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Growth and differentiation of human induced pluripotent stem cell(hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels

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Bioactive Materials 2023年第3期21卷 142-156页

作者： Niall J.Treacy Shane Clerkin jessica l.davis Ciar´an Kennedy Aline F.Miller Alberto Saiani Jacek K.Wychowaniec Dermot F.Brougham John Crean Diabetes Complications Research Centre University College Dublin(UCD)Conway Institute of Biomolecular and Biomedical Research and BelfieldDublin 4Ireland UCD School of Biomolecular and Biomedical Science BelfieldDublin 4Ireland Department of Materials&Manchester Institute of Biotechnology(MIB) School of Natural SciencesFaculty of Science and EngineeringThe University of ManchesterUK UCD School of Chemistry University College DublinBelfieldDublin 4Ireland

Human induced pluripotent stem cell(hiPSC)-derived kidney organoids have prospective applications ranging from basic disease modelling to personalised ***,there remains a necessity to refine the bio-physical and biochemical parameters that govern kidney organoid *** within fully-controllable and physiologically relevant 3D growth environments will be critical to improving organoid reproducibility and ***,we matured hiPSC-derived kidney organoids within fully synthetic self-assembling peptide hydrogels(SAPHs)of variable stiffness(storage modulus,G′).The resulting organoids con-tained complex structures comparable to those differentiated within the animal-derived matrix,***-cell RNA sequencing(scRNA-seq)was then used to compare organoids matured within SAPHs to those grown within Matrigel or at the air-liquid interface.A total of 13,179 cells were analysed,revealing 14 distinct *** compositional analysis revealed a larger proportion of nephron cell types within Transwell-derived organoids,while SAPH-derived organoids were enriched for stromal-associated cell ***,dif-ferentiation within a higher G’SAPH generated podocytes with more mature gene expression ***-tionally,maturation within a 3D microenvironment significantly reduced the derivation of off-target cell types,which are a known limitation of current kidney organoid *** work demonstrates the utility of syn-thetic peptide-based hydrogels with a defined stiffness,as a minimally complex microenvironment for the selected differentiation of kidney organoids.

关键词： Human kidney organoids Fully synthetic matrices Self-assembling peptide hydrogels Single-cell RNA sequencing

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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An evaluation of a catch and release trout regulation in Rapid Creek,South Dakota

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Aquaculture and Fisheries 2023年第5期8卷 558-563页

作者： Jacob l.davis South Dakota Department of Game Fish and Parks4130 Adventure TrailRapid CitySD57702USA

Often,catch and release regulations are meant to maximize a fisheries potential to create trophy fish.I evaluated adult Brown Trout populations at five locations within Rapid Creek within Rapid City,SD over a two-year *** each year,one of these locations was within a catch and release area,while two were *** 2012,density and biomass estimates were higher in a site located outside of the catch and release ***,size structure within the catch and release area was only significantly larger than one of the two sites outside of the regulation *** relative weight values were inversely related to density estimates,with the lowest density sites having the highest mean relative ***,a site outside of the catch and release area had the highest abundance and biomass estimates in *** cumulative length distribution was significantly different between the site within the catch and release area and the two located *** weight was significantly higher in the catch and release area than the two sites *** population characteristics within the catch and release area were not consistently better than outside,it is more likely that factors such as habitat and density dependence are impacting the Brown Trout population more than the regulation itself.

关键词： Trout Regulations Catch and release

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Mycetismus:a review

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Gastroenterology Report 2016年第2期4卷 107-112,I0001页

作者： Michael R.Smith Robert l.davis Department of Surgery St.Barnabas HospitalBronxNYUSA Department of Surgery Lutheran Medical CenterBrooklynNYUSA

Although rare,death from amanitin exposure poses a significant health risk and a diagnostic challenge to the clinician due to its *** is one of the few conditions to be voluntarily reported by healthcare *** antidote exists for this poisoning and,perhaps due to its rarity or lack of attention,the United States has lagged behind Europe for almost three decades in treatment,diagnostics and *** regrettable fact warrants the formation of a centralized agency for education,the advancement of research and the collection of data,to provide better treatment for the population.

