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Molecular characterization of two candidate genes associated with coat color in Tibetan sheep(Ovis arise)

Journal of Integrative Agriculture 2015年第7期14卷 1390-1397页

作者： han ji-long YANG Min GUO Ting-ting YUE Yao-jing LIU jian-bin NIU Chun-e WANG Chao-feng YANG Bo-hui Lanzhou Institute of Husbandry and Pharmaceutical Sciences Chinese Academy of Agricultural Sciences Institute of Animal Science Chinese Academy of Agricultural Sciences College of Veterinary Medicine Gansu Agricultural University

Coat color is a key economic trait in sheep. Some candidate genes associated with animal＇s coat color were found. Partic- ularly, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog （KIT） and microphthalmia-associated transcription factor （MITF） play a key role in the modulation of hair pigmentation in mammals. This study investigated those two candidate genes＇ mutations and expressions associated with wool color in Tibetan sheep. First, the gene polymorphisms of those two genes were analyzed, and then, relative mRNA expression levels of those two genes in skin tissue with different coat colors were compared. Thirdly, KIT and MITF protein expression levels were detected through Western blot and immune- histochemical. Allele C was predominant allele in the white coat color Tibetan sheep population of the MITF coding region g. 1548 C/T loci. The relative MITF mRNA expression in black coat skin tissue was significantly higher than white （P〈0.01）. However, no significant differences were detected in the KIT gene＇s mRNA expression of these two different coat color skin tissues （P〉0.05）, while the level of KIT protein expression in skin tissues of white and black coats was also roughly equivalent. Our study observed that, the level of MITF protein expression in black coat skin tissue was significantly higher than that in white coat skin tissue, and positive staining for MITF protein expression was detected mainly in the epidermis and the dermal papilla, bulb, and outer root sheath of hair follicles. We conclude that the black coat of Tibetan sheep is related to high MITF expression in the hair follicles, and MITF may be important for coat color formation of Tibetan sheep.

关键词： Tibetan sheep KIT MITF gene polymorphism gene expression coat color

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BORDER PORT MANZHOULI:URBAN FUNCTION AND SPACE DEVELOPMENT

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Chinese Geographical Science 2002年第4期12卷 315-320页

作者： ZhanG Ping-yu,MA Yan-ji,YU Zhen-han(Changchun Institute of Geography,t he Chinese Academy of Sciences,Changchun 130012,P.R.China) Changchun Institute of Geography the Chinese Academy of Sciences Changchun P. R. China

Manzhouli is the largest land port city on the Sino-Russia border,transit cargo through the land port amount -ed to 5.95million tons,transit tour ists were 304500in *** stands at the joint place of China,Mongolia an d Russi-a,faces to Siberia area of Russia,re ceives direct support from the North east China and Bohai Sea Rim Area,and possess-es priorities in geographical location,land port infrastructure,wate r resources,coal resources,touris t resources and great potentiality in economic coop eration with *** future urban function is a key port on the First Eurasia Continen-tal *** Port will keep its first place between China and Russia land transport,and it is forecasted that the transit amount through Manzhouli Port will go up to 10million tons in 2005and 20million tons in *** will be construct-ed to be a trade center of the peripheral area extending to Russia and Mongolia,a key export-oriented processing industri-al zone supported by industries such as export processing industries,export agriculture,trade services,t echnology trad-ing and the other service *** keeps being a well-known touring city for trade,shopping,sightseeing,vocation,local food,recreation and cultural *** build Manzhouli Export Pr ocessing Industry Zone will improve city econom-ic structure,and the main sectors are organic food processing,livestock products processing,garment and f urniture ***,Manzhouli Export Pro cessing Industry Zone will eventually be upgraded to be a border free trad e *** city functional transition will inevitably affect urban spatial restructure and its *** city space transforma-tion will develop as such:one develo pment axis of No.301highway paralle ling with Bin -Zhou(Harbin -Manzhouli)rail-way which cuts through central part o f Manzhouli City,and links Zhalainuoer District with central city;thre e urban units including central city,Zhalainuoer District and Manzhouli Interchange Trade Zone;coh

关键词： manzhouli land port city development sino-russia border trade

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Applying Cognitive Behavior Therapy to Patients with Lung Cancer

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Psychosomatic Medicine Research 2021年第1期3卷 1-7页

作者： Xiao-Feng Su ji-Ming han Medical College Yan’an UniversityYan’anShanxiChina

Requirements for intervention measures for lung cancer have increased in number and difficulty due to the progress of patients and influence of complex groups of *** cure rate for patients with lung cancer has improved with the vigorous development of new technologies in modern ***,their mental health status and physical quality of life have continued to warrant scholarly *** field of cognitive behavior therapy(CBT)provides innovative ideas for addressing this ***,the study reviews the origin and concept of CBT,CBT technology,and effect of its application to patients with lung cancer to provide a feasible reference for intervention on physical and mental adverse symptoms in patients with lung cancer.

