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Clinical outcomes of endoscopic papillectomy of ampullary adenoma: A multi-center study

World Journal of Gastroenterology 2022年第17期28卷 1845-1859页

作者： Seong ji Choi Hong Sik lee jiyeong Kim Jung Wan Choe Jae Min lee Jong jin Hyun Jai hoon Yoon Hyo Jung Kim Jae Seon Kim Ho Soon Choi Department of Internal Medicine Hanyang University College of MedicineSeoul 04763South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University College of MedicineSeoul 02841South Korea Lab of Biostatistical Consulting and Research Medical Research Collaborating CenterIndustry-University Cooperation FoundationHanyang UniversitySeoul 04763South Korea

BACKGROUND Ampullary adenoma is a rare premalignant lesion,but its incidence is *** papillectomy has become the first treatment of choice for ampullary adenomas due to its safety and effectiveness,thereby replacing surgical ***,recurrence rates and adverse events after endoscopic papillectomy were reported in up to 30%of *** To review the long-term outcomes of endoscopic papillectomy and investigate the factors that affect these *** We retrospectively analyzed the data of patients who underwent endoscopic papillectomy for ampullary adenoma at five tertiary hospitals between 2013 and *** evaluated clinical outcomes and their risk *** definitions of outcomes were as follow:(1)curative resection:complete endoscopic resection without recurrence;(2)endoscopic success:treatment of ampullary adenoma with endoscopy without surgical intervention;(3)early recurrence:reconfirmed adenoma at the first endoscopic surveillance;and(4)late recurrence:reconfirmed adenoma after the first endoscopic *** A total of 106 patients were included for *** the included patients,81(76.4%)underwent curative resection,99(93.4%)had endoscopic success,showing that most patients with noncurative resection were successfully managed with *** patients(15.1%)had piecemeal resection,22 patients(20.8%)had shown positive/uncertain resection margin,11 patients(16.1%)had an early recurrence,13 patients(10.4%)had a late recurrence,and 6 patients(5.7%)had a *** multivariate analysis,a positive/uncertain margin[Odds ratio(OR)=4.023,P=0.048]and piecemeal resection(OR=6.610,P=0.005)were significant risk factors for early and late recurrence,*** resection was also a significant risk factor for non-curative resection(OR=5.424,P=0.007).Twenty-six patients experienced adverse events(24.5%).CONCLUSION Endoscopic papillectomy is a safe and effective treatment for ampullary ***

关键词： Endoscopic papillectomy Ampullary adenoma Clinical outcome Recurrence Adverse event

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Advanced heterolytic H_(2) adsorption of K-added Ru/MgO catalysts for accelerating hydrogen storage into aromatic benzyltoluenes

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Journal of Energy Chemistry 2022年第8期31卷 333-343,I0009页

作者： Tae Wan Kim Hwiram Jeong Yeongin Jo Dongun Kim ji hoon Park Seok Ki Kim Young-Woong Suh Department of Chemical Engineering Hanyang UniversitySeoul 04763Republic of Korea Environmental&Sustainable Resources Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Department of Chemical Engineering Ajou UniversitySuwon 16499Republic of Korea

Herein,we report a highly active K-added Ru/MgO catalyst for hydrogen storage into aromatic benzyltoluenes at low temperatures to advance liquid organic hydrogen carrier *** hydrogenation activity of Ru/K/MgO catalysts exhibits a volcano-shaped dependence on the K content at the maximum with 0.02 wt%.This is in good agreement with the strength and capacity of H_(2) adsorption derived from basicity,despite a gradual decrease in the textural property and the corresponding increase in the Ru particle size with increasing the K *** functional theory calculations show that heterolytic hydrogen adsorption properties(strength and polarization)are facilitated up to a specific density of K on the Ru–MgO interface and excessive K suppresses heterolytic H_(2) adsorption by direct interaction between K and hydrogen,assuring the hydrogenation activity and H_(2) adsorption capability of Ru/K/MgO ***,the Ru/K/MgO catalyst,when K is added in an optimal amount,is highly effective to accelerate hydrogen storage kinetics at low temperatures owing to the enhanced heterolytic H_(2) adsorption.

