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MEC-based architecture for interoperable and trustworthy internet of moving things

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Digital Communications and Networks 2023年第1期9卷 270-279页

作者： jesus Sanchez-gomez Rafael Marin-Perez Ramon Sanchez-Iborra Miguel Angel Zamora Department of Information and Communications Engineering University of MurciaMurciaSpain Odin Solutions S.L. MurciaSpain University Center of Defense San Javier Air Force BaseMurciaSpain

The expansion of the Internet of Moving Things(IoMT)leads to limitless and continuous working playgrounds exploited by highly dynamic end *** requires the adoption of multi-Radio Access Technologies(RATs)-based strategies to provide IoMT units with ubiquitous *** this end,the development of secure bootstrapping and authentication mechanisms is necessary to permit the secure operation of end *** the transmission and power limitations of these elements,current cryptographic solutions do not address these stringent *** that reason,in the study we present a Multi-Access Edge Computing(MEC)-based endto-end architecture that enables an efficient and secure authentication and key agreement between end devices and network servers over heterogeneous resource-limited networks such as the Low Power Wide Area Networks(LPWANs).Our proposal is based on the Authentication,Authorization,and Accounting(AAA)architecture and the recent Internet Engineering Task Force initiatives Static Context Header Compression and Low-Overhead *** results obtained from experimental tests reveal the validity of the proposal as it enables constrained IoMT devices to gain IPv6 connectivity as well as performs end-to-end secure authentication with notable reliability and controlled latency.

关键词： Internet of moving things LPWAN Authentication LO-CoAP-EAP SCHC

Evaluation of bias on the assessment of diet breadth of herbivorous insects using molecular methods

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Insect Science 2017年第2期24卷 194-209页

作者： Gissela De la Cadena Anna Papadopoulou Jean-Michel Maes jesus gomez-Zurita Animal Biodiversity and Evolution Institut de Biologia Evolutiva (CSIC-Univ. Pompeu Fabra) Barcelona Spain Department of Integrative Ecology Estacion Biologica de Donana (EBD-CSIC) Seville Spain Museo entomologico de Leon Leon Nicaragua

The interactions between herbivores and their host plants play a key role in ecological processes. Understanding the width and nature of these interactions is funda- mental to ecology and conservation. Recent research on DNA-based inference of trophic associations suggests that the host range of phytophagous insects in the tropics may be wider than previously thought based on traditional observation. However, the reliability of molecular inference of ecological associations, still strongly dependent on PCR and thus exposed to the risk of contamination with environmental DNA, is under debate. Here, we explored alternative procedures to reduce the chance of amplification of external, nondiet DNA, including surface decontamination and analysis of mid/hind guts, comparing the results with those obtained using the standard protocol. We studied 261 specimens in eight species of Neotropical Chrysomelidae that yielded 316 psbA-trnH intergenic spacer sequences （cpDNA marker of putative diets） from unique and multiple-band PCR results. The taxonomic identity of these sequences was inferred using the automated pipeline BAGpipe, yielding results consistent with 31 plant families. Regardless of the proto- col used, a wide taxonomic spectrum of food was inferred for all chrysomelid species. Canonical Correspondence Analysis using these data revealed significant differences at- tributed mainly to species （expectedly, since they represent different ecologies）, but also to treatment （untreated vs. cleaned/gut samples） and PCR results （single vs. multiple bands）. Molecular identification of diets is not straightforward and, regardless of the species＇ niche breadth, combining approaches that reduce external contamination and studying multiple individuals per species may help increasing confidence in results.

关键词： food-webs gut content insect plant interaction molecular ecology molec-ular taxonomy psbA-trnH intergenic spacer

Full-thickness scleral incisions technique for the treatment of a cyclodialysis cleft following ab interno trabeculotomy

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1662-1665页

作者： Daniela Alvarez-Ascencio jesus Jimenez-Roman Rafael Castaneda-Diez Gabriel Lazcano-gomez Glaucoma Department Asociacion Para Evitar la Ceguera en Mexico

Dear Editor, I am *** Alvarez-AscenciofromtheGlaucoma Department at Asociacion Para Evitar la Ceguera (APEC)in Mexico City, Mexico. I write to present a successful case of cyclodyalisis repair in a direct visualizatio... 详细信息

关键词： CC OS UBM Full-thickness scleral incisions technique for the treatment of a yclodialysis cleft following ab interno trabeculotomy

