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Synthesis,structural characterization and solubility of 2-(1-substituted-1,11-undecylidene)-5-arylimino-△~3 -1,3,4-thiadiazolines

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Chinese Chemical Letters 2009年第11期20卷 1267-1270页

作者： Shu Hui jin xiao Mei liang Xu Yang Fu Heng Chen Dao Quan Wang Key Laboratory of Pesticide Chemistry and Application Technology Department of Applied Chemistry China Agricultural University Beijing 100193 China

A series of novel 2-（1-substituted-1,11-undecylidene）-5-arylimino-△^3-1,3,4-thiadiazolines （4） were synthesized and their structure was characterized by ^1H NMR, ^13C NMR and elemental analysis. Their solubility in both polar and non-polar solvents is significantly improved owing to the introduction of ethyl or methylthio group at cyclododecyl ring as compared with parent compounds [1, 2-（1,11-undecylidene）-5-arylimino-△^3-1,3,4-thiadiazolines]. However, their fungicidal activity against Rhizoctonia solani is less than that of parent compounds. X-ray diffraction analysis of a representative compound （4d） showed that the conformation of 12-membered ring is still [3333], in which the ethyl group present at the side-exo position and the thiadiazoline ring at the comer carbon. The thiadiazoline plane is perpendicular to the cyclododecyl one.

关键词： 2-(1-Substituted-1,11-undecylidene)-5-arylimino-△^3-1,3,4-thiadiazoline Solubility Crystal structure Synthesis

Synthesis of 12-alkoxycarbonylmethylene-1,15-pentadecanolides

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Chinese Chemical Letters 2007年第8期18卷 915-916页

作者： Jian Jun Li Shu Hui jin xiao Mei liang De Kai Yuan Dao Quan Wang Key Lab of Pesticide Chemistry and Application Technology Department of Applied Chemistry China Agricultural University Beijing 100094 China

Six novel 12-alkoxycarbonylmethylene-1,15-pentadecanolides （3） were synthesized from 2-nitrocyclo-dodecanone by the Michael addition with acrolein followed by ring enlargement, Nef reaction and Wittig-Homer reaction. Their structures were confirmed bv 1H NMR, IR and elemental analysis. The preliminary bioassay showed that they have some fungicidal activity.

关键词： 12-Alkoxycarbonylmethylene-1, 15-pentadecanolide Macrolide Acrylic ester Wittig-Horner reaction Fungicidal actictity

Effects of presenilins and β-amyloid precursor protein on delayed rectifier potassium channels in cultured rat hippocampal neurons

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Acta Pharmacologica Sinica 2004年第2期25卷 55-59页

作者： Wei ZHANG, Hong-wei jin, xiao-liang WANG2 Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Science, Beijing 100050, China Department of Pharmacology Institute of Materia Medica Peking Union Medical College and Chinese Academy of Medical Science Beijing 100050 China Wyatt Technology Corporation 6300 Hollister Avenue Santa Barbara CA 93117-3253

AIM: To study the effects of presenilin-1 (PS-1), presenilin-2 (PS-2), and amyloid beta-protein precursor (APP695) on delayed rectifier potassium channels (IK) in the cultured rat hippocampal neurons. METHODS: PS-1, PS-2, and APP695 were transfected into the cultured rat hippocampal neurons by transient transfection techniques. The IK current was observed by the whole cell patch-clamp techniques. RESULTS: IK was increased in cultured rat hippocampal neurons, after transient transfection of PS-1, PS-2, and APP695. IK amplitudes and densities were significantly increased from (1689±412) pA, (48±18) pA/pF (mock cells, GFP alone, n=17) to (5565±1403) pA, (252±107) pA/pF (PS-1/GFP, n=22, P0.05). CONCLUSION: Overexpression of PS-1, PS-2, and APP695 increased IK in the cultured rat hippocampal neurons. The upregulation of IK may be related to neuronal apoptosis after PS-1, PS-2, and APP695 were transfected.