关键词： Chemical hydrogen storage Supported Ru catalysts Ru–MgO interface Heterolytic H_(2)adsorption Charge transfer Potassium promotion

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Sex-based differences in histology,staging,and prognosis among 2983 gastric cancer surgery patients

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World Journal of Gastroenterology 2022年第9期28卷 933-947页

作者： Yonghoon Choi Nayoung Kim Ki Wook Kim Hyeong Ho Jo Jaehyung Park Hyuk Yoon Cheol Min Shin Young Soo Park Dong Ho lee Hyeon Jeong Oh Hye Seung lee Young Suk Park Sang-hoon Ahn Yun-Suhk Suh Do Joong Park Hyung-Ho Kim ji-Won Kim jin Won Kim Keun-Wook lee Won Chang ji hoonPark Yoon jin lee Kyoung Ho lee Young hoon Kim Department ofInternal Medicine Seoul National University Bundang HospitalSeongnam 13620South Korea Nayoung Department of Internal Medicine Seoul National University College of MedicineSeoul 03080South Korea Department of Pathology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Pathology Seoul National University College of MedicineSeoul 03080South Korea Department of Surgery Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Surgery Seoul National University College of MedicineSeoul 03080South Korea Department of Radiology Seoul National University Bundang HospitalSeongnam 13620South Korea Department of Radiology Seoul National University College of MedicineSeoul 03080South Korea

BACKGROUND Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer(GC).AIM To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for *** A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were *** clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were *** Among the 2983 patients, 2005(67.2%) and 978(32.8%) were males and females, *** average age of the female group(59.36 years) was significantly younger than that of the male group(61.66 years;P < 0.001).Cancer of the gastric body(P < 0.001) and diffuse-type histology(P < 0.001) were more common in females than in *** trend was more prominent in females younger than 60 years of age, with a significantly higher proportion of diffuse-type cancer than in the male *** of sex, diffuse-type GC was more common in younger patients, and the proportion of intestinal-type GC increased with *** overall survival rate was significantly higher in females(P < 0.001).However, this difference disappeared for GC-specific survival(P = 0.168), except for the poor GC-specific survival rate in advanced-stage cancer(stage Ⅲ or above) in females(P = 0.045).The risk factors for GC-related mortality were older age, upper location of GC, and diffuse-or mixed-type *** terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in *** Sex-based differences in GC were

关键词： Gastric cancer Histology Prognosis Sex difference Survival

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Utilizing 3,4-ethylenedioxythiophene(EDOT)-bridged non-fullerene acceptors for efficient organic solar cells

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Journal of Energy Chemistry 2022年第2期31卷 194-204页

作者： Sung Jae Jeon Young hoon Kim Ie Na Kim Nam Gyu Yang ji Hee Yun Doo Kyung Moon Nano and Information Materials(NIMs)Laboratory Department of Chemical EngineeringKonkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea Department of Academy of Applied Science and Technology Konkuk University120 Neungdong-ro Gwangjin-guSeoul 05029South Korea

