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Biomedical and Environmental Sciences 2023年第8期36卷 725-731页

作者： MAO Yu GAO li Qin jia li yun HOU Si Meng XIAO Yuan Yuan JI Xi Wen WANG Shuang Beijing Tongren Eye Center Beijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Ophthalmology and Visual Science Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Objective To investigate the clinical efficacy of dexamethasone vitreous cavity implants(Ozurdex)for the treatment of macular edema(Irvine-Gass Syndrome)after cataract *** Eight patients(eight eyes)with Irvine-Gass syndrome were enrolled for vitreous injections with *** patients included six men(six eyes)and two women(two eyes)with a mean age of 67.12±11.92 *** in the patients best-corrected visual acuity(BCVA),central macular thickness(CMT),and intraocular pressure were compared before and after *** The mean visual acuity BCVA of the patients was 0.81±0.26 before implantation,which improved to 0.20±0.12,0.13±0.09,and 0.15±0.13 at 2 weeks,1 month,and 3 months after implantation,respectively(P<0.001).The patient’s mean CMT before implantation was 703.00±148.88μm,and it reduced to 258.87±37.40μm,236.25±28.74μm,and 278.00±76.82μm at 2 weeks,1 month,and 3 months after implantation,respectively(P<0.001).Conclusion The dexamethasone vitreous cavity implant(Ozurdex)is a safe and effective treatment,which can effectively improve patient’s visual acuity and reduce macular edema associated with cataract surgery.

关键词： Irvine-Gass Syndrome Macular edema Dexamethasone Vitreous injection

Temperature-induced resistance transition behaviors of melamine sponge composites wrapped with different graphene oxide derivatives

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Journal of Materials Science & Technology 2021年第26期85卷 194-204页

作者： Cheng-Fei Cao Wen-Jun liu Hui Xu Ke-Xin Yu li-Xiu Gong Bi-Fan Guo Yu-Tong li Xiao-Lan Feng ling-Yu Lv Hong-Tao Pan li Zhao jia-yun li Jie-Feng Gao Guo-Dong Zhang Long-Cheng Tang Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education College of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China

Temperature-re s ponsive resistance transition behaviors of the melamine sponges wrapped with different graphene oxide derivatives(***,wide-ribbon and sheet)were *** sponge composites coated by three types of GO derivatives were prepared by a simple dip-coating *** these composites show good mechanical flexibility and reliability(almost unchanged compressive stress at 70%strain after 100 cycles),high hydrophobicity(water contact angle>120°),excellent flame resistance(self-extinguishing)and structural stability even after burning,which was used to construct the resistance-based fire alarm/warning ***,the different resistance response behaviors of such sensors are strongly dependent on the GO size and network formed on the MF skeleton ***,at a fixed high temperature of~350℃,the three fire alarm sensors show different response time(to trigger the alarm light)of 6.3,8.4 and 11.1 s for nanoribbon,wide-ribbon and sheet at the same concentration,*** structural observation and chemical analysis demonstrated that the discrepancy of temperature-responsive resistance transition behaviors of various GO derivatives was strongly determined by their different thermal reduction degrees during the high-tempe rature or flame treating *** work offers a design and development for construction of smart fire alarm device for potential fire prevention and safety applications.

关键词： Graphene oxide derivatives Fire warning response Structure and morphology Thermal reduction Temperature-responsive resistance transition

TLR2 and TLR4 signaling pathways are required for recombinant Brucella abortus BCSP31-induced cytokine production, functional upregulation of mouse macrophages, and the Th1 immune response in vivo and in vitro

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Cellular & Molecular Immunology 2014年第5期11卷 477-494页

作者： jia-yun li Yuan liu Xiao-Xue Gao Xiang Gao Hong Cai State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Beijing China Model Animal Research Center Nanjing University Nanjing China

