检索结果-南通市图书馆

Invasive black spiny-tailed iguanas(Ctenosaura similis)on Gasparilla Island,Florida,USA

Integrative Zoology 2014年第5期9卷 590-597页

作者： Michael L.AVERY Eric A.TILLMAN Conny SPURFELD Richard M.ENGEMAN Kelin P.MACIEJEWSKI jessica D.brown Emily A.FETZER United States Department of Agriculture Wildlife Services(USDA-WS)National Wildlife Research CenterFlorida Field StationGainesvilleFloridaUSA USDA-WS GainesvilleFloridaUSA USDA-WS National Wildlife Research CenterFort CollinsColorado USA Berryman Institute Mississippi State UniversityStarkvilleMississippiUSA

The native range of Ctenosaura similis extends from southern Mexico through Panama. From an initial introduction of 3 animals in 1979, the species now numbers in the thousands on Gasparilla Island in southwest Florida. In response to complaints of property damage from residents and threats to native species, local officials and the US Department of Agriculture Wildlife Services began a removal program in 2008. Through 2011, trappers removed 9467 ctenosaurs. The number removed declined from 32 iguanas/day in 2008 to 1.9 iguanas/day in 2011 despite no easing of the control effort. We necropsied 2757 ctenosaurs to document aspects of their natural history. Females outnumbered males overall, although the largest size class (>300 mm snout-vent length) included 32 males and just 2 females. Reproduction was seasonal. We found oviducal eggs in females from early Apr to early Jun, approximately 2 months later than C. similis in its native range. We trapped hatchlings from late Jul to early Oct coincident with the summer rainy season. Clutch size increased with female body size, with 62 being the largest clutch size recorded. In general, the biology of the invasive population on Gasparilla Island resembles native C. similis populations in Central America, except for the lack of large individuals. We suggest that shorter day length and colder temperatures create environmental conditions that are suboptimal for individual growth compared to those in the native range.

关键词： Ctenosaura similis Florida invasive reptile population control spiny-tailed iguana

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immuno-oncology combinations： raising the tail of the survival curve

引用

Cancer Biology & Medicine 2016年第2期13卷 171-193页

作者： Samuel J. Harris jessica brown Juanita Lopez Timothy A. Yap Drug Development Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK Lung Unit Royal Marsden Hospital and The Institute of Cancer Research London SM2 5PT UK

There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer,immune checkpoint inhibitors also appears to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, not all patients benefit, and efforts should thus now focus on improving the efficacy of immunotherapy through the use of combination approaches and predictive biomarkers of response and resistance. There are multiple potential rational combinations using an immunotherapy backbone, including existing treatments such as radiotherapy, chemotherapy or molecularly targeted agents, as well as other immunotherapeutics. The aim of such antitumor strategies will be to raise the tail on the survival curve by increasing the number of long term survivors, while managing any additive or synergistic toxicities that may arise with immunotherapy combinations. Rational trial designs based on a clear understanding of tumor biology and drug pharmacology remain paramount. This article reviews the biology underpinning immuno-oncology, discusses existing and novel immunotherapeutic combinations currently in development, the challenges of predictive biomarkers of response and resistance and the impact of immuno-oncology on early phase clinical trial design.

关键词： Combination drug therapy oncology clinical trials PD-1 PD-L1 CTLA4 biomarkers immunotherapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple sclerosis is at a checkpoint: advancing the program

引用

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

引用

Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Making Artificial Meat in‘Hog Country’

引用

空中英语教室(高级版.彭蒙惠英语) 2025年第2期 24-25,45,46页

作者： jessica Hullinger 不详

North Carolina might not seem like an obvious place for a research hub dedicated to breakthroughs in lab-grown *** all,the Tar Heel so other universities that were up for the *** proximity to the neighboring educational powerhouses of the University of North Carolina at Chapel Hill and Duke University was a bonus,state is a leader in producing meat the old-fashioned way:Its top agricultural commodity is chickens.

关键词： breakthrough Carolina proximity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Chinese medicine and modern technology:Network pharmacology and omics sequencing in gastric cancer

引用

World Journal of Gastrointestinal Oncology 2025年第3期17卷 38-43页

作者： jessica Shapiro Gemmell Brandon Lucke-Wold College of Medicine University of FloridaGainesvilleFL 32601United States Department of Neurosurgery University of FloridaGainesvilleFL 32608United States

In this editorial,we comment on the article by Micucci et al published in the recent *** focus on the heterogenous nature of gastric cancer(GC)and the potential benefits of integrating traditional Chinese medicine(TCM)with the modern technology of network pharmacology(NP)and omics *** is a heterogenous disease,as it incorporates several biochemical pathways that contribute to *** acknowledges the multifactorial,heterogenous nature of disease and utilizes an integrative approach to ***,a modern philosophy within drug development,integrates traditional knowledge of nutraceuticals and modern technologies to address the complex interactions of pathways within the *** technologies,which is at the core of precision medicine,has allowed for this newfound principle of drug *** pathways are better distinguished,leading to more targeted drug ***,the use of omics technology needs to be employed to better characterize the subtypes of *** will allow TCM’s use of nutraceuticals in the application of NP to better target metabolic pathways that may aid in the prevention of GC as well as enhance treatment.

