检索结果-南通市图书馆

Journal of Integrative Plant Biology 2005年第11期47卷 1303-1314页

作者： Sheng-Chun XIAO Hong-Lang XIAO jian-Hua SI Xi-Bin ji Fa-min liu Cold and Arid Regions Environmental and Engineering Research Institute the Chinese Academy of Sciences Lanzhou 730000 China

Variation in water resources is a main factor influencing ecohydrological processes and sustainable development in arid regions. Lake level changes are a useful indicator of the variability in water resources. However, observational records of changes in lake levels are usually too short to give an understanding of the long-term variability. In the present study, we investigated the tree rings of shrubs growing on the lakeshore of Lake West-Juyan, the terminus of the Heihe River in western China, and found that Lake West-Juyan had undergone degradation three times over the past 200 years. The lake level decreased from 904.3 to 896.8 m above sea level （a.s.1.） during the period 1800-1900, to 892.0 m a.s.1, from around 1900 to the late 1950s, and the lake dried out in 1963. The trend for changes in lake levels, which was represented by the composite chronology of three beach bars, showed that the phases of increasing lake levels over the past 150 years were during the periods 1852-1871, 1932-1952, 1973-1982, and 1995-1999. Comparison with the history of regional economic development showed that human activity has played an important role in regulating the water resources of the lower reaches of the Heihe watershed over the past 200 years.

关键词： dendrochronology lake degradation events Lake West-Juyan lakeshore shrubs reconstruction of the lake level changes tamarisk.

Association between ADIPOQ gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 602-609页

作者： Chao Cen Hai-Xing Fang Song-Feng Yu ji-min liu Yuan-Xing liu Lin Zhou Jun Yu Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Key Laboratory of Combined Multi-organ TransplantationMinistry of Public HealthCollaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary Surgery the First People's Hospital of Fuyang Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster University

BACKGROUND:New-onset diabetes after transplantation(NODAT) has become one of the major factors that affect the overall survival and long-term life quality in liver transplantation(LT) recipients. Previous studies found that the serum adiponectin concentration of diabetic patients is significantly lower than that of healthy subjects. Adiponectin regulates the blood glucose level by increasing body sensitivity to insulin through various mechanisms. In this study, we aimed to investigate the impact of diabetes related gene polymorphisms on the development of NODAT in liver ***:A total of 256 LT patients in a single-center were selected retrospectively for the study. Genomic DNA was extracted from explanted liver tissues, and tested for twelve diabetes mellitus associated single nucleotide polymorphisms by Sequenom Mass ARRAY. Modified clinical models in predicting NODAT were established and ***:The GG genotype of ADIPOQ rs1501299 gene polymorphism was significantly more frequent in NODAT than non-NODAT LT patients(56% vs 39%, P=0.014). Dominant model(GG vs GT+TT, P=0.030) and recessive model(GT+GG vs TT, P=0.005) also confirmed the genotype distribution difference between NODAT and non-NODAT groups. Age(OR=1.048, P=0.004), BMI(OR=1.107, P=0.041), and blood tacrolimus level at 1-month LT(OR=1.170, P=0.003) were clinical independent risk factors of NODAT. Furthermore, rs1501299 could improve the ability of clinical model in predicting NODAT(AUROC=0.743, P<0.001).CONCLUSION:ADIPOQ rs1501299 gene polymorphism is associated with an increased risk of NODAT, which should be added to the clinical models in predicting the occurrence of NODAT in LT recipients.

关键词： ADIPOQ gene polymorphisms diabetes mellitus liver transplantation

Percutaneous liver biopsy： retrospective study of primary and secondary hepatic lymphoma in twenty-one patients

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 58-64页

作者： Yan-Feng Bai ji-min liu Xiu-ming Zhang Chao-Zhe jiang Xiao Xu Shu-Sen Zheng Department of Pathology the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Division of Hepatobiliary Pancreatic Surgery the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Department of Pathology and Molecular Medicine Faculty of Health Sciences McMaster University Hamilton L8S 4K1 Canada

