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International Journal of Ophthalmology(English edition) 2014年第6期7卷 935-940页

作者： Seong-Jae Kim Hwajin Kim Jeongsook Park Inyoung Chung Hyug-Moo kwon Wan-Sung Choi ji-Myong Yoo Department of Ophthalmology School of MedicineGyeongsang National University Institute of Health Science Gyeongsang National University Department of Anatomy and Neurobiology BK21 Biomedical CenterSchool of MedicineGyeongsang National University School of Nano-Bioscience and Chemical Engineering Ulsan National Institute and Science and Technology

AIM: To study the contribution of tonicity response element binding protein(Ton EBP) in retinal ganglion cell(RGC) death of diabetic retinopathy(DR).METHODS: Diabetes was induced in C57BL/6 mice by five consecutive intraperitoneal injections of 55 mg/kg streptozotocin(STZ). Control mice received vehicle(phosphate-buffered saline). All mice were killed 2mo after injections, and the extent of cell death and the protein expression levels of Ton EBP and aldose reductase(AR) were ***: The Ton EBP and AR protein levels and the death of RGC were significantly increased in the retinas of diabetic mice compared with controls 2mo after the induction of diabetes. Terminal deoxynucleotidyl transferase(Td T)-mediated d UTP nick end labeling(TUNEL)-positive signals co-localized with Ton EBP immunoreactive RGC. These changes were increased in the diabetic retinas compared with ***: The present data show that AR and Ton EBP are upregulated in the DR and Ton EBP may contribute to apoptosis of RGC in the DR.

关键词： aldose reductase diabetes tonicity response element binding protein retinopathy

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4223-4234页

作者： Yeong-Bin Baek Hyung-Jun kwon Muhammad Sharif Jeongah Lim In-Chul Lee Young Bae Ryu Jae-In Lee ji-Sun Kim Young-Seung Lee Dong-Hoon Kim Sang-Ik Park Don-Kyu Kim Jeong-Sun Kim Hyon EChoy Sunwoo Lee Hueng-Sik Choi Timothy FOsborne Tae-Il Jeon Kyoung-Oh Cho Laboratory of Veterinary Pathology College of Veterinary MedicineChonnam National UniversityGwangju61186Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Chemistry Chonnam National UniversityGwangju61186Republic of Korea Korean Collection for Type Cultures Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Animal Science Chonnam National UniversityGwangju61186Republic of Korea Department of Pharmacology Korea University College of MedicineSeoul02841Republic of Korea Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju61186Republic of Korea Department of Microbiology Chonnam National University Medical SchoolGwangju61486Republic of Korea School of Biological Sciences and Technology Chonnam National UniversityGwangju61186Republic of Korea Institute for Fundamental Biomedical Research Department of Medicine and Biological ChemistryJohns Hopkins University School of MedicineSt.PetersburgFL33701USA

The biosynthesis of host lipids and/or lipid droplets(LDs)has been studied extensively as a putative therapeutic target in diverse viral ***,directly targeting the LD lipolytic catabolism in virus-infected cells has not been widely ***,we show the linkage of the LD-associated lipase activation to the breakdown of LDs for the generation of free fatty acids(FFAs)at the late stage of diverse RNA viral infections,which represents a broad-spectrum antiviral *** of membrane transporter systems due to virus-induced cell injury results in intracellular malnutrition at the late stage of infection,thereby making the virus more dependent on the FFAs generated from LD storage for viral morphogenesis and as a source of *** replication of SARS-CoV-2 and influenza A virus(IAV),which is suppressed by the treatment with LD-associated lipases inhibitors,is rescued by supplementation with *** administration of lipase inhibitors,either individually or in a combination with virus-targeting drugs,protects mice from lethal IAV infection and mitigates severe lung lesions in SARS-CoV-2-infected ***,the lipase inhibitors significantly reduce proinflammatory cytokine levels in the lungs of SARS-CoV-2-and IAV-challenged animals,a cause of a cytokine storm important for the critical infection or mortality of COVID-19 and IAV *** conclusion,the results reveal that lipase-mediated intracellular LD lipolysis is commonly exploited to facilitate RNA virus replication and furthermore suggest that pharmacological inhibitors of LD-associated lipases could be used to curb current COVID-19-and future pandemic outbreaks of potentially troublesome RNA virus infection in humans.