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在墨西哥蒙特雷市设立快餐车点的商业计划

在墨西哥蒙特雷市设立快餐车点的商业计划

作者： Mendiola gomez, jesus Manuel 上海外国语大学

学位级别：硕士

越来越多的年轻白领们被墨西哥各大重要城市中出现的快餐车概念所吸引,基于他们对更健康食品的需求,并利用在一些地点可提供海鲜美食的选择,一个当地食品市场中的新商机被发现了。受海洋风味的启发,这个名为7-Mares的商业理念是在墨西... 详细信息

越来越多的年轻白领们被墨西哥各大重要城市中出现的快餐车概念所吸引,基于他们对更健康食品的需求,并利用在一些地点可提供海鲜美食的选择,一个当地食品市场中的新商机被发现了。受海洋风味的启发,这个名为7-Mares的商业理念是在墨西哥蒙特雷市设立一个快餐车点,供应海鲜玉米薄饼卷。旨在为当地传统快餐车的顾客们提供一个健康和美味的传统美食替代品。销售点由一辆快餐车和三辆配车组成,这将为墨西哥流动食品行业开发一个全新的概念:食品嘟嘟车。凭借这一创新理念,7-Mares将成为第一个在墨西哥用小型车辆提供街头美食的品牌。此外,为了开创品牌知名度并与客户建立紧密的关系,7-Mares将通过线上和线下战略推动各种社会事业和环保实践活动。通过这些举措,7-Mares将与主要客户群建立更好的联系,并通过此举鼓励其竞争对手实施类似的举措。公司的初始投资、运营和行政管理将由生意合作伙伴全部负责,公司的本质将维持不变,在符合公司的核心价值观的基础上允许保持一致的品牌发展。合作伙伴在最关键的业务领域的专业技能,及独特的使用配车实施的分销系统成为了主要的差异因素,将有助于企业从其竞争对手中脱颖而出。得益于精益创业方法的实施,该项目将优化初始投资的使用,允许将更高的预算分配到其他更可能需要的领域,诸如数字化营销和电子广告投放。此优化对第一年的财务预测产生了积极影响,在前三个月内即可达到盈亏平衡点,并在第一年年底获得1,200,000墨西哥比索的现金流。作为快餐车食品业,这个数字足以让人震惊,但是由于有着众多的销售点,这将是可以实现的。有了这些预测,外部因素将不会构成对企业发展的严重威胁。尽管如此,还是制定了一项风险管理计划,以确保计划能够如期成功。最后,重点要提到业务在未来几年可能具备的增长潜力。利用数字化战略创造的品牌知名度以及凭借实施社会责任计划所创造的品牌声誉,该项目可以扩展到附近城市的类似市场。这个扩张机会在本计划中未涉及,但在将来还是应该提上日程。

关键词：食品卡车商业计划海鲜墨西哥

Generation of Higher Terahertz Harmonics in Nonlinear Paraelectrics under Focusing in a Wide Temperature Range

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Journal of Electromagnetic Analysis and Applications 2023年第4期15卷 43-58页

作者： Volodymyr Grimalsky jesus Escobedo-Alatorre Christian Castrejon-Martinez Yered gomez-Badillo Center for Investigations on Engineering and Applied Science (CIICAp) Institute for Investigations on Basic and Applied Science (IICBA) Autonomous University of State Morelos (UAEM) Cuernavaca Mor. Mexico Tecnológico Nacional de México/Instituto Tecnológico de Zacatepec Zacatepec Mor. Mexico

It is theoretically investigated the generation of higher harmonics of two-dimensional and three-dimensional terahertz electromagnetic beams in nonlinear crystals. The attention is paid to crystalline paraelectrics like SrTiO3 under the temperatures 60 - 200 K, these crystals possess the cubic nonlinearity. The bias electric field is applied to provide the dominating quadratic nonlinearity. The initial focusing of the beams not only increases the efficiency of generation of higher harmonics, but alto makes possible to select maxima of different higher harmonics at some distances from the input. At lower temperatures the nonlinearity behaves at smaller input amplitudes, whereas at higher temperatures the harmonic generation can be observed at higher frequencies up to 1.5 THz. In three-dimensional beams the peak amplitudes of higher harmonics can be bigger than in two-dimensional beams, but the ratios of these peak values to the maximum values of the focused first harmonic are smaller than in two-dimensional beams.