Brucella abortus is a zoonotic Gram-negative pathogen that causes brucelosis in ruminants and humans. Toll-like receptors （TLRs） recognize Brucella abortus and initiate antigen-presenting cell activities that affect both innate and adaptive immunity. In this study, we focused on recombinant Brucella cell-surface protein 31 （rBCSP31） to determine its effects on mouse macrophages. Our results demonstrated that rBCSP31 induced TNF-α, IL-6 and IL-12p40 production, which depended on the activation of mitogen-activated protein kinases （MAPKs） by stimulating the rapid phosphorylation of p38 and JNK and the activation of transcription factor NF-KB in macrophages. In addition, continuous exposure （〉24 h） of RAW264.7 cells to rBCSP31 significantly enhanced I FN-y-induced expression of MHC-II and the ability to present rBCSP31 peptide to CD4＋ T cells. Furthermore, we found that rBCSP31 could interact with both TLR2 and TLR4. The rBCSP31-induced cytokine production by macrophages from TLR2-/- and TLR4-/- mice was lower than that from C57BL/6 macrophages, and the activation of NF-KB and MAPKs was attenuated in macrophages from TLR2-/- and TLR4-/- mice. In addition, CD4＋ T cells from C57BL/6 mice immunized with rBCSP31 produced higher levels of IFN-y and IL-2 compared with CD4＋ T cells from TLR2-/- and TLR4-/- mice. Macrophages from immunized C57BL/6 mice produced higher levels of IL-12p40 than those from TLR2-/- and TLR4-/- mice. Furthermore, immunization with rBCSP31 provided better protection in C57BL/6 mice than in TLR2-/- and TLR4-/- mice after B. abortus 2308 challenge. These results indicate that rBCSP31 is a TLR2 and TLR4 agonist that induces cytokine production, upregulates macrophage function and induces the Thl immune response.

关键词： BCSP31 Brucella abortus cytokine macrophage Th i immune response TLR

The rLrp of Mycobacterium tuberculosis inhibits proinflammatory cytokine production and downregulates APC function in mouse macrophages via a TLR2-mediated PI3K/Akt pathway activation-dependent mechanism

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Cellular & Molecular Immunology 2016年第6期13卷 729-746页

作者： Yuan liu jia-yun li Su-Ting Chen Hai-Rong Huang Hong Cai State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Beijing 100871 China National Clinical Laboratory on Tuberculosis Beijing Key Laboratory on Drug-Resistant Tuberculosis Research Beijing Chest Hospital Capital Medical University Beijing Tuberculosis and Thoracic Tumor Institute Beijing 101149 China

We demonstrate that Mycobacterium tuberculosis recombinant leucine-responsive regulatory protein （rLrp） inhibits lipopolysaccharide （LPS）-induced tumor necrosis factor alpha （TNF-a）, interleukin-6, and interleukin-12 production and blocks the nuclear translocation of subunits of the nuclear-receptor transcription factor NF-KB （Nuclear factor-kappa B）. Moreover, rLrp attenuated LPS-induced DNA binding and NF-κB transcriptional activity, which was accompanied by the degradation of inhibitory IκBα and a consequent decrease in the nuclear translocation of the NF-κB p65 subunit. RLrp interfered with the LPS-induced clustering of TNF receptor-associated factor 6 and with interleukin-1 receptor-associated kinase 1 binding to TAKI. Furthermore, rLrp did not attenuate proinflammatory cytokines or the expression of CD86 and major histocompatibility complex class-II induced by interferon-gamma in the macrophages of Toll-like receptor 2 deletion （TLR2-/-） mice and in protein kinase b （Akt）-depleted mouse cells, indicating that the inhibitory effects of rLrp were dependent on TLR2-mediated activation of the phosphatidylinositol 3-OH kinase （PI3K）/ Akt pathway. RLrp could also activate the PI3K/Akt pathway by stimulating the rapid phosphorylation of PI3K, Akt, and glycogen synthase kinase 3 beta in macrophages. In addition, 19 amino acid residues in the N-terminus of rLrp were determined to be important and required for the inhibitory effects mediated by TLR2. The inhibitory function of these 19 amino acids of rLrp raises the possibility that mimetic inhibitory peptides could be used to restrict innate immune responses in situations in which prolonged TLR signaling has deleterious effects. Our study offers new insight into the inhibitory mechanisms by which the TLR2-mediated PI3K/Akt pathway ensures the transient expression of potent inflammatory mediators.

