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China & The World Cultural Exchange 2024年第9期 16-25页

作者： wu liyun Chen Hong the China Academy of Culture and Tourism Industry Beijing International Studies University School of Tourism Science Beijing International Studies University

Beijing Central Axis is the backbone of the ancient capital,a cultural spine shaped by the passage of time and spatial *** successful inscription as a World Heritage site presents new opportunities for the conservation of the Central Axis cultural heritage,while also offering a fresh chance to link cultural and tourism sites along the Axis,fostering coordinated development.

关键词： backbone offering passage

Identifying and Managing Technical Risks in the Process of Innovative Drugs Development in China

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Asian Journal of Social Pharmacy 2024年第2期19卷 126-134页

作者： Diao Yuanyuan wu Zhiang School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China Yeehong Business School Shenyang Pharmaceutical UniversityBeijing 100055China

Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and *** The initial risk index was investigated by literature ***,the likert scale was used to design a questionnaire,and the experts’opinion was used to analyze the risk factors affecting the different stages of the development of innovative drugs in *** and Conclusion Based on the analysis of questionnaire,31 risk indicators of five key stages in the development of innovative drugs from drug discovery to marketing authorization were *** key risk indicators constructed in this study can provide reference for technology-related risk management in the process of innovative drug development.

关键词： innovative drug development technology risk risk management

脉冲激光熔覆Inconel 718涂层热行为数值模拟及其对显微组织的影响

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表面技术 2024年第11期53卷 217-227页

作者：吴军蔡建臣王胜李董航周寒文衢州学院浙江衢州324000 浙江省空气动力装备技术重点实验室浙江衢州324000 衢州职业技术学院浙江衢州324000

目的揭示脉冲激光作用下Inconel 718合金涂层凝固传热行为的演化机制,改善涂层中Nb、Mo元素偏析现象,提升Inconel 718合金熔覆涂层的力学性能,为优化Inconel 718熔覆涂层质量提供理论依据。方法综合考虑物性参数随温度、脉冲激光热源、... 详细信息

目的揭示脉冲激光作用下Inconel 718合金涂层凝固传热行为的演化机制,改善涂层中Nb、Mo元素偏析现象,提升Inconel 718合金熔覆涂层的力学性能,为优化Inconel 718熔覆涂层质量提供理论依据。方法综合考虑物性参数随温度、脉冲激光热源、粉末传输形式,以及凝固过程中相变潜热对涂层凝固热行为的影响,构建脉冲激光熔覆传热模型。基于数值模拟技术和激光熔覆试验,利用VHX-2000电子显微镜对涂层显微组织形态进行分析验证,采用日立SU8010场发式扫描电镜观察分析显微组织和元素偏析情况,并使用显微硬度计测试涂层的硬度值。结果由数值模拟分析结果可知,脉冲激光涂层的冷却速度、温度梯度、凝固速度均大于连续激光涂层,其枝晶生长细密且No、Mo元素呈弥散分布,显微组织自底向顶以平面晶、胞状枝晶、柱状枝晶、等轴枝晶等形式存在,Laves相的体积分数降低至2.93%,在细晶强化和固溶强化作用下,熔覆涂层的平均显微硬度提升至307HV0.1。结论脉冲激光涂层热行为数值模拟分析结果符合Inconel 718涂层组织形态快速凝固变化的规律,数值模型可靠。脉冲激光形成的高冷却速度和高温度梯度,能在一定程度上抑制Inconel 718合金涂层中Nb、Mo元素的偏析,离散并细化γ枝晶组织,降低Laves相的体积分数,显微组织在细晶强化和固溶强化双重作用下,提升涂层的力学性能。

关键词：激光熔覆 Inconel 718 脉冲激光数值模拟组织性能

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重症监护病房内急性胰腺炎并发脓毒症的风险

中华急诊医学杂志 2024年第10期33卷 1390-1397页

作者：李壮丽李跃东苑俊吴泽华孙昀安徽医科大学第二附属医院重症医学一科合肥230601 中国人民解放军联勤保障部队第901医院(安徽医科大学临床学院)重症医学科合肥230031

目的探讨重症监护病房(intensive care medcine,ICU)内急性胰腺炎患者(acute pancreatitis,AP)发生脓毒症的危险因素,构建列线图(nomogram)模型并进行评价。方法回顾性分析2013年10月至2023年10月在安徽医科大学第二附属医院重症医学一... 详细信息