关键词： Terahertz Wave Beams Nonlinear Crystalline Paraelectrics Different Temperatures Generation of Harmonics Initial Focusing

Arabidopsis SWC4 Binds DNA and Recruits the SWR1 Complex to Modulate Histone H2A.Z Deposition at Key Regulatory Genes

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Molecular Plant 2018年第6期11卷 815-832页

作者： Angeles gomez-Zambrano Pedro Crevillen Jose M. Franco-Zorrilla Juan A. Lopez Jordi Moreno-Romero Pawel Roszak Juan Santos-Gonzalez Silvia Jurado jesus Vazquez Claudia Kohler Roberto Solano Manuel Pineiro Jose A. Jarillo Centro de Biotecnologia y Genomica de Plantas Universidad Politecnica de Madrid (UPM) - Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA) Campus Montegancedo UPM Pozuelo de Alarcon 28223 Madrid Spain Plant Molecular Genetics Department and Genomics Unit Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientfficas 28049 Madrid Spain Proteomics Unit Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) 28029 Madrid Spain Department of Plant Biology Uppsala BioCenter Swedish University of Agricultural Sciences and Linnean Center for Plant Biology Uppsala 75652 Sweden Laboratory of Cardiovascular Proteomics Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) 28029 Madrid Spain Instituto de Bioquimica Vegetal y Fotosintesis Consejo Superior de Investigaciones Cientfficas and Universidad de Sevilla 41092 Sevilla Spain Centre for Research in Agricultural Genomics (CRAG) CSIC-IRTA-UAB-UB Campus UAB Bellaterra Barcelona Spain The Sainsbury Laboratory Cambridge CB2 1LR UK

Deposition of the H2A.Z histone variant by the SWR1 complex （SWRI-C） in regulatory regions of specific loci modulates transcription. Characterization of mutations in Arabidopsis thaliana homologs of yeast SWRI-C has revealed a role for H2A.Z exchange in a variety of developmental processes. Nevertheless, the exact composition of plant SWRI-C and how it is recruited to target genes remains to be established. Here we show that SWC4, the Arabidopsis homolog of yeast SANT domain protein Swc4/Eaf2, is a DNA-binding protein that interacts with SWR1-C subunits. We demonstrate that the swc4-1 knockout mutant is embryo- lethal, while SWC4 RNAi knockdown lines display pleiotropic phenotypic alterations in vegetative and repro- ductive traits, including acceleration of flowering time, indicating that SWC4 controls post-embryonic processes. Transcriptomic analyses and genome-wide profiling of H2A.Z indicate that SWC4 represses tran- scription of a number of genes, including the floral integrator FT and key transcription factors, mainly by modulating H2A.Z deposition. Interestingly, SWC4 silencing does not affect H2A.Z deposition at the FLC locus nor expression of this gene, a master regulator of flowering previously shown to be controlled by SWR1-C. Importantly, we find that SWC4 recognizes specific AT-rich DNA elements in the chromatin regions of target genes and that SWC4 silencing impairs SWRI-C binding at FT. Collectively, our data suggest that SWC4 regulates plant growth and development by aiding SWR1-C recruitment and modulating H2A.Z deposition.

关键词： Arabidopsis SWC4 chromatin SWR1 complex H2A.Z deposition flowering time

Effect of phacoemulsification on intraocular pressure in patients with primary open angle glaucoma and pseudoexfoliation glaucoma

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1374-1378页

作者： jesus Jimenez-Roman Gabriel Lazcano-gomez Karina Martínez-Baez Mauricio Turati Rosario Gulías-Canizo Luis F.Hernández-Zimbrón Lenin Ochoa-De la Paz Rubén Zamora Roberto Gonzalez-Salinas Glaucoma Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Research Department Asociation to Prevent Blindness inMexicoMexico City 04030Mexico Cell Biology Department Advanced Research CenterI.P.N.(CINVESTAV)in Mexico CityMexico City 07360Mexico

