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Varus ankle arthritis: a modified operation with a novel osteotomy and lateral hinge plate fixation technique

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Chinese Medical Journal 2019年第24期132卷 2998-3000页

作者： Xiao-Hui Gu xin-ji chen Chao Sun jian-Zhong Zhang Zong-Ping Luo Drthopaedic Institute Department of OrthopaedicsThe First Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215007China Department of Orthopaedic Surgery Zhejiang Provincial People's Hospital and People's Hospital of Hangzhou Medical CollegeHangzhouZhejiang 310014China Department of Orthopedics The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China Department of Orthopedics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

Ankle arthritis is a disease characterized by degeneration of articular cartilage,which is always accompanied with pain,decreased mobility,and varus *** osteotomy is a reliable techniques in the treatment of *** can correct deformities at the distal tibia and normalize the load-bearing axis,and thereby reduce the unusual compression to the articular cartilage,alleviate pain,and improve *** shortcomings include the frequent intra-operative fluoroscopy and no early exercise or *** is more,in the process of distracting the tibia after osteotomy,the separation of contralateral cortical bone often *** et al[1]reported that fracture and disruption of the lateral cortex would result in distinct instability to the *** et al[2]noted that this complication contributed to the loss of angular correction,implant failure,delayed union even non-union of the *** this study,we reported a modified osteotomy with a preshaped plate and novel osteotomy to overcome these shortcomings.

关键词： osteotomy operation union

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： chen Li Leilei Liang Baoshan Zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

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Rab4:细胞囊泡循环运输过程的重要因子

生物化学与生物物理进展 2016年第12期43卷 1163-1172页

作者：陈辉积刘新光陈维春广东医科大学衰老研究所东莞523808 广东省医学分子诊断重点实验室东莞523808 广东医科大学生物化学与分子生物学研究所湛江524023

囊泡运输是真核细胞中物质运输及信息交流的重要形式,Rab蛋白在这个过程中发挥着重要功能.Rab4是Rab蛋白家族的成员之一,参与调控早期内体的分选与内体循环途径.Rab4包括Rab4A、Rab4B和Rab4C 3个亚型.本文主要阐述了Rab4的结构特征、主... 详细信息

囊泡运输是真核细胞中物质运输及信息交流的重要形式,Rab蛋白在这个过程中发挥着重要功能.Rab4是Rab蛋白家族的成员之一,参与调控早期内体的分选与内体循环途径.Rab4包括Rab4A、Rab4B和Rab4C 3个亚型.本文主要阐述了Rab4的结构特征、主要的效应蛋白和参与运输的货物蛋白以及影响细胞自噬、葡萄糖摄取、神经调节、心脏功能及肿瘤发生方面的功能.

关键词： Rab4 囊泡运输自噬葡萄糖摄取

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing chen jiafu ji Xiaofang xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution

AMF colonization and community of a temperate invader and co-occurring natives grown under different CO_(2) concentrations for 3 years

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Journal of Plant Ecology 2022年第3期15卷 437-449页

作者： Xiu-Rong Lu Wei-Wei Feng Wen-Jun Wang ji-xin chen jian-Kun Sun Bo Qu Ming-Chao Liu Yu-Long Feng Liaoning Key Laboratory for Biological Invasions and Global Changes College of Bioscience and BiotechnologyShenyang Agricultural UniversityShenyangLiaoning 110866China

Global changes such as atmospheric CO_(2)enrichment often facilitate exotic plant invasions and alter soil arbuscular mycorrhizal fungi(AMF)***,it is still unclear whether the effects of CO_(2)enrichment on exotic plant invasions are associated with its effects on root-AMF symbiosis of invasive and native *** address this issue,the annual invasive plant Xanthium strumarium and two phylogenetically related annual natives were compared under ambient and elevated CO_(2)concentrations for three consecutive *** CO_(2)enrichment increased AMF colonization rates for the species only in few cases,and the invader did not benefit more from CO_(2)enrichment in terms of AMF *** ambient CO_(2)concentration,however,the invader had a higher AMF colonization rate than the natives in the first year of the study,which disappeared in the second and third year of the study due to the increase of AMF colonization rates in the natives but not in the *** influences of species,CO_(2)concentrations and planting year on AMF colonization were associated with their effects on both soil nutrient and AMF community,and the former may be more important as it also influenced the *** results indicate that the invader could more quickly form symbiosis with soil AMF,contributing to adaptation and occupation of new habitats,and that it is necessary to consider the roles of AMF and the effects of time when determining the effects of global changes such as atmospheric CO_(2)enrichment on exotic plant invasions.