BACKGROUND： Hepatic lymphoma （HL） is categorized as primary and secondary hepatic lymphoma （PHL and SHL）. This disorder can present as hepatic mass or mass-like lesion. Chemotherapy often is the first line treatment for patients with HL. Thus, an accurate pre-management histological diagnosis is essential to potentially improve clinical outcomes. The present study was to explore the prevalence of HL in ultrasound guided liver biopsies for hepatic mass or mass-like lesions, to investigate HL associated clinicopathological features, to raise the awareness of early recognition and proper diagnosis of this entity, and to assess specimen adequacy in needle core biopsy. METHODS： Twenty-one cases of HL were enrolled. Clinical and pathological characteristics were evaluated, quality of biopsies was assessed and pertinent literature was reviewed. RESULTS： HL was diagnosed in 0.94% of 2242 liver biopsy cases with ambiguous clinical presentation, laboratory tests and image studies. There were two cases of PHL （0.09%）, and nineteen cases of SHL （0.85%）. Histopathologically, diffuse large B-cell lymphoma was the most common type, followed by B-cell lymphoma not otherwise specified, T-ceU lymphoma, Hodgkin＇s lymphoma, and B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma. Additionally, three lym- phocytic infiltration patterns were documented microscopically. The nodular infiltration was the most common type. CONCLUSIONS： HL is a rare entity and histopathology along with ancillary tests remains the only way to make the ***＇ awareness of this entity and early liver biopsy are essential in patient management.

关键词： hepatic lymphoma primary and secondary percutaneous needle core biopsy

Gastrointestinal tract post-transplant lymphoproliferative disorder after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 556-558页

作者： Qin-Fen Xie Ping Chen Xin-Hua Chen ji-min liu Jan Lerut Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou) Hospital (Zhejiang University International Hospital) Hangzhou 310000 China Pancreatic Surgery and Department of Infectious Disease Shulan(Hangzhou) Hospital (Zhejiang University International Hospital) Hangzhou 310000 China Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China Department of Pathology and Molecular Medicine Faculty of Health Science McMaster UniversityHamilton Ontario Canada Starzl Unit of Abdominal Transplantation Université catholique Louvain (UCL) Brussels Belgium

To the Editor:Post-transplant lymphoproliferative disorder（PTLD）is a rare and potentially fatal complication occurring after all types of solid organ transplantation.;PTLD accounts for 20%of all de novo post-transplant tumors.;The most important risk factors for PTLD are prolonged intense immunosuppression and Epstein-Barr virus（EBV）

关键词： DLBCL EBV Gastrointestinal tract post-transplant lympho proliferative disorder after liver transplantation HBV MOP BPR GI OLT

Comparison and development of advanced machine learning tools to predict nonalcoholic fatty liver disease:An extended study

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 409-415页

作者： Yuan-Xing liu Xi liu Chao Cen Xin Li ji-min liu Zhao-Yan ming Song-Feng Yu Xiao-Feng Tang Lin Zhou Jun Yu Ke-jie Huang Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China College of Information Science and Electrical Engineering Zhejiang UniversityHangzhou 310027China Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster University1200 Main Street WestHamilton L8S 4K1Canada College of Computer Science and Technology Zhejiang UniversityHangzhou 310027China

Background:Nonalcoholic fatty liver disease(NAFLD)is a public health challenge and significant cause of morbidity and mortality *** identification is crucial for disease *** recently proposed a nomogram-based NAFLD prediction model from a large population *** aimed to explore machine learning tools in predicting ***:A retrospective cross-sectional study was performed on 15315 Chinese subjects(10373 training and 4942 testing sets).Selected clinical and biochemical factors were evaluated by different types of machine learning algorithms to develop and validate seven predictive *** evaluation indicators including area under the receiver operating characteristic curve(AUROC),area under the precision-recall curve(AUPRC),accuracy,positive predictive value,sensitivity,F1 score,Matthews correlation coefficient(MCC),specificity and negative prognostic value were applied to compare the performance among the *** selected clinical and biochemical factors were ranked according to the importance in prediction ***:Totally 4018/10373(38.74%)and 1860/4942(37.64%)subjects had ultrasound-proven NAFLD in the training and testing sets,*** machine learning based models were developed and demonstrated good performance in predicting *** these models,the XGBoost model revealed the highest AUROC(0.873),AUPRC(0.810),accuracy(0.795),positive predictive value(0.806),F1 score(0.695),MCC(0.557),specificity(0.909),demonstrating the best prediction ability among the built *** mass index was the most valuable indicator to predict NAFLD according to the feature ranking ***:The XGBoost model has the best overall prediction ability for diagnosing *** novel machine learning tools provide considerable beneficial potential in NAFLD screening.

