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Gene Therapy of Cancer:Induction of Anti-Tumor Immunity

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Cellular & Molecular Immunology 2004年第2期1卷 105-111页

作者： jesus Prieto Division

Many malignancies lack satisfactory treatment and new therapeutic options are urgently *** therapy is a new modality to treat both inherited and acquired diseases based on the transfer of genetic material to the *** gene therapy strategies against cancers have been developed.A considerable number of preclinical studies indicate that a great variety of cancers are amenable to gene *** these strategies, induction of anti-tumor immunity is the most promising *** therapy with cytokines has reached unprecedented success in preclinical models of *** rather than additive effects have been demonstrated by combination of gene transfer of cytokines/chemokines,costimulatory molecules or adoptive cell *** progress in vector technology and in imaging techniques allowing in vivo assessment of gene expression will facilitate the development of clinical applications of gene therapy,a procedure which may have a notorious impact in the management of cancers lacking effective *** & Molecular Immunology.2004;1(2):105-111.

关键词： gene therapy anti-tumor immunity cytokines costimulatory molecules dendritic cell

Integrating Levels of Hierarchical Organization in Porous Organic Molecular Materials

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Nano-Micro Letters 2024年第5期16卷 134-153页

作者： jesus Ferrando‑Soria Antonio Fernandez Instituto de Ciencia Molecular(ICMol) Universidad de Valencia46980 ValenciaSpain School of Science Loughborough UniversityLoughborough LE113TUUK

Porous organic molecular materials(POMMs)are an emergent class of molecular-based materials characterized by the formation of extended porous frameworks,mainly held by non-covalent *** represent a variety of chemical families,such as hydrogen-bonded organic frameworks,porous organic salts,porous organic cages,C-H···πmicroporous crystals,supramolecular organic frameworks,π-organic frameworks,halogen-bonded organic framework,and intrinsically porous molecular *** some porous materials such as zeolites and metal organic frameworks,the integration of multiscale has been adopted to build materials with multifunctionality and optimized ***,considering the significant role of hierarchy in porous materials and the growing importance of POMMs in the realm of synthetic porous materials,we consider it appropriate to dedicate for the first time a critical review covering both ***,we will provide a summary of literature examples showcasing hierarchical POMMs,with a focus on their main synthetic approaches,applications,and the advantages brought forth by introducing hierarchy.

关键词： Porous organic molecular materials Hierarchy Hydrogen-bonded organic frameworks Porous cages Fullerene

Effect of magnesium on the aluminothermic reduction rate of zinc oxide obtained from spent alkaline battery anodes for the preparation of Al–Zn–Mg alloys

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International Journal of Minerals,Metallurgy and Materials 2016年第4期23卷 458-465页

作者： Rocio Ochoa Alfredo Flores jesus Torres Cinvestav-Saltillo

The aluminothermic reduction of zinc oxide（ZnO） from alkaline battery anodes using molten Al may be a good option for the elaboration of secondary 7000-series alloys. This process is affected by the initial content of Mg within molten Al, which decreases the surface tension of the molten metal and conversely increases the wettability of ZnO particles. The effect of initial Mg concentration on the aluminothermic reduction rate of ZnO was analyzed at the following values： 0.90wt%, 1.20wt%, 4.00t%, 4.25wt%, and 4.40wt%. The ZnO particles were incorporated by mechanical agitation using a graphite paddle inside a bath of molten Al maintained at a constant temperature of 1123 K and at a constant agitation speed of 250 r/min, the treatment time was 240 min and the ZnO particle size was 450？500 mesh. The results show an increase in Zn concentration in the prepared alloys up to 5.43wt% for the highest initial concentration of Mg. The reaction products obtained were characterized by scanning electron microscopy and X-ray diffraction, and the efficiency of the reaction was measured on the basis of the different concentrations of Mg studied.