AIM：To compare the effect of phacoemulsification on intraocular pressure（IOP）in patients with primary open angle glaucoma（POAG）and pseudoexfoliation glaucoma（PXG）.METHODS：A retrospective comparative case series conducted at the Glaucoma Department at the Association to Prevent Blindness in *** study enrolled consecutive patients having phacoemulsification with intraocular lens（IOL）implantation and a diagnosis of POAG or *** about IOP values and number of glaucoma medications used was collected at baseline,1,3,6 and12mo ***：The study enrolled 88 patients（88 eyes）.After phacoemulsification,there was a statistically significant reduction in IOP values and glaucoma medications use compared to baseline in both POAG and PXG patients（P〈0.001）.In the POAG group,a 20%decrease in IOP values was evidenced,and a 56.5%reduction in the number of medications used at the one-year *** PXG group showed a 20.39%,and a 34.46%decrease in IOP and number of medications used,respectively.A significant difference in the meanΔIOP（postoperative changes in IOP）was evidenced between groups（P=0.005）.The reduction of the postsurgical IOP mean values in both groups,the POAG group showed a greater reduction in IOP values compared to the PXG ***：In both types of glaucoma,phacoemulsification cataract surgery can result in a significant IOP reduction（20%）over a 12mo follow-up *** number of medications used is also significantly reduced up to 12mo after surgery,especially in the PXG group.

关键词： cataract surgery pseudoexfoliation glaucoma secondary glaucoma primary open angle glaucoma intraocularpressure

Sustainable Development of Ecotourism in Mexico

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Economics World 2014年第3期2卷 188-195页

作者： Velazquez-Sainchez Rosa Maria gomez-Velazquez jesus Gaytan Bohorquez Laura Irene Nunez Contreras Carlos Abdiel Benito Juarez Autonomous University of Oaxaca Oaxaca Mexico

Dimensions of sustainable development were analyzed based on the commonality, services, and ecotourism activities of 35 indigenous communities in Mexico. Based on indicators of local development in indigenous communities with ecotourism activities available and environmental indicators given by the Ministry of Tourism of Mexico SECTUR and of communitarian sustainability developed in Mexico. Data from a 118 items questionnaire from inhabitants participating in ecotourism projects of indigenous groups within 13 states of the Mexican Republic were tested. The results showed the definition of five categories of local development, two environmental categories, and four categories of communitarian sustainability in the Mexican states with the largest indigenous populations. A positive relationship between the community perspective and the indigenous ecotourism and the three dimensions of sustainable development was observed. This study provides an alternative methodology for the analysis of the sustainable development dimensions in projects of indigenous communities.

关键词： sustainable development ecotourism sustainable community local development environment

Multiple myeloma mesenchymal stromal cells: Contribution to myeloma bone disease and therapeutics

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World Journal of Stem Cells 2014年第3期6卷 322-343页

作者： Antonio Garcia-gomez Fermin Sanchez-Guijo M Consuelo del Caizo jesus F San Miguel Mercedes Garayoa Cancer Research Center IBMCC(University of Salamanca-CSIC) Institute of Biomedical Research of Salamanca University Hospital Network of Centers for Regenerative Medicine and Cellular Therapy fromCastilla y León Spanish Cooperative Research Network in Cellular Therapy Center for Applied Biomedical Research Clinic University of Navarra

Multiple myeloma is a hematological malignancy inwhich clonal plasma cells proliferate and accumulate within the bone marrow. The presence of osteolytic le-sions due to increased osteoclast(OC) activity and sup-pressed osteoblast(OB) function is characteristic of the disease. The bone marrow mesenchymal stromal cells(MSCs) play a critical role in multiple myeloma patho-physiology, greatly promoting the growth, survival, drug resistance and migration of myeloma cells. Here, we specifically discuss on the relative contribution of MSCs to the pathophysiology of osteolytic lesions in light of the current knowledge of the biology of my-eloma bone disease(MBD), together with the reported genomic, functional and gene expression differences between MSCs derived from myeloma patients(pMSCs) and their healthy counterparts(dMSCs). Being MSCs the progenitors of OBs, pMSCs primarily contribute to the pathogenesis of MBD because of their reduced osteogenic potential consequence of multiple OB inhibi-tory factors and direct interactions with myeloma cells in the bone marrow. Importantly, pMSCs also readily contribute to MBD by promoting OC formation and ac-tivity at various levels(i.e., increasing RANKL to OPG expression, augmenting secretion of activin A, uncou-pling ephrinB2-EphB4 signaling, and through augment-ed production of Wnt5a), thus further contributing to OB/OC uncoupling in osteolytic lesions. In this review, we also look over main signaling pathways involved in the osteogenic differentiation of MSCs and/or OB activity, highlighting amenable therapeutic targets; in parallel, the reported activity of bone-anabolic agents(at preclinical or clinical stage) targeting those signaling pathways is commented.

关键词： Mesenchymal stromal cells Multiple myelo-ma Osteolytic lesions Myeloma bone disease Bone-directed therapy Bone-anabolic drugs