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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee ji hun park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee Jeong-Yun Sun Jong Woong park Jae Ho Shin Myoung-Ryul Ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

Multiplexed electrospraying of water in cone-jet mode using a UV-embossed pyramidal micronozzle film

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Microsystems & Nanoengineering 2022年第5期8卷 247-256页

作者： ji-hun Jeong Kwangseok park Hyoungsoo Kim Inyong park jinyoung Choi Seung S.Lee Department of Mechanical Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea Department of Environmental Machinery Korea Institute of Machinery and MaterialsDaejeon 34103Republic of Korea Department of Mechanical Engineering Dongshin UniversityNaju 58245Republic of Korea

The electrospraying of water in the cone-jet mode is difficult in practical applications owing to its low throughput and the electrical discharge caused by the high surface tension of water.A film with multiple dielectric micronozzles is essential for multiplexed electrospraying of water in cone-jet mode without electrical ***,a pyramidal micronozzle film with five nozzles was fabricated using the UV-embossing *** pyramidal micronozzle film consisted of pyramidal micronozzles,a micropillar array,and an in-plane extractor,which were proposed to minimize wetting and concentrate the electric field to the water meniscus at the tip of the pyramidal *** electrospraying of water using a single pyramidal micronozzle was visualized by a high-speed camera at a flow rate of 0.15–0.50ml/h with voltages of 0.0–2.3 kV,−1.6 kV,and−4.0 kV at the water,guide ring,and collector,*** distinct modes,the dripping,spindle,and cone-jet modes,were observed and distinguished according to the motion of the water meniscus at the nozzle *** steady Taylor cone and jet were observed in a voltage range of 1.3–2.0 kV in water,particularly in cone-jet *** electrospraying of water in cone-jet mode at a flow rate of 1.5ml/h was performed using a pyramidal micronozzle film,demonstrating the potential for a high-throughput electrospraying system.

关键词： process. film pyramidal

Rhamnus crenata leaf extracts exhibit anti-inflammatory activity via modulating the Nrf2/HO-1 and NF-κB/MAPK signaling pathways

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Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 430-436页

作者： Hyun ji Eo Da Som Kim Gwang hun park Special Forest Resources Division Department of Forest Bio-ResourcesNational Institute of Forest ScienceSuwon 16631Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceYeongju 36040Korea

Objective:To elucidate the potential anti-inflammatory mechanisms of Rhamnus crenata leaf extracts using RAW264.7 ***:We used 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay to measure cell *** oxide(NO)production was measured using Griess *** blotting and RT-PCR assays were carried out for analyzing the protein and gene expressions of pro-inflammatory mediators,***,PD98059(ERK1/2 inhibitor),SB203580(p38 inhibitor),SP600125(JNK inhibitor),and BAY11-7082(NF-κB inhibitor)were used to evaluate the anti-inflammatory mechanism of Rhamnus crenata leaf ***:Rhamnus crenata leaf extracts significantly inhibited the production of the pro-inflammatory mediators such as NO,iNOS,COX-2,IL-1β,and TNF-αin lipopolysaccharide(LPS)-stimulated RAW264.7 *** crenata leaf extracts also suppressed LPS-induced degradation of IκB-αand nuclear accumulation of p65,which resulted in the inhibition of NF-κB activation in RAW264.7 ***,the extracts attenuated the phosphorylation of p38,ERK1/2,and JNK in LPS-stimulated RAW264.7 ***,HO-1 expression induced by Rhamnus crenata leaf extracts was significantly downregulated by SB230580,PD98059,SP600125 and ***:Rhamnus crenata leaf extract may upregulate HO-1 expression through inhibition of p38,ERK1/2,and NF-κB activation,which may contribute to the anti-inflammatory activity of the *** crenata leaf extracts may have great potential for the development of anti-inflammatory drugs to treat acute and chronic inflammatory diseases.

