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Physical activity, obesity and gastroesophageal reflux disease in the general population

World Journal of Gastroenterology 2012年第28期18卷 3710-3714页

作者： Therese Djrv Anna Wikman Helena Nordenstedt Asif Johar jesper lagergren Pernilla lagergren Unit of Upper Gastrointestinal Research Department of Molecular Medicine and Surgery Karolinska Institutet SE-17176 Stockholm Sweden jesper lagergren Division of Cancer Studies King's College London London WC2R 2LS United Kingdom

AIM: To clarify the association between physical activity and gastroesophageal reflux disease (GERD) in nonobese and obese people. METHODS: A Swedish population-based cross-sectional survey was conducted. Participants aged 40-79 years were randomly selected from the Swedish Registry of the Total Population. Data on physical activity, GERD, body mass index (BMI) and the covariates age, gender, comorbidity, education, sleeping problems, and tobacco smoking were obtained using validated questionnaires. GERD was self-reported and defined as heartburn or regurgitation at least once weekly, and having at least moderate problems from such symptoms. Frequency of physical activity was categorized into three groups: (1) "high" (several times/week); (2) "intermediate" (approximately once weekly); and (3) "low" (1-3 times/mo or less). Analyses were stratified for participants with "normal weight" (BMI 30 kg/m 2 ). Multivariate logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for potential confounding by covariates. RESULTS: Of 6969 eligible and randomly selected individuals, 4910 (70.5%) participated. High frequency of physical activity was reported by 2463 (50%) participants, GERD was identified in 472 (10%) participants, and obesity was found in 680 (14%). There were 226 (5%) individuals with missing information about BMI. Normal weight, overweight and obese participants were similar regarding distribution of gender and tobacco smoking status, while obese participants were on average slightly older, had fewer years of education, more comorbidity, slightly more sleeping problems, lower frequency of physical activity, and higher occurrence of GERD. Among the 2146 normal-weight participants, crude point estimates indicated a decreased risk of GERD among individuals with high frequency of physical activity (OR: 0.59, 95% CI: 0.39-0.89), compared to low

关键词： Physical exercise Gastroesophageal reflux disease Population-based study Risk factor Body mass index Obesity

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急性上消化道出血

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英国医学杂志中文版 2019年第7期22卷 411-415页

作者： Emma Sverden Sheraz R Markar Lars Agreus jesper lagergren 龚亮(译) 吴东(校) 无 Upper Gastrointestinal Surgery Department of Molecular Medicine and Surgery Karolinska Institutet Karolinska University Hospital. StockholmSweden Department of Upper Gastrointestinal Surgery South Hospital Stockholm Sweden Department of Surgery and Cancer imperial College London UK Division of Family Medicine and Primary Care Department of Neurobiology Care Sciences and Society Karolinska InstitutetKarolinska University Hospital Stockholm Sweden University of Newcastle Australia School of Cancer and Pharmaceutical Sciences King's College London and Guy' s and St Thomas' NHS Foundation Trust UK 中国医学科学院北京协和医学院北京协和医院消化科

每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消... 详细信息

每年,每10万人中就有约100例发生上消化道(食道、胃和十二指肠)出血“。这是一个具有较高病死率的内科急症。2007年英国的一项调査发现,上消化道出血的总病死率为10%。消化性溃疡是上消化道出血最常见的原因(框图1),这一实践指南为上消化道出血的初期处理以及消化性溃疡出血的后续管理提供了指导。

关键词：急性上消化道出血消化性溃疡出血十二指肠内科急症后续管理初期处理实践指南病死率

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食管癌

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英国医学杂志中文版 2011年第2期14卷 90-95页

作者： jesper lagergren Pernilla lagergren 闵先军(译) 李辉(校) Upper Gasnointestinal Research. and Surgery Karolinska Institutet Stockholm SE-17176 Division of Cancer Studies King's College London UK 首都医科大学附属北京朝阳医院胸外科

尽管食管鳞癌的发病率近几年趋于稳定，在西方国家甚至有所下降，但全球食管癌的总体发病率仍在逐年增加，特别是20世纪70年代以来，许多国家的食管腺癌发病率快速增长，其速度超过其他肿瘤，

