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Recent advancements in noninvasive brain modulation for individuals with autism spectrum disorder

Neural Regeneration Research 2023年第6期18卷 1191-1195页

作者： jessica R.Griff j.ke Langlie Nathalie B.Bencie Zachary j.Cromar j.enu Mittal Idil Memis steven Wallace Alexander E.Marcillo Rahul Mittal Adrien A.Eshraghi Hearing Research and Communication Disorders Laboratory Department of OtolaryngologyNeurotology DivisionUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Neurological surgery University of Miami Miller School of MedicineMiamiFLUSA Department of Biomedical Engineering University of MiamiCoral GablesFLUSA Department of Pediatrics University of Miami Miller School of MedicineMiamiFLUSA

Autism spectrum disorder is classified as a spectrum of neurodevelopmental disorders with an unknown definitive *** with autism spectrum disorder show deficits in a variety of areas including cognition,memory,attention,emotion recognition,and social *** no definitive treatment or cure,the main interventions for individuals with autism spectrum disorder are based on behavioral ***,noninvasive brain modulation techniques including repetitive transcranial magnetic stimulation,intermittent theta burst stimulation,continuous theta burst stimulation,and transcranial direct current stimulation have been studied for their therapeutic properties of modifying neuroplasticity,particularly in individuals with autism spectrum *** evidence from small cohort studies,pilot studies,and clinical trials suggests that the various noninvasive brain stimulation techniques have therapeutic benefits for treating both behavioral and cognitive manifestations of autism spectrum ***,little data is available for quantifying the clinical significance of these findings as well as the long-term outcomes of individuals with autism spectrum disorder who underwent transcranial *** obj.ctive of this review is to highlight the most recent advancements in the application of noninvasive brain modulation technology in individuals with autism spectrum disorder.

关键词： autism spectrum disorder behavior cognition neurostimulation interventions noninvasive brain modulation theta burst stimulation transcranial direct current stimulation transcranial magnetic stimulation

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In vitro and in vivo evaluation of cerium oxide nanoparticles in respiratory syncytial virus infection

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Bioactive Materials 2023年第6期24卷 124-135页

作者： Akhil Patel jessica Kosanovich sameera sansare sricharani Balmuri Vinayak sant Kerry M.Empey shilpa sant Department of Pharmaceutical sciences School of PharmacyUniversity of PittsburghPittsburghPA15261USA Center for Clinical Pharmaceutical sciences Department of Pharmacy and TherapeuticsSchool of PharmacyClinical and Translational Science InstituteDepartment of ImmunologySchool of MedicineUniversity of PittsburghPittsburghPA15261USA Department of Bioengineering Swanson School of EngineeringMcGowan Institute for Regenerative MedicineUPMC Hillman Cancer CenterUniversity of PittsburghPittsburghPA15261USA

Respiratory syncytial virus(RsV)is the most common cause of viral bronchiolitis among children worldwide,yet there is no vaccine for RsV *** study investigates the potential of cube and sphere-shaped cerium oxide nanoparticles(CNP)to modulate reactive oxygen(ROs)and nitrogen(RNs)species and immune cell phenotypes in the presence of RsV infection in vitro and in *** and sphere-shaped CNP were synthesized by hydrothermal and ultrasonication methods,***-chemical characterization confirmed the shape of sphere and cube CNP and effect of various parameters on their particle size distribution and zeta *** vitro results revealed that sphere and cube CNP differentially modulated ROs and RNs levels in j.74 ***,cube CNP significantly reduced RsV-induced ROs levels without affecting RNs levels while sphere CNP increased RsV-induced RNs levels with minimal effect on ROs *** CNP drove an M1 phenotype in RsV-infected macrophages in vitro by increasing macrophage surface expression of CD80 and CD86 with a concomitant increase in TNFαand IL-12p70,while simultaneously decreasing M2 CD206 *** administration of sphere and cube-CNP were well-tolerated with no observed toxicity in BALB/c ***,cube CNP preferentially accumulated in murine alveolar macrophages and induced their activation,avoiding enhanced uptake and activation of other inflammatory cells such as neutrophils,which are associated with RsV-mediated *** conclusion,we report that sphere and cube CNP modulate macrophage polarization and innate cellular responses during RsV infection.

