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Chinese Science Bulletin 2002年第8期47卷 647-653页

作者： CHEN Weiru FENG yingjin LIU jiangkuang ZHANG Haili GUO ying ZHANG Yan DUAN Shiying PENG Xintao SUN Tianping jiA Baoshan ZHAO Junxian LI hua Department of Aeromedicine Civil Aviation University of ChinaTianjin 300300China College of Medicine Nankai UniversityTianjin 300071China Xinjiang Aviaton Company Urumuqi 830016China

This study looks into the influence of cosmic radiation at high altitudes on human bodies. Results reveal that the cytokinesis-block micronuclei (CBMN) and conventional cultured micronuclei in peripheral blood lymphocytes, serum levels of lipid peroxide, superoxide dismutase, and the total antioxidation capacity by chemical colorimetry all increased significantly in aircrew members. There exists a linear relationship between the CBMN and the average annual effective doses of radiation received or the average annual flying hours. With both of them, a trend shows that the serum lipid peroxide levels increase as well. Either the lipid peroxide or CBMN can sensitively reflect the recent changes in flight load. These findings indicate that cosmic radiation impairs the stability of chromosomes and genome, and induces lipid oxidative damage in aircrews; Lymphocyte CBMN and serum lipid peroxide can be used as monitoring indicators in the cosmic radiation protection for aircrew members.

关键词： cosmic radiation aircrew micronucleus lipid peroxide antioxidation capacity.

上海市宝山区中小学生超重肥胖与视力不良流行趋势及其相关性研究

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国际医药卫生导报 2024年第20期30卷 3503-3508页

作者：麦依依黄爱益赵海磊李光萍吉伟罗颖孙秀丽戎芬上海中医药大学公共健康学院流行病与卫生统计学教研室上海201203 上海中医药大学公共健康学院预防医学教研室上海201203 上海市宝山区中西医结合医院健康管理中心上海201999 上海中医药大学图书馆(杂志社) 上海201203

目的了解2013—2019年上海市宝山区中小学生超重肥胖和视力不良流行趋势及其相关性,为预防中小学生超重肥胖和视力不良提供依据。方法基于2013—2019年上海市宝山区中小学生体检数据,选取资料完整的507993名中小学生作为研究对象,其中男... 详细信息

目的了解2013—2019年上海市宝山区中小学生超重肥胖和视力不良流行趋势及其相关性,为预防中小学生超重肥胖和视力不良提供依据。方法基于2013—2019年上海市宝山区中小学生体检数据,选取资料完整的507993名中小学生作为研究对象,其中男269327人(53.0%)、女238666人(47.0%),小学330621人(65.0%)、初中131796人(25.9%)、高中45576人(8.9%)。分析中小学生超重肥胖和视力不良流行趋势及其相关性,趋势分析采用趋势卡方检验,组间比较采用Kruskal-Wallis H检验。结果2013—2019年中小学生超重肥胖和视力不良检出率均呈上升趋势(均P<0.001)。小学生超重肥胖率[35.47%(117272/330621)]高于初中生[31.88%(42010/131796)]和高中生[27.39%(12485/45576)](P<0.001),男生超重肥胖率[40.37%(108725/269327)]高于女生[26.41%(63042/238666)](P<0.001)。高中生视力不良率[89.13%(40623/45576)]高于小学生[51.08%(168877/330621)]和初中生[79.72%(105065/131796)](P<0.001),女生视力不良率[64.02%(155191/238666)]高于男生[59.17%(159374/269327)](P<0.001)。小学生超重/肥胖者中度视力不良检出率较高[20.19%(11173/55343)、20.73%(12833/61919)],初中生和高中生超重/肥胖者重度视力不良检出率较高[初中生:51.70%(11790/22804),49.31%(9471/19206);高中生:69.86%(5422/7761),68.88%(3254/4724)]。结论2013—2019年上海市宝山区中小学生超重肥胖和视力不良检出率呈上升趋势,且超重肥胖与视力不良存在相关性,应采取综合防控措施。

关键词：中小学生超重肥胖视力不良上海市宝山区调查

Mapping and genetic validation of a grain size QTL qGS7.1 in rice(Oryza sativa L.)