关键词： presenilin-1 presenilin-2 amyloid beta-protein precursor potassium channels transfection patch- clamp techniques

Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs

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Chinese Journal of Natural Medicines 2017年第10期15卷 775-784页

作者： WANG Shu-Yao A Ji-Ye FEI Fei GENG Jian-liang PENG Ying OUYANG Bing-Chen WANG Pei jin xiao-liang ZHAO Yu-Qing WANG Jian-Kun GENG Ting LI Yan-jing HUA NG Wen-Zhe WANG Zhen-Zhong xiao Wei WANG Guang-Ji School of Chinese Pharmacy Beijing University of Chinese Medicine Beijing 100102 China Jiangsu Kanion Modern Chinese Medicine Institute Nanjing 210017 China State Key Labonatory of Pharmaceutical New-Techfor Chinese Medicine Jiangsu Kanion Pharmaceutical Co. Ltd. Lianyungang222001 China Key Lab of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009 China

Ginkgo diterpene lactones meglumine injection(GDLI)is a commercially available product used for ***,the pharmacokinetic properties of the prototypes and hydrolyzed carboxylic forms of the primary components in GDLI,i.e.,ginkgolide A(GA),ginkgolide B(GB),and ginkgolide K(GK),have never been fully evaluated in beagle *** this work,a simple,sensitive,and reliable method based on ultra-fast liquid chromatography-tandem mass spectrometry(UFLC-MS/MS)was developed,and the prototypes and total amounts of GA,GB,and GK were determined in beagle dog *** plasma concentrations of the hydrolyzed carboxylic forms were calculated by subtracting the prototype concentrations from the total lactone *** the first time,the pharmacokinetics of GA,GB,and GK were fully assessed in three forms,i.e.,the prototypes,the hydrolyzed carboxylic forms,and the total amounts,after intravenous administration of GDLI in beagle *** was shown that ginkgolides primarily existed in the hydrolyzed form in plasma,and the ratio of hydrolysates to prototype forms of GA and GB decreased gradually to a homeostatic *** of the three forms of the three ginkgolides showed linear exposure of AUC to the ***,GB,and GK showed a constant half-life approximately 2.7,3.4,and 1.2 h,respectively,which were consistent for the forms at three dose levels(0.3,1.0,and 3.0 mg·kg^(-1))and after a consecutive injection of GDLI for 7 days(1.0 mg·kg^(-1)).

关键词： Hydrolysates of ginkgolides LC-MS/MS Pharmacokinetics Ginkgo diterpene lactones Beagle dog

Effect of oxymatrine on the p38 mitogen-activated protein kinases signalling pathway in rats with CCl4 induced hepatic fibrosis

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Chinese Medical Journal 2009年第12期122卷 1449-1454页

作者： DENG Zi-yu LI Jun jin Yong CHEN xiao-liang LU Xiong-wen School of Pharmacy Anhui Medical University Hefei Anhui 230032 China

Background Recent studies have suggested that p38 mitogen-activated protein kinases （MAPK） signalling pathway plays an important role in hepatic fibrosis. This study explored the antifibrotic effect of oxymatrine on tetrachloromethane induced liver fibrosis in rats and its modulation on the p38 MAPK signalling pathway. Methods One hundred and twenty healthy male Sprague-Dawley rats were randomly assigned to six groups： normal （n=20）, induced fibrosis （n=20）, colchicine （n=20） and three treatment groups of oxymatrine （n=20x3）. We obesrved changes in deposition of collagen, hyaluronic acid （HA）, laminin （LN）, collagen type IV （CIV）, procollagen III （PCIll） and hydroxyproline （Hyp）, a-smooth muscle actin （α-SMA） and phosphor-p38 （pp38）. Results The relative indicators of changes in histopathology, HA, LN, CIV, PCIII, Hyp, a-SMA and pp38 were raised significantly in the induced fibrosis group （P〈0.01 vs normal group）. The semiquantitative hepatic fibrosis staging scores of middle dose group and high dose group were decreased （P 〈0.05 and P 〈0.01 respectively vs the induced fibrosis group）, as was the average area of collagen in rats＇ liver, the concentrations of serum HA, LN, CIV, PCIII and liver tissue homogenate Hyp. The gene expression of α-SMA mRNA was considerably decreased in the treated animals, as was the protein espression of pp38 protein. Conclusions Oxymatrine is effective in reducing the production and deposition of collagen in the liver tissue of experimental rats in ways which relate to modulating the fibrogenic signal transduction via p38 MAPK signalling pathway.

