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Chinese Journal of Chemistry 2024年第17期42卷 2029-2034页

作者： Zhi-Cheng Yu Xi shen You Zhou Xiang-long Chen Li-sheng Wang Yan-Dong Wu An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Centerfor Intelligent BiosensorTechnologyand HealthCollegeof ChemistryCentral ChinaNormal UniversityWuhanHubei 430079China

A[2+1+1+1]cyclization reaction has been developed for the synthesis of multisubstituted 6-pyrrolidinones from commercially available aryl methyl ketones,primary amines,and ethyl *** this I_(2)-DMSO-meditated process,the C-NO_(2) bond of ethyl nitroacetate is cleaved,affording a C1 synthon,and the formation of two C-C and two C-N bonds and a quaternary carbon center are constructed in one *** method has good substrate compatibility and permits the late-stage modification of pharmaceutical compounds.

关键词： Cyclization Multisubstituted 6-pyrrolidinones I_(2)-DMSO C1 building blocks Quaternary carbon center Late-stage modification Cracking

Simultaneous Bulk-and Surface-initiated Living Polymerization Studied with a Heterogeneous Stochastic Reaction Model

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Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： jia-Shu Ma Zhi-Ning Huang jia-Hao Li Bang-Ping jiang Yan-Da Liao Shi-Chen ji Xing-Can shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model Heterogeneous polymerization Simultaneous polymerization

Robotic-assisted low anterior resection for rectal cancer shows similar clinical efficacy to laparoscopic surgery: A propensity score matched study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1558-1570页

作者： shen-Xiang long Xin-Ning Wang Shu-Bo Tian Yu-Fang Bi shen-Shuo Gao Yu Wang Xiao-Bo Guo Department of Gastrointestinal Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Nursing The People’s Hospital of Zhangqiu AreaJinan 250200Shandong ProvinceChina Medical Center for Gastrointestinal Surgery Weifang People’s HospitalWeifang 261000Shandong ProvinceChina

BACKGROUND Rectal cancer ranks as the second leading cause of cancer-related mortality worldwide,necessitating surgical resection as the sole treatment *** the years,there has been a growing adoption of minimally invasive surgical techni-ques such as robotic and laparoscopic *** surgery represents an innovative modality that effectively addresses the limitations associated with traditional laparoscopic *** previous studies have reported favo-rable perioperative outcomes for robot-assisted radical resection in rectal cancer patients,further evidence regarding its oncological safety is still *** To conduct a comparative analysis of perioperative and oncological outcomes between robot-assisted and laparoscopic-assisted low anterior resection(LALAR)*** The clinical data of 125 patients who underwent robot-assisted low anterior resection(RALAR)and 279 patients who underwent LALAR resection at Shandong Provincial Hospital Affiliated to Shandong First Medical University from December 2019 to November 2022 were retrospectively *** performing a 1:1 propensity score matching,the patients were divided into two groups:The RALAR group and the LALAR group(111 cases in each group).Subsequently,a comparison was made between the short-term outcomes within 30 d after surgery and the 3-year survival outcomes of these two *** Compared to the LALAR group,the RALAR group exhibited a significantly earlier time to first flatus[2(2-2)d vs 3(3-3)d,P=0.000],as well as a shorter time to first fluid diet[4(3-4)d vs 5(4-6)d,P=0.001].Additionally,the RALAR group demonstrated reduced postoperative indwelling catheter time[2(1-3)d vs 4(3-5)d,P=0.000]and decreased length of hospital stay after surgery[5(5-7)d vs 7(6-8)d,P=0.009].Moreover,there was an observed increase in total cost of hospitalization for the RALAR group compared to the LALAR group[10777(10780-11850)dollars vs 10550(8766-11715)dollars,P=0.012].No signi

关键词： Rectal cancer Robotic surgical procedures Laparoscopy Low anterior resection Clinical efficacy

Rational design multi-color-emissive chemiluminescent carbon nanodots in a single solvothermal reaction

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Nano Research 2024年第6期17卷 4651-4660页

作者： Guang-Song Zheng Cheng-long shen Yuan Deng Kai-Kai Liu jin-Hao Zang Lin Dong Qing Lou Chong-Xin Shan Henan Key Laboratory of Diamond Optoelectronic Materials and Devices Key Laboratory of Materials PhysicsMinistry of Educationand School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China

