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Uptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome

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World Journal of Clinical Oncology 2021年第11期12卷 1023-1036页

作者： Jeshua DeJesse Ravy K Vajravelu Christina Dudzik Gillain Constantino jessica m long Kirk J Wangensteen Kathleen D Valverde Bryson W Katona Department of Genetics University of PennsylvaniaPhiladelphiaPA 19104United States Division of Gastroenterology and Hepatology University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104United States Division of Hematology and Oncology University of PennsylvaniaPhiladelphiaPA 19104United States

BACKGROUND Lynch syndrome(LS)is a hereditary cancer predisposition syndrome associated with increased risk of multiple *** colorectal cancer surveillance decreases mortality in LS and is recommended by guidelines,there is lack of evidence for the efficacy of surveillance for extra-colonic cancers associated with LS,including small intestinal cancer(SIC)and urinary tract cancer(UTC).Given the limited evidence,guidelines do not consistently recommend surveillance for SIC and UTC,and it remains unclear how often individuals will choose to undergo and follow through with extra-colonic surveillance *** To study factors associated with SIC and UTC surveillance uptake and outcomes in *** This is an IRB-approved retrospective analysis of individuals with LS seen at a tertiary care referral *** individuals had a pathogenic or likely pathogenic variant in mLH1,mSH2,mSH6,PmS2,or EPCAm,or were a confirmed obligate carrier,and had at least one documented visit to our *** regarding SIC and UTC surveillance was captured for each individual,and detailed personal and family history was obtained for individuals who had an initial LS management visit in our center’s dedicated high-risk LS clinic between January 1,2017 and October 29,*** these initial management visits,all patients had in-depth discussions of SIC and UTC surveillance with 1 of 3 providers experienced in LS management to promote informed decision-making about whether to pursue SIC and/or UTC *** analysis using Pearson’s chi-squared test and Wilcoxon rank-sum test was completed to understand the factors associated with pursuit and completion of SIC and UTC surveillance,and a P value below 0.05 was deemed statistically *** Of 317 individuals with LS,86(27%)underwent a total of 105 SIC surveillance examinations,with 5 leading to additional work-up and no SICs ***,99(31%)patients underwent a total of 3

关键词： Lynch syndrome Urinary tract cancer Intestinal neoplasms Early diagnosis of cancer Patient preference Gastrointestinal surgical procedure

The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan long Jiajia Liu Yu Wang Haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

moS_(2)Lubricate‑Toughened mXene/ANF Composites for multifunctional Electromagnetic Interference Shielding

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Nano-micro Letters 2025年第2期17卷 358-371页

作者： Jiaen Wang Wei ming longfu Chen Tianliang Song moxi Yele Hao Zhang long Yang Gegen Sarula Benliang Liang Luting Yan Guangsheng Wang School of Physical Science and Engineering Beijing Jiaotong UniversityBeijing 100044People’s Republic of China Key Laboratory of Bio‑Inspired Smart Interfacial Science and Technology of ministry of Education School of ChemistryBeihang UniversityBeijing 100191People’s Republic of China