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Journal of Integrative Agriculture 2019年第8期18卷 1838-1850页

作者： XUE Pao ZHANG ying-xin LOU Xiang-yang ZHU Ai-ke CHEN Yu-yu SUN Bin YU Ping CHENG Shi-hua CAO Li-yong ZHAN Xiao-deng Zhejiang Key Laboratory of Super Rice Research/State Key Laboratory of Rice Biology/China National Rice Research Institute Hangzhou 310006 P.R.China Nanchong Academy of Agricultural Sciences Nanchong 637000 P.R. China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 P.R.China Institute of Crop Breeding and Cultivation Shanghai Academy of Agricultural Sciences Shanghai 201403 P.R.China

Grain size is a major determinant of grain weight, which is one of the components of rice yield. The objective o this study was to identify novel, and important quantitative trait loci(QTLs) for grain size and weight in rice. QTLs were mapped using a BC4F4 population including 192 backcross inbred lines(BILs) derived from a backcross between Xiaolijing(XLJ) and recombinant inbred lines(RILs). The mapping population was planted in both Lingshui(Hainan, 2015) and Fuyang(Zhejiang, 2016), with the short-and long-day conditions, respectively. A total of 10 QTLs for grain length, four for grain width, four for the ratio of grain length to width, and 11 for grain weight were detected in at least one environment and were distributed across 11 chromosomes. The phenotypic variance explained ranged from 6.76–25.68%, 14.30–34.03%, 5.28–26.50%, and 3.01–22.87% for grain length, grain width, the ratio of grain length to width, and thousand grain weight, respectively. Using the sequential residual heterozygotes(SeqRHs) method, qGS7.1, a QTL for grain size and weight, was mapped in a 3.2-Mb interval on chromosome 7. No QTLs about grain size and weight were reported in previous studies in this region, providing a good candidate for functional analysis and breeding utilization.

关键词： rice (Oryza sativa L.) quantitative trait loci grain size grain weight residual heterozygote

Os DXR interacts with Os MORF1 to regulate chloroplast development and the RNA editing of chloroplast genes in rice

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Journal of Integrative Agriculture 2023年第3期22卷 669-678页

作者： CAO Peng-hui WANG Di GAO Su LIU Xi QIAO Zhong-ying XIE Yu-lin DONG Ming-hui DU Tan-xiao ZHANG Xian ZHANG Rui ji jian-hui Institute of Agricultural Sciences in Taihu Area of jiangsu Suzhou 215155P.R.China huaiyin Institute of Agricultural Sciences of Xuhuai Region in jiangsu Huai’an 223001P.R.China School of Life Sciences Huaiyin Normal UniversityHuai’an 223300P.R.China Key Laboratory of Eco-Agricultural Biotechnology around Hongze Lake Regional Cooperative Innovation Center for Modern Agriculture and Environmental ProtectionHuaiyin Normal UniversityHuai’an 223300P.R.China

Plant chlorophyll biosynthesis and chloroplast development are two complex processes that are regulated by exogenous and endogenous factors. In this study, we identified OsDXR, a gene encoding a reductoisomerase that positively regulates chlorophyll biosynthesis and chloroplast development in rice. OsDXR knock-out lines displayed the albino phenotype and could not complete the whole life cycle process. OsDXR was highly expressed in rice leaves, and subcellular localization indicated that OsDXR is a chloroplast protein. Many genes involved in chlorophyll biosynthesis and chloroplast development were differentially expressed in the OsDXR knock-out lines compared to the wild ***, we found that the RNA editing efficiencies of ndhA-1019 and rpl2-1 were significantly reduced in the OsDXR knock-out lines. Furthermore, OsDXR interacted with the RNA editing factor OsMORF1 in a yeast two-hybrid screen and bimolecular fluorescence complementation assay. Finally, disruption of the plastidial 2-C-methyl-derythritol-4-phosphate pathway resulted in defects in chloroplast development and the RNA editing of chloroplast genes.

