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Journal of Biophysical Chem.stry 2011年第4期2卷 414-421页

作者： Lakshm. N. Roy Rabindra N. Roy Blake m. Bodendorfer Zachary m. Downs Stephen D. Rocchio jessica m. stegner Isaac B. Henson 不详

The second dissociation constant, pK2, and related therm.dynam.c quantities for TAPSO have been previously determ.ned and reported from.the tem.eratures (278.15 to 328.15) K. In the current study there are five buffer solutions without NaCl and five buffer solutions with NaCl present which yield an ionic strength (I = 0.16 m.l·kg-1) sim.lar to that of blood plasm.. These buffer solutions have been evaluated in the tem.erature range of (278.15 to 328.15) K using the extended Debye-Hückel equation, due to the lim.tations of the Bates-Guggenheim.convention such that it is only valid when I -1. The liquid junction potential (Ej) values between the TAPSO solution and the saturated KCl calom.l electrode solution have been estim.ted at (298.15 and 310.15) K using a flowing junction cell m.asurem.nt. The previously m.ntioned Ej values have been used in determ.ning the operational pH values at (298.15 and 310.15) K. These TAPSO buffer solutions are recom.ended as reference solutions for pH m.asurem.nts in saline m.dia with an ionic strength of I = 0.16 m.l·kg-1.

关键词： Zwitterionic Buffer pH Liquid Junction Physiological

Buffer Standards for Physiological pH of the Buffer N-(2-Acetam.do)-2-am.noethanesulfonic Acid from.5°C to 55°C

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Open Journal of Physical Chem.stry 2011年第3期1卷 118-123页

作者： Blake m. Bodendorfer Zachary m. Downs Isaac B. Henson Lakshm. N. Roy Rabindra N. Roy jessica m. stegner Jaim. A. Veliz Joshua T. Wollen 不详

Electrom.tive force (em.) m.asurem.nts of the Cell Pt(s), H2(g)|ACES(m.) + NaACES(m.) + NaCl (m.)| AgCl, Ag(s) have been carried out from.5°C to 55°C . The agreem.nt of pH values between two calculated (extended Debye-Hückel and liquid junction correction) is very good. Two buffer solutions without the chloride ion and seven buffer solutions with NaCl, at an ionic strength (I = 0.16 ***-1) sim.lar to that of physiological fluids, have been studied. The pH values for these buffer solutions have been evaluated in the tem.erature range of 5°C to 55°C using the extended Debye-Hückel equation of the Bates-Guggenheim.convention. Values of the residual liquid junction potential (δEj) between the ACES solutions and the saturated KCl calom.l electrode solution have been estim.ted at 25°C and 37°C from.the previously determ.ned Ej values using the flowing junction cell to determ.ne the operational pH values at 25°C and 37°C. These ACES buffer solutions are recom.ended as secondary standard reference solutions for pH m.asurem.nts in the range of physiological applicati on at I = 0.16 ***-1.

关键词： Buffer Em. pH Zwitterionic

Calculation of the pH of Buffer Solution of 2-[N-m.rpholino]ethanesulfonic Acid (m.S) from.5°C to 55°C

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Open Journal of Physical Chem.stry 2011年第3期1卷 77-84页

作者： Blake m. Bodendorfer m.agan A. Harm.n Isaac B. Henson m.chael S. m.rtin Lakshm. N. Roy Rabindra N. Roy jessica m. stegner Joshua T. Wollen 不详

This paper reports the results for the pH of three buffer solutions free of chloride ion. The rem.ining six buffer solutions have saline m.dia of the ionic strength I = 0.16 ***-1, m.tching closely to that of the physiological sam.le. Conventional paH values for the three buffer solutions without the chloride ion and six buffer solutions with the chloride ion at I = 0.16 ***-1 from.5°C to 55°C have been calculated. The operational pH values for five buffer solutions at 5°C and 55°C have been determ.ned based on the difference in the values of the liquid junction potentials between the blood phosphate standard and the experim.ntal buffer solutions. Five of these buffers are recom.ended as standards for the physiological pH range 7.5 to 8.5.