关键词： linkage furthermore thereby

Immunomodulatory nanodiamond aggregate-based platform for the treatment of rheumatoid arthritis

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Regenerative Biomaterials 2019年第3期6卷 163-174页

作者： Amanda Pentecost Min Ju Kim Sangmin Jeon Young ji Ko Ick Chan kwon Yury Gogotsi Kwangmeyung Kim Kara L.Spiller Department of Materials Science and Engineering College of EngineeringDrexel UniversityPhiladelphiaPAUSA School of Biomedical Engineering Scienceand Health SystemsDrexel UniversityPhiladelphiaPAUSA KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Biomedical Research Institute Center for TheragnosisKorea Institute of Science and TechnologySeoulSouth Korea

We previously demonstrated that octadecylamine-functionalized nanodiamond(ND-ODA)and dexamethasone(Dex)-adsorbed ND-ODA(ND-ODA–Dex)promoted anti-inflammatory and proregenerative behavior in human macrophages in *** this study,we performed a pilot study to investigate if these immunomodulatory effects translate when used as a treatment for rheumatoid arthritis in *** local injection in limbs of mice with collagen type II-induced arthritis,microcomputed tomography showed that mice treated with a low dose of ND-ODA and ND-ODA–Dex did not experience bone loss to the levels observed in non-treated arthritic controls.A low dose of ND-ODA and ND-ODA–Dex also reduced macrophage infiltration and expression of proinflammatory mediators iNOS and tumor necrosis factor-a compared to the arthritic control,while a high dose of ND-ODA increased expression of these ***,these results suggest that ND-ODA may be useful as an inherently immunomodulatory platform,and support the need for an in-depth study,especially with respect to the effects of dose.

关键词： drug delivery nanobiomaterials biomaterial–cell interaction

Estimated prevalence and trends in smoking among adolescents in South Korea,2005-2021:a nationwide serial study

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World Journal of Pediatrics 2023年第4期19卷 366-377页

作者： Hyoin Shin Sangil Park Hyunju Yon Chae Yeon Ban Stephen Turner Seong Ho Cho Youn Ho Shin Jung U.Shin Ai Koyanagi Louis Jacob Lee Smith Chanyang Min Young Joo Lee So Young Kim jinseok Lee Rosie kwon Min ji Koo Guillaume Fond Laurent Boyer Jong Woo Hahn Namwoo Kim Sang Youl Rhee Jae Il Shin Ho Geol Woo Hyeowon Park Hyeon jin Kim Yoonsung Lee Man S.Kim Eléa Lefkir Vlasta Hadalin Jungwoo Choi Seung won Lee Dong Keon Yon Sunyoung Kim Department of Medicine Kyung Hee University College of MedicineSeoulSouth Korea Department of Neurology Kyung Hee University College of MedicineSeoulSouth Korea Maternity and Child Health Division NHS Grampian AberdeenAberdeenUK Division of Allergy-Immunology University of South Florida Morsani College of MedicineTampaFLUSA Department of Pediatrics CHA Gangnam Medical CenterCHA University School of MedicineSeoulSouth Korea Department of Dermatology CHA Bundang Medical CenterCHA University School of MedicineSeongnamSouth Korea Research and Development Unit Parc Sanitari Sant Joan de DeuCIBERSAMISCIIIBarcelonaSpain Catalan Institution for Research and Advanced Studies(ICREA) Pg.Lluis CompanysBarcelonaSpain Faculty of Medicine University of Versailles Saint-Quentin-en-YvelinesMontigny-Le-BretonneuxFrance Centre for Health Performance and WellbeingAnglia Ruskin UniversityCambridgeUK Center for Digital Health Medical Science Research InstituteKyung Hee University Medical CenterKyung Hee University College of Medicine23 Kyungheedae-RoDongdaemun-GuSeoul02447South Korea Department of Obstetrics and Gynecology Kyung Hee University College of MedicineSeoulSouth Korea Department of Otorhinolaryngology-Head and Neck Surgery CHA Bundang Medical CenterCHA University School of MedicineSeongnamSouth Korea Department of Biomedical Engineering Kyung Hee UniversityYonginSouth Korea Department of Biomedical Engineering University of MichiganAnn ArborMIUSA Department of Human Biology University of TorontoTorontoONCanada AP-HM Aix-Marseille Univ.CEReSS—Health Service Research and Quality of Life CenterMarseilleFrance FondaMental Foundation CreteilFrance Department of Pediatrics Seoul National University College of MedicineSeoulSouth Korea Department of Neuropsychiatry Seoul National University College of MedicineSeoulSouth Korea Department of Endocrinology and Metabolism Kyung Hee University School of MedicineSeoulSouth Korea Department of Pediatrics Yonsei University College of