关键词：食管癌癌发病率食管鳞癌西方国家食管腺

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Neural membrane repair at the core of regeneration

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Neural Regeneration Research 2024年第7期19卷 1399-1400页

作者： Catarina Dias jesper Nylandsted Danish Cancer Institute Membrane IntegrityCopenhagenDenmark Champalimaud Research Champalimaud FoundationLisbonPortugal Department of Molecular Medicine University of Southern DenmarkOdenseDenmark

Loss of plasma membrane integrity can compromise cell functioning and *** countera ct this eminent threat,euka ryotic cells have developed efficient repair mechanisms,which seem to have co-evolved with the emergence of vital membrane processes(Cooper and McNeil,2015).This relationship between basic cellular functioning and membrane repair highlights the fundamental significance of preserving membrane integrity for cellular life.

关键词： repair preserving integrity

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Losartan to prevent hyperenzymemia after endoscopic retrograde cholangiopan-creatography: A randomized clinical trial

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World Journal of Gastrointestinal Endoscopy 2012年第11期4卷 506-512页

作者： Tomas Sjberg Bexelius John Blomberg Hans-Olof Hkansson Peter Mller Carl-Eric Nordgren Urban Arnelo jesper lagergren Mats Lindblad Upper Gastrointestinal Research Department of Molecular Medicine and Surgery Karolinska Institutet 176 70 Stockholm Sweden Department of Surgery Gastro Center Karolinska University Hospital Department of Surgery Kalmar County Hospital Department of Clinical Science Intervention and Technology Karolinska Institutet 176 70 Stockholm Sweden

AIM: To study if the angiotensin II receptor blockers (ARB) losartan counteracts pancreatic hyperenzymemia as measured 24 h after endoscopic retrograde cholangiopancreatography (ERCP). METHODS: A triple-blind and placebo-controlled randomized clinical trial was performed at two Swedish hospitals in 2006-2008. Patients over 18 years of age undergoing ERCP, excluding those with current pancreatitis, current use of ARB, and severe disease, such as sepsis, liver and renal failure. One oral dose of 50 mg losartan or placebo was given one hour before ERCP. The relative risk of hyperenzymemia 24 h after ERCP was estimated using multivariable logistic regression, and expressed as odds ratio with 95% confidence intervals (CIs), including adjustment for potential remaining confounding. RESULTS: Among 76 participating patients, 38 were randomized to the losartan and the placebo group, respectively. The incidence rates of hyperenzymemia and acute pancreatitis among all 76 participating patients were 21% and 12%, respectively. Hyperenzymemia was detected in 9 and 7 patients in the losartan and placebo group, respectively. There were no major differences between the comparison groups regarding cannulation difficulty, findings, or proportion of patients requiring drainage of the bile ducts. There were, however, more pancreatic duct injections, a greater extent of pancreatography, and more biliary sphincterotomies in the losartan group than in the placebo group. Losartan was not associated with risk of hyperenzymemia compared to the placebo group after multi-varible logistic regression analysis (odds ratio 1.6, 95%CI 0.3-7.8). CONCLUSION: In this randomized trial 50 mg losartan given orally had no prophylactic effect on development of hyperenzymemia after ERCP.

关键词： Renin-angiotensin system Pancreatitis Prophylaxis Placebo-controlled trial

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对于重度胃食管反流病，何种治疗方式最有效？

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英国医学杂志中文版 2016年第7期19卷 416-418页

作者： John Maret-Ouda Nele Brusselaers jesper lagergren 朱佳杰魏玮 Upper Gastrointestinal Surgery Department of Molecular Medicire and Surgery Karolinska Instituter Norra Stationsgatan 67 171 76 Stockholm Sweden Section of Gastrointestinal Caner r Division of Cancer Studies King's College London Guy's and St Thomas' NHS Foundation Trust London SE1 7EH UK 中国中医科学院望京医院消化科

概述胃食管反流病（gastro—oesophagealreflux disease，GORD）的定义是指因胃内容物反流而引起不适症状和（或）其他并发症。GORD可分为轻度和重度，重度是指患者与反流相关的症状严重和（或）产生并发症。

