检索结果-南通市图书馆

Accumulation of poly(adenosine diphosphate-ribose)by sustained supply of calcium inducing mitochondrial stress in pancreatic cancer cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第27期28卷 3422-3434页

作者： Keun-Yeong Jeong Jae Jun Sim Minhee park hwan Mook Kim Research and Development Metimedi PharmaceuticalsIncheon 22006South Korea

BACKGROUND The biochemical phenomenon defined as poly adenosine diphosphate(ADP)-ribosylation(PARylation)is essential for the progression of pancreatic ***,the excessive accumulation of poly ADP-ribose(PAR)induces apoptosis-inducing factor(AIF)release from mitochondria and energy deprivation resulting in the caspase-independent death of cancer *** To investigate whether sustained calcium supply could induce an anticancer effect on pancreatic cancer by PAR *** Two pancreatic cancer cell lines,AsPC-1 and CFPAC-1 were used for the *** influx and mitochondrial reactive oxygen species(ROS)were observed by fluorescence *** in enzyme levels,as well as PAR accumulation and energy metabolism,were measured using assay ***-dependent cell death was investigated followed by confirming in vivo anticancer effects by sustained calcium *** Mitochondrial ROS levels were elevated with increasing calcium influx into pancreatic cancer ***,excess PAR accumulation,decreased PAR glycohydrolase and ADP-ribosyl hydrolase 3 levels,and energy deprivation were *** vitro and in vivo antitumor effects were confirmed to accompany elevated AIF *** This study visualized the potential anticancer effects of excessive PAR accumulation by sustained calcium supply on pancreatic cancer,however elucidating a clear mode of action remains a challenge,and it should be accompanied by further studies to assess its potential for clinical application.

关键词： Pancreatic cancer Calcium Reactive oxygen species Poly adenosine diphosphate-ribose Poly adenosine diphosphate-ribosylation Poly adenosine diphosphate-ribose polymerase Apoptosis-inducing factor Nicotinamide adenine dinucleotide Anticancer effect

Rhamnus crenata leaf extracts exhibit anti-inflammatory activity via modulating the Nrf2/HO-1 and NF-κB/MAPK signaling pathways

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2022年第10期12卷 430-436页

作者： Hyun ji Eo Da Som Kim Gwang Hun park Special Forest Resources Division Department of Forest Bio-ResourcesNational Institute of Forest ScienceSuwon 16631Korea Forest Medicinal Resources Research Center National Institute of Forest ScienceYeongju 36040Korea

Objective:To elucidate the potential anti-inflammatory mechanisms of Rhamnus crenata leaf extracts using RAW264.7 ***:We used 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay to measure cell *** oxide(NO)production was measured using Griess *** blotting and RT-PCR assays were carried out for analyzing the protein and gene expressions of pro-inflammatory mediators,***,PD98059(ERK1/2 inhibitor),SB203580(p38 inhibitor),SP600125(JNK inhibitor),and BAY11-7082(NF-κB inhibitor)were used to evaluate the anti-inflammatory mechanism of Rhamnus crenata leaf ***:Rhamnus crenata leaf extracts significantly inhibited the production of the pro-inflammatory mediators such as NO,iNOS,COX-2,IL-1β,and TNF-αin lipopolysaccharide(LPS)-stimulated RAW264.7 *** crenata leaf extracts also suppressed LPS-induced degradation of IκB-αand nuclear accumulation of p65,which resulted in the inhibition of NF-κB activation in RAW264.7 ***,the extracts attenuated the phosphorylation of p38,ERK1/2,and JNK in LPS-stimulated RAW264.7 ***,HO-1 expression induced by Rhamnus crenata leaf extracts was significantly downregulated by SB230580,PD98059,SP600125 and ***:Rhamnus crenata leaf extract may upregulate HO-1 expression through inhibition of p38,ERK1/2,and NF-κB activation,which may contribute to the anti-inflammatory activity of the *** crenata leaf extracts may have great potential for the development of anti-inflammatory drugs to treat acute and chronic inflammatory diseases.

