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Prognostic value of glypican-3 in patients with HBV-associated hepatocellular carcinoma after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 157-163页

作者： Xiao Cui Zhao Li Peng-ji Gao jie Gao ji-ye zhu Department of Hepatobiliary Surgery Peking University People's Hospital

BACKGROUND：Glypican-3（GPC-3）is frequently overexpressed in hepatocellular carcinoma（HCC）.Recent studies have shown that GPC-3 is a highly efficient diagnostic biomarker of HCC and an indicator of poor prognosis in HCC patients who have undergone ***,its prognostic value in patients with HBV-associated HCC after liver transplantation（LT）is not *** present study is to evaluate the prognostic value of GPC-3 in patients with HBV-associated HCC after ***： A cohort of 104 HCC patients with HBV-associ- ated cirrhosis who had undergone LT at our hospital between 2002 and 2011 were enrolled in this study. Samples of HCC were taken from these patients. GPC-3 protein expression was detected in paraffin-embedded specimens using immunohis- tochemistry. All related clinical data were obtained from the China Liver Transplant Registry. The relationship between GPC-3 expression and clinicopathological parameters was analyzed. Univariate and multivariate Cox-regression analyses were used to identify risk factors for poor prognosis. RESULTS： GPC-3 was expressed in samples from 74 （71.2%） of the 104 patients. GPC-3 was expressed only in HCC cells. Positive staining was correlated with tumor size （P=0.004）, encapsulation （P=0.018）, pathological stage （P--0.027）, portal vein invasion （P=0.043）, tumor differentiation （P=0.002） and the Milan criteria （P=0.016）. The 5-year survival rate and dis- ease-free survival rate of patients with GPC-3-positive were lower than those （38.2% vs 75.4%, P〈0.001; 30.8% vs 69.7%, P=0.001） of patients with GPC-3-negative. Multivariate Coxregression analysis revealed that GPC-3 was an independent risk factor for 5-year survival rate （P=0.031） and disease-free survival rate （P=0.047）, together with tumor differentiation, Milan criteria and pre-operative ***： GPC-3 is a potential biomarker for poor prognosis after LT in HCC patients with HBV-associated cirrhosis.

关键词： liver transplantation hepatitis B hepatocellular carcinoma glypican-3

Esophagogastric devascularization without splenectomy in portal hypertension: safe and effective?

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Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 276-280页

作者： Yan-Bin Ni Peng-ji Gao Dong Wang Zhao Li ji-ye zhu Department of Hepatobiliary Surgery Peking University People's Hospital

BACKGROUND： Esophagogastric variceal hemorrhage is a life-threatening complication of portal hypertension. In this study, we compared the therapeutic effect of a novel surgi- cal procedure, esophagogastric devascularization without splenectomy （EDWS）, with the widely used modified esopha- gogastric devascularization （MED） with splenectomy for the treatment of portal hypertension.

关键词： portal hypertension esophagogastric devascularization without splenectomy portal vein system thrombosis

Ileo-colonic intussusception secondary to small-bowel lipomatosis:A case report

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World Journal of Gastroenterology 2014年第8期20卷 2117-2119页

作者： Peng-ji Gao Lei Chen Fu-Shun Wang ji-ye zhu Department of Hepatobiliary Surgery Peking University People’s Hospital

Intestinal lipomatosis is a rare disease with an incidence at autopsy ranging from 0.04% to 4.5%.Because the lipomas are diffusely distributed in the intestine,most patients are symptom-free,and invasive intervention is not advised by most ***,we describe a case with intussusception due to small-bowel *** small bowel resection and anastomosis were performed because the intestinal wall was on the verge of *** case indicates that regular followup is necessary and endoscopic treatment should be considered to avoid surgical procedures if the lipoma is large enough to cause intestinal obstruction.

关键词： Intussusception Lipomatosis Lipoma Obstruction Endoscopy

DEGREE ELEVATION AND KNOT INSERTION FOR GENERALIZED BEZIER SURFACES AND THEIR´APPLICATION TO ISOGEOMETRIC ANALYSIS

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Journal of Computational Mathematics 2024年第5期42卷 1197-1225页

作者： Mengyun Wang ye ji Chungang zhu School of Mathematical Sciences Dalian University of TechnologyDalian 116024China Key Laboratory for Computational Mathematics and Data Intelligence of Liaoning Province Dalian 116024China

Generalized B´ezier surfaces are a multi-sided generalization of classical tensor product B´ezier surfaces with a simple control structure and inherit most of the appealing properties from B´ezier ***,the original degree elevation changes the geometry of generalized B´ezier surfaces such that it is undesirable in many applications,*** *** this paper,we propose an improved degree elevation algorithm for generalized B´ezier surfaces preserving not only geometric consistency but also parametric *** on the knot insertion of B-splines,a novel knot insertion algorithm for generalized B´ezier surfaces is also *** the proposed algorithms are employed to increase degrees of freedom for multi-sided computational domains parameterized by generalized B´ezier surfaces in isogeometric analysis,corresponding to the traditional p-,h-,and *** examples demonstrate the effectiveness and superiority of our method.