关键词： APC function cytokine Mycobacterium tuberculosis rLrp TLR2 and PI3 K/Akt pathway

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun li Junfang Wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats

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World Journal of Gastroenterology 2021年第8期27卷 708-724页

作者： Jin-Dong Zhao Yan li Min Sun Chan-Juan Yu jia-yun li Si-Hai Wang Di Yang Cheng-lin Guo Xue Du Wen-Jin Zhang Ruo-Dong Cheng Xiao-Chuan Diao Zhao-Hui Fang Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Anhui University of Chinese MedicineHefei 230031Anhui ProvinceChina School of life Sciences Anhui UniversityHefei 230039Anhui ProvinceChina

BACKGROUND A recent investigation showed that the prevalence of type 2 diabetes mellitus(T2DM)is 12.8%among individuals of Han *** microbiota has been reported to play a central role in ***-Kakizaki(GK)rats show differences in gut microbiota compared to non-diabetic *** studies have indicated that berberine could be successfully used to manage *** sought to understand its hypoglycaemic effect and role in the regulation of the gut *** To determine whether berberine can regulate glucose metabolism in GK rats via the gut *** GK rats were acclimatized for 1 *** GK rats were randomly divided into three groups and administered saline(Mo),metformin(Me),or berberine(Be).The observation time was 8 wk,and weight,fasting blood glucose(FBG),insulin,and glucagon-like peptide-1(GLP-1)were *** tissue was observed for pathological ***,we sequenced the 16S rRNA V3-V4 region of the gut microbiota and analysed the *** Compared with the Mo group,the Me and Be groups displayed significant differences in FBG(Plin resistance was noted in the Be group compared with those in the Me group(P<0.01).The pancreatic islets of the Me-and Be-treated rats showed improvement in number,shape,and necrosis compared with those of Mo-treated rats.A total of 580 operational taxonomic units were obtained in the three *** to the Mo group,the Me and Be groups showed a shift in the structure of the gut *** analysis indicated that FBG was strongly positively correlated with Clostridia_UCG-014(P<0.01)and negatively correlated with Allobaculum(P<0.01).Body weight showed a positive correlation with Desulfovibrionaceae(P<0.01)and a negative correlation with Akkermansia(P<0.01).Importantly,our results demonstrated that Me and Be could significantly decrease Bacteroidetes(P<0.01)and the Bac

关键词： Type 2 diabetes mellitus Amelioration of hyperglycaemia Modulation of gut microbiota Berberine Metformin Goto-Kakizaki rats

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu jia Rui Mao Xiang Cao yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

逆全球化视角下我国跨境资本流动监测预警指标体系构建研究

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中央财经大学学报 2019年第6期 119-128页

作者：刘玚李佳耘天津财经大学金融学院

在逆全球化背景下,我国跨境资本双向波动愈加频繁。笔者基于2008—2017年我国跨境资本月度波动情况,识别风险点,挖掘出表征流动危机的四大类23个备选指标,运用格兰杰因果检验法和主成分分析法筛选出影响跨境资本流动的先行指标和同步指... 详细信息

在逆全球化背景下,我国跨境资本双向波动愈加频繁。笔者基于2008—2017年我国跨境资本月度波动情况,识别风险点,挖掘出表征流动危机的四大类23个备选指标,运用格兰杰因果检验法和主成分分析法筛选出影响跨境资本流动的先行指标和同步指标,构建跨境资本流动监测预警指数。结果显示,宏观经济运行状况指标在预警指数中占比最大,预警能力较强,表明我国跨境资本流动具有明显的顺周期性,与国内经济运行高度吻合。进一步对预警指数进行有效性检验,其中格兰杰因果检验结果显示样本内预警指数对跨境资本流动具有显著的引领作用;利用2017年实际跨境资本流动数据与预警指数的GARCH模型外推结果进行比较,发现跨境资本流动预测值与实际走势基本相符,说明预警指数对中国跨境资本流动具有较好的预警效力。基于此,笔者认为:我国政府在宏观层面应当建立逆周期跨境资本流动管理机制,使用适当的逆周期调节工具,合理引导市场预期,减少跨境资本流动的顺周期性特征。