关键词： Anti-inflammatory activity Heme oxygenase-1 Nrf2 Mitogen-activated protein kinase Nuclear factor kappa B Rhamnus crenata

Orthotic approach to prevention and management of diabetic foot:A narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2022年第11期13卷 912-920页

作者： Min Cheol Chang Yoo jin Choo In Sik park Myung Woo park Du hwan Kim Rehabilitation Medicine Yeungnam UniversityDaegu 42415South Korea Korean Podiatry and Pedorthics Institute Goyang 10442South Korea Physical Medicine and Rehabilitation Chung-Ang UniversitySeoul 06973South Korea

Diabetic foot is a common complication affecting more than one-fifth of patients with *** not treated in time,it may lead to diabetic foot ulcers or Charcot *** the management of diabetic foot,shoe modifications and orthoses can be used to reduce pressure on the affected foot or provide the foot with increased *** addition,the shoe modifications and orthotic devices can relieve patient discomfort during *** shoe modifications include changing the insole material,modifying the heel height,adding a steel shank or rocker sole,and using in-depth ***,a walking brace or ankle-foot orthosis can be used to reduce the pressure on the affected *** purpose of this narrative review was to provide a reference guide to support clinicians in prescribing shoe modifications and foot orthoses to treat diabetic foot ulcers and Charcot arthropathy.

关键词： Diabetic foot Foot ulcers Charcot arthropathy Shoes Foot orthosis

Integrating Deep Learning and Machine Translation for Understanding Unrefined Languages

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第1期70卷 669-678页

作者： Hong Geun ji Soyoung Oh jina Kim Seong Choi Eunil park Department of Applied Artificial Intelligence Sungkyunkwan UniversitySeoul03063Korea Raon Data Seoul03073Korea Department of Computer Science and Engineering University of MinnesotaMinneapolis55455MNUSA

In the field of natural language processing(NLP),the advancement of neural machine translation has paved the way for cross-lingual ***,most studies in NLP have evaluated the proposed language models on well-refined *** investigatewhether amachine translation approach is suitable for multilingual analysis of unrefined datasets,particularly,chat messages in *** order to address it,we collected the dataset,which included 7,066,854 and 3,365,569 chat messages from English and Korean streams,*** employed several machine learning classifiers and neural networks with two different types of embedding:word-sequence embedding and the final layer of a pre-trained language *** results of the employed models indicate that the accuracy difference between English,and English to Korean was relatively high,ranging from 3%to 12%.For Korean data(Korean,and Korean to English),it ranged from 0%to 2%.Therefore,the results imply that translation from a low-resource language(e.g.,Korean)into a high-resource language(e.g.,English)shows higher performance,in contrast to vice *** implications and limitations of the presented results are also *** instance,we suggest the feasibility of translation from resource-poor languages for using the tools of resource-rich languages in further analysis.

关键词： Twitch multilingual machine translation machine learning

Management of post-liver transplantation biliary stricture inaccessible by endoscopic retrograde cholangiopancreatography:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2023年第34期11卷 8235-8241页

作者： Yohan Lee Chang hwan park Eunae Cho Ki-Hyun Kim Division of Gastroenterology and Hepatology Department of Internal MedicineChonnam National University HospitalGwangju 61469South Korea