The design and fabrication of high toughness electromagnetic interference(EmI)shielding composite films with diminished reflection are an imperative task to solve electromagnetic pollution *** mXene/ANF(aramid nanofibers)–moS_(2)composite films with nacre-like layered structure here are fabricated after the introduction of moS_(2)into binary mXene/ANF composite *** introduction of moS_(2)fulfills an impressive“kill three birds with one stone”improvement effect:lubrication toughening mechanical performance,reduction in secondary reflection pollution of electromagnetic wave,and improvement in the performance of photothermal *** the introduction of moS_(2)into binary mXene/ANF(mass ratio of 50:50),the strain to failure and tensile strength increase from 22.1±1.7%and 105.7±6.4 mPa and to 25.8±0.7%and 167.3±9.1 mPa,*** toughness elevates from 13.0±4.1 to 26.3±0.8 mJ m^(−3)(~102.3%)*** the reflection shielding effectiveness(SE_(R))of mXene/ANF(mass ratio of 50:50)decreases~10.8%.EmI shielding effectiveness(EmI SE)elevates to 41.0 dB(8.2–12.4 GHz);After the introduction of moS_(2)into binary mXene/ANF(mass ratio of 60:40),the strain to failure increases from 18.3±1.9%to 28.1±0.7%(~53.5%),the SE_(R)decreases~22.2%,and the corresponding EmI SE is 43.9 *** moS_(2)also leads to a more efficient photothermal conversion performance(~45 to~55℃).Additionally,mXene/ANF–moS_(2)composite films exhibit excellent electric heating performance,quick temperature elevation(15 s),excellent cycle stability(2,2.5,and 3 V),and long-term stability(2520 s).Combining with excellent mechanical performance with high mXene content,electric heating performance,and photothermal conversion performance,EmI shielding ternary mXene/ANF–moS_(2)composite films could be applied in many industrial *** work broadens how to achieve a balance between mechanical properties and versatility of composites in the case of high-function fillers.

关键词： mXene-moS_(2) Lubrication toughening EmI shielding Photothermal conversion Electric heating performance

Application of DInSAR for short period monitoring of initial subsidence due to longwall mining in the mountain west United States

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International Journal of mining Science and Technology 2020年第1期30卷 33-37页

作者： jessica m.Wempen Department of mining Engineering University of UtahSalt Lake City 84112USA

Differential Interferometric Synthetic Aperture Radar(DInSAR),a satellite-based remote sensing technique,has application for monitoring subsidence with high resolution over short *** uses radar images to measure centimeter-level surface *** the images,ground resolution can be relatively high,with each data point(pixel)representing the average displacement over an area of several square *** image data are acquired regularly which allows subsidence to be monitored sequentially over short periods;imaging periods typically range from weeks to *** subsidence over short periods with high spatial resolution has potential to provide insight into the dynamics of subsidence and into relationships between mine advance and *** this study,for three longwall mines in the western United States,initial subsidence occurring at the start of longwall advance is quantified over short periods(12–72 days).C-band interferometric wide swath Synthetic Aperture Radar(SAR)images from the Sentinel satellites are used to quantify the ***,the data show initial development of subsidence,expansion of the subsidence trough,and the advance of subsidence in the direction of mining.

关键词： longwall mining Interferometry Subsidence

Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen Yong-Qi Li Yu-long Wang mei-Chen Liu Yun-Bo Ruan Yang Zhang Shu-Juan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

Quantifying relationships between subsidence and longwall face advance using DInSAR

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International Journal of mining Science and Technology 2021年第1期31卷 91-94页

作者： Bailey S.Simmons jessica m.Wempen Department of mining Engineering University of UtahUT 84112United States

Surface subsidence that results from longwall mining can be large magnitude and can affect significant *** methods for subsidence monitoring include leveling,global positioning system(GPS),and photogrammetric *** sensing techniques including,aerial LiDAR,terrestrial laser scanning,and satellite-based Differential Interferometric Synthetic Aperture Radar(DInSAR),are also used to measure deformation associated with *** data are different than data from conventional subsidence *** capture data over large areas(hundreds of kilometers),and each pixel(data point)in an image quantifies the average displacement over an area of square *** data can have fairly high time resolution;imaging periods typically range from weeks to *** data can be useful to monitor subsidence sequentially over short *** monitoring subsidence may help define if caving is progressing normally and can establish relationships between surface deformation and longwall face advance,which has potential to help quantify possible risks to mine *** this study,subsidence at a longwall trona mine is monitored over short periods,typically 12 days,as the longwall face is advanced through a panel.C-band interferometric wide swath synthetic aperture radar(SAR)images from the sentinel satellites are used to quantify the *** onset of subsidence occurs close in time to the beginning of the longwall face advance,and overall,the development of subsidence closely follows the longwall face advance.

