated karyotype 46,*** the possibility of 17-OHD,the cytochrome P450 family 17 subfamily A member 1(CYP17A1)test was performed to confirm the *** The clinical manifestations of 17-OHD are *** determination,imaging examination,chromosome determination and CYP17A1 gene test are helpful for early diagnosis.

关键词： Congenital adrenal cortex hyperplasia Cytochrome P450 family 17 subfamily A member 1 17α-Hydroxylase deficiency Pseudohermaphroditism Case report

Megafossils of Betulaceae from the Oligocene of Qaidam Basin and their paleoenvironmental and phytogeographic implications

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Plant Diversity 2024年第1期46卷 101-115页

作者： Tao Yang jia-Hao Cai Yan-Zhi Dai Hong-Yu Chen Lei Han li Zhang Wei-Yu liang Xu-Jun li wen-jia li Jing-Yu Wu San-Ping Xie De-Fei Yan School of Earth Sciences and Key Laboratory of Mineral Resources in Western China(Gansu Province) Lanzhou UniversityLanzhou 730000China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China Center for Research and Education on Biological Evolution and Environments School of Earth Sciences and EngineeringNanjing UniversityNanjing 210023China

Understanding the paleoenvironment and phytogeographical history of the Tibetan Plateau,China relies on discovering new plant *** Qaidam Basin has long been regarded as an ideal‘field laboratory’to investigate the paleoclimate and paleobiological evolution of the northern Tibetan ***,fossil angiosperms from the Qaidam Basin are rare,and our knowledge of its paleovegetation is ***,we report fossil leaves and fruits of Betulaceae found from the Oligocene Shangganchaigou Formation of northwestern Qaidam Basin(Huatugou area).Comparative morphological analysis led us to assign the fruits to the Betula subgenus Betula and the leaves to Carpinus *** findings,together with other reported fossil plants from the same locality,reveal a close floristic linkage between the Qaidam Basin and Europe during the *** northern pathway of this floristic exchange may have crossed through the Qaidam Basin during the late *** floristic linkage may have been facilitated by the continuous narrowing of the Turgai Strait and stronger westerlies,which transported moisture and provided favorable climatic ***,fossil plants collected from the Qaidam Basin suggest that during the Oligocene this region had warm and humid deciduous broad-leaf forest,which differs from the region’s modern vegetation and indicates that the Qaidam Basin may have been a suitable region for these plants to flourish and spread during the Oligocene.

关键词： Paleoenvironment Biogeography Betulaceous fossil Qaidam basin Tibetan Plateau Oligocene

Effect of Selective Dorsal Neurectomy on Erectile Function in Rats

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Current Medical Science 2023年第2期43卷 324-328页

作者： Jin WANG Sen li wen-jia li wen-li ZHU Yuan-bin XIA Yao HE You-peng ZHANG Han-qing ZENG Yong-biao CHENG Zhao-hui ZHU Department of Urology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Geriatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China

Objective This study aimed to investigate the effect of penile selective dorsal neurectomy(SDN)on erectile function in *** Twelve adult male Sprague-Dawley rats(15 weeks old)were divided into three groups(n=4 per group):in control group,rats received no treatment;in sham group,rats underwent a sham operation;in SDN group,rats underwent SDN with half of the dorsal penile nerve *** mating test was performed,and the intracavernous pressure(ICP)assessed six weeks after the surgical *** At postoperative six weeks,the mating test revealed no significant difference in mounting latency and mounting frequency among the three groups(P>0.05),while the ejaculation latency(EL)was significantly longer and ejaculation frequency(EF)lower in the SDN group than in the control and sham groups(P0.05).Conclusion SDN does not adversely affect the erectile function and sexual desire of rats,and at the same time it can reduce EL and EF,providing an application basis for SDN in the clinical treatment of premature ejaculation.

关键词： dorsal penile nerve selective dorsal neurectomy erectile dysfunction premature ejaculation

Biosafety of a 3D-printed intraocular lens made of a poly (acrylamide-co-sodium acrylate) hydrogel in vitro and in vivo

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1521-1530页

作者： jia-wen li Yi-jian li Xi-Su Hu Yu Gong Ben-Bin Xu Hai-Wei Xu Zheng-Qin Yin Southwest Hospital/Southwest Eye Hospital Third Military Medical University(Army Medical University)Chongqing 400038China Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Chongqing 400038China Smart Materials and Surfaces Lab Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon Tyne NE18STUK

AIM:To assess the biosafety of a poly(acrylamide-cosodium acrylate)hydrogel(PAH)as a 3D-printed intraocular lens(IOL)***:The biosafety of PAH was first evaluated in vitro using human lens epithelial cells(LECs)and the ARPE19 cell line,and a cell counting kit-8(CCK-8)assay was performed to investigate alterations in cell proliferation.A thin film of PAH and a conventional IOL were intraocularly implanted into the eyes of New Zealand white rabbits respectively,and a sham surgery served as control *** anterior segment photographs,intraocular pressure(IOP),blood parameters and electroretinograms(ERG)were *** cytokines in the aqueous humor,such as TNFαand IL-8,were examined by *** apoptosis of the retina was investigated by TUNEL assay,and macro PAHge activation was detected by ***:PAH did not slow cell proliferation when cocultured with human LECs or ARPE19 *** implantation of a thin film of a 3 D-printed IOL composed of PAH did not affect the IOP,blood parameters,ERG or optical structure in any of the three experimental groups(n=3 for each).Both TNFαand IL-8 in the aqueous humor of PAH group were transiently elevated 1 wk post-operation and recovered to normal levels at 1 and 3 mo ***1+macroPAHges in the anterior chamber angle in PAH group were increased markedly compared to those of the control group;however,there was no significant difference compared to those in the IOL ***:PAH is a safe material for 3D printing of personal IOLs that hold great potential for future clinical applications.