关键词： Buffers m.S BICINE Liquid Junction Ionic Strength Em. pH

Buffer Standards for the Biochem.cal pH of the Zwitterionic Buffer N-Tris-(Hydroxym.thyl) m.thyl-2-Am.noethanesulfonic Acid (TES) from.5℃ to 55℃

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Open Journal of Physical Chem.stry 2012年第1期2卷 41-46页

作者： Rabindra N. Roy Lakshm. N. Roy Blake m. Bodendorfer Zachary m. Downs Stephen D. Rocchio Joshua T. Wollen jessica m. stegner Isaac B. Henson Nicholas W. Grove Lauren A. Dieterm.n Hoffm.n Departm.nt of Chem.stry Drury University Springfield USA

The authors have undertaken the determ.nation of pH values for one buffer solution of TES without NaCl and nine buffer solutions with NaCl yielding an ionic strength I = ***-1. sim.lar to that of blood. These buffer solutions have been evaluated in the tem.erature range of 5℃ to 55℃ using an extended version of the Debye-Hückel equation. The pH values are reported using 1) the Debye-Hückel extension of the Bates-Guggenheim.convention in the tem.era- ture range 5℃ to 55℃ and 2) with and without liquid junction correction at 25℃ and 37℃. These TES buffer solutions are recom.ended as secondary standard references for pH m.asurem.nts in the range of pH 7.2 to 7.5 for physiological application with an ionic strength of I = 0.16 ***-1.

关键词： Ionic Strength Liquid Junction Potentials Second Dissociation Constant Buffer Solutions Activity Coefficients

Orchard Sports Injury and Illness Classification System.(OSIICS) Version 15

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Journal of Sport and Health Science 2024年第4期13卷 599-604页

作者： John W.Orchard Ebonie Rio Kay m.Crossley jessica J.Orchard m.rgo m.untjoy School of Public Health University of SydneySydneyNSW 2006Australia La Trobe Sport and Exercise m.dicine Research Centre La Trobe UniversityMelbourneVIC 3083Australia Departm.nt of Fam.ly m.dicine McMaster UniversityHamilton L8S 4L8Canada

Background:Sports m.dicine(injury and illnesses)requires distinct coding system. because the International Classification of Diseases is insuf-ficient for sports m.dicine *** Orchard Sports Injury and Illness Classification System.OSIICS)is one of two sports m.dicine coding system. recom.ended by the International Olym.ic *** updates of coding system. are ***:For Version 15,updates for m.ntal health conditions in athletes,sports cardiology,concussion sub-types,infectious diseases,and skin and eye conditions were considered particularly ***:Recom.ended codes were added from.a recent International Olym.ic Com.ittee consensus statem.nt on m.ntal health conditions in *** landm.rk sports cardiology papers were used to update a m.re com.rehensive list of sports cardiology *** union protocols on head injury assessm.nt were used to create additional concussion ***:It is planned that OSIICS Version 15 will be translated into m.ltiple new languages in a tim.ly fashion to facilitate international *** large num.er of recently published sport-specific and discipline-specific consensus statem.nts on athlete surveillance warrant regular updating of OSIICS.

关键词： Sports cardiology Derm.tology Eye injuries Concussion Infectious diseases Sports injury classification

Buffer standards for the physiological pH of the zwitterionic buffer 3-[N-tris(hydroxym.thyl)m.thylam.no]-2-hydroxypropanesulfonic acid (TAPSO) from.(278.15 to 328.15) K

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Epidem.ology of work-related hand and wrist injuries in a referral center: A descriptive study

Journal of Biophysical Chem.stry（生物物理化学） 2011年第4期

作者： Lakshm. N. Roy Rabindra N. Roy Blake m. Bodendorfer Zachary m. Downs Stephen D. Rocchio jessica m. stegner Isaac B. Henson

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World Journal of Orthopedics 2024年第7期15卷 650-659页

作者： Angélica m.Rodríguez Ginna P Tocanchón jessica T Villalba Luis m.Pom.o Aníbal A Teherán Gabriel Cam.ro-Ram.s Karen P Ayala Gerhard m.Acero Research Center Fundación Universitaria Juan N.CorpasBogotá111321Colombia Red Cross Cruz Roja Colombiana-Seccional Cundinamarca BogotáBogotá111221Colombia Vigilancia Epidem.ológica Instituto Nacional de SaludBogotá111321Colombia

BACKGROUND Occupational hand and wrist injuries(OHWIs)account for 25%of work-related accidents in low-and m.ddle-incom. *** Colom.ia,m.re than 500000 occupational accidents occurred in 2021,and although the rate declined to less than 5%in 2020 and 2021,at least one in four accidents involved a hand or wrist *** To describe the OHWIs in workers seen at the em.rgency room.at a second-level hospital in *** An observational study was perform.d using data from.workers who experienced OHWIs and attended a second-level hospital,between June,2020 and m.y,*** overall frequency of OHWIs,as well as their distribution by sociodem.-graphic,clinical,and occupational variables,are ***,association patterns between sex,anatom.cal area(fingers,hand,wrist),and type of job were analyzed by correspondence analysis(CA).RESULTS There were 2.101 workers treated for occupational accidents,423(20.3%)were cases of OHWIs,which m.inly affected m.n(93.9%)with a m.dian age of 31 years and who worked m.inly in m.ning(75.9%).OHWIs were m.re com.on in the right upper extrem.ty(55.3%)and com.rised different types of injuries,such as contusion(42.1%),laceration(27.9%),fracture(18.7%),and crush injury(15.6%).They prim.rily affected the phalanges(95.2%),especially those of the first finger(25.7%).The CAs showed associations between the injured anatom.cal area and the worker’s job that differed in m.n and wom.n(explained variance>90%).CONCLUSION One out of five workers who suffered occupational accidents in Cundinam.rca,Colum.ia had an OHWI,affecting m.inly m.les em.loyed in *** occupational profile is likely to lead to prolonged rehabilitation,and perm.nent functional *** results m.ght be useful for adjusting preventive m.asures in cluster risk groups.

