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Neuroprotective effect of the ethanol extract of Artemisia capillaris on transient forebrain ischemia in mice via nicotinic cholinergic receptor

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Chinese Journal of Natural Medicines 2018年第6期16卷 428-435页

作者： Huiyoung Kwon ji wook jung Young Choon Lee Jong Hoon Ryu Dong Hyun Kim Department of Medicinal Biotechnology College of Health SciencesDong-A UniversityBusan 49315Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityKyungsan 38610Republic of Korea Institute of Convergence Bio-Health Dong-A UniversityBusan 49315Republic of Korea Department of Life and Nanopharmaeeutical Sciences Kyung Hee UniversityKyung Hee UniversitySeou102447Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityKyung Hee UniversitySeoul 02447Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute Kyung Hee UniversityKyung Hee UniversitySeoul 02447Republic of Korea

Artemisia capillaris Thunberg is a medicinal plant used as a traditional medicine in many cultures. It is an effective remedy for liver problems including hepatitis. Recent pharmacological reports have indicated that Artemisia species can exert various neurological effects. Previously, we reported a memory-enhancing effect of Artemisia species. However, the mechanisms underlying the neuroprotective effect of A. capillaris(AC) are still unknown. In the present study, we investigated the effect of an ethanol extract of AC on ischemic brain injury in a mouse model of transient forebrain ischemia. The mice were treated with AC for seven days, beginning one day before induction of transient forebrain ischemia. Behavioral deficits were investigated using the Y-maze. Nissl and Fluoro-jade B staining were used to indicate the site of injury. To determine the underlying mechanisms for the drug, we measured acetylcholinesterase activity. AC(200 mg·kg-1) treatment reduced transient forebrain ischemia-induced neuronal cell death in the hippocampal CA1 region. The AC-treated group also showed significant amelioration in the spontaneous alternation of the Y-maze test performance, compared to that in the untreated transient forebrain ischemia group. Moreover, AC treatment showed a concentration-dependent inhibitory effect on acetylcholinesterase activity in vitro. Finally, the effect of AC on forebrain ischemia was blocked by mecamylamine, a nonselective nicotinic acetylcholine receptor antagonist. Our results suggested that in a model of forebrain ischemia, AC protected against neuronal death through the activation of nicotinic acetylcholine receptors.

关键词： Artemisia capillaris Transient forebrain ischemia Acetylcholinesterase Nicotinic acetylcholine receptor

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Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 864-870页

作者： Sa-Rang Oh Seon Ok Tae-Sung jung Sang-Ok Jeon ji-Min Park ji-wook jung Deok-Seon Ryu Department of Wellbeing Products Co. LtdGimhaeGyeongnam 50969Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaeguHaany UniversityKyungsanRepublic of Korea Department of Biomedical Laboratory Science College of Medical SciencesSoonchunhyang UniversityAsanRepublic of Korea

Objective: To investigate the anti-inflammatory effects of decursin and decursinol angelate-rich Angelica gigas Nakai(AGNE) on dextran sulfate sodium(DSS)-induced murine ulcerative colitis(UC).Methods: The therapeutic effect of an AGNE was analyzed in a mouse model of UC induced by DSS. Disease activity index values were measured by clinical signs such as a weight loss, stool consistency, rectal bleeding and colon length. A histological analysis was performed using hematoxylin and eosin staining. Key inflammatory cytokines and mediators including IL-6, TNF-a, PGE2, COX-2 and HIF-1 a were assayed by enzymelinked immunosorbent assay or western ***: Treatment with the AGNE at 10, 20, and 40 mg/kg alleviated weight loss,decreased disease activity index scores, and reduced colon shortening in mice with DSSinduced UC. AGNE inhibited the production of IL-6 and TNF-a in serum and colon tissue. Moreover, AGNE suppressed the increased expression of COX-2 and HIF-1 a and the increased production of PGE2 in colon tissue were observed in mice with DSSinduced UC. Additionally, histological damage was also alleviated by AGNE ***: The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC.