关键词： Cerium oxide nanoparticles Reactive oxygen species Respiratory syncytial virus Macrophage phenotypes Immunomodulation Nanoparticle shape Bioactive nanoparticles

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software improvement for evaluation of laryngopharyngeal pH testing(Restech)——a comparison between Data View 3 and 4

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World j.urnal of Gastrointestinal surgery 2020年第5期12卷 236-246页

作者： Dolores Thea Müller Elena schulte Benj.min Babic Laura Knepper Claudia Fuchs Wolfgang schroder Christiane j.Bruns jessica M Leers Hans Friedrich Fuchs Department of General VisceralCancer and Transplant SurgeryUniversity of CologneKoln 50937Germany

BACKGROUND When gastroesophageal reflux contents reach above the upper esophageal sphincter,patients may,in addition to typical reflux symptoms,present with atypical,extraesophageal symptoms related to laryngopharyngeal reflux(LPR).surgical treatment of LPR has shown to lead to 70%symptom improvement,however no gold standard for the diagnosis of LPR *** 2007,the Restech Dx-pH was released as a valid method to measure acid exposure above the upper esophageal ***,a new software update was introduced for analysis of measured pH data and calculation of composite *** effect of the changes applied to the new software version have not yet been *** To compare results generated by Data View 3 to the most recently released Data View *** All patients with gastroesophageal reflux disease symptoms were seen in a specialized surgical outpatient clinic for gastrointestinal function *** chart review was performed of all patients presenting with suspected gastroesophageal reflux disease and extraesophageal reflux symptoms,who underwent laryngopharyngeal pH monitoring using the Restech Dx-pH system(Respiratory Technology Corp.,Houston,TX,United states)and simultaneous esophageal pH *** View 3 and Data View 4 were used to evaluate Restech studies *** entries such as mealtimes,supine and upright periods,and symptoms were entered manually to ensure accuracy and precise conversion of data between both software *** t test was performed for statistical analysis of *** A total of 174 patients(63.8%female)met inclusion criteria,all suffering from extraesophageal reflux symptoms as well as typical gastroesophageal reflux disease *** RYAN score upright was 48.77 in Data View 3 compared to 22.17 in Data View 4,showing a significant difference(~aP=0.0001).similar results were shown for supine period(mean RYAN score Data View 35.29 vs 1.42 in Data View 4,~cP=0.0001).For upright pe

关键词： Gastroesophageal reflux disease Laryngopharyngeal reflux disease Esophageal pH testing Oropharyngeal pH testing Restech Dx pH DeMeester score RYAN score

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The Role of T Lymphocytes in Bone Remodeling

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Open j.urnal of Orthopedics 2023年第4期13卷 131-146页

作者： j.ymes L. Fuller Renee E. samuel j.son j. Abraham Dina Gad Dana M. Padilla jessica A. Cottrell Department of Biological sciences Seton Hall University South Orange USA

Bone remodeling is a tightly regulated resorption and formation of bone matrix for physiological processes or to maintain bone function. Bone remodeling involves the synchronized differentiation and activity of bone-related cell types including bone matrix-depositing osteoblasts, bone matrix-resorbing osteoclasts, collagen/extracellular matrix-producing chondrocytes, and the progenitors of these cell types. T and B cells are adaptive immune cells that can influence bone remodeling by directly regulating the function of bone-related cells under normal and pathophysiological conditions. The specific mechanisms through which T cells control remodeling are not well defined. Here, we review the impact and influence of T cells and their products on the differentiation and function of bone cells during bone remodeling. synthesizing new connections and highlighting potential mechanisms may promote additional avenues of study to elucidate the full role that immune cells play in regulating bone homeostasis.

关键词： Osteoimmunology Bone Homeostasis Fracture T Cells B Cells Osteoblasts Osteoclasts Chondrocytes

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Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms

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stroke & Vascular Neurology 2018年第3期3卷 169-175页