Background Although smoking is classified as a risk factor for severe COVID-19 outcomes,there is a scarcity of studies on prevalence of smoking during the COVID-19 ***,this study aims to analyze the trends of prevalence of smoking in adolescents over the COVID-19 pandemic *** The present study used data from middle to high school adolescents between 2005 and 2021 who participated in the Korea Youth Risk Behavior Web-based Survey(KYRBS).We evaluated the smoking prevalence(ever or daily)by year groups and estimated the slope in smoking prevalence before and during the *** A total of 1,137,823 adolescents participated in the study[mean age,15.04 years[95%confidence interval(CI)15.03-15.06];and male,52.4%(95%CI 51.7-53.1)].The prevalence of ever smokers was 27.7%(95%CI 27.3-28.1)between 2005 and 2008 but decreased to 9.8%(95%CI 9.3-10.3)in 2021.A consistent trend was found in daily smokers,as the estimates decreased from 5.4%(95%CI 5.2-5.6)between 2005 and 2008 to 2.3%(95%CI 2.1-2.5)in ***,the downward slope in the overall prevalence of ever smokers and daily smokers became less pronounced in the COVID-19 pandemic period than in the pre-pandemic *** the subgroup with substance use,the decreasing slope in daily smokers was significantly more pronounced during the pandemic than during the pre-pandemic *** The proportion of ever smokers and daily smokers showed a less pronounced decreasing trend during the *** findings of our study provide an overall understanding of the pandemic's impact on smoking prevalence in adolescents.

关键词： Adolescent COVID-19 Daily smokers Ever smokers Pandemic Smoking

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马来西亚传统与补充医学监管二十年及其影响

亚太传统医药 2022年第4期18卷 1-4页

作者： ji-Eun Park Junhyeok Yi Ohmin kwon 韩国东方医学研究所全球合作中心韩国大田韩国东方医学研究所韩国传统医学政策小组韩国大田韩国韩医学研究所韩医学数据部韩国大田

目的:从马来西亚传统与补充医学(T&CM)纳入国家医疗保健系统(NHS)的案例中汲取政策成果和经验教训。方法:通过在数据库和网站搜索文献,并使用滚雪球抽样技术保护数据信息,根据世界卫生组织卫生系统框架对数据进行分类和整理。结果:马来... 详细信息

目的:从马来西亚传统与补充医学(T&CM)纳入国家医疗保健系统(NHS)的案例中汲取政策成果和经验教训。方法:通过在数据库和网站搜索文献,并使用滚雪球抽样技术保护数据信息,根据世界卫生组织卫生系统框架对数据进行分类和整理。结果:马来西亚一直致力于传统医学安全和质量的管理,通过制定法律以及循序渐进推进政策和措施的方法将T&CM制度化。结论:马来西亚在实施T&CM政策的经验将对那些正在努力将传统医学纳入NHS的国家产生深远的影响。