关键词： Nonalcoholic fatty liver disease Machine learning Population screening Prediction model Body mass index

New-onset hyperglycemia immediately after liver transplantation:A national survey from China Liver Transplant Registry

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 310-315页

作者： Qing-Hong Ke Hai-Tao Huang Qi Ling ji-min liu Si-Yi Dong Xiang-Xiang He Wen-jin Zhang Shu-Sen Zheng Department of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Combined Multi-Organ Transplantation Ministry of Public HealthHangzhou 310003China Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster UniversityHamiltonON L8S 4L8Canada China Liver Transplant Registry Hangzhou 310003China

Background: New-onset hyperglycemia(NOH) is a common phenomenon after liver transplantation(LT),but its impact on clinical outcomes has not yet been fully assessed. We aimed to evaluate the etiology and prognosis of NOH within 1 month after ***: The data of 3339 adult patients who underwent primary LT from donation after citizen death between January 2010 and June 2016 were extracted from China Liver Transplant Registry database and analyzed. NOH was defined as fasting blood glucose ≥7.0 mmol/L confirmed on at least two occasions within the first post-transplant month with or without hypoglycemic ***: Of 3339 liver recipients, 1416(42.4%) developed NOH. Recipients with NOH had higher incidence of post-transplant complications such as graft and kidney failure, infection, biliary stricture, cholangitis,and tumor recurrence in a glucose concentration-dependent manner as compared to non-NOH recipients(P 10 min, cold ischemic time >10 h, anhepatic time >60 min, recipient model for end-stage liver disease score >30, moderate ascites and corticosteroid usage(P minotransferase and gammaglutamyltranspeptidase) on post-transplant day 7 significantly correlated with NOH(P < 0.001).Conclusions: NOH leads to increased morbidity and mortality in liver recipients. Close surveillance and tight control of blood glucose are desiderated immediately following LT particularly in those with delayed graft function and receiving corticosteroid. Strategic targeting graft ischemic injury may help maintain glucose homeostasis.

关键词： New-onset hyperglycemia Liver transplantation Surveillance Ischemic injury Homeostasis

Diode-pumped Q-switched Extra-cavity Frequency-dou bled Nd∶YVO_4/KTP Green Laser

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Semiconductor Photonics and Technology 2005年第3期11卷 166-169页

作者： YANG ji-min liu jie HE jing-liang College of Phys. and Electron. Shandong Normal University Jinan 250014 CHN

A diode-pumped acousto-op ti cal(A-O) Q-switched extra-cavity frequency-doubled Nd∶YVO_ 4/ KTP (KTiO PO_ 4) green laser formed with a simple plane-plane cavity has been demonst rated. With the incident pump power of 12.7 W, A-O Q-switched average output power at 1 064 nm was 3.81 W with a duration of 25 ns at a repetition rate of 20 kHz, extra-cavity frequency doubling with KTP as the nonlinear crystal y ielded the maximum output power of 1.92 W at 532 nm, the corresponding optical conversion efficiency from 1 064 nm to 532 nm light is 50.4%. The continuous -wave(CW) laser properties of diode-pumped Nd∶YVO_ 4 crystal operating at 1 064 nm have been studied. With the incident pump power of 25 W, the maximu m CW output power of 13.81 W was obtained with the corresponding optical conver sion efficiency of 55.24%.

关键词： Diode-pump A-O Q-switch Extra-cavity frequency-doubled Nd:YVO4

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高浓度游离氨冲击负荷对生物硝化的影响机制

环境科学 2017年第1期38卷 260-268页

作者：季民刘灵婕翟洪艳刘京苏晓天津大学环境科学与工程学院天津300350

工业废水厂或含工业废水较多的城市污水处理厂,在运行过程中可能会意外受到高浓度氨氮废水急性冲击负荷的影响,造成生物硝化反应受到抑制,出水不能稳定达标.为了指导实际污水处理厂应对游离氨(FA)急性冲击负荷造成的出水不达标问题,本... 详细信息