关键词：逆全球化跨境资本流动预警指标体系顺周期性

Cytogenetic Mapping of Disease Resistance Genes and Analysis of Their Distribution Features on Chromosomes in Maize

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Wuhan University Journal of Natural Sciences 2003年第04A期8卷 1167-1172页

作者： li li-jia, Song yun-chun Key Laboratory of MOE for Plant Developmental Biology, Wuhan University, Wuhan 430072, Hubei, China Wuhan University Key Laboratory of MOE for Plant Development Biology Wuhan 430072 Hubei China (GRID:grid.49470.3e) (ISNI:***)

Cytogenetic maps of four clusters of disease resistance genes were generated by ISH of the two RFLP markers tightly linked to and flanking each of maize resistance genes and the cloned resistance genes from other plant species onto maize chromosomes, combining with data published before. These genes include Helminthosporium turcium Pass resistance genes Ht1, Htn1 and Ht2, Helminthosporium maydis Nisik resistance genes Rhm1 and Rhm2, maize dwarf mosaic virus resistance gene Mdm1, wheat streak mosaic virus resistance gene Wsm1, Helminthosporium carbonum ULLstrup resistance gene Hml and the cloned Xanthomonas oryzae pv. Oryzae resistance gene Xa21 of rice, Cladosporium fulvum resistance genes Cf-9 and Cf-2.1 of tomato,and Pseudomonas syringae resistance gene RPS2 of Arabidopsis. Most of the tested disease resistance genes located on the four chromosomes, i.e., chromosomes1, 3, 6 and 8, and they closely distributed at the interstitial regions of these chromosomal long arms with percentage distances ranging 31.44(±3.72)-72.40(±3.25) except for genes Rhm1, Rhm2, Mdm1 and Wsm1 which mapped on the satellites of the short arms of chromosome6. It showed that the tested RFLP markers and genes were duplicated or triplicated in maize genome. Homology and conservation of disease resistance genes among species, and relationship between distribution features and functions of the genes were discussed. The results provide important scientific basis for deeply understanding structure and function of disease resistance genes and breeding in maize.

关键词： Maize four clusters of resistance genes in situ hybridization cytogenetic mapping distribution features

IoT Empowered Early Warning of Transmission line Galloping Based on Integrated Optical Fiber Sensing and Weather Forecast Time Series Data

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Computers, Materials & Continua 2025年第1期82卷 1171-1192页

作者： Zhe li yun liang Jinyu Wang Yang Gao State Grid Henan Electric Power Company Electric Power Scientific Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China

Iced transmission line galloping poses a significant threat to the safety and reliability of power systems,leading directly to line tripping,disconnections,and power *** early warning methods of iced transmission line galloping suffer from issues such as reliance on a single data source,neglect of irregular time series,and lack of attention-based closed-loop feedback,resulting in high rates of missed and false *** address these challenges,we propose an Internet of Things(IoT)empowered early warning method of transmission line galloping that integrates time series data from optical fiber sensing and weather ***,the method applies a primary adaptive weighted fusion to the IoT empowered optical fiber real-time sensing data and weather forecast data,followed by a secondary fusion based on a Back Propagation(BP)neural network,and uses the K-medoids algorithm for clustering the fused ***,an adaptive irregular time series perception adjustment module is introduced into the traditional Gated Recurrent Unit(GRU)network,and closed-loop feedback based on attentionmechanism is employed to update network parameters through gradient feedback of the loss function,enabling closed-loop training and time series data prediction of the GRU network ***,considering various types of prediction data and the duration of icing,an iced transmission line galloping risk coefficient is established,and warnings are categorized based on this ***,using an IoT-driven realistic dataset of iced transmission line galloping,the effectiveness of the proposed method is validated through multi-dimensional simulation scenarios.

关键词： Optical fiber sensing multi-source data fusion early warning of galloping time series data IoT adaptive weighted learning irregular time series perception closed-loop attention mechanism