关键词： rice OsDXR Chloroplast development RNA editing OsMORF1

艾普拉唑肠溶片不同给药方案对其抑制胃酸分泌影响的研究

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中国临床药理学杂志 2024年第1期40卷 92-96页

作者：庞廷媛王芷胡姊姝申子涵王悦琦陈雅倩钱学兵梁锦莹易良英李俊龙韩智慧钟国平程国华胡海棠广州医科大学附属肿瘤医院药学部广东广州510095 东莞康华医院临床试验研究中心广东东莞523080 暨南大学药学院广东广州511400 丽珠医药集团股份有限公司广东珠海519090 中山大学临床药理研究所广东广州510080

目的比较艾普拉唑肠溶片2种给药方案(20 mg qd和10 mg bid)对健康受试者的胃酸控制效果的影响。方法采用随机、单中心、平行对照试验设计,纳入8例健康受试者。随机分为2组,20 mg qd给药组:早上服用艾普拉唑肠溶片20 mg;10 mg bid给药组... 详细信息

目的比较艾普拉唑肠溶片2种给药方案(20 mg qd和10 mg bid)对健康受试者的胃酸控制效果的影响。方法采用随机、单中心、平行对照试验设计,纳入8例健康受试者。随机分为2组,20 mg qd给药组:早上服用艾普拉唑肠溶片20 mg;10 mg bid给药组:早、晚各服用艾普拉唑肠溶片10 mg。用pH计监测受试者给药前及给药后24 h的胃内pH值,用液质联用技术(HPLC-MS/MS)测定受试者给药后血浆中的艾普拉唑浓度,用Phoenix WinNonlin(V8.0)软件计算主要药代动力学参数。结果空腹组的艾普拉唑肠溶片受试制剂和参比制剂主要PK参数:20 mg qd组和10 mg bid组Cmax分别为(595.75±131.15)和(283.50±96.98)ng·mL^(-1),AUC0-t分别为(5531.94±784.35)和(4686.67±898.23)h·ng·mL^(-1),AUC0-∞分别为(6003.19±538.59)和(7361.48±1816.77)h·ng·mL^(-1)。受试者接受20 mg qd与10 mg bid给药后胃内pH>3的平均时间百分比为82.64%及61.92%,24 h内胃pH中位数分别为6.25±1.49及3.53±2.05,24 h内胃pH平均数分别为5.71±1.36及4.23±1.45。同时药代动力学/药效学相关性分析表明,血浆中药物峰浓度与抑酸作用没有明显相关性。结论艾普拉唑20 mg qd与10 mg bid给药组相比,抑酸效果更优,给药次数少,且2种给药方案安全性均良好。

关键词：艾普拉唑中国健康受试者胃酸pH监测药代动力学

Acceleration feedback control (AFC) enhanced by disturbance observation and compensation (DOC) for high precision tracking in telescope systems

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Research in Astronomy and Astrophysics 2016年第8期16卷 51-60页

作者： Qiang Wang hua-Xiang Cai Yong-Mei huang Liang Ge Tao Tang Yan-Rui Su Xiang Liu jin-ying Li Dong He Sheng-Ping Du Yu Ling Institute of Optics and Electronics Chinese Academy of Sciences Chengdu 610209 China Key Laboratory of Optical Engineering Chinese Academy of Sciences Chengdu 610209 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

Abstract In this paper, a cascade acceleration feedback control （AFC） enhanced by a disturbance observa- tion and compensation （DOC） method is proposed to improve the tracking precision of telescope systems. Telescope systems usually suffer some uncertain disturbances, such as wind load, nonlinear friction and other unknown disturbances. To ensure tracking precision, an acceleration feedback loop which can in- crease the stiffness of such a system is introduced. Moreover, to further improve the tracking precision, we introduce the DOC method which can accurately estimate the disturbance and compensate it. Furthermore, the analysis of tracking accuracy used by this method is proposed. Finally, a few comparative experimental results show that the proposed control method has excellent performance for reducing the tracking error of a telescope system.

关键词： telescopes -- instrumentation control method - instrumentation miscellaneous high angularresolution - instrumentation detector -- control software

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基于相关系数特性的实时匹配算法

光学技术 2008年第S1期34卷 100-102页

作者：魏继华伏思华二炮装备研究院北京100085 国防科技大学长沙410073

提出了一种高精度的快速匹配算法。其基本思想是根据相关系数矩阵的特性来动态改变相关搜索步长的。对于已知目标特性和点扩展函数的情况,求出其理想情况下的相关系数矩阵函数,确定可信阈值和搜索步长;对于不知道目标特性和点扩展函数... 详细信息

提出了一种高精度的快速匹配算法。其基本思想是根据相关系数矩阵的特性来动态改变相关搜索步长的。对于已知目标特性和点扩展函数的情况,求出其理想情况下的相关系数矩阵函数,确定可信阈值和搜索步长;对于不知道目标特性和点扩展函数的情况,通过相关系数矩阵拟合函数或简单变步长法来确定可信阈值和搜索步长。在得到相关系数最大值后,拟合得到亚像素定位精度。与一般相关方法比较,该方法具有定位精度高、稳健性强和运算速度快等优点。