工业废水厂或含工业废水较多的城市污水处理厂,在运行过程中可能会意外受到高浓度氨氮废水急性冲击负荷的影响,造成生物硝化反应受到抑制,出水不能稳定达标.为了指导实际污水处理厂应对游离氨(FA)急性冲击负荷造成的出水不达标问题,本文探究高浓度氨氮废水对污水生物硝化系统的影响机制.本文利用序批式活性污泥反应器(SBR)处理模拟高氨氮废水,通过监测氨氮最大比降解速率、硝酸盐氮最大比生成速率、亚硝化和硝化比耗氧速率,硝化菌丰度等指标,研究高浓度氨氮废水中FA对硝化菌活性的影响规律.结果表明,FA在低浓度范围内,增加FA急性负荷能够促进硝化活性,而当FA急性冲击负荷大于一定值时,会对硝化作用造成抑制;FA浓度越大,受到抑制的硝化生物活性所需要的恢复周期越长.利用荧光原位杂交分析技术,发现当进水FA浓度(以N计)从3.6 mg·L^(-1)升高到8.1 mg·L^(-1)时,氨氧化菌(AOB)和亚硝酸盐氧化菌(NOB)菌群数量都略微升高,而当FA浓度大于8.1 mg·L^(-1)时,AOB和NOB菌群数量明显下降.FA对AOB和NOB菌群的临界抑制浓度分别为8.1 mg·L^(-1)和6.6 mg·L^(-1),NOB相对于AOB菌群更敏感.

关键词：高浓度氨氮废水硝化硝化菌抑制游离氨

Hangzhou criteria as downstaging criteria in hepatocellular ca

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Hepatobiliary & Pancreatic Diseases International 2020年第4期19卷 349-357页

作者： Qi-Fan Zhan Sun-Bin Ling Yi-Nan Deng Qiao-Nan Shan Qian-Wei Ye Sheng-Jun Xu Guang-jiang jiang Di Lu Xu-Yong Wei Li Zhuang Wu Zhang Tian Shen Bei-Ni Cen Hai-Yang Xie ji-min liu jian Wu Shu-Sen Zheng Yang Yang Xiao Xu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation Key Laboratory of the Diagnosis and Treatment of Organ TransplantationCAMSHangzhou 310003China Department of Hepatic Surgery and Liver Transplantation Center the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310000China Department of Pathology and Molecular Medicine Faculty of Health SciencesMcMaster UniversityHamiltonOntario L8S 4K1Canada

Background:The downstaging of hepatocellular carcinoma(HCC)has been confirmed to benefit liver transplantation(LT)patients whose tumors are beyond the transplantation *** criteria(MC),a tumor size and number-based assessment,is currently used as the endpoint in these ***,many studies believe that tumor biological behavior should be added to the evaluation criteria for downstaging ***,this study aimed to explore the feasibility of Hangzhou criteria(HC),which introduced tumor grading and alpha-fetoprotein in addition to tumor size and number,as an endpoint of ***:We performed a multicenter and retrospective study of 206 patients accepted locoregional therapy(LRT)as downstaging/bridge treatment prior to LT in three centers of ***:Recipients were divided into four groups:failed downstaging to the HC(group A,n=46),successful downstaging to the HC(group B,n=30),remained within the HC all the time(group C,n=113),and tumor progressed(group D,n=17).The 3-year HCC recurrence probabilities of groups B and C were not significantly different(10.3%vs.11.6%,P=0.87).The HCC recurrent rate was significantly higher in group A(52.3%)compared with that in group B/C(P<0.05).Seven patients(7/76,9.2%)whose tumor exceeded the the HC were successfully downstaged to the MC,and 39.5%(30/76)to the the *** group B,23 patients remained beyond the MC and their survivals were as well as those of patients within the ***:Compared to the MC,HC downstaging criteria can give more HCC patients access to LT and furthermore,the outcome of these patients is the same as those matching MC downstaging *** downstaging criteria therefore is applicable in clinical practice.

关键词： Hepatocellular carcinoma Liver transplantation Downstaging

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MTBE裂解制异丁烯分离工艺的研究

石油化工 2002年第8期31卷 638-640页

作者：周继东刘敏北京燕山石油化工公司研究院北京102500

对MTBE裂解制异丁烯分离工艺进行了研究 ,在分离实验的基础上 ,设计了前水洗和后水洗两种分离工艺流程 ,采用Aspenplus软件对这两种分离流程进行模拟。模拟结果表明 ,两种流程均能得到合格的异丁烯 ,两种分离工艺流程各有其特点。前水... 详细信息

对MTBE裂解制异丁烯分离工艺进行了研究 ,在分离实验的基础上 ,设计了前水洗和后水洗两种分离工艺流程 ,采用Aspenplus软件对这两种分离流程进行模拟。模拟结果表明 ,两种流程均能得到合格的异丁烯 ,两种分离工艺流程各有其特点。前水洗分离流程已成功地应用到多套MTBE裂解制异丁烯的工业生产装置中。

关键词： MTBE 裂解异丁烯分离工艺研究制备