关键词：传统与补充医学东盟马来西亚整合制度化世界卫生组织卫生系统框架

Duodenal obstruction after successful embolization for duodenal diverticular hemorrhage: A case report

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World Journal of Gastroenterology 2009年第30期15卷 3819-3822页

作者： Yu jin kwon ji Hun Kim Seung Hyoung Kim Bong Soo Kim Heung Up Kim Eun Kwang Choi In Ho Jeong Department of Surgery Seoul National University College of Medicine28 Yeongeon-dongSeoul 110-744South Korea Department of Surgery Ajou University School of MedicineSan-5WonchondongYeongtongguSuwon 442-749South Korea Department of radiology Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of internal medicine Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea Department of surgery Jeju National University School of Medicine1753-3Ara 1-DongJeju 690-121South Korea

We present a 69-year-old woman with a duodenal obstruction after successful selective transcatheter arterial embolization (TAE) for a duodenal diverticular hemorrhage. Two weeks after TAE, the patient showed abrupt symptoms of duodenal obstruction. Resolving hematomas after successful selective transcatheter arterial embolization should be thoroughly observed because they might result in duodenal fibrotic encasement featuring inflammatory duodenal wall thickening, duodenal deformity, dysmotility, and fi nally obstruction.

关键词：十二指肠肠梗阻栓塞病例报告出血运动障碍肝动脉纤维化

Gender differences in clinical outcomes of acute myocardial infarction undergoing percutaneous coronary intervention: insights from the KAMIR-NIH Registry

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Journal of Geriatric Cardiology 2020年第11期17卷 680-693页

作者： Myunhee Lee Dae-won Kim Mahn-won Park Kyusup Lee Kiyuk Chang Wook Sung Chung Tae Hoon Ahn Myung Ho Jeong Seung-Woon Rha Hyo-Soo Kim Hyeon Cheol Gwon In Whan Seong Kyung Kuk Hwang Shung Chull Chae kwon-Bae Kim Young Jo Kim Kwang Soo Cha Seok Kyu Oh Jei Keon Chae ji-Hoon Jung 无 KAMIR-NIH registry investigators Division of Cardiology Daejeon St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Division of Cardiology Seoul St.Mary’s hospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Gachon University Gil Medical CenterIncheonSouth Korea Chonnam National University Hospital GwangjuSouth Korea d Korea University Korea University Guro Hospital SeoulSouth Korea Seoul National University Hospital SeoulSouth Korea Sungkyunkwan Universtiy Samsung Medical CenterSeoulSouth Korea Chungnam National University Hospital DaejeonSouth Korea Chungbuk National University Hospital CheongjuSouth Korea Kyungpook National University Hospital DaeguSouth Korea Keimyung University Dongsan Medical Center DaeguSouth Korea Yeungnam University Hospital DaeguSouth Korea Pusan National University Hospital BusanSouth Korea wonkwang University Hospital IksanSouth Korea Chonbuk National University Hospital JeonjuSouth Korea Institute of Toxicology DaejeonSouth Korea 不详

Background There are numerous but conflicting data regarding gender differences in outcomes following percutaneous coronary intervention(PCI). Furthermore, gender differences in clinical outcomes with acute myocardial infarction(AMI) following PCI in Asian population remain uncertain because of the under-representation of Asian in previous trials. Methods A total of 13,104 AMI patients from Korea Acute Myocardial Infarction Registry-National Institute of Health(KAMIR-NIH) between November 2011 and December 2015 were classified into male(n = 8021, 75.9%) and female(n = 2547, 24.1%). We compared the demographic, clinical and angiographic characteristics, 30-days and 1-year major adverse cardiac and cerebrovascular events(MACCE) in women with those in men after AMI by using propensity score(PS) matching. Results Compared with men, women were older, had more comorbidities and more often presented with non-ST segment elevation myocardial infarction(NSTEMI) and reduced left ventricular systolic function. Over the median follow-up of 363 days, gender differences in both 30-days and 1-year MACCE as well as thrombolysis in myocardial infarction minor bleeding risk were not observed in the PS matched population(30-days MACCE: 5.3% vs. 4.7%, log-rank P = 0.494, HR = 1.126, 95% CI: 0.800-1.585;1-year MACCE: 9.3% vs. 9.0%, log-rank P = 0.803, HR = 1.032, 95% CI: 0.802-1.328;TIMI minor bleeding: 4.9% vs. 3.9%, log-rank P = 0.215, HR = 1.255, 95% CI: 0.869-1.814). Conclusions Among Korean AMI population undergoing contemporary PCI, women, as compared with men, had different clinical and angiographic characteristics but showed similar 30-days and 1-year clinical outcomes. The risk of bleeding after PCI was comparable between men and women during one-year follow up.