关键词：信息光学模板匹配亚像素点扩展函数相关系数

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两类分包供应模式的激励机制

上海交通大学学报 2005年第10期39卷 1627-1630页

作者：王卫华季建华上海交通大学安泰管理学院上海200052

针对分包供应的合作关系模式和一般交易关系模式的不同特点,对不同制度安排对供应商的激励效果进行了研究.结果表明,采用双供应商的激励效果优于采用单供应商的激励效果.而对关系持续期和信息交流的影响分析发现,当合作关系中得到的额... 详细信息

针对分包供应的合作关系模式和一般交易关系模式的不同特点,对不同制度安排对供应商的激励效果进行了研究.结果表明,采用双供应商的激励效果优于采用单供应商的激励效果.而对关系持续期和信息交流的影响分析发现,当合作关系中得到的额外信息足够准确时,采用合作关系的长期合约激励更优;当额外信息不准确时,采用一般交易关系的合约激励更优.

关键词：分包激励机制合作关系一般交易关系

Dynamic changes and surveillance function of prion protein expression in gastric cancer drug resistance

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World Journal of Gastroenterology 2011年第35期17卷 3986-3993页

作者： ji-Heng Wang jing-Ping Du ying-Hai Zhang Xiao-Jun Zhao Ru-ying Fan Zhi-Hong Wang Zi-Tao Wu ying Han Department of Gastroenterology Beijing Army General Hospital Beijing 100700 China Department of General Surgery Jiamusi University Medical College Jiamusi 154004 Heilongjiang Province China

AIM:To explore the dynamic changes of prion protein (PrPc) in the process of gastric cancer drug resistance and the role of PrPc expression in the prognosis of gastric cancer patients receiving ***:A series of gastric cancer cell lines resistant to different concentrations of adriamycin was established,and the expression of PrPc,Bcl-2 and Bax was detected in these *** was determined using Annexin V *** blotting and immunohisto-chemistry were performed to detect the expression of PrPc in patients receiving chemotherapy and to explore the role of PrPc expression in predicting the chemosensitivity and the outcome of gastric cancer patients receiving ***-up was performed for 2 ***:PrPc expression was increased with the increase in drug ***-2,together with PrPc,increased the level of anti-apoptosis of cancer *** PrPc expression predicted the enhanced level of anti-apoptosis and resistance to anticancer *** expression could be used as a marker for predicting the efficacy of chemotherapy and the prognosis of gastric *** PrPc expression predicted both poor chemosensitivity and a low 2-year survival ***,low PrPc expression predicted favorable chemosensitivity and a relatively high 2-year survival ***:PrPc expression is associated with histological types and differentiation of gastric cancer cells;The PrPc expression level might be a valuable marker in predicting the efficacy of chemotherapy and the prognosis of gastric cancer patients receiving chemotherapy.

关键词： Prion protein Gastric cancer Drug resistance Chemotherapy Apoptosis

氨甲环酸在关节置换术和关节镜手术围术期中的应用现状

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中国临床药理学杂志 2024年第7期40卷 1080-1084页

作者：元宝华柳海平李兴勇刘晓婷马继海张旭升杨昊飞李金生韩升龙甘肃中医药大学中医临床学院甘肃兰州730030 甘肃省中医院关节骨一科甘肃兰州730030 甘肃省人民医院骨三科甘肃兰州730030

氨甲环酸在关节骨科手术应用较广,同时具有较高的安全性和极少的药物不良反应,可以有效改善术中出血,促进患者早期功能恢复。本文通过氨甲环酸在关节置换术与关节镜手术围术期中的给药方式、安全剂量、给药时间、药物不良反应等方面进... 详细信息

氨甲环酸在关节骨科手术应用较广,同时具有较高的安全性和极少的药物不良反应,可以有效改善术中出血,促进患者早期功能恢复。本文通过氨甲环酸在关节置换术与关节镜手术围术期中的给药方式、安全剂量、给药时间、药物不良反应等方面进行综述,以期为氨甲环酸的临床应用提供参考。

关键词：氨甲环酸关节置换术关节镜手术围手术期药物