关键词： Cognitive behavioral therapy Cancer Quality of life Pain Cancer-related fatigue Fear of cancer recurrence Anxiety Depression Psychosocial support Psycho-oncology

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Research on Affordability Modeling of Aircraft Based on Effectiveness Indexes

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International Journal of Plant Engineering and Management 2011年第1期16卷 15-20页

作者： YAN Sheng-wen GUO ji-han School of Management Northwestern Polytechnical University Xi'an 710072 P. R. China Engineering College Air Force Engineering University Xi'an 710038 P. R. China

With the cost estimation of military aircraft as the research object, this paper aims to study the contradiction between the choice of explanatory variables in index modeling and the maintaining of model validity. It analyzes and establishes a cost estimation modeling concept based on an Effectiveness Index and studies the way to construct Effectiveness Indexes for the sake of cost estimation modeling. Based on a case study, the paper establishes and analyzes the Effectiveness Index-based cost estimation models and DAPCA （Development And Procurement Costs of Aircraft） models developed by the RAND Corparation . The comparison of these models shows that the Effective- ness Index-based cost parameter models not only comprehensively consider the obvious driving parameter indexes of the cost, but reduces the variables of regressive analysis, hence giving the model a higher reliability.

关键词： military aircraft effectiveness index affordability cost parameter model

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Simulation and Experimental Method for Microwave Oven

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Journal of Electronic Science and Technology of China 2009年第2期7卷 188-191页

作者： han-ji Ju Qing Zhao School of Physical Electronics University of Electronic Science and Technology of China Chengdu 610054 China.

The simulation software, HFSS （high frequency structure simulator）, is introduced in microwave oven design. In the cold test, a network analyzer is used to measure the reflection coefficient （S11） of the cavity under empty and loaded states over the frequency range from 2.448 GHz to 2.468 GHz. In the hot test, a piece of wet thermal paper and an infrared thermal imaging camera are used to measure the electric field distributions on the mica and turntable. In the cold test, the simulation agrees well with the experiment no matter in empty state or loaded state. In the hot test, the simulation agrees well with the experiment in general in empty state and approximately in loaded state. The little difference in both cold and hot test may be due to that the model in simulation is not absolutely identical with that in experiment or the inadequate precision of infrared thermal imaging camera.

关键词： Index Terms-Far-infrared thermal imaging camera,microwave oven simulation network analyzer wetthermal paper.

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构筑物混凝土火灾损伤红外热像-电化学检测

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同济大学学报（自然科学版） 2000年第4期28卷 422-425页

作者：韩继红张雄上海市建设工程质量检测中心上海200032 同济大学混凝土材料研究国家重点实验室上海200092

根据混凝土火灾损伤特点，采用红外热像检测技术与电化学检测方法相结合，表里兼顾地检测分析混凝土受火温度、强度损失率和损伤深度．现场检测案例表明：红外热像－电化学综合法检测构筑物混凝土火灾损伤可获得比较翔实的混凝土火灾损... 详细信息

根据混凝土火灾损伤特点，采用红外热像检测技术与电化学检测方法相结合，表里兼顾地检测分析混凝土受火温度、强度损失率和损伤深度．现场检测案例表明：红外热像－电化学综合法检测构筑物混凝土火灾损伤可获得比较翔实的混凝土火灾损伤资料，为构筑物修复加固提供科学依据．

关键词：火灾构筑物红外热像电化学

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Clinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma

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World Journal of Gastroenterology 2011年第35期17卷 4023-4030页

作者： Hyun Ah Yoon Myung Hwan Noh Byung Geun Kim ji Sun han jin Seok Jang Seok Ryeol Choi jin Sook Jeong jin Ho Chun Department of Gastroenterology Dong-A University Hospital3-1Dong dae shindongSeo-guBusan 602-715South Korea Department of Pathology Dong-A University Hospital3-1Dong dae shin-dongSeo-guBusan 602-715 South Korea Department of Preventive Medicine Inje University HospitalGae gum 2-dongBusanjinguBusan 614-735 South Korea

AIM:To investigate the role and clinicopathological significance of aberrant expression of Notch receptors and Delta-like ligand-4 (DLL4) in extrahepatic cholangiocarcinoma and gallbladder ***:One hundred and ten patients had surgically resected extrahepatic cholangiocarcinoma (CC) and gallbladder carcinoma specimens examined by immunohistochemistry of available paraffin *** was performed using anti-Notch receptors 1-4 and anti-DLL4 *** scored the immunopositivity of Notch receptors and DLL4 expression by percentage of positive tumor cells with cytoplasmic expression and intensity of *** nuclear localization was ***-logical parameters and survival data were compared with the expression of Notch receptors 1-4 and ***:Notch receptor proteins showed in the cytoplasm with or without nuclear expression in cancer cells,as well as showing weak cytoplasmic expression in non-neoplastic *** semiquantitative evaluation,positive immunostaining of Notch receptor 1 was detected in 96 cases (87.3%),Notch receptor 2 in 97 (88.2%),Notch receptor 3 in 97 (88.2%),Notch receptor 4 in 103 (93.6),and DLL4 in 84 (76.4%).In addition,coex- istent nuclear localization was noted [Notch receptor 1;18 cases (18.8%),Notch receptor 2;40 (41.2%),Notch receptor 3;32 (33.0%),Notch receptor 4;99 (96.1%),DLL4;48 (57.1%)].Notch receptor 1 expression was correlated with advanced tumor,node,metastasis (TNM) stage (P=0.043),Notch receptor 3 with advanced T stage (P=0.017),tendency to express in cases with nodal metastasis (P=0.065) and advanced TNM stage (P=0.052).DLL4 expression tended to be related to less histological differentiation (P=0.095).Coexistent nuclear localization of Notch receptor 3 was related to no nodal metastasis (P=0.027) and Notch receptor 4 with less histological differentiation (P=0.036),while DLL4 tended to be related inversely with T stage (P=0.053).Coexistent nuclear localizatio