关键词： Anti-inflammatory activity Heme oxygenase-1 Nrf2 Mitogen-activated protein kinase Nuclear factor kappa B Rhamnus crenata

Observation of baroclinic eddies southeast of Okinawa Island

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Science China Earth Sciences 2008年第12期51卷 1802-1812页

作者： park Jae-hun Graduate School of Oceanography University of Rhode Island

In the region southeast of Okinawa, during May to July 2001, a cyclonic and an anticyclonic eddy were observed from combined measurements of hydrocasts, an upward-looking moored acoustic Doppler current profiler (MADCP), pressure-recording inverted echo sounders (PIESs), satellite altimetry, and a coastal tide gauge. The hydrographic data showed that the lowest/highest temperature (T) and salinity (S) anomalies from a 13-year mean for the same season were respectively ?3.0/+2.5°C and ?0.20/+0.15 psu at 380/500 dbar for the cyclonic/anticyclonic eddies. From the PIES data, using a gravest empirical mode method, we estimated time-varying surface dynamic height (D) anomaly referred to 2000 dbar changing from ?20 to 30 cm, and time-varying T and S anomalies at 500 dbar ranging through about ±2 and°C ±0.2 psu, respectively. The passage of the eddies caused variations of both satellite-measured sea surface height anomaly (SSHA) and tide-gauge-measured sea level anomaly to change from about ?20 to 30 cm, consistent with the D anomaly from the PIESs. Bottom pressure sensors measured no variation related to these eddy activities, which indicated that the two eddies were dominated by baro-clinicity. Time series of SSHA map confirmed that the two eddies, originating from the North Pacific Subtropical Countercurrent region near 20°–30°N and 150°–160°E, traveled about 3000 km for about 18 months with mean westward propagation speed of about 6 cm/s, before arriving at the region southeast of Okinawa Island.

关键词： baroclinic eddy southeast of Okinawa Island PIES ADCP

Integrated guidance and control for damping augmented system via convex optimization

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Chinese Journal of Aeronautics 2022年第7期35卷 30-39页

作者： Bong-Gyun park Tae-hun KIM The 1^(st)R&D Institute-4 Agency for Defense DevelopmentDaejeon 34186Republic of Korea

In this paper,an integrated guidance and control approach is presented to improve the performance of the missile *** approach includes damping augmented system with attitude rate feedback to decrease the oscillation during the homing phase for missiles with low *** addition,physical constraints,which can affect the performance of the missile interception,such as acceleration limit,seeker’s look angle,and look angle rate constraints are *** integrated guidance and control problem is formulated as a convex quadratic optimization problem with equality and inequality constraints,and the solution is obtained by a primal–dual interior point *** performance of the proposed method is verified through several numerical examples.

关键词： Convex optimization Damping augmented system Integrated guidance and control Physical constraint Primal-dual interior point method

Enhanced third-harmonic generation by manipulating the twist angle of bilayer graphene

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Light(Science & Applications) 2021年第2期10卷 176-185页

作者： Seongju Ha Nam hun park Hyeonkyeong Kim jiseon Shin Jungseok Choi Sungmin park ji-Yun Moon Kwanbyung Chae Jeil Jung Jae-Hyun Lee Youngdong Yoo ji-Yong park Kwang Jun Ahn Dong-Il Yeom Department of Energy Systems Research Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Korea Research Institute of Standards and Science Daejeon 34113Republic of Korea Department of Physics University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Smart Cities University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Materials Science and Engineering Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Chemistry Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Physics Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea

Twisted bilayer graphene(tBLG)has received substantial attention in various research fields due to its unconventional physical properties originating from Moire *** electronic band structure in tBLG modified by interlayer interactions enables the emergence of low-energy van Hove singularities in the density of states,allowing the observation of intriguing features such as increased optical conductivity and photocurrent at visible or near-infrared ***,we show that the third-order optical nonlinearity can be considerably modified depending on the stacking angle in *** third-harmonic generation(THG)efficiency is found to significantly increase when the energy gap at the van Hove singularity matches the three-photon resonance of incident *** study on electrically tuneable optical nonlinearity reveals that the gate-controlled THG enhancement varies with the twist angle in tBLG,resulting in a THG enhanced up to 60 times compared to neutral monolayer *** results prove that the twist angle opens up a new way to control and increase the optical *** tBLG,,suggesting rotation-induced tuneable nonlinear optics in stacked two-dimensional material systems.