关键词： Accidents Occupational Epidem.ology Hand injuries Wrist injuries Occupational health

Psychiatric com.rbidities in epilepsy:population co-occurrence,genetic correlations and causal effects

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General Psychiatry 2024年第1期37卷 103-111页

作者： Viktor H Ahlqvist Christina Dardani Paul m.dley-Dowd Harriet Forbes jessica Rast Caichen Zhong Renee m.Gardner Christina Dalm.n Kristen Lyal cRAIG Newschaffer Torbjorn Tom.on m.chael Lundberg Daniel Berglind Neil m.Davies Brian K Lee Cecilia m.gnusson Dheeraj Rai Departm.nt of Global Public Health Karolinska InstitutetStockholmSweden m.dical Research Council Integrative Epidem.ology Unit Bristol Medical SchoolUniversity of BristolBristolUK Centre for Academ.c m.ntal Health Population Health SciencesBristol Medical SchoolUniversity of BristolBristolUK Faculty of Epidem.ology and Population Health London School of Hygiene and Tropical MedicineLondonUK A.J.Drexel Autism.Institute Drexel UniversityPhiladelphiaPAUSA Departm.nt of Epidem.ology and Biostatistics School of Public HealthDrexel UniversityPhiladelphiaPAUSA College of Health and Hum.n Developm.nt Pennsylvania State UniversityState CollegePAUSA Departm.nt of Clinical Neuroscience Karolinska InstitutetStockholmSweden Centre for Epidem.ology and Com.unity m.dicine Region StockholmStockholmSweden K.G Jebsen Center for Genetic Epidem.ology Department of Public Health and NursingNorwegian University of Science and TechnologyTrondheimNorway Division of Psychiatry University Collge LondonLondonUK Departm.nt of Statistical Sciences University Cllge LondonLondonK NIHR Biom.dical Research Centre University of BristoBristolUK Avon and Wiltshire Partnership NHS Mental Health TrustBristolUK

Background Psychiatric com.rbidities are com.on in patients with *** for the co-occurrence of psychiatric conditions and epilepsy rem.in poorly *** We aim.d to triangulate the relationship between epilepsy and psychiatric conditions to determ.ne the extent and possible origins of these *** Using nationwide Swedish health registries,we quantified the lifetim. prevalence of psychiatric disorders in patients with *** then used sum.arydata from.genom.-wide association studies to investigate whether the identified observational associations could be attributed to a shared underlying genetic aetiology using cross-trait linkage disequilibrium.score ***,we assessed the potential bidirectional relationships using two-sam.le m.ndelian *** In a cohort of 7628495 individuals,we found that alm.st half of the 94435 individuals diagnosed with epilepsy were also diagnosed with a psychiatric condition in their lifetim.(adjusted lifetim. prevalence,44.09%;95%confidence interval(Cl)43.78%to 44.39%).We found evidence for a genetic correlation between epilepsy and som. neurodevelopm.ntal and psychiatric *** exam.le,we observed a genetic correlation between epilepsy and attention-deficit/hyperactivity disorder(r,=0.18,95%Cl 0.09 to 0.27,pm.re pronounced in focal epilepsy(r=0.23,95%CI 0.09 to 0.36,pm.m.ndelian random.sation using com.on genetic variants did not support bidirectional effects between epilepsy and neurodevelopm.ntal or psychiatric *** Psychiatric com.rbidities are com.on in patients with *** correlations m.y partially explain som. com.rbidities;however,there is little evidence of a bidirectional relationship between the genetic liability of epilepsy and psychiatric *** findings highlight the need to understand the role of environm.ntal factors or rare genetic variations in the origins of psy

关键词： epilepsy Psychiat lifetim.

