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Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats

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Acta Pharmacologica Sinica 2005年第3期26卷 353-358页

作者： Yang-mei DENG qiang-min XIE~2 Shui-juan ZHANG ji-qiang CHEN Qiu-huo YANG Ru-lian BIAN Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China,Medical School of Zhejiang University,Hangzhou 310031,China Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China Medical School of Zhejiang University Hangzhou China

Aim:To explore the change of 5-lipoxygenase (5-LO) pathway expression andproinflammatory mediators level of lung tissue and cerebral cortex,and the pos-sible regulatory mechanism through central nervous 5-LO pathways to pulmo-nary inflammatory status in antigen repeated challenged ***:Fourgroups of rats were treated as control,asthma model,asthma model treatmentwith dexamethasone (DXM,0.5 mg/kg,ip) and ketotifen (5 mg/kg,ig).Tumornecrosis factor (TNF)-α,interleukin (IL)-4,interferon (IFN)-γ,and nitric oxide(NO) were detected by ELISA *** mRNA expression of 5-LO and LTA4-hydrolase (LTA4-H) was analyzed by reverse transcription-polymerase chain re-action (RT-PCR),and the protein content of 5-LO was measured by Western ***:Increase of TNF-α,IL-4,NO level,and decrease of IFN-γ level inbronchoalveolar lavage fluid (BALF) and cerebral cortex in sensitized rats wereshown after repeated antigen *** expression of 5-LO and LTA4-HmRNA,and 5-LO protein levels were increased in lung tissue and cerebral cortexin asthma *** comparison with the asthma model,DXM significantly inhib-ited the increase of cytokine levels and the expression of 5-LO pathway enzyme(P<0.05).Ketotifen also inhibited the increase of TNF-α level and 5-LO path-way enzyme expression in lung and cerebral cortex,but had no effect on the levelof NO,IL-4,and IFN-γ.Conclusion:The correlative increase of 5-LO pathwayenzyme expression and proinflammatory mediators of brain may have a regula-tory effect on pulmonary inflammation in asthma.

关键词： 5-1ipoxygenase leukotriene A4-hydrolase cytokine brain lung asthma

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导弹折叠翼展开过程的动力学仿真及试验研究

兵工学报 2016年第8期37卷 1409-1414页

作者：甄文强姬永强石运国中国工程物理研究院总体工程研究所四川绵阳621000

对导弹中常用的横向折叠翼展开过程进行研究,考虑折叠翼展开过程中气动阻力和摩擦力的作用,建立了导弹发射及地面试验时折叠翼展开过程的数学模型,使用动力学仿真软件建立相应动力学仿真模型,设计并制作了折叠翼,使用高速摄影获取折叠... 详细信息

对导弹中常用的横向折叠翼展开过程进行研究,考虑折叠翼展开过程中气动阻力和摩擦力的作用,建立了导弹发射及地面试验时折叠翼展开过程的数学模型,使用动力学仿真软件建立相应动力学仿真模型,设计并制作了折叠翼,使用高速摄影获取折叠翼展开过程图像,开展地面试验研究。研究结果表明,试验结果与数学模型及动力学仿真模型结果的一致性较好,验证了折叠翼展开过程数学及动力学仿真模型的正确性。根据试验结果给出摩擦力矩的具体取值范围,为折叠翼的工程设计和应用提供了参考。

关键词：兵器科学与技术折叠翼展开动力学仿真试验

Amygdalin Ameliorates Liver Fibrosis through Inhibiting Activation of TGF-β/Smad Signaling

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Chinese Journal of Integrative Medicine 2023年第4期29卷 316-324页

作者： XIAO Zhun ji qiang FU Ya-dong GAO Si-qi HU Yong-hong LIU Wei CHEN Gao-feng MU Yong-ping CHEN jia-mei LIU Ping Institute of Liver Diseases Key Laboratory of Liver and Kidney Diseases(Ministry of Education)Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China E-Institute of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine Shanghai 201203China Shanghai Key Laboratory of Traditional Chinese Medicine Shanghai 201203China