关键词： Generalized B´ezier surface Degree elevation Knot insertion Isogeometric analysis Refinement

Estimating health damage cost from secondary sulfate particles—a case study of Hunan Province,China

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Journal of Environmental Sciences 2003年第5期15卷 611-617页

作者： HAO ji ming, LI ji, ye Xue mei, zhu Tian le (Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China. ) Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

China's coal dominated energy pattern has resulted in large amount of SO 2 emissions. Estimate of the sulfur related health damage cost is necessary to help perform systematic cost benefit analysis and set national energy and emissions control priorities. Current researches were confined to gaseous SO 2 in urban areas; however, secondary sulfate (SO 2- 4) particles can exert serious impact in a wider region. Based on the concept of “intake fraction', CALPUFF long range dispersion model and 180 sample emission sources, multiple regression equation was obtained with good correlation( r =0 85), which illustrates that populations were key parameters to determine intake fraction but source characteristics were insignificant. Based on the formula and the population distribution data, county level intake fractions were mapped for Hunan Province(range: 1 1×10 -6 -3 2×10 -6 ) of China. A combination of county level SO 2 emissions with the intake fractions yields a total 1 98 tons of sulfate(SO 2- 4) inhalation, and resulting total health damage cost to be 0 76(willingness to pay approach, WTP) or 0 16(human capital approach, HC) billion USD in 1997, about 2.1% or 0 45% of GDP in Hunan in 1997. Average health damage cost per ton of SO 2 emission is 930(WTP) or 200 USD(HC). The results demonstrated that more stringent regulation should be forced.

关键词： intake fraction health impact Hunan Province sulfate regression analysis

Risk Factors And Outcome of Pancreatic Fistula after Consecutive Pancreaticoduodenectomy with Pancreaticojejunostomy for Patients with Malignant Tumor

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Chinese Journal of Cancer Research 2010年第1期22卷 32-41页

作者： Wei-hua zhu Shu Li Da-fang Zhang ji-run Peng Zhong-tian jin Guang-ming Li Fu-shun Wang ji-ye zhu Xi-sheng Leng Department of Hepatobiliary surgery Peiking University People＇s Hospital Beijing 100044 China

Objective： Pancreatic fistula （PF） is a common complication after pancreaticoduodenectomy （PD） and there is no consensus regarding the criteria to define PF. The study was undertaken to determine the risk factors for PF according to the definition of the International Study Group on Pancreatic Fistula （ISGPF） and to delineate its impact on patient outcome. Methods： Between March 1994 and May 2009, data from 153 consecutive patients with malignant tumors underwent a PD with pancreaticojejunostomy in the Peking University People＇s Hospital were recorded prospectively A total of 24 factors were examined with univariate analysis and multivariate logistic regression analysis was used to estimate relative risks, and their 95% confidence intervals （95% CI） and odds ratio （OR）. Results： Our institution belonged to medium-volume center and PF occurred in 30 patients （19.6%）. Pancreatic texture, early postoperative hemorrhage and pancreatic pathologies correlated with PF rates significantly in univariate analyses. But in multivariate regression, soft gland （OR, 4.934; 95% CI, 1.132-7.312） and early postoperative hemorrhage with conservative therapy （OR, 4.130; 95% CI, 1.057-21.112） were predictive. The mean postoperative length of stay in patients with PF was longer （32.7±23.9 versus 60.5±56.2 days） than patients without PF （P=0.001）. Overall 30-day mortality was not affected by the development of PF （P=0.657）. There was no difference in reoperation rates between patients with and without PF （10.0% versus 6.5%, P=0.787）. Concerning the sum of postoperative complications, there were 36 complications for 30 patients with PF, while 64 for 123 patients without PF. When patients with distal cholangiocarcinoma, ampullary and duodenal cancer were considered as a whole for survival analysis, the median survival for patients with PF was 20 months, whereas the median survival for patients without PF was 26 months. Kaplan-Meier survival curves for patients with and without PF were not

关键词： Pancreatieoduodenectomy Pancreatic fistula Morbidity Mortality Surgical outcome

