检索结果-南通市图书馆

SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-Hong Ding fang Liu Shi-jie Chen Chen-Kai Huang Meng-chao Xiao Xia-Lu Hong Ming-Chen Wang fang-Zhi Yan Kai Ding Ya-Lu Cui Bai-Nan Zheng jin Ding Cheng Luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

Correction:Current overview on the genetic basis of key genes involved in soybean domestication

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

aBIOTECH 2024年第2期5卷 279-279页

作者： Sijia Lu chao fang Jun Abe Fanjiang Kong Baohui Liu Innovative Center of Molecular Genetics and Evolution School of Life SciencesGuangzhou UniversityGuangzhou 510006China Guangzhou Key Laboratory of Crop Gene Editing Guangzhou UniversityGuangzhou 510006China Research Faculty of Agriculture Hokkaido UniversitySapporoHokkaido 060-0808Japan

Correction:aBIOTECH(2022)3:126–139 https://***/10.1007/s42994-022-00074-5 The article‘‘Current overview on the genetic basis of key genes involved in soybean domestication’’,written by Sijia Lu,chao fang,Jun Abe,Fanjiang Kong and Baohui Liu,was originally published Online First without Open *** publication in volume 3,issue 2,pages 126–139 the authors decided to opt for Open Choice and to make the article an Open Access ***,the copyright of the article has been changed to The Authors 2024 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were made.

关键词： soybean Open Access

Pancreatic panniculitis as the first presentation of pancreatic ductaladenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 106-108页

作者： Wei-fang Zhu Shan fang jian-Jun Qiao Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Pancreatic panniculitis,also known as pancreatic fat necrosis or enzymatic panniculitis,is a rare type of panniculitis that occurs in 0.3%−3%of patients with pancreatic disease such as acute or chronic pancreatitis and pancreatic carcinoma,especially acinar cell carcinoma[1,2].The clinical manifestations are nonspecific erythema tender nodules.

关键词： Pancreatic acute adenocarcinoma

Nociceptors and Macrophages in Bacterial Meningitis:Partners in Crime?

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2024年第3期40卷 418-420页

作者： fang Gao Hongzhen Hu The Kimberly and Eric J.Waldman Department of Dermatology Icahn School of Medicine at Mount SinaiNew York NY10029USA The Nash Family Department of Neuroscience Icahn School of Medicine at Mount SinaiNew York NY10029USA The Mark Lebwohl Center for Neuroinfammation and Sensation Icahn School of Medicine at Mount SinaiNew York NY10029USA Friedman Brain Institute Icahn School of Medicine at Mount SinaiNew York NY10029USA

Bacterial meningitis is a serious and potentially life-threatening infection that affects the protective layers surrounding the brain and spinal cord,known as the *** types of bacteria,including Streptococcus pneumoniae,Neisseria meningitidis,and Haemophilus influenzae,can cause this *** populations,such as infants,children,immunocompromised adults,and the elderly,are particularly vulnerable to these *** of bacterial meningitis can manifest suddenly and may include high fever,severe and persistent headache,stiff neck,vomiting,sensitivity to light,and confusion or changes in mental state[1,2].Identifying these symptoms in infants can be more challenging and may lead to long-term disability or death[3].Despite the effectiveness of vaccines,it is crucial to understand how bacteria invade the brain and how our innate immune system responds to infection(Fig.1).

关键词： protective infection suddenly

Borohydride Ammoniate Solid Electrolyte Design for All-Solid-State Mg Batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Energy & Environmental Materials 2024年第1期7卷 104-110页

作者： Yuepeng Pang Zhengfang Nie Fen Xu Lixian Sun Junhe Yang Dalin Sun fang fang Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and Technology Guangxi Key Laboratory of Information Materials & Guangxi Collaborative Innovation Centre of Structure and Property for New Energy and Materials Guilin University of Electronic Technology Department of Materials Science Fudan University

Searching for novel solid electrolytes is of great importance and challenge for all-solid-state Mg *** this work, we develop an amorphous Mg borohydride ammoniate,Mg（BH4）2·2NH3,as a solid Mg electrolyte that prepar... 详细信息

关键词： all-solid-state Mg batteries amorphization Mg borohydride ammoniate Mg vacancy migration solid electrolyte

Multimodal Dependence Attention and Large-Scale Data Based Offline Handwritten Formula Recognition

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2024年第3期39卷 654-670页

作者：刘汉超董兰芳张信明 School of Computer Science and Technology University of Science and Technology of ChinaHefei 230022China CCF IEEE

Offline handwritten formula recognition is a challenging task due to the variety of handwritten symbols and two-dimensional formula ***,the deep neural network recognizers based on the encoder-decoder frame-work have achieved great improvements on this ***,the unsatisfactory recognition performance for formulas with long LTeX strings is one shortcoming of the existing ***,lacking sufficient training data also limits the capability of these *** this paper,we design a multimodal dependence attention(MDA)module to help the model learn visual and semantic dependencies among symbols in the same formula to improve the recognition perfor-mance of the formulas with long LTeX *** alleviate overfitting and further improve the recognition performance,we also propose a new dataset,Handwritten Formula Image Dataset(HFID),which contains 25620 handwritten formula images collected from real *** conduct extensive experiments to demonstrate the effectiveness of our proposed MDA module and HFID dataset and achieve state-of-the-art performances,63.79%and 65.24%expression accuracy on CROHME 2014 and CROHME 2016,respectively.