目的探讨重症监护病房(intensive care medcine,ICU)内急性胰腺炎患者(acute pancreatitis,AP)发生脓毒症的危险因素,构建列线图(nomogram)模型并进行评价。方法回顾性分析2013年10月至2023年10月在安徽医科大学第二附属医院重症医学一科收治的306例AP患者的临床资料,根据是否发生脓毒症分为脓毒症组和非脓毒症组。比较两组患者基线资料以及实验室检查指标,将研究对象随机(随机数字法)分为训练集和验证集,采用最小绝对收缩与选择算子(least absolute shrinkage and selection operator,LASSO)回归筛选出最优变量,然后进行多因素Logistic回归分析并构建Nomogram图风险预测模型,再对模型进行预测效能进行评估。结果共纳入306例AP患者,其中,发生脓毒症患者127例,未发生脓毒症患者179例。按照7:3的比例随机分为训练集215例和验证集91例。多因素logistic回归分析发现,BMI、APACHEⅡ评分、血小板,IL-6、总胆红素和并发症是AP患者发生脓毒症的独立危险因素,据此构建Nomogram图风险预测模型;训练集和验证集的模型ROC曲线下面积分别是0.913(95%CI 0.875~0.951)和0.901(95%CI 0.837~0.965);校准曲线显示预测概率与实际概率基本一致。决策曲线分析显示其在较大的阈值范围内具有良好的临床净收益。结论ICU内AP并发脓毒症的独立危险因素为BMI、APACHEⅡ评分、血小板,IL-6、总胆红素和并发症,据此建立的Nomogram图风险预测模型具有较高的预测价值。

关键词：重症监护病房急性胰腺炎脓毒症危险因素预测模型

大型炼油厂PSA氢提纯单元运行经验与故障处理

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炼油技术与工程 2024年第3期54卷 24-27,31页

作者：吴越冯多学李盼吴长安中国石油大连石化公司辽宁省大连市116000

通过分析某大型炼油厂制氢装置PSA(变压吸附)单元实际生产情况,发现PSA单元运行中出现的问题主要集中在吸附剂粉碎和程控阀故障两方面。经分析认为:吸附剂粉碎主要原因为均压过程压差和气体流速太大、吸附塔顶吸附剂压网和压板的影响、... 详细信息

通过分析某大型炼油厂制氢装置PSA(变压吸附)单元实际生产情况,发现PSA单元运行中出现的问题主要集中在吸附剂粉碎和程控阀故障两方面。经分析认为:吸附剂粉碎主要原因为均压过程压差和气体流速太大、吸附塔顶吸附剂压网和压板的影响、原料气带水;程控阀故障则主要包括阀检报警、电磁阀故障、阀芯密封面损坏、填料压盖泄漏以及阀板轴套开裂和阀销折断等。根据长期实践经验,总结列出判断故障的依据,分析造成各类故障的原因,制定出细化设备安装检查、加强日常维护保养、优化操作参数设置、升级相关配件材质等有效措施,可以消除PSA单元的常见故障,确保其长周期稳定运行。

关键词：炼油厂 PSA 氢提纯吸附剂粉碎均压压差阀检报警程控阀故障泄漏

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复合钝化剂对原位镉污染土壤的钝化效果及其对白菜镉富集的影响

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热带作物学报 2024年第5期45卷 1084-1093页

作者：冯继红何季吴传美李龙贵祖罡罗雪宋理洪贵州大学农学院贵州贵阳550025

探究复合钝化剂对原位镉(Cd)污染土壤的钝化效果及其对白菜吸收积累Cd的影响,为中轻度Cd污染农田土壤的治理修复提供科学依据。以赤泥+石灰+磷矿粉(T_(1))、赤泥+石灰+生物炭(T_(2))、石灰+腐殖酸+海泡石(T_(3))、海泡石+生物炭+赤泥(T_... 详细信息