关键词： Angelica gigas Nakai Ulcerative colitis Dextran sulfate sodium Anti-inflammatory effects Cytokine

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Hydrangeae Dulcis Folium Attenuates Physical Stress by Supressing ACTH-Induced Cortisol in Zebrafish

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Chinese Journal of Integrative Medicine 2020年第2期26卷 130-137页

作者： Junyoung Oh Dong Hyun Kim Gi-young Kim Eun-jin Park Jong Hoon Ryu ji wook jung Se jin Park Gwang-Woo Kim Seungheon Lee Department of Marine Life Science College of Ocean ScienceJeju National UniversityJeju(63243)Republic of Korea Departme nt of Medicinal Biotech no logy College of Health SciencesDong-A UniversityBusan(604-714)Republic of Korea Department of Food Bioengineering Jeju National UniversityJeju(63243)Republic of Korea Institute of Convergence BioHealth Dong-A UniversityBusan(604-714)Republic of Korea Department of Oriental Pharmaceutical Science College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoon・KuSeoul(130-701)Republic of Korea Kyung Hee East-West Pharmaceutical Research Institute College of PharmacyKyung Hee UniversityHoeki-dongDongdaemoorvKuSeoul(130-701)Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaegu Haany UniversityYugok-dongGyeongsan(712-715)Republic of Korea School of Natural Resources and Environmental Sciences Kangwon National UniversityChuncheon(24341)Republic of Korea Marine Bio Con verge nee Center Gangneung Science&In dustry Promotion AgencyGangneung(25440)Republic of Korea

Objective:To determine the effects of Hydrangeae Dulcis Folium(EHDF)on physical stress,changes in the whole-body cortisol level and behaviour in zebrafish(Danio rerio).Methods:One hundred and seventy-four fish were randomly divided into 4[adrenocorticotropin hormone(ACTH)challenge test:4 fish per group]or 6 groups(behavioural test:10–12 fish per group,whole-body cortisol:4 fish per group).Net handling stress(NHS)was used to induce physical *** were treated with vehicle or EHDF(5–20 mg/L)for 6 min before they were exposed to *** then,fish were sacrificed for collecting body fluid from whole-body or conducted behavioural tests,including novel tank test and open field test,and were evaluated to observe anxiety-like behaviours and *** addition,to elucidate the mode of action of the anti-stress effects of EHDF,ACTH(0.2 IU/g,i.p.)challenge test was ***:The increased anxiety-like behaviours in novel tank test and open field test under stress were prevented by treatment with EHDF at 5–20 mg/L(P<0.05).Moreover,compared with the unstressed group,which was not treated with NHS,the whole-body cortisol level was significantly increased by treatment with NHS(P<0.05).Compared with the NHS-treated stressed control group,pre-treatment with EHDF at concentrations of 5–20 mg/L for 6 min significantly prevented the NHS-increased whole-body cortisol level(P<0.05).In addition,ACTH challenge test showed that EHDF completely blocked the effects of ACTH on cortisol secretion(P<0.05).Conclusion:EHDF may be a good antistress candidate and its mechanism of action may be related to its positive effects on cortisol release.

关键词： net handling stress zebrafish Hydrangeae Dulcis Folium whole-body cortisol behavioural tests

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Internal modification in transparent hybrid germanium-silica plates using plasma formation induced by a femtosecond laser

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中国有色金属学会会刊：英文版 2012年第S3期22卷 808-812页

作者： ji-wook YOON jung-Kyu PARK Kwang-Ho KIM Myung-Chang KANG Sung-Hak CHO Nano Machining Laboratory Korea Institute of Machinery and Materials Department of Nano-Mechatronics University of Science and Technology National Core Research Center for Hybrid Materials Solution Pusan National University

The fabrication of an internal diffraction grating with photoinduced refractive index modification in planar hybrid germanium-silica plates was demonstrated using low-density plasma formation excited by a high-intensity femtosecond (150 fs) Ti:sapphire laser (λp=790 nm).The refractive index modifications with diameters ranging from 400 nm to 3 μm were photoinduced after plasma formation occurred upon irradiation with peak intensities of more than 2×1013 W/*** graded refractive index profile was fabricated to be a symmetric around from the center of the point at which low-density plasma occurred.