关键词： Gastric cancer Traditional Chinese medicine Omics Network pharmacology Nutraceuticals Precision medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A macro-transection model of brain trauma for neuromaterial testing with functional electrophysiological readouts

引用

Neural Regeneration Research 2025年第12期20卷 3539-3552页

作者： jessica Wiseman Raja Haseeb Basit Akihiro Suto Sagnik Middya Bushra Kabiri Michael Evans Vinoj George Christopher Adams George Malliaras Divya Maitreyi Chari School of Medicine Keele UniversityNewcastle-under-LymeUK Sheffield Institute for Translational Neuroscience University of SheffieldSheffieldUK Academic Department of Surgery Queen Elizabeth Hospital&University of BirminghamEdgbastonUK Guy Hilton Research Center School of Pharmacy&BioengineeringKeele UniversityNewcastle-under-LymeUK Electrical Engineering Division Department of EngineeringUniversity of CambridgeCambridgeUK School of Life Sciences Keele UniversityNewcastle-under-LymeUK

Functional recovery in penetrating neurological injury is hampered by a lack of clinical regenerative *** therapies show promise as medical materials for neural repair through immunomodulation,structural support,and delivery of therapeutic ***,a lack of facile and pathology-mimetic models for therapeutic testing is a bottleneck in neural tissue engineering *** have deployed a two-dimensional,high-density multicellular cortical brain sheet to develop a facile model of injury(macrotransection/scratch wound)in *** model encompasses the major neural cell types involved in pathological responses ***,we observed hallmark pathological responses in injury foci including cell scarring,immune cell infiltration,precursor cell migration,and shortrange axonal *** test magnetic particles to evaluate the potential of the model for biomaterial screening shows a high uptake of introduced magnetic particles by injury-activated immune cells,mimicking in vivo ***,we proved it is feasible to create reproducible traumatic injuries in the brain sheet(in multielectrode array devices in situ)characterized by focal loss of electrical spiking in injury sites,offering the potential for longer term,electrophysiology plus histology *** our knowledge,this is the first in vitro simulation of transecting injury in a two-dimensional multicellular cortical brain cell sheet,that allows for combined histological and electrophysiological readouts of damage/*** patho-mimicry and adaptability of this simplified model of brain injury could benefit the testing of biomaterial therapeutics in regenerative neurology,with the option for functional electrophysiological readouts.

关键词： in vitro modelling multielectrode array interfacing nanoparticles neuromaterials scratch assay transecting injury traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimizing non-invasive vagus nerve stimulation for treatment in stroke

引用

Neural Regeneration Research 2025年第12期20卷 3388-3399页

作者： Sheharyar S.Baig Samantha Dorney Mudasar Aziz Simon M.Bell Ali N.Ali Li Su jessica N.Redgrave Arshad Majid Sheffield Institute for Translational Neuroscience Department of NeuroscienceUniversity of SheffieldSheffieldUK Doncaster and Bassetlaw Teaching Hospitals NHS Foundation Trust DoncasterUK

Stroke remains a leading cause of long-term disability *** is an unmet need for neuromodulatory therapies that can mitigate against neurovascular injury and potentially promote neurological *** vagus nerve stimulation has been demonstrated to show potential therapeutic effects in both acute and chronic ***,previously published research has only investigated a narrow range of stimulation settings and *** this review,we detail the ongoing studies of transcutaneous vagus nerve stimulation in stroke through systematic searches of registered clinical *** summarize the upcoming clinical trials of transcutaneous vagus nerve stimulation in stroke,highlighting their indications,parameter settings,scope,and *** further explore the challenges and barriers associated with the implementation of transcutaneous vagus nerve stimulation in acute stroke and stroke rehabilitation,focusing on critical aspects such as stimulation settings,target groups,biomarkers,and integration with rehabilitation interventions.

关键词： neuromodulation neuroplasticity rehabilitation stroke vagal nerve stimulation vagus nerve stimulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ecology and management of Bactericera cockerelli and Candidatus Liberibacter solanacearum in New Zealand

引用

Journal of Integrative Agriculture 2020年第2期19卷 333-337页

作者： jessica VEREIJSSEN Applied Entomology the New Zealand Institute for Plant and Food Research Limited

The psyllid Bactericera cockerelli was first reported in New Zealand in 2006 and spread quickly throughout all potato growing *** 2009,*** was associated with the plant pathogenic bacterium Candidatus Liberibacter solanacearum,the putative causal agent of zebra chip disease in *** the psyllid and the bacterium have non-crop host plants which can serve as reservoirs when the crop is not *** apply different management strategies that fit integrated pest management programmes to manage *** and subsequently lower incidence of zebra chip disease in potato *** best management efforts,complete control of *** and zero incidence of zebra chip disease are not achievable at the current time.

关键词： Bactericera cockerelli Candidatus Liberibacter solanacearum potato insect vector

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Application of DInSAR for short period monitoring of initial subsidence due to longwall mining in the mountain west United States

引用

International Journal of Mining Science and Technology 2020年第1期30卷 33-37页

作者： jessica M.Wempen Department of Mining Engineering University of UtahSalt Lake City 84112USA

Differential Interferometric Synthetic Aperture Radar(DInSAR),a satellite-based remote sensing technique,has application for monitoring subsidence with high resolution over short *** uses radar images to measure centimeter-level surface *** the images,ground resolution can be relatively high,with each data point(pixel)representing the average displacement over an area of several square *** image data are acquired regularly which allows subsidence to be monitored sequentially over short periods;imaging periods typically range from weeks to *** subsidence over short periods with high spatial resolution has potential to provide insight into the dynamics of subsidence and into relationships between mine advance and *** this study,for three longwall mines in the western United States,initial subsidence occurring at the start of longwall advance is quantified over short periods(12–72 days).C-band interferometric wide swath Synthetic Aperture Radar(SAR)images from the Sentinel satellites are used to quantify the ***,the data show initial development of subsidence,expansion of the subsidence trough,and the advance of subsidence in the direction of mining.

关键词： Longwall mining Interferometry Subsidence

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：