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Intravascular large B-cell lymphoma presenting with altered mental status: A case report

World Journal of Clinical Oncology 2019年第12期10卷 402-408页

作者： Christopher Robert D’Angelo Kimberly Ku jessica gulliver Julie Chang Department of Medicine Section of Hematology/OncologyUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53792United States Department of Pathology University of Wisconsin School of Medicine and Public HealthMadisonWI 53792United States

BACKGROUND Intravascular large B-cell lymphoma(IVLBCL)is a rare and aggressive subtype of non-Hodgkin lymphoma with a varied presentation and no pathognomonic *** diagnosis is critical to altering the disease course as early treatment with chemoimmunotherapy is required to prevent a rapidly fatal *** including improved awareness of this clinical entity through publication of cases with unique presentations are essential to prompt consideration of IVLBCL early in the disease ***,we present a case of IVLBCL presenting with altered mental status and systemic organ *** SUMMARY A 61-year-old male patient presented with flu-like symptoms and a high *** experienced rapid clinical deterioration with liver,kidney failure,and shock despite rapid antibiotic administration and supportive care.A broad infectious workup was *** imaging revealed nonspecific changes to the corpus callosum suspicious for *** biopsy was *** further progression of his symptoms,the family elected to withdraw care and the patient died shortly ***-mortem analysis revealed clear multi-organ involvement by IVLBCL,prompting re-examination of the ante-mortem renal biopsy that also identified IVLBCL *** IVLBCL is a rare *** with specialties and early biopsy is critical to establishing the diagnosis and initiating therapy.

关键词： Intravascular lymphoma Altered mental status Case report

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