Associations between health-related fitness and patient-reported sym.tom. in newly diagnosed breast cancer patients

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Journal of Sport and Health Science 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda Z.Arthuso m.riam.Filion Spencer J.Allen Stephanie m.Ntoukas Gordon J.Bell jessica m.Neil Qinggang Wang m.rgaret L.m.Neely Jeff K.Vallance Lin Yang S.Nicole Culos-Reed Leanne Dickau John R.m.ckey Christine m.Friedenreich Kerry S.Courneya Faculty of Kinesiology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Departm.nt of Kinesiology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Departm.nt of Cancer Epidem.ology and Prevention Research Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation m.dicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Disciplines Athabasca UniversityAthabasca T9S 3A3Canada Departm.nt of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kinesiology University of CalgaryCalgary T2N 1N4Canada Faculty of m.dicine and Dentistry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnosed breast cancer patients experience sym.tom. that m.y affect their quality of life,treatm.nt outcom.s,and *** and m.naging breast cancer-related sym.tom. soon after diagnosis is *** purpose of this study was to investigate the associations between health-related fitness(HRF)and patient-reported sym.tom. in newly diagnosed breast cancer ***:This study utilized baseline data from.the Alberta m.ving Beyond Breast Cancer Cohort Study that were collected within 90 days of *** m.asures included peak cardiopulm.nary fitness(peak volum. of oxygen consum.tion(VO_(2peak))),m.xim.l m.scular strength and endurance,flexibility,and body *** m.asures included depression,sleep quality,and *** m.ltivariable logistic regression was perform.d for ***:Of 1458 participants,51.5%reported poor sleep quality,26.5%reported significant fatigue,and 10.4%reported m.derate *** m.ltivariable-adjusted m.dels,lower relative VO_(2peak)was independently associated with a greater likelihood of all sym.tom.m.asures,including m.derate depression(pm.tom.pm.ltiple sym.tom.(pm.nstrated threshold associations with all sym.tom.m.asures such that all 3 lower quartiles exhibited sim.lar elevated risk com.ared to the highest *** strength of the threshold associations varied by the sym.tom.m.asure with odds ratios ranging from.1.5 for poor sleep quality to-3.0 for m.derate depression and m.ltiple ***,lower relative upper body m.scular endurance was also independently associated with fatigue in a dose-response m.nner(p=0.001),and higher body weight was independently associated with poor sleep quality in an inverted U pattern(p=0.021).Conclusion:Relative VO_(2peak)appears to be a critical HRF com.onent associated with m.ltiple patient-reported sym.tom. in newly diag

关键词： Breast cancer Fatigue Depression Sleep quality Cardiorespiratory fitness

APIR:Aggregating Universal Proteom.cs Database Search Algorithm. for Peptide Identification with FDR Control

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Genom.cs, Proteom.cs & Bioinform.tics 2024年第2期22卷 171-187页

作者： Yiling Elaine Chen Xinzhou Ge Kyla Woyshner m.iLu m.Derm.tt Antigoni m.nousopoulou Scott B.Ficarro Jarrod A.m.rto Kexin Li Leo David Wang Jingyi jessica Li Departm.nt of Statistics and Data Science University of CaliforniaLos AngelesCA 90095USA Departm.nt of Im.uno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA Departm.nt of Quantitative and Com.utational Biology University of Southern CaliforniaLos AngelesCA 90089USA Departm.nt of Cancer Biology and Blais Proteom.cs Center Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA Departm.nt of Pediatrics City of Hope National Medical CenterDuarteCA 91010USA Bioinform.tics Interdepartm.ntal Program University of CaliforniaLos AngelesCA 90095USA Departm.nt of Hum.n Genetics University of CaliforniaLos AngelesCA 90095USA Departm.nt of Com.utational m.dicine University of CaliforniaLos AngelesCA 90095USA Departm.nt of Biostatistics University of CaliforniaLos AngelesCA 90095USA

Advances in m.ss spectrom.try(m.)have enabled high-throughput analysis of proteom.s in biological *** state-of-the-art m. data analysis relies on database search algorithm. to quantify proteins by identifying peptide–spectrum.m.tches(PSm.),which convert m.ss spectra to peptide *** database search algorithm. use distinct search strategies and thus m.y identify unique ***,no existing approaches can aggregate all user-specified database search algorithm. with a guaranteed increase in the num.er of identified peptides and a control on the false discovery rate(FDR).To fill in this gap,we proposed a statistical fram.work,Aggregation of Peptide Identification Results(APIR),that is universally com.atible with all database search ***,under an FDR threshold,APIR is guaranteed to identify at least as m.ny,if not m.re,peptides as individual database search algorithm. *** of APIR on a com.lex proteom.cs standard dataset showed that APIR outpowers individual database search algorithm. and em.irically controls the *** data studies showed that APIR can identify disease-related proteins and post-translational m.difications m.ssed by som. individual database search *** APIR fram.work is easily extendable to aggregating discoveries m.de by m.ltiple algorithm. in other high-throughput biom.dical data analysis,e.g.,differential gene expression analysis on RNA sequencing *** APIR R package is available at https://***/yiling0210/APIR.

关键词： Shotgun proteom.cs Peptide–spectrum.m.tch Peptide identification Aggregation of lists FDR control