Objective:To observe the effect of amygdalin on liver fibrosis in a liver fibrosis mouse model,and the underlying mechanisms were partly dissected in vivo and in ***:Thirty-two male mice were randomly divided into 4 groups,including control,model,low-and high-dose amygdalin-treated groups,8 mice in each *** the control group,mice in the other groups were injected intraperitoneally with 10%carbon tetrachloride(CCl4)-olive oil solution 3 times a week for 6 weeks to induce liver *** the first 3 weeks,amygdalin(1.35 and 2.7 mg/kg body weight)were administered by gavage once a *** in the control group received equal quantities of subcutaneous olive oil and intragastric water from the fourth *** the end of 6 weeks,liver tissue samples were harvested to detect the content of hydroxyproline(Hyp).Hematoxylin and eosin and Sirius red staining were used to observe the inflammation and fibrosis of liver *** expressions of collagenⅠ(Col-Ⅰ),alpha-smooth muscle actin(α-SMA),CD31 and transforming growth factorβ(TGF-β)/Smad signaling pathway were detected by immunohistochemistry,quantitative real-time polymerase chain reaction and Western blot,*** activation models of hepatic stellate cells,JS-1and LX-2 cells induced by TGF-β1 were used in vitro with or without different concentrations of amygdalin(0.1,1,10μmol/L).The effect of different concentrations of amygdalin on the expressions of liver sinusoidal endothelial cells(LSECs)dedifferentiation markers CD31 and CD44 were ***:High-dose of amygdalin significantly reduced the Hyp content and percentage of collagen positive area,and decreased the mRNA and protein expressions of Col-Ι,α-SMA,CD31 and p-Smad2/3 in liver tissues of mice compared to the model group(P<0.01).Amygdalin down-regulated the expressions of Col-Ⅰandα-SMA in JS-1 and LX-2 cells,and TGFβR1,TGFβR2 and p-Smad2/3 in LX-2 cells compared to the model group(P<0.05 or P<0.01).Moreover,1 and 10μmol/L amygdal

关键词： amygdalin liver fibrosis hepatic stellate cells liver sinusoidal endothelial cells TGF-β/Smad signalingpathway

Persistent left superior vena cava associating with anomalous right superior vena cava drainage, atrial septal defect and atrial fibrillation: a case report

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Chinese Medical Journal 2019年第2期132卷 220-222页

作者： Lei Li Ke-qiang ji Chun-Yuan YOU Department of Cardiology The affiliated Wuxi No.2 People's Hospital of Nanjing Medical UniversityWuxiJiangsu 214000China Department of Cardiothoracic Surgery The affiliated Wuxi No.2 People's Hospital of Nanjing Medical UniversityWuxiJiangsu 214000China

To the Editor:A 53-year-old man recently presented to our hospital with a history of palpitations, lightheadedness, dyspnea and chest tightness over the past half *** addition, the patient had been prone to activity-induced fatigue since childhood, and had a history of being susceptible to respiratory tract *** physical examination, there was a detected an irregular pulse and cardiac *** of the pulmonary valve revealed accentuation of the second heart sound at the left side of the sternum, between the first and second ribs, and grade 3/6 systolic murmur.

关键词： To the Editor recently presented hospital

New Advances in the Study of the Devonian-Carboniferous Boundary Stratotype in Muhua,Changshun,Guizhou——An Introduction to the Daposhang Devonian-Carboniferous Boundary Section

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Acta Geologica Sinica(English Edition) 1988年第4期1卷 349-363+464-466页

作者： ji qiang Wei jiayong Wang Hongdi Wang Ning Luo Xiaosong Chinese Academy of Geological Sciences, Beijing Guizhou Regional Geological Survey Party, Guiyang, Guizhou Chinese Academy of Geological Sciences Beijing China

The Daposhang section at Muhua, Changshun. Guizhou. is an excellent and attractive DevonianCarboniferous boundary section. The transitional beds between the Devonian and Carboniferous of the sectionare continuous and well exposed. belonging to the deep-water basin facies Abundant fossil groups have beendiscovered from this section: conodonts. ammonoids. trilobites. ostracods. vertebrate microfossils and so *** far as known. it has the most continuous and complete conodont zonation for the Devonian-Carboniferousboundary beds in the world. It is especially worth pointing out that both typical Siponodella pracsulcata andthe transitional forms between S. praesulcata and S. sulcata have been found from the upper pracsulcata Zoneof the Daposhang section. Evidently. we can not only prove the actual existence of the evolutionary lineagefrom S. praesulcata to S. sulcata, but also exactly define the level of the Devonian-Carboniferous boundary. Inthis paper. the development of the Devonian-Carboniferous boundary beds at the Daposhang section is dealtwith and the section is compared with the Muhua section and the Nanbiancun section which are the candidatesfor the Devonian-Carboniferous boundary stratotype. In the authous opinion the Daposhang section is obvi-ously better than the Muhua and the Nanbiancun sections. hence it can be recommended as one of the candi-dates for the international Devonian-Carboniferous boundary stratotype.