关键词： Notch receptors Delta-like ligand-4 Cholangio-carcinoma Gallbladder carcinoma Immunohistochemistry

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Recent advances in interfacial modification of zinc anode for aqueous rechargeable zinc ion batteries

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Journal of Energy Chemistry 2023年第8期83卷 287-303,I0009页

作者： Qing Wen Hao Fu Ru-de Cui He-Zhang Chen Rui-han ji Lin-Bo Tang Cheng Yan jing Mao Ke-Hua Dai Xia-Hui Zhang Jun-Chao Zheng School of Metallurgy and Environment Central South UniversityChangsha 410083HunanChina Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083HunanChina School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201HunanChina School of Mechanical Medical and Process EngineeringQueensland University of TechnologyBrisbaneQueensland 4001Australia School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina College of Chemistry Tianjin Normal UniversityTianjin 300387China School of Mechanical and Materials Engineering Washington State UniversityPullman 99164WashingtonUnited States

To tackle energy crisis and achieve sustainable development, aqueous rechargeable zinc ion batteries have gained widespread attention in large-scale energy storage for their low cost, high safety, high theoretical capacity, and environmental compatibility in recent years. However, zinc anode in aqueous zinc ion batteries is still facing several challenges such as dendrite growth and side reactions(e.g., hydrogen evolution), which cause poor reversibility and the failure of batteries. To address these issues, interfacial modification of Zn anodes has received great attention by tuning the interaction between the anode and the electrolyte. Herein, we present recent advances in the interfacial modification of zinc anode in this review. Besides, the challenges of reported approaches of interfacial modification are also ***, we provide an outlook for the exploration of novel zinc anode for aqueous zinc ion *** hope that this review will be helpful in designing and fabricating dendrite-free and hydrogenevolution-free Zn anodes and promoting the practical application of aqueous rechargeable zinc ion batteries.

关键词： Zinc ion batteries Zinc anode Interfacial modification Functional coating

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家庭风险态度对房地产财富效应的影响

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财经问题研究 2016年第5期 62-68页

作者：纪晗东北财经大学社会与行为跨学科研究中心辽宁大连116025

本文首次研究了家庭风险态度对我国房地产财富效应的影响。基于家庭微观调查数据的研究结果表明:经济社会生活中的不确定性会提高家庭风险厌恶程度;而家庭风险态度对房地产财富效应产生了显著影响,住房财富对消费的影响随着风险厌恶程... 详细信息

本文首次研究了家庭风险态度对我国房地产财富效应的影响。基于家庭微观调查数据的研究结果表明:经济社会生活中的不确定性会提高家庭风险厌恶程度;而家庭风险态度对房地产财富效应产生了显著影响,住房财富对消费的影响随着风险厌恶程度的增大而减弱,较高的风险厌恶程度显著削弱了正向的房地产财富效应。这一结论可以为房地产财富效应与微观主体行为特征间的关系研究提供更多依据,并且预示着提高各项政策的持续性以降低居民面临的不确定性,可以有效提升房地产正向财富效应,进一步促进居民消费影响。

关键词：家庭风险态度房地产财富效应居民消费

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基于灵活平衡约束的图聚类方法

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自动化学报 2023年第4期49卷 778-789页

作者：罗辉韩纪庆哈尔滨工业大学计算机科学与技术学院哈尔滨150001

现有的图聚类方法主要存在两方面的问题,一是对各个类规模一致的假设,在许多实际应用中并不成立;二是在处理多类聚类问题时,其所常借助的递归技术或启发式算法会影响聚类的性能.为此,本文提出一种基于灵活平衡约束的多类图聚类方法.其... 详细信息

现有的图聚类方法主要存在两方面的问题,一是对各个类规模一致的假设,在许多实际应用中并不成立;二是在处理多类聚类问题时,其所常借助的递归技术或启发式算法会影响聚类的性能.为此,本文提出一种基于灵活平衡约束的多类图聚类方法.其能够覆盖从绝对平衡约束到无平衡约束的范围,可同时处理类别规模一致和不一致的问题.为有效求解新方法中的参数,进一步提出一个紧松弛方法来使所提出的图聚类方法不仅易于求解,且在处理多类聚类问题时不必依赖递归技术,而能直接得到聚类结果.另外,本文还给出一种实现松弛图聚类的有效求解算法.在合成数据和真实数据上的实验结果表明,所提出的方法具有良好的性能.

关键词：图聚类图分割平衡约束紧松弛

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