关键词： handwritten formula recognition multimodal dependence attention semantic dependence visual dependence Handwritten Formula Image Dataset

A comparison of statistical learning of naturalistic textures between DCNNs and the human visual hierarchy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2024年第8期67卷 2310-2318页

作者： LU XinCheng YUAN ZiQi ZHANG YiChi AI HaiLin CHENG SiYuan GE YiRan fang fang CHEN NiHong Department of Psychological and Cognitive Sciences Tsinghua UniversityBeijing 100084China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084China Department of Computer Science and Technology Tsinghua UniversityBeijing 100084China School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health Peking UniversityBeijing 100871China Key Laboratory of Machine Perception(Ministry of Education) Peking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Peking UniversityBeijing 100871China IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China State Key Laboratory of Brain and Cognitive Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China

The visual system continuously adapts to the statistical properties of the environment. Existing evidence shows a close resemblance between deep convolutional neural networks(CNNs) and primate visual stream in neural selectivity to naturalistic textures above the primary visual processing stage. This study delves into the mechanisms of perceptual learning in CNNs,focusing on how they assimilate the high-order statistics of natural textures. Our results show that a CNN model achieves a similar performance improvement as humans, as manifested in the learning pattern across different types of high-order image statistics. While L2 was the first stage exhibiting texture selectivity, we found that stages beyond L2 were critically involved in learning. The significant contribution of L4 to learning was manifested both in the modulations of texture-selective responses and in the consequences of training with frozen connection weights. Our findings highlight learning-dependent plasticity in the mid-to-high-level areas of the visual hierarchy. This research introduces an AI-inspired approach for studying learning-induced cortical plasticity, utilizing DCNNs as an experimental framework to formulate testable predictions for empirical brain studies.

关键词： CNN perceptual learning naturalistic texture psychophysics

Compatibility evaluation between waterborne epoxy resin and SBR latex modified asphalt emulsion

在线全文

学校读者我要写书评

暂无评论

Journal of Traffic and Transportation Engineering(English Edition) 2024年第1期11卷 160-171页

作者： jianhua Yang Zhengqi Zhang Ying fang Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang'an UniversityXi'an 710064China

Good compatibility between waterborne epoxy resin(WER)modifier and styrene-butadiene rubber(SBR)latex modified asphalt emulsion(SBRE)is an essential premise for good pavement performance of WER and SBR latex compositely modified asphalt emulsion(WSAE).This study aims to explore the compatibility between WER modifier and *** achieve the goal,several WER modifiers produced by two methods were first selected to modify SBRE,thus the WSAEs were ***,storage stability and workability of the WSAEs themselves,and high-temperature performance,rheological behavior and temperature sensitivity of their evaporated residues were compared and evaluated via performing a series of experiments,respectively,thus the WER modifier possessing an optimal modification effect was *** show that the storage stability of WSAEs is sensitive to the amount of *** incorporation of 1%WERs by the mass of SBRE improves the storage stability of SBRE,while WERs that exceed 1%weaken its storage *** the WERs reach 3%and 4%,the 5 d storage stability of prepared WSAEs will be beyond the limitation of *** WERs into SBRE negatively affects the workability of SBRE,and the workability of WSAEs is adversely influenced by the WERs content and the storage *** ensure the construction,the WSAEs with 3%and 4%WERs should not be stored for more than 36 h and 48 h,*** WERs effectively improve the high-temperature performance of SBRE residue,especially the 3%***,the WERs notably enhance the rheological property and thermal stability of SBRE *** contrast,the WER modifier produced by chemically modified method has a smaller adverse impact on the storage stability and workability of WSAE,and a larger enhancement on the high-temperature performance,rheological property and thermal stability of SBRE residue,which is thus recommended to modify SBRE.

关键词： Waterborne epoxy resin SBR modified asphalt emulsion Workability Rheological property Temperature sensitivity Compatibility evaluation

AI enhances drug discovery and development

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第3期11卷 52-54页

作者： fang Bai Shiliang Li Honglin Li Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech University Lingang Laboratory Innovation Center for AI and Drug Discovery East China Normal University

The advent of the third wave of artificial intelligence(AI) heralds a new era in drug discovery. AI-powered techniques can be characteristic of identifying features that are difficult for humans to interpret from big ...

关键词：