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Original article Efficacy and safety of Changfu peritoneal dialysis solution： a multi-center prospective randomized controlled trial

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Chinese Medical Journal 2013年第22期126卷 4204-4209页

作者： ZHOU jian-hui NI zhao-hui MEI Chang-lin yu Xue-qing LIU Fu-you MIAO Li-ning LIU Zhi-hong yuAN wei-jie ZHAng Ai-ping LIN hong-li CHEN Meng-hua CHEN jiang-hua ZHAng jin-yuan HE Ya-ni CHEN jian zhao jiu-yang DIng Xiao-qiang LI Ying LI Rong-shan XIE Ru-juan LIU wen-hu XIng Chang-ying w.ng Rong DEng yue-yi CAO Xue-ying CAI Guang-yan MOU Shan MAO Zhi-guo YAng Xiao LIU hong SUN jing yu yu-sheng LIU jun SHI Shu-mei LI Long-kai TIAN Na ZHAng Xiao-hui ZHOU wei YAng jie ZHAng yong SUN jing-di ji jun ZHAng Tao YAN Yan LIU Xiao-gang w.ng Gang ZHAng Li ZHAng hong LUO jian-hua CHEN Xiang-mei Department of Nephrology State Key Laboratory of Kidney Disease Chinese People's Liberation Army General Hospital Beijing 100853 China Renal Division Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

Background A multi-center large scale study is needed to confirm the efficacy and safety of domestic peritoneal dialysis （PD） solutions. Some researchers believe that 6 Lid is enough for adequate dialysis, but there is no multi-center prospective study on Chinese population to confirm this. In this study, we evaluated the efficacy and safety of domestic PD solution （Changfu） and its difference between 6 L and 8 L dosage. Methods Adult PD patients who had taken PD therapy for at least one month were selected and divided into four groups according to two dialysis solution brands and two dialysis dosages, i.e., 6 L dose with Changfu dialysis solution, 6 L dose with Baxter dialysis solution, 8 L dose with Changfu dialysis solution, and 8 L dose with Baxter dialysis solution. After 48 weeks, the changes of primary and secondary efficacy indices were compared between different types and different dosages. we also analyzed the changes of safety indices. Results Changes of Kt/V from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of creatinine clearance rate （Ccr）. Normalized protein catabolic rate （nPCR） from baseline to 48 weeks between Changfu and Baxter showed no statistical differences; so did those of net ultrafiltration volume （nUF） and estimated glomerular filtration rate （eGFR）. Changes of nPCR from baseline to 48 weeks between 6 L and 8 L showed no statistical differences; so did those of nUF and eGFR. The decline of Kt/V from baseline to 48 weeks in 6 L group was more than that in 8 L group. Change of Ccr was similar. During the 48-week period, the mean Kt/V was above 1.7/w, and mean Ccr was above 50 L.1.73 m-2.w1. More adverse events were found in Changfu group before Changfu Corporation commenced technology optimization, and the statistical differences disappeared after that. Conclusions The domestic PD solution （Changfu） was proven to be as effective as Baxter dialysis solution. During 48- week period, a dosage o

关键词： Changfu peritoneal dialysis solution efficacy safety

Panda X-III： Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers

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Science China(Physics,Mechanics & Astronomy) 2017年第6期60卷 8-47页

作者： Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling hui Gu Ke Han Xiang Dong ji Heng Lin jiang Lai Liu kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo w.ng yong Yang Dan Zhang Tao Zhang Li zhao Xiang Ming Sun Shou Yang Hu Si yu jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui zhao jing Zhou Ya jun Mao Hao Qiao Si Guang w.ng Ying yuan Meng w.ng Amir N.Khan Neill Raper jian Tang wei w.ng jia Ning Dong Chang qing Feng Cheng Li jian Bei Liu Shu Bin Liu Xiao Lian w.ng Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan wick Haxton yuan Mei Chinorat Kobdaj yu-Peng Yan NPAC and Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai Laboratory for Particle Physics and Cosmology Shanghai 200240 China College of Physical Science and Technology Central China Normal University Wuhan 430079 China China Institute of Atomic Energy Beijing 102413 China School of Physics Peking University Beijing 100871 China School of Physics and Key Laboratory of Particle Physics and Particle Irradiation (MOE) Shandong University Jinan 250100 China School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275 China Department of Modern Physics University of Science and Technology of China Hefei 230026 China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Hefei 230026 China University ofZaragoza C/P Cerbuna 12 50009 Zaragoza Spain IRFU CEA Universite Paris-Saclay F-91191 Gif-sur-Yvette France Department of Physics University of Maryland College Park MD 20742 USA Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Center for Excellence in High Energy Physics and Astrophysics Suranaree University of Technology Nakhon Ratchasima 30000 Thailand

Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation *** X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 *** pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the *** signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial *** detector will be immersed in a large water tank to ensure～5 m of water shielding in all *** second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds.