关键词： DInSAR Subsidence monitoring longwall Trona

Circadian rhythms and inflammatory diseases of the liver and gut

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Liver Research 2023年第3期7卷 196-206页

作者： jessica m.Ferrell Department of Integrative medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Circadian rhythms play a central role in maintaining metabolic homeostasis and orchestrating interorgan *** evidence indicates that disruption to rhythms,which occurs through shift work,chronic sleep disruption,molecular clock polymorphisms,or the consumption of alcohol or highfat diets,can influence inflammatory status and disrupt timing between the brain and periphery or between the body and the external *** the liver and gut,circadian rhythms direct the timing of glucose and lipid homeostasis,bile acid and xenobiotic metabolism,and nutrient absorption,making these systems particularly susceptible to the effects of disrupted *** this review,the impacts of circadian disruption will be discussed with emphasis on inflammatory conditions affecting the liver and gut,and the potential for chronotherapy for these conditions will be explored.

关键词： Circadian rhythm Liver Gut Inflammation Non-alcoholic fatty liver disease(NAFLD) Alcohol-associated liver disease(AALD)

Comparison of L-band and X-band differential interferometric synthetic aperture radar for mine subsidence monitoring in central Utah

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International Journal of mining Science and Technology 2017年第1期27卷 159-163页

作者： jessica m.Wempen michael K.mcCarter Department of mining Engineering University of UtahSalt Lake City 84112USA

Differential interferometric synthetic aperture radar(DIn SAR), a satellite-based remote sensing technique, has potential application for measuring mine subsidence on a regional scale with high spatial and temporal resolutions. However, the characteristics of synthetic aperture radar(SAR) data and the effectiveness of DIn SAR for subsidence monitoring depend on the radar band(wavelength). This study evaluates the effectiveness of DIn SAR for monitoring subsidence due to longwall mining in central Utah using L-band(24 cm wavelength) SAR data from the advanced land observing satellite(ALOS)and X-band(3 cm wavelength) SAR data from the Terra SAR-X mission. In the Wasatch Plateau region of central Utah, which is characterized by steep terrain and variable ground cover conditions, areas affected by longwall mine subsidence are identifiable using both L-band and X-band DIn ***, using L-band data, subsidence magnitudes are measurable. Compared to X-band, L-band data are less affected by signal saturation due to large deformation gradients and by temporal decorrelation due to changes in the surface conditions over time. The L-band data tend to be stable over relatively long periods(months). Short wavelength X-band data are strongly affected by signal saturation and temporal decorrelation, but regions of subsidence are typically identifiable over short periods(days). Additionally,though subsidence magnitudes are difficult to precisely measure in the central Utah region using X-band data, they can often be reasonably estimated.

关键词： mine subsidence DInSAR Terra SAR-X ALOS Interferometry

Analysis of Discretionary Lane Changing Parameters on Freeways

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International Journal of Transportation Science and Technology 2014年第3期3卷 277-296页

作者： Esmaeil Balal Ruey long Cheu Thompson Gyan-Sarkodie jessica miramontes Department of Civil Engineering The University of Texas at El Paso500 W.University AveEl PasoTX 79968U.S.A. Department of Electrical&Computer Engineering The University of Texas at El Paso500 W.University AveEl PasoTX 79968U.S.A.

A lane changing event,at the instant when a vehicle crosses the lane marker,involves up to five vehicles:the subject vehicle,preceding and following vehicles in the original lane,and the preceding and following vehicles in the target *** the interactions of the subject vehicle with the surrounding vehicles is fundamental to the study of the safety and modeling of lane changing *** research studies the statistical properties of 10 lane changing *** parameters describe the gaps,times to collision between vehicles and the subject vehicle’s *** parameter values were extracted from the vehicle trajectory data in the Next Generation Simulation data *** results show that(i)all the parameters are positively correlated with each other;(ii)the gaps and distance are best described by the lognormal distribution;(ii)the times to collision are best described by the Laplace distribution;(iii)the speed may be described by the log-logistic distribution and the normal *** results suggest that using one or few selected parameters may be sufficient to quantify the risk of a lane changing event.

关键词： parameters. collision distribution