BACKGROUND One challenging scenario in the treatment of biliary stricture is that post-liver transplantation(LT)biliary strictures cannot be accessed using endoscopic retrograde cholangiopancreatography(ERCP).Here,we report such a case that was successfully treated using a novel endoscopic *** SUMMARY A 60-year-old man presented with obstructive jaundice caused by a post-LT biliary *** underwent LT for compensated alcoholic liver cirrhosis and hepatocellular *** investigations unveiled a cholestatic pattern of abnormalities in liver function and a total bilirubin level of 16 mg/*** resonance cholangiopancreatography revealed a stricture extending from the right intrahepatic bile duct into the common hepatic *** postoperative deformities made accessing the ampulla of Vater with a sideviewing duodenoscope *** transhepatic biliary drainage(PTBD)was performed to treat biliary ***,to resolve the stricture completely,a fully covered self-expandable metal stent(FC-SEMS)with a novel proximal retrievable string was deployed into the post-LT biliary stricture through the PTBD *** inserting the stent through the PTBD tract,the stent with the distal string was manually inverted to ensure that the distal part with the string became the proximal part for later endoscopic *** 6 mo,the FC-SEMS was successfully removed without complications,as the string was pulled out using a forward-viewing *** Deployment and endoscopic removal of an FC-SEMS with a novel proximal string through the PTBD tract may be a viable option for treating post-LT biliary strictures that are inaccessible by ERCP.

关键词： Jaundice Obstructive Percutaneous transhepatic cholangioscopy Self-expandable metallic stents Case report

Efficient Gauss-Seidel Precoding with Parallel Calculation in Massive MIMO Systems

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2022年第1期70卷 491-504页

作者： Hyun-Sun hwang Jae-Hyun Ro Chan-Yeob park Young-hwan You Hyoung-Kyu Song Department of Information and Communication Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea Department of Convergence Engineering for Intelligent Drone Sejong UniversitySeoul05006Korea Department of Computer Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea

A number of requirements for 5G mobile communication are satisfied by adopting multiple input multiple output(MIMO)*** inter user interference(IUI)which is an inevitable problem in MIMO systems becomes controllable when the precoding scheme is *** this paper,the horizontal Gauss-Seidel(HGS)method is proposed as precoding scheme in massive MIMO *** massive MIMO systems,the exact inversion of channel matrix is impractical due to the severe computational ***,the conventionalGauss-Seidel(GS)method is used to approximate the inversion of channel *** GS has good performance by using previous calculation results as ***,the required time for obtaining the precoding symbols is too long due to the sequential process of ***,the HGS with parallel calculation is proposed in this paper to reduce the required *** rows of channel matrix are eliminated for parallel calculation *** addition,HGSuses the ordered channelmatrix to prevent performance degradation which is occurred by parallel *** HGS with proper number of parallelly computed symbols has better performance and reduced required time compared to the traditional GS.

关键词： Massive MIMO GS matrix inversion linear precoding

Incidence and Related Risk Factors of Junctional Ectopic Tachycardia in Infants after Cardiac Surgery for Congenital Heart Disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2022年第5期17卷 569-578页

作者： Jae Hee Seol Se Yong Jung Jae Young Choi Han Ki park Young hwan park Nam Kyun Kim Department of Pediatrics Congenital Heart Disease CenterDivision of Pediatric CardiologySeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics Yonsei University Wonju College of MedicineWonjuKorea Department of Thoracic and Cardiovascular Surgery Division of Cardiovascular SurgeryCongenital Heart Disease CenterSeverance Cardiovascular HospitalYonsei University College of MedicineSeoulKorea Department of Pediatrics and Biomedical Engineering School of MedicineEmory UniversityAtlantaUSA

Objective:Junctional ectopic tachycardia is common after cardiac surgery for congenital heart ***,its incidence and related risk factors in infants after cardiac surgery are not well *** objective of this study was to determine the overall incidence and related risk factors for junctional ectopic tachycardia in neonates and ***:We enrolled a total of 271 patients aged<1 year who underwent open cardiac surgery at Severance Cardiovascular Hospital from January 2018 to December *** criteria were immediate postoperative mortality,other arrhythmias detected in the perioperative period,and ***:The overall incidence of junctional ectopic tachycardia was 12.9%.The logistic regression analysis revealed that longer cardiopulmonary bypass time,surgery involving atrioventricular node stretching,and the presence of early repolarization on preoperative electrocardiography increased the risk of junctional ectopic *** with junctional ectopic tachycardia had longer intubation time and intensive care unit ***:Junctional ectopic tachycardia is a common arrhythmia after cardiac surgery for congenital heart disease in ***,infants developing junctional ectopic tachycardia after cardiac surgery have specific preoperative electrocardiography *** risk factors for junctional ectopic tachycardia were associated not only with surgical procedural factors but also with preoperative electrocardiographic parameters.