关键词： neutrinoless double beta decay lepton number violation underground experiment TPC Micromegas

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Biomarkers of aging

Science China(Life Sciences) 2023年第5期66卷 893-1066页

作者： Aging Biomarker Consortium Hainan Bao jiani Cao Mengting Chen Min Chen wei Chen Xiao Chen Yanhao Chen yu Chen yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding junlin Feng jun Guo Mengmeng Guo Chuting He yujuan jia Haiping jiang Ying jing Dingfeng Li jiaming Li jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar junhong Luo jianwei Lv jingyi Ma Kehang Mao jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang jianfang w.ng Qiaoran w.ng Siyuan w.ng Xuan w.ng Yaning w.ng yuhan w.ng Rimo wu kai Xia Fu-hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang yuanxin Yang Yilin Ying Le Zhang weiwei Zhang wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen jun Chen weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao jing-Dong JHan kai Huang Zhenyu Ju qing-Peng Kong ji Li jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao jing Nie Yaojin Peng jing Qu jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun yu Sun Mei Tian Shusen w.ng Si w.ng Xia w.ng Xiaoning w.ng Yan-jiang w.ng yunfang w.ng Catherine CL w.ng Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu jing Ye Rui yue Cuntai Zhang hongbo Zhang Liang Zhang weiqi Zhang yong Zhang yun-wu Zhang Zhuohua Zhang tongbiao zhao yuzheng zhao Dahai Zhu weiguo Zou Gang Pei Guang-hui Liu Aging Biomarker Consortium(ABC) Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China Clinic Center of Human Gene Research Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Clinical Research Center of Metabolic and Cardiovascular Disease Huazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging Huazhong University of Science and TechnologyWuhan 430022China Stem Cell Translational Research Center Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Nuclear Medicine Daping HospitalThird Military Medical UniversityChongqing 400042China CAS Key Laboratory of Nutrition Metabolism and Food SafetyShanghai Institute of Nutrition and HealthUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchShanghai Key Laboratory of Signaling and Disease ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China The Department of Endovascular Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Key Laboratory of Regenerative Medicine of Ministry of Education Institute of Ageing and Regenerative MedicineJ

Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological *** a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly *** immediate goal of biomarkers is to help us answer the follow.ng three fundamental questions in aging research:How old are we?why do we get old?And how can we age slower?This review aims to address this ***,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory *** fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant.

关键词： aging senescence biomarker clock

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem wolfgang Altmannshofer Fabio Alves weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai wenyong Cai wujun Cai Yijian Cai Yizhou Cai yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi junsong Cang Guofu Cao jianshe Cao Antoine Chance Xuejun Chang yue Chang Zhe Chang Xinyuan Chang wei Chao Auttakit Chatrabhuti Yimin Che yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen huirun Chen jinhui Chen ji-yuan Chen kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng tongguang Cheng yunlong Chi Pietro Chimenti wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui zhaoyuan Cui Brunella D'Anzi Ling-yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu kaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China west Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP jiNR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,w,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 Mw per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 Mw per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

吲哚菁绿荧光成像技术在口腔鳞癌治疗中的应用:中国专家共识

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中国口腔颌面外科杂志 2022年第1期20卷 1-6页

作者：王育新王志勇王永功王慧明王丽珍田皞叶金海付坤阮敏孙长伏孙国文刘法昱许碧云后军刘冰刘亮陈永锋陈占伟肖灿李思毅李志勇李勇李楠张陈平张东升张胜张凯杨溪何巍苏彤季彤林李嵩罗瑞华赵志立胡勤刚唐瞻贵徐蔚嘉黄志权黄晓峰梁玉洁韩正学韩伟蒋灿华喻建军蔡志刚廖贵清廖圣恺蔡惠明魏建华南京大学医学院附属口腔医院河南省人民医院浙江大学医学院附属口腔医院上海交通大学医学院附属第九人民医院湖南省肿瘤医院南京医科大学附属口腔医院郑州大学医学院附属第一医院中国医科大学附属口腔医院南京大学医学院附属鼓楼医院安徽医科大学第一附属医院武汉大学口腔医院蚌埠医学院第一附属医院山东第一医科大学附属省立医院苏州大学附属第一医院重庆医科大学附属口腔医院中南大学湘雅二医院中南大学湘雅医院福建医科大学附属口腔医院河南省肿瘤医院中南大学湘雅第二医院中南大学湘雅口腔医院中山大学孙逸仙纪念医院中山大学光华口腔医学院·附属口腔医院首都医科大学附属北京口腔医院北京大学口腔医院南京诺源医疗器械有限公司空军军医大学第三附属医院