关键词： Acute myocardial infarction Asian population Gender difference Percutaneous coronary intervention

Reduction of gastrointestinal motility by unilateral thyroparathyroidectomy plus subdiaphragmatic vagotomy in rats

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World Journal of Gastroenterology 2012年第33期18卷 4570-4577页

作者： Jun Ho Lee Oh Deog kwon Seon Ho Ahn Keun Han Choi ji Hye Park Seoul Lee Bong Kyu Choi Kyu Yong Jung Department of Pharmacology Wonkwang University School of Medicine Jeonbuk 570-749 South Korea Department of Clinical Pathology College of Veterinary Medicine Kyungpook National University Daegu 702-701 South Korea Department of Internal Medicine Wonkwang University School of Medicine Jeonbuk 570-749 South Korea

AIM: To investigate whether the combined methods of unilateral thyroparathyroidectomy (TPX) and subdiaphragmatic vagotomy (VAX) can be adapted for rats and used as a reliable method to produce a rat model of long-term reduction of gastrointestinal (GI) motor function. METHODS: Male Sprague-Dawley rats were randomly divided into 3 groups, normal, sham-operated and unilateral TPX plus VAX. The TPX plus VAX rats received VAX 7 d after application of TPX, and dietary intake and fecal output were then measured daily for 1 *** completion of the experiments, gastric emptying and small bowel transit were measured in vivo, and the contractile responses of colonic strips to excitatory and inhibitory neurotransmitters were estimated using isometric force transducers in vitro. RESULTS: In comparison with normal and sham-operated rats, rats which received unilateral TPX plus VAX showed a significant decrease in body weight and in fecal pellet number and weight throughout the entire week. Application of TPX plus VAX to rats markedly delayed gastric emptying and small bowel transit. In TPX plus VAX rats, the longitudinal muscles of the proximal colon showed a significant reduction in contractile responses to acetylcholine (5 × 10-6 mol/L), and a dramatic attenuation of contractile responses was also observed in both the longitudinal and circular muscles of the distal colon. However, the spontaneous contractility of the colonic strips from TPX plus VAX rats was not significantly affected by treatment with N-nitro-Larginine-methyl ester (0.1 mol/L). CONCLUSION: The results indicate that unilateral TPX plus VAX reduced the motor function of the GI tract in rats, and the reduced gut motility is likely mediated, at least in part, by inhibition of the excitatory neurotransmitter system.

关键词：大鼠模型迷走神经胃肠道胃蠕动单方兴奋性神经递质抑制性神经递质 VAX

Krill oil ameliorates benign prostatic hyperplasia by regulating G-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers

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Food Science and Human Wellness 2023年

作者： Hoon Kim Jongyeob Kim Byungdoo Hwang Sang Yong Park ji-Yeon Shin Eun Byeol Go Jae Sil Kim Youngjin Roh Soon Chul Myung Seok-Joong Yun Yung Hyun Choi Wun-Jae Kim Sung-kwon Moon Department of Biochemistry College of Oriental Medicine Dongeui University Institute of Urotech Cheongju Department of Urology Chungbuk National University Cheongju SD Biotechnologies 66 Magojungang 8-ro 1-gil Gangseo-gu Department of Food and Nutrition Chung-Ang University Department of Urology College of Medicine Chung-Ang University