探究复合钝化剂对原位镉(Cd)污染土壤的钝化效果及其对白菜吸收积累Cd的影响,为中轻度Cd污染农田土壤的治理修复提供科学依据。以赤泥+石灰+磷矿粉(T_(1))、赤泥+石灰+生物炭(T_(2))、石灰+腐殖酸+海泡石(T_(3))、海泡石+生物炭+赤泥(T_(4))、海泡石+生物炭+磷矿粉(T_(5))共5种复合钝化剂在原位Cd污染农田土壤中开展田间试验,研究5种复合钝化剂对耕作层土壤中各形态Cd含量、酶活性、微生物碳(MBC)、微生物氮(MBN)和白菜各部位吸收积累Cd的影响。结果表明:(1)5种复合钝化剂能不同程度提高土壤pH,降低耕作层土壤中Cd的有效性,T_(3)、T_(4)、T_(5)处理的土壤pH显著高于CK,T_(2)、T_(3)、T_(4)、T_(5)处理的土壤有效态Cd含量显著低于CK,在Cd的各个形态中,T_(5)处理的弱酸提取态Cd含量、可还原态Cd含量显著低于CK,而残渣态Cd含量显著高于CK;(2)T_(1)、T_(3)、T_(4)、T_(5)处理的土壤蔗糖酶和酸性磷酸酶活性分别比CK显著提高42.06%~152.46%、15.95%~26.48%,T_(1)、T_(2)、T_(3)、T_(4)处理的脲酶活性比CK显著提高18.43%~35.19%,T_(3)、T_(4)处理的过氧化氢酶活性比CK显著提高18.78%~19.01%,T_(1)、T_(2)、T_(3)处理的土壤MBC含量比CK显著提高31.83%~53.19%,T_(2)、T_(3)、T_(4)处理的土壤MBN含量比CK显著提高19.14%~59.89%;(3)不同处理对白菜各部位吸收积累Cd的影响有一定差异,与CK相比,T_(1)、T_(4)、T_(5)处理显著降低根部、茎部的Cd含量,5种处理均显著降低叶部的Cd含量,且白菜叶部富集、转运Cd的能力大于茎部和根部。综合钝化效果,T_(4)、T_(5)处理即海泡石+生物炭+赤泥(3∶5∶3)、海泡石+生物炭+磷矿粉(3∶5∶3)在原位钝化修复中轻度Cd污染农田土壤中的钝化效果较好,可有效降低植物对土壤重金属Cd的吸收。

关键词： Cd污染土壤修复复合钝化剂白菜土壤酶活性钝化效果富集

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An ecological perspective on Joseph Rock’s(1884-1962)plant collection activities in China

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Journal of Plant Ecology 2024年第4期17卷 100-113页

作者： jifan Luo Ruozhi Huang Hai Yan Renwu wu Shuai liao Zhoubing Xiang Yongxi Zou liangchen Shi Ke Wang Zhiyi Bao College of Landscape Architecture Zhejiang Agriculture and Forestry UniversityHangzhou 311300China Zhejiang Agriculture and Forestry University Landscape Architecture Institute Hangzhou 311300China South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

In the early 20th century,numerous western botanists,often referred to as‘plant hunters’,embarked on ambitious expeditions to China,playing a crucial role in the study of botany and botanical *** their contributions,comprehensive assessments of their explorations are *** bridge this gap,this article focuses on the work of Joseph Charles Francis Rock,a notable figure in that *** work revisits Rock’s botanical expeditions within the broader context of botanical diversity *** outlines his historical experiences in collecting plants in China and enumerates the species composition and phenotypic traits of the plants he ***,it also analyzes the spatial distribution of the species,the completeness of his collection and the α-and β-diversity of the plants he *** findings reveal that Rock led four major botanical expeditions in China between 1922 and 1933,amassing a total of 28184 sheets and 16608 numbers across 204 families,1081 genera and 4231 *** focus was predominantly on ornamental species,which exhibit a variety of flower colors and *** collection work spanned 5 provinces,35 cities and 72 counties,with a notable concentration in the Hengduan Mountains,a current biodiversity *** study not only reconstructs Rock’s botanical legacy but also offers valuable historical data and fresh analytical insights for understanding contemporary plant *** contributes to the ongoing discourse on the importance of preserving plant diversity as a cornerstone of environmental sustainability.

关键词： Joseph Charles Francis Rock plant specimen collection history plant diversity plant collector

采前喷施氯化钙和糖醇钙对‘蜂糖李’果实品质及贮藏性能的影响

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食品与发酵工业 2024年第2期50卷 191-196页

作者：吴运星董晓庆李悦陈红贵州大学农学院/贵州省果树工程技术研究中心贵州贵阳550025 贵州大学科技学院贵州贵阳550024

为探讨采前喷钙对‘蜂糖李’品质的影响,该文以‘蜂糖李’为材料,在采前喷施质量分数为1%、1.5%、2%的氯化钙和稀释800、1200、1600倍糖醇钙溶液,并在八成熟时采收果实,将果实在温度(4±1)℃、相对湿度(90±5)%条件下进行贮藏,贮藏0 d... 详细信息

