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3-manifold Containing Separating Incompressible Surfaces of All Positive Genera

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Acta mathematica Sinica,English Series 2005年第6期21卷 1315-1318页

作者： ji ming ma Rui Feng QIU Department of mathematics Jilin University Changchun 130023 P. R. China Department of mathematics Dalian University of Technology Dalian 116024 P. R. China

In this paper, we shall prove that for any orientable 3-manifold M, there is a link L - K U K1 U K2 U K3 with four components in M, such that the complement of L, say ML, contains separating essential closed surfaces ... 详细信息

关键词： Incompressible surface Knot 3-manifolds

Analytical study on water hammer pressure in pressurized conduits with a throttled surge chamber for slow closure

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Water Science and Engineering 2010年第2期3卷 174-189页

作者： Yong-liang ZHANG ming-fei MIAO ji-ming ma State Key Laboratory of Hydroscience and Hydraulic Engineering Department of Hydraulic Engineering Tsinghua University Beijing 100084 P. R. China

This paper presents an analytical investigation of water hammer in a hydraulic pressurized pipe system with a throttled surge chamber located at the junction between a tunnel and a penstock, and a valve positioned at the downstream end of the penstock. Analytical formulas of maximum water hammer pressures at the downstream end of the tunnel and the valve were derived for a system subjected to linear and slow valve closure. The analytical results were then compared with numerical ones obtained using the method of characteristics. There is agreement between them. The formulas can be applied to estimating water hammer pressure at the valve and transmission of water hammer pressure through the surge chamber at the junction for a hydraulic pipe system with a surge chamber.

关键词： throttled surge chamber water hammer orifice analytical formula

Synthesis of Crystalline Nanosized Titanium Dioxide via a Reverse Micelle Method at Room Temperature

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Chinese Chemical Letters 2003年第1期14卷 100-103页

作者： Dong Bai ZHANG Li Min QI Hu Min CHENG ji ming ma College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871

Crystalline TiO2 nanoparticles were synthesized by hydrolysis of titanium tetrabutoxide in the presence of hydrochloric acid in NP-5 (Igepal CO-520)/ cyclohexane reverse micelle solution at room temperature. Pure rutile nanoparticles were obtained at an appropriate acid concentration. The influences of various reaction conditions such as the concentration of acids, water content value (w=[H2O]/[NP-5]) on the formation, crystal phase, morphology, and size of the TiO2 particles were investigated.

关键词： Reverse micelle nanoparticle titanium dioxide.

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei ma Yuying Guan Mengyuan Guo Qianqian Shao Xunming ji jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Nitrogen addition promotes soil carbon accumulation globally

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Science China Life Sciences 2025年第1期 284-293页

作者： Xuemei Yang Suhui ma Erhan Huang Danhua Zhang Guoping Chen jiangling Zhu Chengjun ji Biao Zhu Lingli Liu jingyun Fang Institute of Ecology College of Urban and Environmental Sciencesand Key Laboratory for Earth Surface Processes of the Ministry of EducationPeking University Ministry of Education Key Laboratory for Transboundary Ecosecurity of Southwest China School of Ecology and Environmental ScienceYunnan University State Key Laboratory of Vegetation and Environmental Change Institute of BotanyChinese Academy of Sciences

Soil is the largest carbon(C) reservoir in terrestrial ecosystems and plays a crucial role in regulating the global C cycle and climate *** nitrogen(N) deposition has been widely considered as a critical factor affecting soil organic carbon(SOC) storage, but its effect on SOC components with different stability remains unclear. Here, we analyzed extensive empirical data from 304 sites worldwide to investigate how SOC and its components respond to N addition. Our analysis showed that N addition led to a significant increase in bulk SOC(6.7%), with greater increases in croplands(10.6%) and forests(6.0%) compared to grasslands(2.1%). Regarding SOC components, N addition promoted the accumulation of plant-derived C(9.7%–28.5%) over microbial-derived C(0.2%), as well as labile(5.7%) over recalcitrant components(–1.2%), resulting in a shift towards increased accumulation of plant-derived labile C. Consistently, N addition led to a greater increase in particulate organic C(11.9%) than mineral-associated organic C(3.6%), suggesting that N addition promotes C accumulation across all pools, with more increase in unstable than stable pools. The responses of SOC and its components were best predicted by the N addition rate and net primary productivity. Overall, our findings suggest that N enrichment could promote the accumulation of plant-derived and non-mineral associated C and a subsequent decrease in the overall stability of soil C pool, which underscores the importance of considering the effects of N enrichment on SOC components for a better understanding of C dynamics in soils.

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-jian Tang Yuan-ming Pan Wei Li Rui-Qiong ma jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li ming-Ke Wang ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection macronutrients Vitamins Minerals

A GPU-accelerated two-phase flow model for fluid-solid interaction using the sharp interface immersed boundary method

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JOURNAL OF HYDRODYNAMICS 2024年第5期36卷 883-897页

作者： ma, Li-ping Lian, ji-jian Liu, Dong-ming Tianjin Univ State Key Lab Hydraul Engn Intelligent Construct & Tianjin 300072 Peoples R China Tianjin Univ Sch Civil Engn Tianjin 300072 Peoples R China Sichuan Univ State Key Lab Hydraul & Mt River Engn Chengdu 610065 Peoples R China

A two-phase flow model accelerated by graphical processing unit (GPU) is developed to solve fluid-solid interaction (FSI) using the sharp-interface immersed boundary method (IBM). This model solves the incompressible Navier-Stokes equations using the projection-based fractional step method in a fixed staggered Cartesian grid system. A volume of fluid (VOF) method with second-order accuracy is employed to trace the free surface. To represent the intricate surface geometry, the structure is discretized using the unstructured triangle mesh. Additionally, a ray tracing method is employed to classify fluid and solid points. A high-order stable scheme has been introduced to reconstruct the local velocity at interface points. Three FSI problems, including wave evolution around a breakwater, interaction between a periodic wave train and a moving float, and a 3-D moving object interacting with the free surface, were investigated to validate the accuracy and stability of the proposed model. The numerical results are in good agreement with the experimental data. Additionally, we evaluated the computational performance of the proposed GPU-based model. The GPU-based model achieved a 42.29 times speedup compared with the single-core CPU-based model in the three-dimension test. Additionally, the results regarding the time cost of each code section indicate that achieving more significant acceleration is associated with solving the turbulence, advection, and diffusion terms, while solving the pressure Poisson equation (PPE) saves the most time. Furthermore, the impact of grid number on computational efficiency indicates that as the number of grids increases, the GPU-based model outperforms the multi-core CPU-based model.

关键词： Fluid-solid interaction (FSI) immersed boundary method (IBM) graphical processing unit (GPU) two-phase flow moving rigid body