Recently,the chemiluminescence(CL)induced by carbon nanodots(CDs)has intrigued researchers’extensive interests in various applications due to its special light emission ***,the difficulty of synthesizing chemiluminescent CDs with full-spectrum emission severely hinders the further regulation of the CL emission ***,the multi-color-emissive chemiluminescent CDs are rational designed and further synthesized by regulating the sp2-hybrid core and sp3-hybrid surface from the citrate-ammonia molecular in a single solvothermal *** experimental characterizations and density functional theory calculations reveal that the higher temperature can promote the crosslinking polymerization/carbonization of carbon core and the higher protonation of solvent can determine the core size of final CDs,resulting in the variant CL emission from molecular-,crosslinking-and ***,the CL emission of the CDs can be further synthesized by tuning the luminescence chromophores in the formation process via regulating the temperature and solvent,enabling the applications of the CL CDs in illumination and information *** study paves a new technology to understand the luminescence of CDs and affords an industry translational potential over traditional chemiluminescent molecular.

关键词： carbon nanodots chemiluminescence regulation energy level alignment mechanism

Occurrence,Spatial Distribution,Sources and Risk Assessment of Per-and Polyfluoroalkyl Substances in Surface Sediments of the Yellow River Delta Wetland

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Journal of Ocean University of China 2024年第5期23卷 1263-1274页

作者： SUN Yu shen Nan ZHANG Dahai CHEN Junhui HE Xiuping ji Yinli WANG Haiyang LI Xianguo Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China Key Laboratory of Marine Eco-Environmental Science and Technology First Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Qingdao Key Laboratory of Analytical Technology Development and Offshore Eco-Environment Conservation Qingdao 266061China The Yellow River Delta Sustainable Development Institute of Shandong Province Dongying 257100China

Per-and polyfluoroalkyl substances(PFASs)are emerging persistent organic pollutants(POPs).In this study,47 surface sediment samples were collected from the Yellow River Delta wetland(YRDW)to investigate the occurrence,spatial distribution,potential sources,and ecological risks of ***-three out of 26 targeted PFASs were detected in surface sediment samples from the YRDW,with totalΣ23PFASs concentrations ranging from 0.23 to 16.30 ng g^(-1) dw and a median value of 2.27 ng g^(-1) *** acid(PFOA),perfluorobutanoic acid(PFBA)and perfluorooctanesulfonic acid(PFOS)were the main *** detection frequency and concentration of perfluoroalkyl carboxylic acids(PFCAs)were higher than those of perfluoroal-kanesulfonic acids(PFSAs),while those of long-chain PFASs were higher than those of short-chain *** emerging PFASs substitutes were dominated by 6:2 chlorinated polyfluoroalkyl ether sulfonic acid(6:2 Cl-PFESA).The distribution of PFASs is significantly influenced by the total organic carbon content in the *** concentration of PFASs seems to be related to human activities,with high concentration levels of PFASs near locations such as beaches and *** using a positive matrix factorization model,the potential sources of PFASs in the region were identified as metal plating mist inhibitor and fluoropolymer manufacturing sources,metal plating industry and firefighting foam and textile treatment sources,and food packaging material *** risk assessment indicated that PFASs in YRDW sediments do not pose a significant ecological risk to benthic organisms in the region overall,but PFOA and PFOS exert a low to moderate risk at individual stations.

关键词： per-and polyfluoroalkyl substances Yellow River Delta wetland sediment source identification risk assessment

Ketogenic diet therapy in children with epilepsy caused by SLC2A1 mutations:a single-center single-arm retrospective study

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World Journal of Pediatrics 2024年第5期20卷 517-524页

作者： Ying-Yan Wang Yun-Qing Zhou Li-Juan Luo Cui-jin Wang Nan shen Hao Li ji-Wen Wang Department of Neurology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Clinical Research Ward Clinical Research CenterShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background This retrospective study assessed the efficacy and safety of ketogenic diet therapies in children with epilepsy caused by SLC2A1 genetic mutations and glucose transporter type 1 deficiency *** Pediatric patients with epilepsy symptoms admitted to our medical center between January 2017 and October 2021 were included if they presented with an SLC2A1 genetic mutation on whole-exome *** analyzed the patients’convulsions and treatment with antiepileptic *** patients were followed up at different time periods after ketogenic diet *** Six patients with SLC2A1 mutations were included in this *** patients had seizures of different types and frequencies,and they took antiepileptic drugs to relieve their *** were then treated with a ketogenic diet for at least four *** analyzed epilepsy control rates at 1,2,3,6,and 12 months after ketogenic diet *** patients were seizure-free within a month of receiving the diet *** patients were followed up for six months,three were followed up for 12 months after the treatment,and there was no recurrence of epilepsy during this *** antiepileptic drug withdrawal,none of the patients experienced seizure relapse when receiving ketogenic diet treatment *** severe adverse events occurred during the *** Ketogenic diet therapy is very effective and safe for the treatment of epilepsy caused by SLC2A1 ***,patients with glucose transporter type 1 deficiency syndrome caused by SLC2A1 mutations should begin ketogenic diet treatment as soon as possible.