关键词： amanita phalloides mushroom poisoning amatoxin amanitin vitamin C cimetidine silibinin N-acetylcysteine liver transplantation Ganzert criteria King’s College criteria mycetismus Clichy criteria

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Retention of fin clips and fin and operculum punch marks in rainbow trout

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Aquaculture and Fisheries 2022年第6期7卷 660-663页

作者： Alex J.Rosburg Jacob l.davis Michael E.Barnes South Dakota Department of Game Fishand Parks4725 Jackson BoulevardRapid CitySD57702USA South Dakota Department of Game Fishand Parks4130 Adventure TrailRapid CitySD57702USA South Dakota Department of Game Fishand Parks19619 Trout Loop SpearfishSouth Dakota57783USA

Fin clips(complete fin removal)or punch marks(stamping of a hole)in fins or operculum are quick and inexpensive methods to identify individuals or groups of *** study evaluated the retention of 6 mm diameter punch marks on the operculum,caudal(upper and lower lobes),dorsal,pelvic,and anal fins,and fin clips on adipose,pectoral,pelvic,dorsal and anal fins of rainbow trout Oncorhynchus mykiss for 279 *** and survival were not significantly different among fish with the different mark types or *** the end of the experiment,100%of adipose clips,97%of pectoral and anal fin clips,and 93%of dorsal clips and pelvic fin clips were *** of punch marks was 57%and 50%for the lower and upper caudal fin lobe locations respectively,23%for the dorsal fin,and 3%for the *** pelvic or anal fin punch marks were identified at the end of the *** differences in retention among the treatment groups did not occur until 125 days post marking,after which all fin clip treatments had significantly greater retention than pelvic and dorsal punch *** 244 days,fin clips outperformed all punch mark locations.

关键词： Marking Rainbow trout Oncorhynchus mykiss Fin punch Fin clip Mark retention

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β-funaltrexamine differentially modulates chemokine and cytokine expression in normal human astrocytes and C20 human microglial cells

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Neuroimmunology and Neuroinflammation 2020年第4期7卷 300-310页

作者： Randall l.davis Kelly McCracken Daniel J.Buck Department of Pharmacology/Physiology Oklahoma State University Center for Health SciencesTulsaOK 74107USA

Aim: Emerging evidence implicates astrocyte/microglia dysregulation in a range of brain disorders, thereby making glial cells potential therapeutic targets. The novel anti-inflammatory actions of beta-funaltrexamine (β-FNA) are of particular interest. β-FNA is a derivative of naltrexone, and recognized as a selective, irreversible antagonist at the mu-opioid receptor (MOR). However, we discovered that β-FNA has novel anti-inflammatory actions that seem to be mediated through a MOR-independent mechanism. Thus far, we have focused on the acute effects of β-FNA on inflammatory ***: The effect of β-FNA treatment on interleukin-1β (Il-1β)-induced inflammatory signaling in normal human astrocytes (NHA) and C20 human microglial cells. Cytokine/chemokine expression was measured using ElISA, and nuclear factor-kappaB (NF-κB) p65 activation was evaluated by immunoblot. Results: Il-1β-induced interferon-γ inducible protein-10 (CXCl10) production in NHA was more sensitive to chronic (3 day) β-FNA as indicated by an approximately 3-fold lower EC50 compared to that observed in acutely treated cells. Chronic β-FNA did not affect Il-1β-induced monocyte chemoattractant protein-1 (CCl2) or Il-6 production in NHA. β-FNA inhibited phosphorylation of NF-κB p65, suggesting that the inhibitory effects may be due in part to reduced NF-κB activation. We showed for the first time that C20 human microglial cells were insensitive to the anti-inflammatory actions of acute β-FNA. Conclusion: β-FNA differentially affects inflammatory cytokine/chemokine expression in human astrocytes and microglia. These findings warrant further investigation into the novel anti-inflammatory actions of β-FNA, with a particular focus on astrocytes. These insights should contribute to the development of strategies to treat brain disorders that involve neuroinflammation.