关键词： aluminothermic reduction alkaline batteries zinc oxide waste utilization aluminum zinc magnesium alloys

Genetic factors associated with the development of inflammatory bowel disease

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World Journal of Gastroenterology 2007年第42期13卷 5594-5597页

作者： jesus K Yamamoto-Furusho Inflammatory Bowel DiseaseClinic Department of Gastroenterology Instituto Nacional deCiencias Médicas y Nutrición Vasco de Quiroga 15 ColoniaSección XVI Tlalpan C.P. 14000 México D.F. México

Crohn's disease(CD)and ulcerative colitis(UC)are complex polygenic disorders,characterized by several genes together with environmental factors contributing to the development of inflammatory bowel disease(IBD).Recent advances in research on genetic susceptibility have allowed the identification of diverse genes at different levels:(1)Innate immunity;(2)Antigen presentation molecules;(3)Epithelial integrity;(4)Drug transporter;(5)Cell *** application of genetic testing into clinical practice is close and all genetic markers may have several clinical implications:prediction of disease phenotype,molecular classification,prevention of complications,and prognosis.

关键词： Genetic Susceptibility Inflammatory bowel disease Ulcerative colitis Crohn's disease

The Full Multi-wake Vortex Lattice Method:a detached flow model based on Potential Flow Theory

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Advances in Aerodynamics 2023年第1期5卷 452-477页

作者： jesus Carlos Pimentel-Garcia The School of Industrial Aerospace and Audiovisual Engineering of Terrassa(ESEIAAT)Polytechnic University of CataloniaTerrassa 08222Spain

One of the main issues concerning the standard Vortex Lattice Method is its application to partially or fully detached flow conditions,where non-linear aerodynamic characteristics appear as the angle of attack increases and/or the aspect ratio *** order to solve such limitations,a pure numerical approach based entirely on the Vortex Lattice Method concepts has been *** so-called steady“Full Multi-wake Vortex Lattice Method”comes from the main hypothesis that each discretized element on the body’s surface detaches their own wakes *** obtained results match for lift,drag and moment coefficients for the entire aspect ratio range configurations(under straight wakes and inviscid assumptions).Future unsteady versions of such a multi-wake approach could improve the current results obtained through Vortex Element Methods(as vortons or isolated vortex filaments).

关键词： Potential Flow Theory Ideal flow Detached flow Vorticity generation Vortex Lattice Method Kutta condition

Morphometry and subpopulation structure of Holstein bull spermatozoa： variations in ejaculates and cryopreservation straws

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Asian Journal of Andrology 2016年第6期18卷 851-857页

作者： Anthony Valverde Hector Arenan Maria Sancho jesus Contell jesus Yaniz Alejandro Fernandez Caries Soler Technological Institute of Costa Rica San Carlos Campus S Xenetica Fontao Fontao-Esperante 27210 Lugo Spain R+D Department Proiser R+D Scientific Park University of Valencia 46980 Paterna Spain Department of Animal Production and Food Science Politechnical School of Huesca University of Zaragoza 22071 Huesca Spain Department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Spain

Sperm quality is evaluated for the calculation of sperm dosage in artificial reproductive programs. The most common parameter used is motility, but morphology has a higher potential as a predictor of genetic quality. Morphometry calculations from CASA-Morph technology improve morphological evaluation and allow mathematical approaches to the problem. Semen from 28 Holstein bulls was collected by artificial vagina, and several ejaculates were studied. After general evaluation, samples were diluted, packaged in 0.25 ml straws, and stored in liquid nitrogen. Two straws per sample were thawed, and slides were processed and stained with Diff-Quik. Samples were analyzed by a CASA-Morph system for eight morphometric parameters. In addition to the ＂classical＂ statistical approach, based on variance analysis （revealing differences between animals, ejaculates, and straws）, principal component （PC） analysis showed that the variables were grouped into PC1, related to size, and PC2 to shape. Subpopulation structure analysis showed four groups, namely, big, small, short, and narrow from their dominant characteristics, representing 31.0%, 27.3%, 24.1%, and 17.7% of the total population, respectively. The distributions varied between animals and ejaculates, but between straws, there were no differences in only four animals. This modern approach of considering an ejaculate sperm population as divided into subpopulations reflecting quantifiable parameters generated by CASA-Morph systems technology opens a new view on sperm function. This is the first study applying this approach to evaluate different ejaculates and straws from the same individual. More work must be done to improve seminal dose calculations in assisted reproductive programs.