作者： Bowen j.ang Matthew T Bender Erick M Westbroek jessica K Campos Li-Mei Lin Risheng Xu Rafael j.Tamargo j.dy Huang Geoffrey P Colby Alexander L Coon Department of Neurosurgery Johns Hopkins University School of MedicineBaltimoreMarylandUSA Department of Neurosurgery University of CaliforniaIrvine School of MedicineOrangeCaliforniaUSA Department of Neurosurgery University of CaliforniaLos AngelesLos AngelesCaliforniaUSA

background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and *** is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic *** is limited knowledge on whether procedural complexity influences these *** Data were collected retrospectively on 742 consecutive PED cases at a single *** with intraprocedural acute thrombosis were compared with patients without these *** A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous *** two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(sAH)and aneurysm *** was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two *** in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,psure(3476 vs 2160 mGy,ps of adj.nctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,psitu thrombosis cohort had higher incidence of maj.r and minor stroke,intracerebral haemorrhage and length of *** Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adj.nctive coiling and need for balloon angioplasty)are asso

关键词： P2Y12 matched balloon

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Hands-on Workshops as An Efective Means of Learning Advanced Technologies Including Genomics,Proteomics and Bioinformatics

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Genomics, Proteomics & Bioinformatics 2013年第6期11卷 368-377页

作者： Nichole Reisdorph Robert stearman Katerina Kechris Tzu Lip Phang Richard Reisdorph jessica Prenni David j.Erle Christopher Coldren Kevin schey Alexey Nesvizhskii Mark Geraci Department of Immunology National Jewish Health Department of Medicine Division of Pulmonary Sciences and Critical Care MedicineUniversity of Colorado School of Medicine Department of Biostatistics and Informatics Colorado School of Public Health Department of Pediatrics National Jewish Health Department of Biochemistry and Molecular Biology Proteomics and Metabolomics FacilityColorado State University Lung Biology Center Department of MedicineUniversity of California Bioinformatics PathgroupNashvilleTN 37027 USA Department of Biochemistry and Mass spectrometry Research Center Vanderbilt School of Medicine Department of Pathology University of Michigan Medical School

Genomics and proteomics have emerged as key technologies in biomedical research, resulting in a surge of interest in training by investigators keen to incorporate these technologies into their research. At least two types of training can be envisioned in order to produce meaningful results, quality publications and successful grant applications：（1） immediate short-term training workshops and （2） long-term graduate education or visiting scientist programs. We aimed to fill the former need by providing a comprehensive hands-on training course in genomics, proteomics and informatics in a coherent, experimentally-based framework. This was accomplished through a National Heart, Lung, and Blood Institute （NHLBI）-sponsored 10-day Genomics and Proteomics Hands-on Workshop held at National j.wish Health （Nj.） and the University of Colorado school of Medicine （UCD）. The course content included comprehensive lectures and laboratories in mass spectrometry and genomics technologies, extensive hands-on experience with instrumentation and software, video demonstrations, optional workshops, online sessions, invited keynote speakers, and local and national guest faculty. Here we describe the detailed curriculum and present the results of short- and long-term evaluations from course attendees. Our educational program consis- tently received positive reviews from participants and had a substantial impact on grant writing and review, manuscript submissions and publications.

关键词： Proteomics Mass spectrometry Genomics Bioinformatics Hands-on Workshops

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Tissue distribution of perfluoroalkyl acids and health status in wild Mozambique tilapia(Oreochromis mossambicus) from Loskop Dam, Mpumalanga, south Africa

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j.urnal of Environmental sciences 2017年第11期29卷 59-67页

作者： j.cqueline T.Bangma jessica L.Reiner Hannes Botha Theresa M.Cantu Marco A.Gouws Matthew P.Guillette j.remy P.Koelmel Wilmien j.Luus-Powell j.n Myburgh Olivia Rynders j.seph R.sara Willem j.smit j.hn A.Bowden Medical University of south Carolina Department of Obstetrics and Gynecology Charleston SC 29412 United States National Institute of standards and Technology Chemical Sciences Division Hollings Marine Laboratory Charleston SC 29412 United States Department of Biodiuersity University of Limpopo Souenga South Africa scientific services Mpumalanga Tourism and Parks Agency Nelspruit 1200 South Africa Department of science School of Natural Resource Management Nelson Mandela Metropolitan University George 6529 South Africa Uniuersity of Florida Department of Chemistry Gainesville FL 32611 United States Department of ParaclinieaI sciences Faculty of Veterinary Science University of Pretoria Onderstepoort South Africa