A rational design of efficient low-band-gap non-fullerene acceptors(NFAs)for high-performance organic solar cells(OSCs)remains challenging;the main constraint being the decrease in the energy level of the lowest unoccupied molecular orbitals(LUMOs)as the bandgap of A-D-A-type NFAs ***,the short current density(J_(sc))and open-circuit voltage(V_(oc))result in a trade-off relationship,making it difficult to obtain efficient ***,three NFAs(IFL-ED-4 F,IDT-ED-4 F,and IDTT-ED-2 F)were synthesized to address the above-mentioned issue by introducing 3,4-ethylenedioxythiophene(EDOT)as aπ-*** NFAs exhibit relatively low bandgaps(1.67,1.42,and 1.49 eV,respectively)and upshifted LUMO levels(-3.88,-3.84,and-3.81 eV,respectively)compared with most reported low-band-gap ***,the photovoltaic devices based on IDT-ED-4 F blended with a PBDB-T donor polymer showed the best power conversion efficiency(PCE)of 10.4%with a high J_(sc) of 22.1 mA cm^(-2) and Voc of 0.884 V among the examined *** contrast,IDTT-ED-4 F,which was designed with an asymmetric structure of the D-p-A type,showed the lowest efficiency of 1.5%owing to the poor morphology and charge transport properties of the binary ***,when this was introduced as the third component of the PM6:BTP-BO-4 Cl,complementary absorption and cascade energy-level alignment between the two substances could be ***,the IDTT-ED-4 F-based ternary blend device not only improved the Jscand Voc,but also achieved a PCE of 15.2%,which is approximately 5.3%higher than that of the reference device with a minimized energy loss of 0.488 *** addition,the universality of IDTT-ED-2 F as a third component was effectively demonstrated in other photoactive systems,specifically,PM6:BTPe C9 and PTB7-Th:IEICO-4 *** work facilitates a better understanding of the structure–property relationship for utilizing efficient EDOT-bridged NFAs in high-performance OSC applications.

关键词： Non-fullerene acceptor 3,4-ethylenedioxythiophene Organic solar cell π-bridge π-spacer

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Reevaluation of the expanded indications in undifferentiated early gastric cancer for endoscopic submucosal dissection

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World Journal of Gastroenterology 2022年第15期28卷 1548-1562页

作者： jiyoung Yoon Seung-Yeon Yoo Young Soo Park Kee Don Choi Beom Su Kim Moon-Won Yoo In Seob lee Jeong Hwan Yook Ga Hee Kim Hee Kyong Na ji Yong Ahn Jeong hoon lee Kee Wook Jung Do hoon Kim Ho June Song Gin Hyug lee Hwoon-Yong Jung Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Surgery Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea

BACKGROUND Although the criteria for the indication of endoscopic submucosal dissection(ESD)for undifferentiated early gastric cancer(UD-EGC)have been recently proposed,accumulating reports on the non-negligible rate of lymph node metastasis(LNM)after indicated ESD raise questions on the reliability of the current *** To investigate the prevalence and risk factors of LNM in UD-EGC cases meeting the expanded indication for *** We retrospectively reviewed 4780 UD-EGC cases that underwent surgical resection between January 2008 and February 2019 at Asan Medical Center,a tertiary university hospital in *** identify the risk factors of LNM of UDEGC meeting the expanded criteria for ESD,we performed a case-control study by matching the cases with LNM to those without at a ratio of 1:*** reviewed the clinical,endoscopic,and histologic features of the cases to identify features with a significant difference according to the presence of *** and multivariate logistic regression analyses were performed to estimate the odds ratios(ORs).RESULTS Of the 4780 UD-EGC cases,1240(25.9%)were identified to meet the expanded indication for *** the 1240 cases,14(1.1%)cases had *** the various clinical,endoscopic,and histopathological features that were evaluated,mixed histology(tumors consisting of 10%-90%of signet ring cells)had a marginally significant association(P=0.059)with the risk of ***,diffuse blurring of the muscularis mucosae(MM)underneath the tumorous epithelium,a previously unrecognized histologic feature,had a significant association with the absence of LNM(P=0.028).Multivariate logistic regression analysis showed that the blurring of MM was the only explanatory variable significantly associated with a reduced risk of LNM(OR:0.12,95%CI:0.02-0.95;P=0.045).CONCLUSION The risk of LNM is higher than expected when using the current expanded indication for *** evaluation could provide useful clues for reducing the

关键词： Gastric cancer Undifferentiated carcinoma Endoscopic submucosal dissection Lymph node metastasis

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Quantitative volumetric analysis of the optic radiation in the normal human brain using diffusion tensor magnetic resonance imaging-based tractography