关键词： Neuroinflammation brain opioid nuclear factor-kappaB pro-inflammatory

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COVID-19:Reducing the risk via diet and lifestyle

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Journal of Integrative Medicine 2023年第1期21卷 1-16页

作者： jessica l.Campbell 160 Goat Island Road LeighAuckland 0985New Zealand

This review shows that relatively simple changes to diet and lifestyle can significantly,and rapidly,reduce the risks associated with coronavirus disease 2019(COVID-19)in terms of infection risk,severity of disease,and even disease-related mortality.A wide range of interventions including regular exercise,adequate sleep,plant-based diets,maintenance of healthy weight,dietary supplementation,and time in nature have each been shown to have beneficial effects for supporting more positive health outcomes with COVID-19,in addition to promoting better overall *** paper brings together literature from these areas and presents the argument that non-pharmaceutical approaches should not be overlooked in our response to *** is noted that,in several cases,interventions discussed result in risk reductions equivalent to,or even greater than,those associated with currently available *** the balance of evidence suggests benefits,and the risk is minimal to none,it is suggested that communicating the power of individual actions to the public becomes morally ***,many lives could be saved,and many harms from the vaccine mandates avoided,if we were willing to embrace this lifestyle-centred approach in our efforts to deal with COVID-19.

关键词： COVID-19 SARS-CoV-2 Exercise Sleep Diet Risk reduction behaviour

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裂缝型油藏描述

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国外油气勘探 1992年第6期 111-113页

作者： Thomas l.davis 马迪生

通过三维、三分量地震勘探,了解油藏的详细情况,可以优化裂缝型油藏的开采。

关键词：油气藏类型三分量记录水平钻井各向异性垂直地震剖面法

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Pain relief in upper abdominal malignancy

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Hepatobiliary & Pancreatic Diseases International 2006年第3期5卷 330-333页

作者： Colin D.Johnson Carol l.davis University Surgical Unit Southampton General Hospital and University of Southampton Countess Mountbatten House Southampton SO16 6YDUK

The symptom of cancer most feared by many patients is pain. The physical and psychological distress of constant pain without relief should not be underestimated, and all complaints of pain should be actively treated. ... 详细信息

关键词： Pain relief in upper abdominal malignancy oral

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Functionalized, carbon nanotube material for the catalytic degradation of organophosphate nerve agents

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Nano Research 2014年第3期7卷 390-398页

作者： Mark M. Bailey John M. Heddleston Jeffrey davis jessica l. Staymates Angela R. Hight Walker National Institute of Standards and Technology (NIST) Semiconductor and Dimensional Metrology Division Gaithersburg MD USA National Institute of Standards and Technology (NIST) Materials Measurement Science Division Gaithersburg MD USA Present Address: United States Army Medical Research Institute of Infectious Diseases (USAMRIID) Center for Aerobiological Sciences Fort Detrick MD USA

Recent world events have emphasized the need to develop innovative, functional materials that will safely neutralize chemical warfare （CW） agents in situ to protect military personnel and civilians from dermal exposure. Here, we demonstrate the efficacy of a novel, proof-of-concept design for a Cu-containing catalyst, chemically bonded to a single-wall carbon nanotube （SWCNT） structural support, to effectively degrade an organophosphate simulant. SWCNTs have high tensile strength and are flexible and light-weight, which make them a desirable structural component for unique, fabric-like materials. This study aims to develop a self-decontaminating, carbon nanotube-derived material that can ultimately be incorporated into a wearable fabric or protective material to minimize dermal exposure to organophosphate nerve agents and to prevent accidental exposure during decontamination procedures. Carboxylated SWCNTs were functionalized with a polymer, which contained Cu-chelating bipyridine groups, and their catalytic activity against an organophosphate simulant was measured over time. The catalytically active, functionalized nanomaterial was characterized using X-ray fluorescence and Raman spectroscopy. Assuming zeroth-order reaction kinetics, the hydrolysis rate of the organophosphate simulant, as monitored by UV-vis absorption in the presence of the catalytically active nanomaterial, was 63 times faster than the uncatalyzed hydrolysis rate for a sample containing only carboxylated SWCNTs or a control sample containing no added nanotube materials.

关键词： single-wall carbonnanotubefunctionalization catalytically-activenanomaterial chemical warfare agent

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