关键词： Junctional ectopic tachycardia congenital heart disease early re-polarization

Nanoscale visualization of hot carrier generation and transfer at non-noble metal and oxide interface

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第3期98卷 151-159页

作者： Ranveer Singh Qadeer Akbar Sial Seung-ik Han Sanghee Nah ji-Yong park Hyungtak Seo Department of Materials Science and Engineering Ajou UniversitySuwon16499Republic of Korea Department of Energy Systems Research Ajou UniversitySuwon16499Republic of Korea Seoul Center Korea Basic Science InstituteSeoul02841Republic of Korea Department of Physics Ajou UniversitySuwon16499Republic of Korea

The conversion efficiency of energy-harvesting devices can be increased by utilizing hot-carriers(HCs).However,due to ultrafast carrier-carrier scattering and the lack of carrier injection dynamics,HC-based devices have low *** the present work,we report the effective utilization of HCs at the nanoscale and their transfer dynamics from a non-noble metal to a metal oxide interface by means of real-space photocurrent mapping by using local probe techniques and conducting femtosecond transient absorption(TA)*** photocurrent maps obtained under white light unambiguously show that the HCs are injected into the metal oxide layer from the TiN layer,as also confirmed by conductive atomic force *** addition,the increased photocurrent in the bilayer structure indicates the injection of HCs from both layers due to the broadband absorption efficiency of TiN layer,passivation of the surface states by the top TiN layer,and smaller barrier height of the ***,electrostatic force microscopy and Kelvin probe force microscopy provide direct evidence of charge injection from TiN to the MoO_(x)film at the *** TA absorption spectra show a strong photo-bleaching signal over wide spectral range and ultrafast decaying behavior at the picosecond time scale,which indicate efficient electron transfer from TiN to MoO_(x).Thus,our simple and effective approach can facilitate HC collection under white light,thereby achieving high conversion efficiency for optoelectronic devices.

关键词： Non-noble metal Hot carrier Real-space photocurrent mapping Local-probe force microscopy

Evaluation of the safety of anterior capsule staining with trypan blue under air: a retrospective analysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2022年第3期15卷 432-437页

作者： Young Min park Jong Soo Lee ji Eun Lee Yeon ji Jo Ik Soo Byon Sung Who park Centum Bright Light Eye Clinic 20Centum 2-roHaeundaeguBusanKorea 48060Republic of Korea Department of Ophthalmology School of MedicinePusan National University and Medical Research InstitutePusan 49241Republic of Korea

AIM: To evaluate the safety of using 0.03% trypan blue under air for anterior capsule staining in cataract ***: The current study involved a retrospective analysis of the medical records of 86 patients with vitreous hemorrhage, who underwent pars plana vitrectomy and cataract *** patients were classified into two *** trypan blue group(n=45) comprised patients who underwent anterior capsule staining with 0.03% trypan blue under an air *** control group(n=41) comprised of patients who underwent intracameral illuminator-assisted *** status of endothelial cell density(ECD) in both the groups was ***: The trypan blue group displayed significant decline in ECD at 1 mo(7.91% loss, P<0.001) and 3 mo(9.65% loss, P<0.001) after the surgery, whereas no significant changes were observed in the control ***, the number of patients who did not display a postoperative decline in ECD was significantly higher in the control group(43.9%;18 patients) than in the trypan blue group(17.1%;7 patients, P=0.004).CONCLUSION: Anterior capsule staining with trypan blue under the air bubble would not be as safe as the intracameral *** ECD loss might be attributed to the air bubble rather than to the deleterious effects of 0.03% trypan *** studies are required to clarify this.

关键词： anterior capsule cataract endothelium trypan blue vitreous hemorrhage