Krill oil (KO) exhibits various biological activities， such as anti-inflammatory and antitumor effects. However， the inhibitory effects of benign prostatic hyperplasia (BPH) in vitro and in vivo have not yet been studied. This study investigated the anti-BPH effects of KO extracted by an enzymatic hydrolysis method. KO treatment inhibited the proliferation of WMPY-1 and BPH-1 cells by induction of G0/G1phase arrest through the modulation of positive and negative regulators in both prostate cell types. KO treatment stimulated phosphorylation of JNK and p38 signaling. In addition， KO changed the expression of BPH-related markers (5α-reductase， androgen receptor， FGF， Bcl-2， and Bax) and the activity of the proliferation-mediated NF-κB binding motif. KO-induced levels of proliferation-mediated molecules of prostate cells were attenuated in the presence of siRNA-specific p-38 (si-p38) and JNK (si-JNK). Furthermore， the administration of KO alleviated prostate size and weight and the cell layer thickness of prostate glands in a testosterone enanthate-induced BPH rat model. KO treatment altered the level of dihydrotestosterone in serum and the expression levels of BPH-related markers in prostate tissues. Finally， KO-mediated inhibition of prostatic growth was validated by histological analysis. These results suggest that KO has an inhibitory effect on BPH in prostate cells in vitro and in vivo. Thus， KO might be a potential prophylactic or therapeutic agent for patients with BPH.

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Treatment for gastric ‘indefinite for neoplasm/dysplasia' lesions based on predictive factors

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World Journal of Gastroenterology 2019年第4期25卷 469-484页

作者： Mi Jung kwon Ho Suk Kang Hyeon Tae Kim jin Woo Choo Bo Hyun Lee Sung Eun Hong Kun Ha Park Dong Min Jung Hyun Lim Jae Seung Soh Sung Hoon Moon Jong Hyeok Kim Hye-Rim Park Soo Kee Min jin won Seo ji-Young Choe Department of Pathology Hallym University Sacred Heart Hospital Hallym University College of Medicine Department of Internal Medicine Hallym University Sacred Heart Hospital

BACKGROUND Gastric ‘indefinite for neoplasm/dysplasia'(IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal *** To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND *** In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection(n = 134), surgery(n = 22), and follow-up endoscopic biopsy(n = 305) were performed to confirm the *** time interval from initial biopsy to cancer diagnosis was measured, and diagnostic delays were categorized as > 2 wk, > 2 mo, > 6 mo, and > 1 year. The IFND lesions presenting as regenerating atypia(60%) or atypical epithelia(40%)at initial biopsy were adenocarcinomas in 22.6%, adenomas in 8.9%, and gastritis in 68.5% of the *** Four clinical factors [age ≥ 60 years(2.445, 95%CI: 1.305-4.580, P = 0.005),endoscopic size ≥ 10 mm(3.519, 95%CI: 1.891-6.548, P < 0.001), single lesion(5.702, 95%CI: 2.212-14.696, P < 0.001), and spontaneous bleeding(4.056, 95%CI:1.792-9.180, P = 0.001)], and two pathologic factors [atypical epithelium(25.575,95%CI: 11.537-56.695, P < 0.001], and repeated IFND diagnosis [6.022, 95%CI:1.822-19.909, P = 0.003)] were independent risk factors for gastric cancer. With two or more clinical factors, the sensitivity and specificity for carcinoma were91.3% and 54.9%, respectively. Ten undifferentiated carcinomas were initially diagnosed as IFND. In the subgroup analysis, fold change(5.594, 95%CI: 1.458-21.462, P = 0.012) predicted undifferentiated or invasive carcinoma in the submucosal layers or deeper. Diagnostic delays shorter than 1 year were not associated with worse prognoses. Extremely well-differentiated adenocarcinomas accounted for half of the repeate

关键词： Gastric cancer Biopsy Endoscopic surgical procedure Diagnostic delay Prognosis