关键词： diffraction grating refractive index modification plasma formation hybrid germanium-silica plate femtosecond laser

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Quantitative comparison of similarity measure and entropy for fuzzy sets

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Journal of Central South University 2011年第6期18卷 2045-2049页

作者： jung Dong-yean CHOI jung-wook PARK wook-Je LEE Sang-Hyuk Daeho Tech Changwon Gyeongnam Institute for Information and Electronics Research Inha University Department of Electrical and Electronic Engineering Xi'an Jiaotong-Liverpool University

Comparison and data analysis with the similarity measures and entropy for fuzzy sets were carried out. The distance proportional value between the fuzzy set and the corresponding crisp set was considered by the fuzzy entropy. The relation between the similarity measure and the entropy for fuzzy set was also analyzed. The fuzzy entropy was reformulated as the dissimilarity measure. Furthermore, crisp set having the minimum uncertainty with respect to the corresponding fuzzy set was also proposed. Finally, derivation of a similarity measure from entropy with the help of total information property was derived. A simple example shows the relation between similarity measure and fuzzy entropy, in which the summation of similarity measure and fuzzy entropy represents a constant value.

关键词： similarity measure fuzzy entropy minimum uncertainty quantitative comparison

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Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration

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Neural Regeneration Research 2018年第10期13卷 1796-1803页

作者： Jongbae Choi Jun Ho Kim ji wook Jang Hyun jung Kim Sung Hoon Choi Sung Won Kwon R&D Center Genewel Co.Ltd. Department of Surgery CHA Bundang Medical CenterCHA University

The use of autologous nerve grafts remains the gold standard for treating nerve defects, but current nerve repair techniques are limited by donor tissue availability and morbidity associated with tissue loss. Recently, the use of conduits in nerve injury repair, made possible by tissue engineering, has shown therapeutic potential. We manufactured a biodegradable, collagen-based nerve conduit containing decellularized sciatic nerve matrix and compared this with a silicone conduit for peripheral nerve regeneration using a rat model. The collagen-based conduit contains nerve growth factor, brain-derived neurotrophic factor, and laminin, as demonstrated by enzyme-linked immunosorbent assay. Scanning electron microscopy images showed that the collagen-based conduit had an outer wall to prevent scar tissue infiltration and a porous inner structure to allow axonal growth. Rats that were implanted with the collagen-based conduit to bridge a sciatic nerve defect experienced significantly improved motor and sensory nerve functions and greatly enhanced nerve regeneration compared with rats in the sham control group and the silicone conduit group. Our results suggest that the biodegradable collagen-based nerve conduit is more effective for peripheral nerve regeneration than the silicone conduit.

关键词： nerve regeneration biodegradable decellularized collagen nerve conduit growth factor peripheral nerve injury regeneration silicone conduit rat model

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Some Results on Noetherian Warfield Domains

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Algebra Colloquium 2022年第1期29卷 67-78页

作者： Kui Hu jung wook Lim Dechuan Zhou College of Science Southwest University of Science and Technology MianyangSichuan 621010China Kyungpook National University Daegu 41566Korea Department of Mathematics College of Natural Sciences Kyungpook National UniversityDaegu 41566Korea

Let R be a *** this paper,we show that if R is one dimensional,then R is a Noetherian Warfield domain if and only if every maximal ideal of R is 2-generated and for every maximal ideal M of R,M is divisorial in the ring(M:M).We also prove that a Noetherian domain R is a Noetherian Warfield domain if and only if for every maximal ideal M of R,M^(2) can be generated by two ***,we give a sufficient condition under which all ideals of R are strongly Gorenstein projective.