关键词： AMF community colonization consecutive planting elevated CO_(2) exotic plant invasions soil characteristics

Preparation and Performance of Ternary Early Strength Agent and Quercetin Composite Cement Sealing Material

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 130-140页

作者： LIU jian chen Meiting ji Xiaoli XU Chao WANG Chunmei Department of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Safety and High Efficient Mining Jointly Built by Province and Education Ministry Anhui University of Science and TechnologyHuainan 232001China Department of Chemical Engineering and Explosives Anhui University of Science and TechnologyHuainan 232001China

A ternary early-strengthening agent consisting of calcium formate+triethanolamine+lithium sulfate was compounded with quercetin to shorten the setting time of cementitious materials while ensuring their early *** optimum ratio of the three early-strengthening agents was determined as 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate by response surface *** effects of the ternary early-strengthening agent composed of calcium formate+triethanolamine(TEA)+lithium sulfate on cementitious pore sealing materials under the synergistic effect of quercetin were studied by means of the performance tests of compressive strength,fluidity,and setting time,and the microstructural characterizations of X-ray powder diffractometer(XRD),thermogravimetry(TG-DSC)and scanning electron microscopy(SEM).The study shows that the synergistic effect of ternary early-strengthening agent and quercetin forms a multi-performance composite admixture for cementitious *** best performance was obtained with the compounding scheme of 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate ternary early-strengthening agent and 0.05%*** compressive strength of 1,3,7,and 28 d are 94.8%,39.8%,42%,and 28%higher than those of the blank group,*** initial time and final setting time are 41 and 57 minutes,*** to the microscopic analysis,the network and fibrous C-S-H gels generated by ternary early-strengthening agents are attached to the surface promoted by quercetin,which forms skeleton support while thickening and solidifying the cement slurry,which enhances the early compressive strength of the cement-based materials.

关键词： sealing material ternary early-strengthening agent quercetin synergetic effect response surface methodology

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三峡水库下游河道冲刷粗化研究

泥沙研究 2017年第5期42卷 19-24页

作者：耿旭毛继新陈绪坚中国水利水电科学研究院北京100048

三峡工程运行10余年以来,水库拦截了上游约75.5%的泥沙,破坏了原天然河道的自然形态与水沙条件的相对平衡,三峡大坝下游河道产生强烈冲刷,致使河床明显粗化。根据三峡水库蓄水后下游河段实测地形及床沙级配资料,分析了河道冲淤变化,并... 详细信息

三峡工程运行10余年以来,水库拦截了上游约75.5%的泥沙,破坏了原天然河道的自然形态与水沙条件的相对平衡,三峡大坝下游河道产生强烈冲刷,致使河床明显粗化。根据三峡水库蓄水后下游河段实测地形及床沙级配资料,分析了河道冲淤变化,并总结了四种床沙粗化计算方法。在此基础上利用接近冲淤平衡的宜枝河段实测资料对四种方法进行了验证计算。研究结果表明,韩其为方法的床沙粗化级配和冲刷深度与实测值吻合较好,较客观地反映了三峡水库下游河道的冲刷粗化过程。

关键词：三峡水库下游河道冲刷粗化

曼氏迭宫绦虫钙/钙调素依赖蛋白激酶I(SmCaMK I)基因的生物信息学分析与表达鉴定

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中国人兽共患病学报 2016年第12期32卷 1044-1050,1057页

