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Two new ent-kaurane diterpenoids from Isodon excisoides

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Chinese Chemical Letters 2009年第2期20卷 201-203页

作者： ji xia zhang Yong Xue Wang Zhi An He Fu Lin Yan Han Dong Sun Pharmaceutical Laboratory Xinxiang Medical University Xinxiang 453003 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

Two new ent-kaurane diterpenoids taihangexcisoidesin A and B （1 and 2）, were isolated from the EtOAc extract of the leaves of lsodon excisoides. Their structures were determined on the basis of spectroscopic methods.

关键词： Isodon excisoides ent-Kaurane Diterpenoid Taihangexcisoidesin A and B

New ent-kaurane-type diterpenoids from Isodon nervosus

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Chinese Chemical Letters 2008年第4期19卷 441-443页

作者： Fu Lin Yan Lan Qing Guo ji xia zhang Su Ping Bai Han Dong Sun Pharmacy College Xinxiang Medical UniversityXinxiang 453003China Kunming Institute of Botany Chinese Academy of SciencesKunming 650204China

Two new ent-kaurane-type diterpenoids,6β,7β,13α-trihydroxy-1α-acetoxy-7α,20-epoxy-ent-kaur-16-en-15-one（1）and 15β- hydroxy-6,7-seco-6,11β：6,20-diepoxy-1α,7-olide-ent-kaur-16-ene（2）were isolated from the I... 详细信息

关键词： Labiatae Isodon nervosus ent-Kaurane diterpenoid

New diterpenoids from Isodon excisoides

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Chinese Chemical Letters 2010年第5期21卷 610-612页

作者： Yong Xue Wang,Lin Lin Zhu,Zhi An He,ji xia zhang Pharmacy College,Xinxiang Medical University,Xinxiang 453003,China [a] Pharmacy College Xinxiang Medical University Xinxiang 453003 China

Two new ent-kaurane diterpenoids,taihangexcisoidesin C(1) and its acetonide,taihangexcisoidesin D(2) were isolated from the leaves of Isodon *** structures were determined by 1D and 2D spectroscopic analysis.

关键词： Isodon excisoides Ent-kaurane Diterpenoid Taihangexcisoidesin C and D

A new ent-abietane diterpenoid from Isodon macrophyllus

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Chinese Chemical Letters 2008年第7期19卷 849-851页

作者： Zheng Yue Chen Pei Yong Qiu Yong Xue Wang Su Ping Bai Fu Lin Yan ji xia zhang Han Dong Sun Pharmaceutical Laboratory Xinxiang Medical University Xinxiang 453003 China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 China

A new ent-abietane diterpenoid, named dayecrystal C, was isolated from the EtOAc extract of the dried leaves of Isodon macrophyllus. Its structure was determined on the basis of spectroscopic methods.

关键词： Isodon macrophyllus ent-Abietane Diterpenoid Dayecrystal C

A missense mutation in the androgen receptor gene causing androgen insensitivity syndrome in a Chinese family

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Asian Journal of Andrology 2017年第2期19卷 260-261页

作者： Lin Li Wen-Miao Liu Mei-Xin Liu Shu-QiZheng ji-xia zhang Feng-Yuan Che Shi-Guo Liu Department of Genetics Counseling Genetics Institute of Linyi People's Hospital Linyi 276003 Shandong China Department of Clinical Laboratory Diagnosis Medical College of Qingdao University Qingdao 266003 Shandong China Department of Ultrasonography The Affiliated Hospital of Qingdao University Qingdao 266003 Shandong China Department of Neurology Linyi People's Hospital Linyi 276003 Shandong China Department of Prenatal Diagnosis Center The Affiliated Hospital of Qingdae University Qingdao 266003 Shandong China

Dear Editor, Androgen Insensitivity Syndrome （AIS） is an X-linked recessive genetic disorder presenting as male pseudohermaphroditism with gender ambiguity or reversal. According to the reaction to androgens, subje... 详细信息

关键词： missense mutation androgen receptor Chinese family

Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： jingxiang zhang xia Sheng Quanju Ding Yujun Wang jiwei Zhao jingfa zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-jie Quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying zhang Ping zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

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缺血性脑卒中患者疾病感知的影响因素分析

中国动脉硬化杂志 2016年第10期24卷 1001-1006页

作者：计海霞张建凤张蕾汪凯龚桂平王霞安徽医科大学附属合肥口腔临床学院护理部安徽省合肥市230006 安徽医科大学第一附属医院神经内科安徽省合肥市230022 安徽医科大学医学心理学系安徽省合肥市230032

目的调查缺血性脑卒中患者的疾病感知,并分析其影响因素。方法对103例缺血性脑卒中患者应用一般资料调查表、疾病感知量表、美国国立卫生研究院卒中量表和简易应对方式量表进行调查,采用单因素方差分析和多元线性回归等方法进行统计分... 详细信息

目的调查缺血性脑卒中患者的疾病感知,并分析其影响因素。方法对103例缺血性脑卒中患者应用一般资料调查表、疾病感知量表、美国国立卫生研究院卒中量表和简易应对方式量表进行调查,采用单因素方差分析和多元线性回归等方法进行统计分析。结果缺血性脑卒中患者疾病感知量表疾病同一性因子得分为3.11±2.53分,严重后果因子得分为16.95±4.39分,情绪陈述因子得分为18.45±5.50分。多元逐步线性回归分析显示,患者年龄、性别、家庭住址、职业、NIHSS评分是缺血性脑卒中患者疾病感知的影响因素。结论缺血性脑卒中患者具有负性的疾病感知,医护人员应根据疾病感知的影响因素提供有针对性的健康干预。

关键词：缺血性脑卒中疾病感知影响因素