关键词： twist angle harmonic

Decomposition of Nitrogen Trifluoride Using Low Power Arc Plasma

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Plasma Science and Technology 2013年第9期15卷 923-927页

作者： Jee-hun KO Sooseok CHOI Hyun-Woo park Dong-Wha park Department of Chemical Engineering and Regional Innovation Center for Environmental Technology of Thermal Plasma (RIC-ETTP)INHA University253 Yonghyun-dongNam-guIncheon 402-751Republic of Korea Department of Environmental Chemistry and Engineering Tokyo Institute of Technology 4259-G1-22Nagatsuta-choMidori-kuYokohama 226-8502Japan

The low power arc plasma is characterized by extremely high enthalpy and temper- ature and it is easy to generate and control, and thus thermal decomposition process based on the plasma torch is receiving a great attention for decomposing non-degradable greenhouse gases. In order to elevate the economic feasibility, the effects of input power, waste gas flow rate and additive gases on the destruction and removal efficiency （DRE） of NF3 are examined. Specific energy density （SED） deceases as the flow rate increases, and accordingly, the DRE is reduced. The DRE is basically determined by the specific energy density. The highest DRE of NF3 was 97% for the waste gas flow rate of 100 L/min at a low input power level of 2 kW with the help of hydrogen additional gas. The inlet and outlet concentration of NF3 was analyzed using Fourier transform infrared spectroscopy （FT-IR） for DRE of NF3 evaluation. As a result, large amount of NF3 can be efficiently decomposed by low power arc plasma systems.

关键词： arc plasma decomposition nitrogen trifluoride

Optimization of rotor shape for constant torque improvement and radial magnetic force minimization

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Journal of Central South University 2012年第2期19卷 357-364页

作者： CHO Gyu-won WOO Seok-hyun ji Seung-hun park Kyoung-won JANG Ki-bong KIM Gyu-tak School of Mechatronics Changwon National University

The design of notch and barrier was optimized in order to improve the characteristics of constant torque while minimizing the cogging torque that occurs as a result of teeth and slot structure. The barrier was installed in order to minimize the cogging torque and torque ripple by finite element method (FEM) with a reduced barrier width toward the center of magnetic pole. The position and width of notch, which can offset cogging torque, can be calculated with energy distribution of air-gap using Fourier series. The optimized model demonstrates a 60% decrease in the cogging torque, a 75.3% decrease in the torque ripple and a 3% increase in the operating torque when compared with the basic model.

关键词： permanent magnet synchronous motor barrier notch radial magnetic force cogging torque

Multidimensional Hybrid Architecture Encapsulating Cobalt Oxide Nanoparticles into Carbon Nanotube Branched Nitrogen-Doped Reduced Graphene Oxide Networks for Lithium–Sulfur Batteries

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Energy & Environmental Materials 2022年第2期5卷 555-564页

作者： Jeong Seok Yeon Young hun Ko Tae Ho park Hyunyoung park Jongsoon Kim Ho Seok park School of Chemical Engineering College of EngineeringSungkyunkwan University2066Seobu-roJangan-guSuwon-si Gyeonggi-do 440-746Korea Advanced Batteries Research Center Korea Electronics Technology Institute25Saenari-roBundang-guSeongnam-si Gyeonggi-do 13509Korea Department of Energy Science Sungkyunkwan University2066Seobu-roJangan-guSuwon-si Gyeonggi-do 440-746Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan University2066SeoburoJangan-guSuwon 440-746South Korea

Lithium–sulfur batteries(LSBs)are regarded as promising candidates for the next-generation energy storage devices owing to their high-theoretical capacity(1675 mAh g^(−1))and affordable ***,several limitations of LSBs such as the lithium polysulfide shuttle,large volume expansion,and low electrical conductivity of sulfur need to be resolved for practical *** address these limitations,herein,a multidimensional architectured hybrid(Co@CNT/nG),where Co_(3)O_(4) nanoparticles are encapsulated into threedimensional(3D)porous N-doped reduced graphene oxide interconnected with carbon nanotube(CNT)branches,is synthesized through a simple pyrolysis *** synergistic effect achieved through the homogeneously distributed and encapsulated Co_(3)O_(4) nanoparticles,the interconnected CNT branches,and the 3D hierarchical porous structure and N-doping of Co@CNT/nG significantly suppresses the shuttle effect of lithium polysulfides and enhances the conversion redox kinetics for the improved sulfur *** validate this effect through various measurements including symmetric cells,Li_(2)S nucleation,shuttle currents,Tafel slopes,diffusion coefficients,and post-mortem ***,Co@CNT/nG-70S-based LSB cells achieve a high-specific capacity of 1193.1 mAh g^(−1) at 0.1 C and a low capacity decay rate of 0.030%per cycle for 700 cycles at 5 C,delivering a high areal capacity of 5.62 mAh cm^(−2) even with a loading of 6.5 mg cm^(−2).

关键词： graphene/CNT hybrid lithium-sulfur batteries multidimensional architecture nanoparticle encapsulation redox promoter