This study examined concentrations of 15 perfluoroalkyl acids（PFAAs） in tissues from male Mozambique tilapia（Oreochromis mossambicus） collected at Loskop Dam, Mpumalanga,south Africa in 2014 and 2016. Nine of the 15 PFAAs were detected frequently and were included in statistical analysis and included two of the most commonly known PFAAs,perfluorooctanesulfonic acid（PFOs）（median, 41.6 ng/g） and perfluorooctanoic acid（PFOA）（median, 0.0825 ng/g）. Of the tissues measured, plasma（2016 and 2014 median, 22.2 ng/g）contained the highest PFAA burden followed by（in descending order）： liver（median,11.6 ng/g）, kidney（median, 9.04 ng/g）, spleen（median, 5.92 ng/g）, adipose（median, 2.54 ng/g）, and muscle（median, 1.11 ng/g）. Loskop Dam tilapia have been affected by an inflammatory disease of the adipose tissue known as pansteatitis, so this study also aimed to investigate relationships between PFAA tissue concentrations and incidence of pansteatitis or fish health status. Results revealed that healthy tilapia exhibited an overall higher（p-value 〈 0.05） PFAA burden than pansteatitis-affected tilapia across all *** analysis showed that organs previously noted in the literature to contain the highest PFAA concentrations, such as kidney, liver, and plasma, were the organs driving the difference in PFAA burden between the two tilapia groups. Care must be taken in the interpretations we draw from not only the results of our study, but also other PFAA measurements made on populations（human and wildlife alike） under differing health status.

关键词： Perfluoroalkyl acids Liquid chromatography mass spectrometry Pansteatitis Perfluorooctanesulfonic acid Tissue distribution

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Changes in insomnia severity with advanced PAP therapy in patients with posttraumatic stress symptoms and comorbid sleep apnea:A retrospective,nonrandomized controlled study

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Military Medical Research 2019年第4期6卷 308-319页

作者： Barry j.Krakow Natalia D.McIver jessica j.Obando Victor A.Ulibarri sleep&Human Health Institute 6739 Academy Rd NE Ste380AlbuquerqueNM 87109USA Maimonides sleep Arts&sciences 6739 Academy Rd NE Ste380AlbuquerqueNM 87109USA Los Alamos Medical Center 3917 W RdLos AlamosNM 87544USA Institution:Mozaik solutions Solana BeachCA 92075USA

Background:sleep disorders frequently occur in posttraumatic stress disorder(PTsD)*** insomnia is a common feature of and criteria for the diagnosis of *** sleep disorder,obstructive sleep apnea(OsA),also occurs frequently in PTsD,and emerging research indicates OsA fuels chronic *** research has investigated the impact of OsA treatment on insomnia outcomes(Insomnia severity Index,IsI)in trauma ***:OsA patients with moderately severe posttraumatic stress symptoms were studied in a retrospective chart ***-six patients who failed CPAP therapy due to expiratory pressure intolerance or complex sleep apnea or both underwent manual titration with advanced PAP modes[autobilevel(ABPAP);adaptive servo-ventilation(AsV)],which were subsequently *** use measured by obj.ctive data downloads divided the sample into three groups:compliant regular users(C-RU):n=68;subthreshold users(sC-RU):n=12;and noncompliant users(NC-MU):n=*** average follow-up was 11.89±12.22 *** and posttreatment IsI scores were analyzed to assess residual insomnia symptoms as well as cure ***:The C-RU group showed significant improvements in insomnia with very large effects compared to those in the NC-MU reference group(P=0.019).Insomnia severity significantly decreased in all three groups with large effects(C-RU,P=0.001;sC-RU,P=0.027;NC-MU,P=0.007).Hours of weekly PAP use and insomnia severity were inversely correlated(P=0.001,r=–0.321).However,residual insomnia symptoms based on established IsI cut-offs were quite common,even among the C-RU *** hoc analysis showed that several categories of sedating medications reported at baseline(hypnotics,anti-epileptic,opiates)as well as actual use of any sedating medication(prescription or nonprescription)were associated with smaller insomnia improvements than those in patients not using any sedating ***:In a retrospective,nonrandomized analysis of a selec

关键词： Insomnia Obstructive sleep apnea Complex insomnia CBT-I Posttraumatic stress symptoms CPAP Auto bi-level Adaptive servo-ventilation

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If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease

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Asian j.urnal of Urology 2019年第1期6卷 10-25页