为探讨采前喷钙对‘蜂糖李’品质的影响,该文以‘蜂糖李’为材料,在采前喷施质量分数为1%、1.5%、2%的氯化钙和稀释800、1200、1600倍糖醇钙溶液,并在八成熟时采收果实,将果实在温度(4±1)℃、相对湿度(90±5)%条件下进行贮藏,贮藏0 d和贮藏60 d测定‘蜂糖李’果实品质,研究采前喷施氯化钙和糖醇钙对果实品质和贮藏性能的影响。结果表明,贮藏0 d时,对于不同质量分数的氯化钙和稀释倍数的糖醇钙处理组,采前喷施1.5%氯化钙处理均能提高‘蜂糖李’果实采收时的单果重、纵横径、果形指数;贮藏60 d时,采前喷施1.5%氯化钙处理的果实失重率最低、硬度下降和多酚氧化酶活力增加的幅度最低,并保持较高的可溶性蛋白含量、可溶性固形物含量、可滴定酸含量、总酚含量及过氧化物酶活力。采前喷施1.5%氯化钙处理有利于‘蜂糖李’果实贮藏保鲜,该研究可为采后‘蜂糖李’果实贮藏保鲜提供参考。

关键词：采前氯化钙糖醇钙 ‘蜂糖李’ 贮藏品质

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Exploration and Application Practice of Energy Conservation Theory and Method in Steel Manufacturing Process System

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Frontiers of Metallurgical Industry

Frontiers of Metallurgical Industry 2024年第2期2卷 37-42页

作者： jiaxiang Hao Yuanyuan wu College of Architecture and Engineering Anhui University of Technology liaoning University of Science and Technology.

This article briefly discusses the theoretical basis and overall goals of energy conservation in the steel manufacturing process *** is proposed that in the process of implementing system energy conservation,it is necessary to fully recognize and utilize the characteristics and functional advantages of the steel manufacturing process,pay more attention to energy quality,firmly grasp the overall goal of system optimization,focus on the integrated optimization of gas,steam,and waste heat systems,and propose the idea of constructing a"steel chemi-cal gas electricity heating cooling multi generation system".Based on practice,the main principles,models,and effects of implementing systematic energy conservation in steel enterprises have been proposed.

关键词： steel manufacturing process system energy-saving system optimization energy conservation and emis-sion reduction waste heat and energy generation polygeneration

Perforated gastric ulcer causing mediastinal emphysema: A case report

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World Journal of Clinical Cases 2024年第4期12卷 859-864页

作者： Zhi-Cheng Dai Xun-wu Gui Feng-He Yang Hao-Yuan Zhang Wen-Feng Zhang Department of General Surgery Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina Department of Medical Imaging Mengcheng County First People's HospitalMengcheng 233500Anhui ProvinceChina

BACKGROUND Mediastinal emphysema is a condition in which air enters the mediastinum between the connective tissue spaces within the pleura for a variety of *** can be spontaneous or secondary to chest trauma,esophageal perforation,medi-cally induced factors,*** common symptoms are chest pain,tightness in the chest,and respiratory *** mediastinal emphysema patients have mild symptoms,but severe mediastinal emphysema can cause respiratory and circulatory failure,resulting in serious *** SUMMARY A 75-year-old man,living alone,presented with sudden onset of severe epigastric pain with chest tightness after drinking *** to the remoteness of his residence and lack of neighbors,the patient was found by his nephew and brought to the hospital the next morning after the disease *** tomography(CT)showed free gas in the abdominal cavity,mediastinal emph-ysema,and subcutaneous *** gastrointestinal angiography showed that the esophageal mucosa was intact and the gastric antrum was ***,we chose to perform open gastric perforation repair on the patient under thoracic epidural anesthesia combined with intravenous *** operative incision of the muscle layer of the patient's abdominal wall was made,and a large amount of subperitoneal gas was *** a continued incision of the peritoneum revealed the presence of a perforation of approx-imately 0.5 cm in the gastric antrum,which we repaired after pathological ***,the patient received high-flow oxygen and cough *** CT was performed on the first and sixth postoperative days,and the mediastinal and subcutaneous gas was gradually *** After gastric perforation,a large amount of free gas in the abdominal cavity can reach the mediastinum through the loose connective tissue at the esophageal hiatus of the diaphragm,and upper gastrointestinal angiography can clarify the site of *** pat

关键词： Gastric ulcer Perforated Mediastinal emphysema Case report