关键词： cataract biosafety lens epithelial cells ARPE19 cells intraocular lens 3D printing poly hydrogel rabbit

Improving efficiency of inverted perovskite solar cells via ethanolamine-doped PEDOT:PSS as hole transport layer

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Chinese Physics B 2022年第8期31卷 631-638页

作者： Zi-Jun Wang jia-wen li Da-Yong Zhang Gen-Jie Yang Jun-Sheng Yu State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China(UESTC)Chengdu 610054China

In order to fabricate high-performance inverted perovskite solar cells(Pe SCs), an appropriate hole transport layer(HTL) is essential since it will affect the hole extraction at perovskite/HTL interface and determine the crystallization quality of the subsequent perovskite films. Herein, a facile and simple method is developed by adding ethanolamine(ETA)into poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS) as HTL. The doping of a low-concentration ETA can efficiently modify the electrical properties of the PEDOT:PSS film and lower the highest occupied molecular orbital(HOMO) level, which is more suitable for the hole extraction from the perovskite to HTL. Besides, ETA-doped PEDOT:PSS will create a perovskite film with larger grain size and higher crystallinity. Hence, the results show that the open-circuit voltage of the device increases from 0.99 V to 1.06 V, and the corresponding power conversion efficiency(PCE)increases from 14.68% to 19.16%. The alkaline nature of ethanolamine greatly neutralizes the acidity of PEDOT:PSS, and plays a role in protecting the anode, leading the stability of the devices to be improved significantly. After being stored for2000 h, the PCE of ETA-doped PEDOT:PSS devices can maintain 84.2% of the initial value, which is much higher than67.1% of undoped devices.

关键词： perovskite solar cells PEDOT:PSS ethanolamine doping

Rapid Analysis of Polar Components in Ophiocordyceps sinensis by Conventional liquid Chromatography System

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Chinese Herbal Medicines 2014年第3期6卷 217-221页

作者： wen-qing li wen-jia li Zheng-ming Qian Shi-lin Chen li Xiang HEC R&D Center Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences

Objective To develop a rapid high-performance liquid chromatography coupled with diode array detection （HPLC-DAD） method for the simultaneous determination of six polar compounds in Ophiocordyceps sinensis. Methods A poroshell SB Aq column （50 mm × 4.6 mm, 2.7 μm） and gradient elution were used; The detection wavelength of compounds was set at 260 nm. The chromatographic peaks of the six investigated compounds in sample were identified by comparing their retention times with reference compounds. Results All calibration curves showed good linearity （r〉 0.999） within the tested ranges. The intra- and inter-day precisions of the six analytes were less than 0.8% and 2.1%, respectively, and the recoveries of the six analytes were between 95% and 103%. The validated method was successfully applied to the determination of six polar compounds in O. sinensis samples. Conclusion The poroshell SB Aq column is suitable for the rapid analysis of polar components in Chinese materia medica on conventional HPLC system and the developed HPLC method is also helpful to the quality control of O. sinensis.

关键词： adenosine cordycepin guanosine high-performance liquid chromatography inosine Ophiocordyceps sinensis polar compounds uracil uridine

Main focus of parents of children with attention deficit hyperactivity disorder and the effectiveness of early clinical screening

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World Journal of Clinical Cases 2024年第19期12卷 3752-3759页

作者： jia-wen li Ke Gao Xiao-Yun Yang Zhi-Fei li Department of Paediatrics The First Affiliated Hospital of Ningbo UniversityNingbo 315021Zhejiang ProvinceChina Department of Paediatrics The First Affiliated Hospital of Bengbu Medical UniversityBengbu 233004Anhui ProvinceChina

BACKGROUND Attention deficit hyperactivity disorder(ADHD)is a common mental and behavioral disorder among *** To explore the focus of attention deficit hyperactivity disorder parents and the effectiveness of early clinical screening METHODS This study found that the main directions of parents seeking medical help were short attention time for children under 7 years old(16.6%)and poor academic performance for children over 7 years old(12.1%).We employed a two-stage experiment to diagnose *** the 5683 children evaluated from 2018 to 2021,360 met the DSM-5 *** diagnosed with ADHD underwent assessments for letter,number,and figure *** the exclusion of ADHD-H diagnoses,the detection rate rose to 96.0%,with 310 out of 323 cases *** This study yielded insights into the primary concerns of parents regarding their children's symptoms and validated the efficacy of a straightforward diagnostic test,offering valuable guidance for directing ADHD treatment,facilitating early detection,and enabling timely *** research delved into the predominant worries of parents across various age ***,we showcased the precision of the simple exclusion experiment in discerning between ADHD-I and ADHD-C in *** Our study will help diagnose and guide future treatment directions for ADHD.

关键词： Attention deficit hyperactivity disorder Children Parents Direction of attention Simple test