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Neural Regeneration Research 2014年第3期9卷 280-284页

作者： Dong-hoon lee ji-Won Park Cheol-Pyo Hong Center for Medical Metrology Division of Convergence Technology Korea Research Institute of Standards and Science (KRISS) Department of Radiological Science College of Health Science Yonsei University Department of Physical Therapy College of Medical Science Catholic University of Daegu

To attain the volumetric information of the optic radiation in normal human brains, we per- formed diffusion tensor imaging examination in 13 healthy volunteers. Simultaneously, we used a brain normalization method to reduce individual brain variation and increase the accuracy of volumetric information analysis. In addition, tractography-based group mapping method was also used to investigate the probability and distribution of the optic radiation pathways. Our results showed that the measured optic radiation fiber tract volume was a range of about 0.16% and that the fractional anisotropy value was about 0.53. Moreover, the optic radiation probability fiber pathway that was determined with diffusion tensor tractography-based group mapping was able to detect the location relatively accurately. We believe that our methods and results are help- ful in the study of optic radiation fiber tract information.

关键词： nerve regeneration optic radiation diffusion tensor imaging diffusion tensor tractogra-phy magnetic resonance imaging volumetric analysis probability map group mapping visualiza-tion individual variation neural regeneration

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Effect of botulinum toxin type A on the cervical sympathetic trunk in chronic relapsing inflammatory optic neuropathy

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Chinese Medical Journal 2021年第22期134卷 2771-2772页

作者： ji Yeong Kim Yong Ho lee Young hoon Kim Department of Anesthesiology and Pain Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

To the Editor:Optic neuritis(ON)usually ends with one episode,but recurs in 3%to 5%of *** recurrent patients,those that emerge negative from multiple sclerosis or neuromyelitis optica(NMO)workup are diagnosed with chronic relapsing inflammatory optic neuropathy(CRION).This disease group,first named by Kidd et al,[1]refers to a clinical situation in which inflammatory optic nerve inflammation on both sides occurs repeatedly and worsens when steroids or immu-nosuppressants are *** diagnosis is important in this group because the risk of blindness is significant,and as such,treatment is focused on preserving ***,because a significant number of CRION patients suffer from ocular pain,alleviation of pain should not be overlooked.

关键词： neuropathy diagnosis inflammation

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Relationship between intraocular pressure and parameters of obesity in ocular hypertension

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 794-800页

作者： Min Won Ahn ji Woong lee Jong hoon Shin Jong Soo lee Busan Sungmo Eye Hospital Busan 48064Korea Department of Ophthalmology Pusan National University College of Medicine and Medical Research Institute of Pusan National University HospitalBusan 49241Korea Department of Ophthalmology Pusan National University Yangsan HospitalYangsan 50612Korea

AIM:To evaluate the correlation between intraocular pressure(IOP)and various obesity-related health factors in patients with ocular hypertension in ***:A total of 40850 subjects underwent age,sex,body weight,and height assessments and automated multiphasic tests,including non-contact tonometry,automated perimetry,fundus photography,systolic/diastolic blood pressure measurement,and evaluation of obesity-related health parameters such as obesity index,body mass index(BMI),a body shape index(ABSI),and waist-to-height ratio(WtHR).Subjects were divided into ocular hypertension group and normal IOP group according to IOP after matching of age and ***:Of 40850 participants,1515(3.7%)had ocular hypertension,and 1515 with normal IOP were selected as controls using propensity score *** mean IOP of control group was 15.3±2.3 mm Hg,compared with 23.3±1.6 mm Hg in ocular hypertension ***,obesity index,BMI,and WtHR in the ocular hypertension group were significantly higher than in the normal IOP group(P<0.001,P<0.001,P=0.009,P=0.002).IOP of ocular hypertension was positively correlated with obesity index(P=0.027)and BMI(P=0.016),whereas IOP of control was positively correlated with blood pressure(P<0.001,P=0.002),obesity index(P<0.001),BMI(P<0.001),and WHtR(P=0.002).Systolic blood pressure(β=0.022,P<0.001)and body weight(β=0.016,P=0.02)were precursors of IOP in normal subjects,but sex(male;β=-0.231,P=0.008)and obesity index(β=-0.007,P=0.017)were precursors of ocular hypertension according to multiple regression ***:Among various obesity-related health parameters,obesity index is the best indicator for further increase in IOP in ocular hypertension group.