关键词： Epilepsy Glucose transporter type 1 Ketogenic diet SLC2A1

Tandem hydroalkylation and deoxygenation of lignin-derived phenolics to synthesize high-density fuels

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Chinese Journal of Chemical Engineering 2024年第2期66卷 104-109页

作者： Rui Yu Zhensheng shen Yanan Liu Chengxiang Shi Juncong Qu Lun Pan Zhenfeng Huang Xiangwen Zhan g ji-Jun Zou Key Laboratory for Green Chemical Technology of Ministry of Education School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China Collaborative Innovative Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China

Lignin is the most abundant naturally phenolic biomass,and the synthesis of high-performance renewable fuel from lignin has attracted significant *** propose the efficient synthesis of high-density fuels using simulated lignin cracked oil in tandem with hydroalkylation and deoxygenation ***,we investigated the reaction pathway for the hydroalkylation of phenol,which competes with the hydrodeoxygenation form *** then,we investigated the effects of metal catalyst types,the loading amount of metallic,acid dosage,and reactant ratio on the reaction *** phenol hydroalkylation and hydrodeoxygenation were balanced when 180℃ and 5 MPa H_(2)with the alkanes yield of 95%.By extending the substrate to other lignin-derived phenolics and simulated lignin cracked oil,we obtained the polycyclic alkane fuel with high density of 0.918 g·ml^(-1)and calorific value of41.2 MJ·L^(-1).Besides,the fuel has good low-temperature properties(viscosity of 9.3 mm^(2)·s^(-1)at 20℃ and freezing point below-55℃),which is expected to be used as jet *** work provides a promising way for the easy and green production of high-density fuel directly from real lignin oil.

关键词： High-density fuel Biofuel Hydrogenation Alkylation Lignin Phenolics

Shared mooring systems for offshore floating wind farms: A review

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Energy Reviews 2024年第1期3卷 76-89页

作者： Hang Xu shengjie Rui Kanmin shen Liangliang jiang Haojie Zhang long Teng Zhejiang Key Laboratory of Offshore Geotechnics and Material College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Norwegian Geotechnical Institute Sandakerveien 140Oslo0484Norway PowerChina Huadong Engineering Corporation Limited Hangzhou311122China Department of Chemical and Petroleum Engineering The University of CalgaryCalgaryAlbertaCanada

Offshore wind energy,as a form of renewable power,has seen rapid development in recent *** fixedbottom wind turbines are typically used in water depths less than 50 m,the utilization of floating offshore wind turbines(FOWTs)becomes essential for deeper *** and effective mooring systems play a crucial role in making FOWTs commercially *** concept of a shared mooring system offers an innovative solution for deploying floating wind farms in clusters or arrays,which can reduce overall construction costs for large-scale floating wind *** is imperative to optimize the shared mooring arrangement for maximum cost-effectiveness and wind farm ***,implementing a shared mooring system introduces complexity to the dynamics of FOWTs,requiring the development of advanced simulation tools to meet modelling *** the shared mooring arrangement,mooring lines and anchors face more significant challenges,such as chain-seabed interactions,soil cyclic weakening,and anchor out-of-plane loading,which underscore the need for innovative,reliable,and efficient shared anchor *** article offers an overview of the current research status on shared mooring systems for floating wind farms,which might serve as a valuable reference for the construction of large-scale floating wind farms worldwide.