关键词： oxymatrine liver fibrosis p38 mitogen-activated protein kinase signalling pathway

Sky location of massive black hole binaries in the foreground of Galactic white dwarf binaries

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 97-108页

作者： Pan Guo Hong-Bo jin Cong-Feng Qiao Yue-liang Wu The International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences The School of Physical Sciences University of Chinese Academy of Sciences Institute for Frontiers in Astronomy and Astrophysics Beijing Normal University National Astronomical Observatories Chinese Academy of Sciences Institute of Theoretical Physics Chinese Academy of Sciences

For space-based gravitational wave （GW） detection,the main noise source for massive black hole binaries （MBHBs） is attributed to approximately 10～7double white dwarf binaries in the *** a GW source,the amplitude of the detector response,recorded by a space-based gravitational wave detector,exhibits a modulation effect with a year period when observing the source from various orbital *** the adverse conditions mentioned above,where there is a strong foreground noise and annual modulation in the signals,we employed the wavelet transform and the strong-amplitude relevant orbital position search methods,which allows the weak MBHB sources to achieve higher locating *** detail,for two MBHB sources of lower intensity,the precision of luminosity distance,represented by the ratio ?DL/DLat the 95%confidence level,is enhanced by factors of ～*** angular resolutions,denoted by??s,are enhanced by a factor of ～*** improvements increase the number of detectable GW sources,facilitate multi-messenger follow-up observations and provide constraints on the cosmological constant.

关键词： space-based gravitational wave detection gravitational waves massive black hole binaries

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： jin-Hui Chen Zuo-Tang liang Yu-Gang Ma Xin-Li Sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze Department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

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基于非线性啁啾光栅和波长扫描的ROF系统

光电子．激光 2015年第3期26卷 480-486页

作者：肖进良蒲涛陈大雷滕义超任珂苏国瑞解放军理工大学通信工程学院江苏南京210007

为了降低光信号在不同传输距离产生的色散对光载射频(ROF)(光载无线电)传输系统的信号质量的影响,提出了一种基于静态非线性啁啾光纤光栅(NLCFBG)和动态波长扫描相结合的可调谐色散补偿ROF传输系统方案。在对所提出系统方案进行理论分... 详细信息

为了降低光信号在不同传输距离产生的色散对光载射频(ROF)(光载无线电)传输系统的信号质量的影响,提出了一种基于静态非线性啁啾光纤光栅(NLCFBG)和动态波长扫描相结合的可调谐色散补偿ROF传输系统方案。在对所提出系统方案进行理论分析的基础上制作了NLCFBG,并对ROF传输中的可调谐色散效果进行半实物仿真,分析和比较了有无光栅色散补偿时系统的传输性能;验证了此方案对不同传输距离、不同激光频率以及不同射频载波频率的光纤传输系统色散补偿性能。

关键词：非线性啁啾光纤光栅(NLCFBG) 色散补偿误码率(BER) 光载射频(ROF)

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层次教学法在篮球教学中应用

湖南城市学院学报（自然科学版） 2016年第5期25卷 449-450页

作者：金肖良台州职业技术学院浙江台州318000

新的课程标准对体育教学内容、方式、目标也提出了新的要求,相应的也有很多教学方法上的尝试和改革。本文就层次教学法在高职篮球课程教学中的组织和实施展开了深入探讨。

关键词：高职篮球课程教学层次教学法组织实施