关键词： intraocular pressure ocular hypertension body mass index body shape index waist-to-height ratio

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The Arabidopsis Floral Repressor BFT DelaysFlowering by Competing with FT for FD Bindingunder High Salinity

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Molecular Plant 2014年第2期7卷 377-387页

作者： Jae Yong Ryu Hyo-Jun lee Pil Joon Seo Jae-hoon Jung ji hoon Ahn Chung-Mo Park Department of Chemistry Seoul National University Seoul 151-742 Korea Present address: Department of Chemistry Chonbuk National University Jeonju 561-756 Korea The Sainsbury Laboratory University of Cambridge Cambridge UK Creative Research Initiatives Division of Life Sciences Korea University Seoul 136-701 Korea PGBI Seoul National University Seoul 151-742 Korea

Soil salinity is one of the most serious agricultural problems that significantly reduce crop yields in the aridand semi-arid regions. It influences various phases of plant growth and developmental processes, such as seed germina-tion, leaf and stem growth, and reproductive propagation. Salt stress delays the onset of flowering in many plant spe-cies. We have previously reported that the Arabidopsis BROTHER OF FT AND TFL1 （BFT） acts as a floral repressor undersalt stress. However, the molecular mechanisms underlying the BFT function in the salt regulation of flowering inductionis unknown. In this work, we found that BFT delays flowering under high salinity by competing with FLOWERING LOCUST （FT） for binding to the FD transcription factor. The flowering time of FD-deficient fd-2 mutant was insensitive to highsalinity. BFT interacts with FD in the nucleus via the C-terminal domain of FD, which is also required for the interactionof FD with FT, and interferes with the FT-FD interaction. These observations indicate that BFT constitutes a distinct saltstress signaling pathway that modulates the function of the FT-FD module and possibly provides an adaptation strategythat fine-tunes photoperiodic flowering under high salinity.

关键词： Arabidopsis BFT FD flowering time FT salt stress

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Tailoring strength-ductility balance of caliber-rolled AZ31 Mg alloy through subsequent annealing

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Journal of Magnesium and Alloys 2020年第1期8卷 163-171页

作者： Taein Kong Byung Je Kwak Jonghyun Kim Jeong Hun lee Sung Hyuk Park ji hoon Kim Young hoon Moon Hyun Sik Yoon Taekyung lee School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Advanced Forming Process R&D Group Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea College of Materials Science and Engineering Chongqing UniversityChongqing 400044China School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Naval Architecture and Ocean Engineering Pusan National UniversityBusan 46241Republic of Korea

Recently,multi-pass caliber rolling has been shown to be effective for Mg *** study investigated the effect of subsequent annealing on the mechanical properties of a caliber-rolled AZ31 Mg alloy to modulate the strength-ductility *** annealing gave rise to different trends in mechanical properties depending on the temperature ***-temperature annealing(T≤473 K)exhibited a typical trade-off relationship,where an increase in annealing temperature resulted in increased ductility but decreased strength and *** a heat treatment did not degrade the high strength-ductility balance of the caliber-rolled alloy,suggesting that the mechanical properties could be tailored for different potential *** contrast,high-temperature annealing(T>473 K)caused a simultaneous deterioration in strength,hardness,and ductility with increasing annealing *** differences are discussed in terms of the varying microstructural features under the different investigated annealing regimes.

关键词： AZ31 Mg alloy Caliber rolling Annealing Grain growth Mechanical improvement Twinning

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