关键词： In oral New Advances in the Study of the Devonian-Carboniferous Boundary Stratotype in Muhua,Changshun,Guizhou

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中国恐龙蛋研究的历史与现状

地球学报 2009年第3期30卷 285-290页

作者：季强中国地质科学院地质研究所北京100037

本文对我国恐龙蛋研究历史作了简略回顾,大致分为三个研究阶段:形态分类、半自然分类和自然分类阶段。本文根据中国江西赣州晚白垩世南雄组产出的两枚含胚胎恐龙蛋的研究,认为这两枚恐龙蛋处于不同的发育阶段,蛋体形态和蛋壳显微结构表... 详细信息

本文对我国恐龙蛋研究历史作了简略回顾,大致分为三个研究阶段:形态分类、半自然分类和自然分类阶段。本文根据中国江西赣州晚白垩世南雄组产出的两枚含胚胎恐龙蛋的研究,认为这两枚恐龙蛋处于不同的发育阶段,蛋体形态和蛋壳显微结构表明它们同属于以往在广东发现的瑶屯巨型蛋(Macroolithus yaotunensis),骨骼学研究表明它们可能是黄氏河源龙(Heyuannia huangi)或与其亲缘关系相近的窃蛋龙所产。江西赣州晚白垩世含胚胎恐龙蛋的首次发现标志着我国恐龙蛋研究已进入自然分类阶段。

关键词：江西晚白垩世恐龙蛋胚胎学

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锁模力检测及P-Q图像绘制智能化

铸造 2019年第6期68卷 628-633页

作者：唐继强力劲集团宁波力劲科技有限公司浙江宁波315806

以30000kN压铸机生产某款L4汽车发动机缸体为例,简要介绍新型柱塞式锁模力检测装置的安装和压铸机操作界面的锁模力设置,实现了生产过程实时监控智能化。基于VB编程语言及换算速度,进行P-Q图像智能化绘制,为压铸机能力与模具的匹配提供... 详细信息

以30000kN压铸机生产某款L4汽车发动机缸体为例,简要介绍新型柱塞式锁模力检测装置的安装和压铸机操作界面的锁模力设置,实现了生产过程实时监控智能化。基于VB编程语言及换算速度,进行P-Q图像智能化绘制,为压铸机能力与模具的匹配提供依据,以此确定压铸工艺参数调整的有效性。

关键词：锁模力监测 P-Q图像绘制智能化

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热流道技术在热室压铸生产中的应用

铸造 2015年第5期64卷 409-414页

作者：唐继强力劲集团宁波力劲科技有限公司浙江宁波315806

对锌合金和镁合金分别进行了热流道压铸成形试验验证,试验结果表明:产品成形品质好,满足了大批量生产的需要。应用了可延长使用寿命的热流道喷嘴和可减少热流道加热组件热量散失的支撑滑块,设计了拼接式热流道板结构以满足支撑热喷嘴要... 详细信息

对锌合金和镁合金分别进行了热流道压铸成形试验验证,试验结果表明:产品成形品质好,满足了大批量生产的需要。应用了可延长使用寿命的热流道喷嘴和可减少热流道加热组件热量散失的支撑滑块,设计了拼接式热流道板结构以满足支撑热喷嘴要求。针对热室压铸合金的工艺特点,介绍了热流道结构、加热功率计算、热膨胀量计算及隔热措施。

关键词：热流道喷嘴支撑滑块拼接式热流道板热流道结构电磁感应加热隔热圈

Probing cytotoxicity of CdSe and CdSe/CdS quantum dots

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Chinese Chemical Letters 2011年第7期22卷 843-846页

作者： Yan jie Bao Jun Jun Li Yi Ting Wang Lei Yu Lei Lou Wei ji Du Zi qiang Zhu Hui Peng jian Zhong Zhu Institutes for Advanced Interdisciplinary Research East China Normal University Shanghai 200062 China

Toxicities of CdSe and CdSe/CdS quantum dots （QDs） synthesized by ultrasound-assisted methods were investigated in vitro and in vivo. Five human cell lines were used to assess the cytotoxicity of as-prepared CdSe and CdSe/CdS by assays of MTT viability, red blood cell hemolysis, flow cytometry, and fluorescence imaging. The results show that these QDs may be cytotoxic by their influence in S and G2 phases in cell cycles. The cytotoxicity of QDs depends on both the physicochemical properties and related to target cells.

关键词： Cytotoxicity Quantum dots CdSe CdSe/CdS Cell