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The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： jieying wu shan Ye Xiangyi Liu Yingsheng Xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

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Neural Regeneration Research 2025年第2期20卷 326-342页

作者： Yi ji Chaoyi Yang Xuerui Pang Yibing Yan Yue wu Zhi Geng Wenjie Hu Panpan Hu Xingqi wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei wu ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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认知空间映射及其神经机制

心理科学进展 2025年第1期33卷 62-76页

作者：吴际李会杰南宁师范大学教育科学学院南宁530001 中国科学院行为科学重点实验室(中国科学院心理研究所) 北京100101 中国科学院大学心理学系北京100049

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生... 详细信息

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生成、将信息与背景结构捆绑,以及海马体与其它脑区的协同。未来研究应关注预测性的认知空间地图、海马体对不同精度和层级信息的表征、认知空间映射微观和介观层面的研究空缺以及物理空间和认知空间映射的共同机制和特异性机制等问题。

关键词：认知地图网格细胞位置细胞海马体

Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen ji Yu Chen Zheng shan Huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

Fusion of visible and thermal images for facial expression recognition

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Frontiers of Computer Science 2014年第2期8卷 232-242页

作者： shangfei WANG shan HE Yue wu Menghua HE Qiang ji School of Computer Science and Technology University of Science and Technology of China Hefei 230027 China Key Lab of Computing and Communicating Software of Anhui Province Hefei 230027 China Department of Electrical Computer and Systems Engineering Rensselaer Polytechnic Institute Troy NY12180-3590 USA

Most present research into facial expression recognition focuses on the visible spectrum, which is sen- sitive to illumination change. In this paper, we focus on in- tegrating thermal infrared data with visible spectrum images for spontaneous facial expression recognition. First, the ac- tive appearance model AAM parameters and three defined head motion features are extracted from visible spectrum im- ages, and several thermal statistical features are extracted from infrared （IR） images. Second, feature selection is per- formed using the F-test statistic. Third, Bayesian networks BNs and support vector machines SVMs are proposed for both decision-level and feature-level fusion. Experiments on the natural visible and infrared facial expression （NVIE） spontaneous database show the effectiveness of the proposed methods, and demonstrate thermal 1R images＇ supplementary role for visible facial expression recognition.

关键词： facial expression recognition feature-level fu-sion decision-level fusion support vector machine Bayesiannetwork thermal infrared images visible spectrum images

Proteomic responses induced by metal pollutions in oysters Crassostrea sikamea

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Journal of Oceanology and Limnology 2019年第2期37卷 685-693页

作者： LU Zhen shan Xiujuan ji Chenglong ZHAO jianmin wu Huifeng Key Laboratory of Coastal Zone Environmental Processes Yantai Institute of Coastal Zone Research (YIC) Chinese Academy of Sciences (CAS) Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes YICCAS Yantai 264003 China Function Laboratory for Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and Technology Qingdao 266237 China University of Chinese Academy of Sciences Beijing 100049 China Key Laboratory of Sustainable Development of Marine Fisheries Ministry of Agriculture Shandong Provincial Key Laboratory of Fishery Resources and Ecological Environment Yellow Sea Fisheries Research Institute Chinese Academy of Fishery Sciences Qingdao 266071 China

There exist severe metal pollutions along the jiulongjiang estuary in South China. In order to unravel the biological eff ects caused by metal pollutions, proteomic responses were investigated by two-dimensional electrophoresis-based proteomics in oysters Crassostrea sikamea from metal pollution sites, jinshan (JS) and Baijiao (BJ), and a relatively clean site, jiuzhen (JZ), along the jiulongjiang estuary. Results indicated that metal pollutions mainly induced cellular injuries, oxidative and immune stresses, and disturbed ion homeostasis in oysters C . sikamea from both JS and BJ sites via diff erential pathways. Furthermore, metal pollution enhanced transcriptional initiation in oysters from JS site. In addition, the Cu and Fe pollution might be indicated by the 78 kDa glucose regulated protein and ferritin GF1 in oysters C . sikamea , respectively. The study confirms that proteomics is a promising approach to characterize the underlying mechanisms of responses to metal pollution in oysters.

关键词： metal pollution Crassostrea sikamea biological eff ect proteomics

Pollutant mixing and transport process via diverse transverse release positions in a multi-anabranch river with three braid bars

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Water Science and Engineering 2013年第3期6卷 250-261页

作者： Zu-lin HUA Wei ji Ning-ning shan Wei wu Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of Education Hohai University College of Environment Hohai University National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai University

A multi-anabranch river with three braid bars is a typical river pattern in nature, but no studies have been conducted to describe mixing characteristics of pollutants in the river. In this study, a physical model of a typical multi-anabranch river with three braid bars was established to explore the pollutant mixing characteristics in different branches. The multi-anabranch reach was separated into seven branches, B1, B2, B3, B4, B5, B6, and BT, by three braid bars. Five tracer release positions located 2.9 m upstream from the inlet section of the multi-anabranch reach were adopted, and the distances from the five positions to the left bank of the upstream main channel were 1/6B, 1/3B, 1/2B, 2/3B, and 5/6B （B is the width of the upstream main channel）, respectively. The longitudinal velocities and pollutant concentrations in the seven branches were measured. The planar flow field and mixing characteristics of pollutants from the bottom to the surface in the multi-anabranch river were obtained and analyzed. The results show that the pollutant release positions are the main influencing factors in the pollutant transport process, and the diversion points and pollutant release positions jointly influence the percentage ratios of the pollutant fluxes in branches B 1, B2, and B3 to the pollutant flux in the upstream main channel.

关键词： multi-anabranch river braid bar, pollutant mixing characteristic pollutanttransport process

Engineered porous Ni2P-nanoparticle/Ni2P-nanosheet arrays via the Kirkendall effect and Ostwald ripening towards efficient overall water splitting

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Nano Research 2020年第8期13卷 2098-2105页

作者： Yutai wu Hui Wang shan ji Bruno G.Pollet Xuyun Wang Rongfang Wang State Key Laboratory Base for Eco-Chemical Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China College of Biological Chemical Science and Chemical EngineeringJiaxing UniversityJiaxing314001China Department of Energy and Process Engineering Faculty of EngineeringNorwegian University of Science and Technology(NTNU)NO-7491TrondheimNorway

Transitional metal phosphides with array-like structure grown on conductive support materials are promising bifunctional catalysts for the oxygen evolution reaction(OER)and hydrogen evolution reaction(HER).In this study,a method was developed to synthesize directly porous Ni2P nanosheet arrays and Ni2P nanoparticles onto nickel foam via a hydrothermal reaction followed by a phosphorization *** studies revealed that the allomorphs of Ni2P nanosheets and Ni2P nanoparticles in the array-like structure were formed via the Kirkendall effect and Ostwald ripening.A fully functional water electrolyzer containing Ni2P as electrodes for the OER and HER exhibited promising activity and *** 10 mA·cm^−2,a Ni2P cell voltage of 1.63 V was obtained,which was only 0.05 V smaller than that found for Pt/C/NF||RuO2/NF *** enhanced electrocatalytic performance resulted from the favorable porosity of the Ni2P arrays and the synergistic effect between Ni2P nanosheets and Ni2P nanoparticles.

关键词： Ni2P catalysts arrays overall water splitting Kirkendall effect Ostwald ripening