作者：李奕基陈新新符瑞佳陈小静吕刚梁培海南医学院热带病转化医学教育部重点实验室海口571199 海南医学院热带医学与检验医学院海口571199 海南大学农学院海口570228

目的开展SmCaMK I(曼氏迭宫绦虫钙/钙调素依赖蛋白激酶I)的潜在生物学特征分析和功能研究。方法利用相关网站和软件对SmCaMK I的同源性核苷酸序列比对分析、保守位点预测、构建分子进化树、编码氨基酸的淋巴细胞表位进行分析预测。此外,... 详细信息

目的开展SmCaMK I(曼氏迭宫绦虫钙/钙调素依赖蛋白激酶I)的潜在生物学特征分析和功能研究。方法利用相关网站和软件对SmCaMK I的同源性核苷酸序列比对分析、保守位点预测、构建分子进化树、编码氨基酸的淋巴细胞表位进行分析预测。此外,SmCaMK I进行扩增,并克隆到表达载体pET-28α(+)中进行蛋白的表达纯化,制备大鼠免疫血清进行虫体免疫组织定位分析。结果 SmCaMK I是一个全长基因,由1 068bp组成,编码355个氨基酸。SmCaMK I与细粒棘球绦虫、多房棘球绦虫的CaMK I保守功能域的氨基酸序列一致性分别为89%和88%,与人的CaMK I氨基酸序列一致性仅仅只有44%。分子进化树分析中SmCaMK I与绦虫属的亲缘关系最近,与其他物种亲缘性较远。与人类CaMK I相比,淋巴细胞表位具有统计学差异。SmCaMK I能够定位在成虫的睾丸和虫卵,在裂头蚴中大量表达和特异定位于体表。结论SmCaMK I是参与虫体生长发育繁殖的重要蛋白分子,还可能是一个潜在的疫苗靶标蛋白。

关键词：曼氏迭宫绦虫 SmCaMK I 生物信息学分析原核表达免疫组织化学定位

Innovative dual-mode device integrating capacitive desalination and solar vapor generation for high-efficiency seawater desalination

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Journal of Energy Chemistry 2025年第1期100卷 171-179页

作者： jiacheng Wang Zhaoyu chen Ruduan Yuan jiaxin Luo Ben Zhang Keju ji Meng Li Juanxiu Xiao Kuan Sun National Innovation Center for Industry-Education Integration of Energy Storage Technology MOE Key Laboratory of Low-grade Energy Utilization Technologies and SystemsCollege of Energy & Power Engineering Chongqing University Xuefeng Mountain Energy Equipment Safety National Observation and Research Station CQU-NUS Renewable Energy Materials & Devices Joint Laboratory Chongqing University Southwest Technology and Engineering Research Institute jiangsu Provincial Key Laboratory of Bionic Functional Materials College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University

Solar-driven interface evaporation with high solar-to-steam conversion efficiency has shown great potential in seawater ***,due to the influence of latent heat and condensation efficiency,the water yield from solar-driven interface evaporation remains insufficient,posing a significant challenge that requires *** this work,we designed a dual-mode high-flux seawater desalination device that combines solar-driven interface evaporation and capacitive *** utilizing coupled desalination materials exhibiting both photothermal conversion and capacitance activity,the device demonstrated photothermal evaporation rates of 1.41 and 0.97 kg m-2h-1for condensate water yield under one-sun ***,the device exhibited a salt adsorption capacity of up to48 mg g-1and a salt adsorption rate of 2.1 mg *** addition,the salt adsorption capacity increased by approximately 32% under one-sun ***,photo-enhanced capacitive desalination performance was explored through numerical simulations and theoretical *** calculations and characterizations confirmed that the defect energy levels formed by the introduction of sulfur vacancies can effectively widen the light absorption range,improve photothermal conversion performance,and stimulate more photoelectrons to participate in capacitive ***,the electron distribution state of molybdenum disulfide with sulfur vacancies and surface defect sites contributes to ion/electron transport at the solid-liquid *** work provides a novel pathway for integrating solar vapor generation with other low-energy desalination technologies.

关键词： Desalination