吲哚菁绿(indocyanine green,ICG)荧光成像是一种基于ICG增强的渗透性和滞留效应(enhanced permeability and retention effect,EPR)的活体组织实时近红外显像技术,临床上可对实体肿瘤及其周围组织进行差异显像,评估肿瘤范围及手术切缘... 详细信息

吲哚菁绿(indocyanine green,ICG)荧光成像是一种基于ICG增强的渗透性和滞留效应(enhanced permeability and retention effect,EPR)的活体组织实时近红外显像技术,临床上可对实体肿瘤及其周围组织进行差异显像,评估肿瘤范围及手术切缘。该荧光成像技术用于口腔鳞癌(oral squamous cell carcinoma,OSCC)外科治疗尚处于起步阶段,在适应证、操作流程、注意事项等方面均缺乏相应规范。在前期开展的ICG近红外荧光成像辅助OSCC外科治疗的多中心临床研究基础上,经国内多家医学院校口腔颌面外科专家的共同商讨,参考国内外相关文献,形成ICG荧光成像技术在OSCC治疗中的应用专家共识,以期指导OSCC外科治疗的临床实践。

关键词：吲哚菁绿荧光成像口腔鳞癌专家共识

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天琴计划简介

中山大学学报（自然科学版） 2021年第1期60卷 1-19页

作者：罗俊艾凌皓艾艳丽安子聪白伟钢白彦峥包佳慧曹斌常文博陈琛陈厚源崔凯单莹丁延卫段会宗范会敏范磊范纹彤范霄冯文凡付新菊付瑜亮高晨光郜青高添泉高鑫高永新龚云贵谷德峰辜凌云郭兴韩西达何芸胡一鸣胡越新胡展黄顺佳黄祥青黄潇博纪沐婕蒋贇焦磊靳鸿鸣康小明匡双阳雷卫华李程远李洪银李珏李康康李萌李明黎明李涛李霄栋李语强李祝李竹溪黎樽彪练军想梁正程林伟凌晨刘辉刘佳恒刘建平刘力刘祺刘尚飞刘胜前刘帅刘旭辉刘雁冲刘源龙江龙军陆璐罗成健骆颖欣马波梅健伟孟云鹤明珉牛翔潘加键庞爱平彭慧生屈少波区子维任亮亮申荣锋沈岩石常富宋佳凝宋培义索晓晨谭柏轩谭定银檀庄斌涂良成王成王铖锐王凤彬王海天王继河王凌风王尚胜王泰卜汪旭东王炎汪洋汪一萍王智钊魏东东文明轩吴庆文吴勤勤吴书朝吴先霖夏冰夏旭肖青肖小圆谢宁徐家豪颜浩闫勇杨铖杨诚鋆杨涓杨列杨山清叶伯兵叶贤基叶小容尹航于达仁袁慧敏曾明张才士张德轩张建东张静怡张锦绣张居正张开张蜡宝张立华张涛张鑫张鑫2 张雪峰赵宏超赵玥赵泽伟周鸿博周金灵周立祥周泽兵朱凡朱炬波訾铁光邹远川 “天琴计划”教育部重点实验室中山大学天琴中心天琴前沿科学中心国家航天局引力波研究中心广东珠海519082 中山大学物理与天文学院广东珠海519082 华中科技大学物理学院湖北武汉430074 航天东方红卫星有限公司北京100094 中国科学院云南天文台云南昆明650011 哈尔滨工业大学能源科学与工程学院黑龙江哈尔滨150001 北京控制工程研究所北京100094 东北大学理学院辽宁沈阳110004 贵州大学电气工程学院贵州贵阳550025 南京大学电子科学与工程学院江苏南京210093 上海交通大学机械与动力工程学院上海200240 深圳技术大学工程物理学院广东深圳518118 武汉大学电子信息学院湖北武汉430072 西北工业大学航空航天学院陕西西安710072 西南大学物理科学与技术学院重庆400715 中国科学院紫金山天文台江苏南京210023 中山大学航空航天学院广东广州510006 冲绳科学技术大学院大学日本冲绳951-8073

天琴计划预期于2035年左右发射并部署边长约17万公里的等边三角形卫星星座,构成一个引力波天文台—天琴。天琴将对10^(-4)~1 Hz频段的引力波进行探测,为人类描绘一幅更全面的宇宙图景。在本文中,我们对天琴计划的背景和提出过程、天琴... 详细信息

天琴计划预期于2035年左右发射并部署边长约17万公里的等边三角形卫星星座,构成一个引力波天文台—天琴。天琴将对10^(-4)~1 Hz频段的引力波进行探测,为人类描绘一幅更全面的宇宙图景。在本文中,我们对天琴计划的背景和提出过程、天琴的主要探测对象和主要科学目标、天琴需要攻克的核心关键技术问题、天琴计划技术路线图及进展等进行介绍,以方便更多人加入这一项富有挑战而又激动人心的工作。

关键词：天琴计划空间引力波探测引力波