关键词： Floating offshore wind turbines Wind farm Shared mooring Shared anchor Renewable energy

Sahara’s surface transformation forced an abrupt hydroclimate decline and Neolithic culture transition in northern China

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The Innovation 2024年第1期5卷 70-79页

作者： Yandong Hou Hao long Sumiko Tsukamoto Zhengyao Lu jie Chen Daniel EIbarra Toru Tamura Qiong Zhang Weiyi Sun jingran Zhang Lei Gao Manfred Frechen ji shen State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of Sciences(NIGLAS)Nanjing 210008China Leibniz Institute for Applied Geophysics(LIAG) Department of Geochronology30655 HannoverGermany Department of Physical Geography and Ecosystem Science Lund University22100 LundSweden Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Institute at Brown for Environment and Society and Department of Earth Environmentaland Planetary SciencesBrown UniversityProvidenceRI 02912USA Geological Survey of Japan National Institute of Advanced Industrial Science and TechnologyTsukubaIbaraki 305-8567Japan Graduate School of Frontier Sciences University of TokyoKashiwaChiba 277-8561Japan Department of Physical Geography and Bolin Centre for Climate Research Stockholm University10691 StockholmSweden School of Geography Nanjing Normal UniversityJiangsu Centre for Collaborative Innovation in Geographical Information Resource Development and ApplicationKey Laboratory of Virtual Geographic EnvironmentMinistry of Education of ChinaNanjing 210023China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China

The remote forcing from land surface changes in the Sahara is hypothesized to play a pivotal role in modulating the intensity of the East Asian summer monsoon(EASM)through ocean-atmospheric *** modulation has far-reaching consequences,particularly in facilitating societal shifts documented in northern ***,we present a well-dated lake-level record from the Daihai Lake Basin in northern China,providing quantitative assessments of Holocene monsoonal precipitation and the consequent migrations of the northern boundary of the *** reconstruction,informed by a water-and-energy balance model,indicates that annual precipitation reached700 mm during 8–5 ka,followed by a rapid decline to tween 5 and 4 *** shift coherently aligns with a signi550 mm be-ficant300 km northwestward movement of the EASM northern boundary during the Middle Holocene(MH),in contrast to its current *** findings underscore that these changes cannot be entirely attributed to orbital forcing,as corroborated by simulation *** model simulations deployed in our study suggest that the presence of the Green Sahara during the MH significantly strengthened the EASM and led to a northward shift of the monsoon rainfall ***,the Sahara’s reversion to a desert landscape in the late Holocene was accompanied by a corresponding southward retraction of monsoon *** dramatic hydroclimate changes during5–4 ka likely triggered or at least contributed to a shift in Neolithic cultures and societal transformation in northern *** decreasing agricultural productivity,communities transitioned from millet farming to a mixed rainfed agriculture and animal husbandry ***,our findings elucidate not only the variability of the EASM but also the profound implications of a remote forcing,such as surface transformations of the Sahara,on climatic changes and cultural evolution in northern China.

关键词： Holocene monsoon abrupt

TREM-1 mediates interaction between substantia nigra microglia and peripheral neutrophils

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Neural Regeneration Research 2024年第6期19卷 1375-1384页

作者： Tong shen Guiyun Cui Hao Chen long Huang Wei Song jie Zu Wei Zhang Chuanying Xu Liguo Dong Yongmei Zhang jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs XuzhouJiangsu ProvinceChina Department of Neurology The Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Microglia-mediated neuroinflammation is considered a pathological feature of Parkinson's *** receptor expressed on myeloid cell-1(TREM-1)can amplify the inherent immune response,and crucially,regulate *** this study,we found marked elevation of serum soluble TREM-1 in patients with Parkinson's disease that positively correlated with Parkinson's disease severity and *** a mouse model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease,we found that microglial TREM-1 expression also increased in the substantia ***,TREM-1 knockout alleviated dyskinesia in a mouse model of Parkinson's disease and reduced dopaminergic neuronal ***,TREM-1 knockout attenuated the neuroinflammatory response,dopaminergic neuronal injury,and neutrophil ***,we established an in vitro 1-methyl-4-phenyl-pyridine-induced BV2 microglia model of Parkinson's disease and treated the cells with the TREM-1 inhibitory peptide *** found that LP17 treatment reduced apoptosis of dopaminergic neurons and neutrophil ***,inhibition of neutrophil TREM-1 activation diminished dopaminergic neuronal apoptosis induced by ***-1 can activate the downstream CARD9/NF-κB proinflammatory pathway via interaction with *** findings suggest that TREM-1 may play a key role in mediating the damage to dopaminergic neurons in Parkinson's disease by regulating the interaction between microglia and peripheral neutrophils.

关键词： 1-methyl-4-phenylpyridiniumion dopaminergic neurons infiltration 1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine microglia neutrophils neuroinflammation Parkinson's disease SYK TREM-1