关键词： strongly Gorenstein projective module Noetherian Warfield domain strongly Gorenstein Dedekind domain

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Dually-functionalized Ni-rich layered oxides for high-capacity lithium-ion batteries

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Journal of Materials Science & Technology 2021年第27期86卷 70-76页

作者： ji Won Kim Kwangeun jung Taeeun Yim Department of Chemistry Incheon National University119 Academy-roYeonsu-guIncheon 22012Republic of Korea

Layered lithium nickel-cobalt-manganese oxides(NCM)have been highlighted as advanced cathode materials for lithium-ion batteries(LIBs);however,their low interfacial stability must be overcome to ensure stable cycling performance of the *** this work,we propose a one-step surface modification method that uses a task-specific precursor,N,N,N,N-tetraethylsulfamide(NTESA),to improve interfacial stability of Ni-rich NCM cathode *** unstable surface properties of Ni-rich NCM cathode material are improved by embedding an artificial cathode-electrolyte interphase(CEI)layer on the cathode surface by heat treatment of the Ni-rich NCM cathode material with an NTESA precursor at low *** material analyses indicate that this approach allows the formation of amine-and sulfone-functionalized CEI layers on the surface of Ni-rich NCM cathode material without changing the layered structure of the cathode ***-functionalized Ni-rich NCM cathode materials exhibit improved cycling retention after 100 cycles:for example,a cell cycled with a 3.0 NTESA-modified NCM811 cathode presents the highest retention ratio of 88.3%,whereas a cell cycled with a non-functionalized NCM811 cathode suffers from rapid fading of the cycling performance(68.4%).Our additional SEM,XPS,and EIS analyses indicate that electrolyte decomposition is suppressed during electrochemical cycling,thereby leading to smaller increases in the internal ***-MS analyses of the cycled anodes also indicate that the NTESA-based artificial CEI layer inhibits the dissolution of transition metal components from the Ni-rich NCM cathode materials,thereby contributing to an improved overall electrochemical performance of the cell.

关键词： Lithium-ion battery Cathode Cathode-electrolyte interphase N,N,N,N-Tetraethylsulfamide Electrochemical performance

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Influence of the preparation method on the catalytic activity of Mg-Al hydrotalcites as solid base catalysts

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Green Energy & Environment 2019年第3期4卷 287-292页

作者： Sungjae Park Dahye Kwon ji Yeon Kang ji Chul jung Department of Chemical Engineering Myongji University

Mg-Al hydrotalcites were synthesized using different preparation methods(a co-precipitation method, a urea method, and a simple one) to analyze their effect on the catalytic activity of these solid base catalysts. The method strongly affected the structure of their layers(e.g., the growth and stacking of the layers, and the type of intercalated anions) and, accordingly, their catalytic activity. The Mg-Al hydrotalcite prepared by co-precipitation showed the best catalytic performance in the isomerization of glucose into fructose, due to the small crystallite size and sand rose morphology enhancing the exposure of surface active sites to reactants.

关键词： Mg-Al hydrotalcite Preparation method Base catalyst Glucose isomerization Fructose

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Room-temperature synthesis of ZrSnO4 nanoparticles for electron transport layer in efficient planar hetrojunction perovskite solar cells

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Journal of Materials Science & Technology 2020年第7期42卷 38-45页

作者： Young wook Noh In Su jin Sang Hyun Park Jae Woong jung Department of Advanced Materials Engineering for Information&Electronics Kyung Hee University1732 Deogyeong-daeroGiheung-guYongin-siGyeonggi-do 446-701Republic of Korea

The interface engineering plays a key role in controlled optoelectronic properties of perovskite photovoltaic devices,and thus the electron transport layer(ETL)material with tailored optoelectronic properties remains a challenge for achieving high photovoltaic performance of planar perovskite solar cells(PSCs).Here,the fine and crystalline zirconium stanate(ZrSnO4)nanoparticles(NPs)was synthesized at low temperature,and its optoelectronic properties are systematically *** from the favorable electronic structure of ZrSnO4 NPs for applications in ETL,efficient electron transport and extraction with suppre s sed charge recombination are achieved at the interface of perovskite *** a result,the optimized ZrSnO4 NPs synthesized at room-temperature deliver the optimized power conversion efficiency up to 16.76%with acceptable *** work opens up a new class of ternary metal oxide for the use in ETL of the planar PSCs and should pave the way toward designing new interfacial materials for practical optoelectronic devices.

关键词： ZrSnO4 Electron transport layer Nanoparticles Perovskite solar cells

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