Overexpression of anillin is related to poor prognosis in patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2021年第4期20卷 337-344页

作者： Long-Hui Zhang Dong Wang Zhao Li Gang Wang Ding-Bao Chen Qian Cheng Shi-Hua Hu ji-ye zhu Department of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100044China Peking University Institute for Organ Transplantation Beijing 100044China Beijing Key Laboratory of Liver Cirrhosis and Liver Cancer Beijing 100044China Department of Pathology Peking University People’s HospitalBeijing 100044China

Background: Anillin(ANLN) is required for tumor growth. It has been proven that knockdown of ANLN effectively reduces the occurrence of hepatocellular carcinoma(HCC) in transgenic mice. However, the functional role of ANLN in HCC patients remains to be elucidated. Methods: Both microarray and TCGA project were used for the analyses of ANLN expression and regulation in HCC. The effect of ANLN on proliferation and cell cycle was detected by CCK-8, colony formation assay and flow cytometry. ANLN expression was measured by immunohistochemistry. Correlation between ANLN expression and clinicopathological features was assessed by Pearson Chi-square test and 5-year overall survival after liver resection was evaluated by Kaplan–Meier method. Results: Increased copy number, decreased methylation levels in the Cp G island and upregulated histone hypermethylation of ANLN were found in HCC. Knockdown of ANLN inhibited proliferation and induced G2/M phase arrest in SMMC-7721 cells. ANLN was mainly expressed in the nucleus and showed significantly higher expression levels in cancerous tissues than those in paired adjacent tissues. Moreover, nuclear ANLN expression levels in HCC metastases were significantly higher than those in primary HCC. The results of Cox proportional hazards regression model suggested that ANLN nuclear expression in HCC was an independent risk factor for poor 5-year overall survival of patients after liver resection. Conclusions: ANLN is a potential therapeutic target for HCC. Patients with nuclear ANLN overexpression in HCC tissue may need adjuvant therapy after liver resection.

关键词： Anillin DNA methylation Copy number variation Hepatocellular carcinoma Prognosis

Graft versus host disease after liver transplantation:A case report

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Frontiers of Medicine 2010年第4期4卷 469-472页

作者： Peng-ji GAO Xi-Sheng LENG Dong WANG Guang-Ming LI Lei HUANG jie GAO ji-ye zhu Center of Hepatobiliary Surgery Peking University People’s HospitalBeijing 100044China

In documenting clinical experience in the diagnosis and treatment of graft versus host disease(GVHD),we retrospectively analyzed data of one case that has developed GVHD after liver *** patient exhibited fever,skin rash,and diarrhea on day 9 after liver *** liver function was *** biopsy showed scattered keratinocytes accompanied by satellite-like lymphocyte inﬁltration and basal cell liquefaction *** carefully analyzing the complications,we took the strategy of decreasing the dose of ***,the patient’s temperature decreased to normal,his skin rashes subsided,and his diarrhea was *** case suggests that reducing the dosage of immunosuppressive agents can be an effective strategy for GVHD after liver transplantation.

关键词： liver transplantation graft versus host disease

Taiji-TianQin-LISA network:Precisely measuring the Hubble constant using both bright and dark sirens

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 59-77页

作者： Shang-jie jin ye-zhu Zhang ji-Yu Song jing-Fei Zhang Xin Zhang Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,TianQin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole binaries(MBHBs).In this work,we investigate the potential of GW standard sirens from the Taiji-TianQin-LISA network in constraining cosmological *** the optimistic scenario in which electromagnetic(EM)counterparts can be detected,we predict the number of detectable bright sirens based on three different MBHB population models,i.e.,popⅢ,Q3d,and *** results show that the TaijiTianQin-LISA network alone could achieve a constraint precision of 0.9%for the Hubble constant,meeting the standard of precision ***,the Taiji-TianQin-LISA network could effectively break the cosmological parameter degeneracies generated by the CMB data,particularly in the dynamical dark energy *** combined with the CMB data,the joint CMB+Taiji-TianQin-LISA data offerσ(w)=0.036 in the wCDM model,which is close to the latest constraint result obtained from the CMB+SN *** also consider a conservative scenario in which EM counterparts are not *** to the precise sky localizations of MBHBs by the Taiji-TianQin-LISA network,the constraint precision of the Hubble constant is expected to reach 1.2%.In conclusion,the GW standard sirens from the Taiji-TianQin-LISA network will play a critical role in helping solve the Hubble tension and shedding light on the nature of dark energy.

关键词： space-based gravitational wave detection standard sirens the Taiji-TianQin-LISA network the Hubble constant dark energy