作者： Karen s.sfanos srinivasan Yegnasubramanian William G.Nelson Tamara L.Lotan Ibrahim Kulac jessica L.Hicks Qizhi Zheng Charles j.Bieberich Michael C.Haffner Angelo M.De Marzo Department of Pathology Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Oncology The Johns Hopkins University School of MedicineBaltimoreMDUSA Department of Pathology Koc Universitesi Tip FakultesiIstanbulTurkey Department of Biological sciences University of Maryland Baltimore CountyBaltimoreMDUSA

Antibodies are employed ubiquitously in biomedical sciences,including for diagnostics and *** of the most important uses is for immunohistochemical(IHC)staining,a process that has been improving and evolving over *** is useful when properly employed,yet misuse of the method is widespread and contributes to the“reproducibility crisis”in *** report some of the common problems encountered with IHC assays,and direct readers to a wealth of literature documenting and providing some solutions to this *** also describe a series of vignettes that include our approach to analytical validation of antibodies and IHC assays that have facilitated a number of biological insights into prostate cancer and the refutation of a controversial association of a viral etiology in *** postulate that a great deal of the problem with lack of accuracy in IHC assays stems from the lack of awareness by researchers for the critical necessity for end-users to validate IHC antibodies and assays in their laboratories,regardless of manufacturer claims or past *** suggest that one reason for the pervasive lack of end-user validation for research antibodies is that researchers fail to realize that there are two general classes of antibodies employed in ***,there are antibodies that are“clinical grade”reagents used by pathologists to help render diagnoses that influence patient *** diagnostic antibodies,which tend to be highly validated prior to clinical implementation,are in the vast minority(e.g.ss of antibodies are“research grade”antibodies(now numbering>3800000),which are often not extensively validated prior to *** increased awareness of the problem,both the United states,National Institutes of Health and some j.urnals are requiring investigators to provide evidence of specificity of their antibody-based assays.

关键词： Prostate cancer Antibodies Immunohistochemistry

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Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn,Mn,and Cu from amino acid complexes and Co from Co glucoheptonate

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j.urnal of Animal science and Biotechnology 2017年第4期8卷 885-896页

作者： Fernanda Batistel j.han s.Osorio Muhammad Rizwan Tariq Cong Li jessica Caputo Michael T.socha j.an j.Loor Department of Animal sciences and Division of Nutritional sciences University of Illinois1207 West Gregory DriveUrbanaIL 61801USA Department of Dairy science South Dakota State UniversityBrookingsSDUSA. Department of Food science and Technology University College of Agriculture&Environmental SciencesThe Islamia University of BahawalpurBahawalpurPunjabPakistan College of Animal science and Technology Key Laboratory of Animal Genetics and Breeding of Ministry of AgricultureNational Engineering Laboratory for Animal BreedingChina Agricultural UniversityBeijing 100193China Zinpro Corporation Eden PrairieMNUSA

Background: Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows. The supply of complexed trace minerals, which are more bioavailable, could help overcome the greater needs of these nutrients in tissues around parturition and early ***: Twenty Holstein cows received an oral bolus with a mix of inorganic trace minerals(INO) or complexed trace minerals(AAC) to achieve 75, 65, 11, and 1 ppm supplemental Zn, Mn, Cu, and Co, respectively, in the total diet dry matter from -30 d through +30 d relative to parturition. Blood for polymorphonuclear leukocyte(PMNL) isolation was collected at-30,-15, +10, and + 30 d relative to parturition, whereas endometrium biopsies were performed at +14 and +30 d. Feeding AAC led to greater PMNL expression of genes related with inflammation response(DDX58), oxidative stress response(MPO), eicosanoid metabolism(PLA2G4A and ALOX5AP), transcription regulation(PPARG), and cellular adhesion(TLN1). The upregulation by AAC in endometrium of genes related with inflammation response( TLR2, TLR4, NFKB1, TNF, IL6, IL1 B, IL10, IL8), prostaglandin synthesis(PTGs2, PTGEs), and antioxidant responses(NFE2 L2, sOD1) indicated a faster remodeling of uterine tissue and potentially greater capacity to control a local bacterial ***: Data indicate that trace mineral supplementation from amino acid complexes improves PMNL activity and allows the prompt recovery of uterine tissue during early lactation. As such, the benefits of complexed trace minerals extend beyond an improvement of liver function and productive performance.

关键词： Inflammation Oxidative stress Trace minerals Transition period

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