关键词： cryopreservation Holstein bull sperm morphometry subpopulations

Challenges in microRNAs’ targetome prediction and validation

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Neural Regeneration Research 2019年第10期14卷 1672-1677页

作者： jesus Eduardo Rojo Arias Volker Busskamp Center for Regenerative Therapies (CRTD) Technische Universit?t Dresden

MicroRNAs(miRNAs)are small RNA molecules with important roles in post-transcriptional regulation of gene *** recent years,the predicted number of miRNAs has skyrocketed,largely as a consequence of high-throughput sequencing technologies becoming *** dramatic increase in miRNA candidates poses multiple challenges in terms of data deposition,curation,and *** multiple databases containing miRNA annotations and targets have been developed,ensuring data quality by validating miRNA-target interactions requires the efforts of the research *** order to generate databases containing biologically active miRNAs,it is imperative to overcome a multitude of hurdles,including restricted miRNA expression patterns,distinct miRNA biogenesis machineries,and divergent miRNA-mRNA interaction *** the present review,we discuss recent advances and limitations in miRNA prediction,identification,and ***,we focus on the most enriched neuronal miRNA,miR-124,and its gene regulatory network in human neurons,which has been revealed using a combined computational and experimental approach.

关键词： miRNAs miRNA regulation miR-124 wTO analysis miRNA biogenesis miRNA prediction miRNA identification miRNA validation

Innovative therapeutics for inflammatory bowel disease

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World Journal of Gastroenterology 2007年第13期13卷 1893-1896页

作者： jesus K Yamamoto-Furusho Inflammatory Bowel Diseas Clinic Department of Gastroenterology Instituto Nacional d Ciencias Médicas y Nutrición. Vasco de Quiroga 15 Coloni Sección XVI Tlalpan México CP 14000 DF México

Inflammatory bowel diseases (IBD) are chronic inflammatory conditions of the gastrointestinal tract, which clinically present as one of two disorders, Crohn's disease or ulcerative colitis. Mainstays of drug treatments for IBD include aminosalicylates, corticosteroids and immunosuppressants such as azathioprine, methotrexate and cyclosporin. Advances in basic research of the pathophysiological process in IBD have been applied to generate a variety of new therapeutics targeting at different levels of the inflammatory processes. New therapies are classified as: (1) Anti-TNFα antibodies; (2) Recombinant cytokines; (3) Selective adhesion blockade; (4) Growth factors; (5) Innate immunostimulation; (6) Nucleic acid based therapies; (7) Gene therapy; (8) Autologous bone-marrow transplantation; (9) Helminths and (10) Extracorporeal immunomodulation. All treatments have the potential to provide more effective and safe treatment for IBD.

关键词： Novel agents Inflammatory bowel diseases Biologic therapy Future agents

Field report:Sailing around the exhumed roots of the Mesozoic Patagonian paleo-accretionary wedge(Diego de Almagro Island,Chile)

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Geoscience Frontiers 2018年第5期9卷 1591-1594页

作者： Samuel Angiboust jesus Munoz Institut de Physique du Globe de Paris Sorbonne Paris CitéUniversity Paris DiderotCNRSF-75005ParisFrance GFZ German Research Centre for Geosciences D-14473PotsdamGermany Carrera de Geología Universidad Andres BelloSazie2119SantiagoChile

We undertook a boat expedition to explore the geological framework of a very remote, lesser-known island, in the Chilean Patagonia: the Diego de Almagro Island(latitude S51°330'). This uninhabited, ca.400 km^2 Island is one of the very rare exposures of the Mesozoic accretionary subduction complex along the Chilean margin. Unstable weather, strong winds, steep topography, and very dense vegetation make an on-land mission difficult. Careful preparation based on high-resolution satellite images is advised to optimize shore access and minimize risks of injury. Despite a relatively important degree of regional reequilibration of metamorphic assemblages due to sluggish exhumation through the forearc crust, our results have shown that the island is composed of a nappe stack of ocean-floor derived slivers of metasedimentary units that exhibit very different pressure-temperature-time paths during burial by subduction under the Chilean margin and subsequent exhumation. These rocks are witness to a complex thermal evolution of the subduction zone between Jurassic and Cretaceous times from granulite facies to blueschist facies conditions as well as multiple episodes of accretion at ca. 35 -40 km in depth for almost100 Ma over the Mesozoic era.

关键词： Patagonia Accretionary wedge Blueschists Subduction Chile