关键词：重度胃食管反流病治疗方式医学研究症状

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数字政府缘何生成行政负担?--对丹麦数字ID升级项目的审视

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中国行政管理 2024年第4期40卷 93-106页

作者： [丹麦]施雷格任运月杨峰浙江工商大学公共管理学院杭州310018 四川大学公共管理学院成都610064

在世界各国默认数字化进程中,普遍存在数字化减轻民众与政府互动过程中行政负担的乐观期望。然而,审视数字化“最佳实践”国丹麦的数字身份系统升级项目,可以发现各行动者有意无意的利益考量和行为模式反而导致了行政负担的形成和加重... 详细信息

在世界各国默认数字化进程中,普遍存在数字化减轻民众与政府互动过程中行政负担的乐观期望。然而,审视数字化“最佳实践”国丹麦的数字身份系统升级项目,可以发现各行动者有意无意的利益考量和行为模式反而导致了行政负担的形成和加重。个中缘由包括不同行动者角色认知和价值判断差异化的影响,数字技术自身的兼容性难题和可及性障碍产生的自动不平等加重了行政负担分配性,数字政府制度建构过程中工具理性扩张带来的“数字牢笼”潜在风险。因此,有必要从建立良好的行动者关系的角度出发寻求减轻民众行政负担之策,以确保数字政府转型升级的顺利进行,要明确政企合作网络中政府“核心行动者”的角色地位,将数字政府注意力转向改善政府与民众关系。

关键词：行政负担数字政府数字身份政商关系

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Multifunctional landscapes—perspectives for the future

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Journal of Environmental Sciences 2003年第2期15卷 187-192页

作者： jesper Brandt Department of Geography and International Development Studies Roskilde University

New methods in landscape ecology to study the link between landscape heterogeneity and landscape functionality are needed. Heterogeneity is a basic characteristic of landscape, and landscape function is the capacity to change the structural heterogeneity of a landscape system. In most developed countries the industrialisation of agriculture has in general resulted in a change of agricultural landscapes from a small-grained heterogeneous pattern towards more monotonous and monofunctional landscapes. During the 1990's this trends seems to have changed due to a diversification of rural land use and new trends in urbanisation. Weather these phases of landscape development should be expected in developing countries is a totally open question. Dealing with the study of multifunctionality of landscapes it is proposed to distinguish between ecological functionality of landscape ecosystems, functionality pertaining to land use and social functionality. Further, the relation between function, space and scale is important by the determination of spatial and time segregation as well as spatial and time integration of multifunctionality in landscapes.

关键词： landscape heterogeneity monotonisation multifunctionality spatial segregation time segregation landscape development

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Application of heat shock protein expression for detecting natural adaptation and exposure to stress in natural populations

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Current Zoology 2010年第6期56卷 703-713页

作者： jesper Givskov SφRENSEN National Environmental Research Institute Aarhus UniversityDepartment of Terrestrial Ecology

Heat-shock proteins （HSPs） play an undisputed role for maintaining cellular functioning under environmental challenges and protein denaturing conditions. Compelling evidence points to an evolutionary important role of HSPs and a strict evolutionary control of these proteins as a balance between benefits and costs. While there is a great potential for using HSP expression for detecting natural adaptation and exposure to stress in natural populations, some obstacles and key issues await investigation. From an ecological perspective these key issues needs to be resolved in order to fully appreciate the complex responses and adaptations to stress and to increase our understanding of HSPs and other molecular chaperones for stress adaptation and potential use as biomarkers. Here, the current knowledge and understanding of HSPs is reviewed and a number of key issues including the interpretation of elevated HSP levels, the complications of extrapolating between laboratory and field conditions, the effects of choice of traits and methodology and the larger intra-and extracellular networks of interactions that HSPs participate in are discussed [Current Zoology 56 （6）： 703-713, 2010].

关键词： Biomarker Hsp Molecular chaperone Thermal adaptation Thermal stress

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Modeling and scale analysis of gaseous fuel reactors in chemical looping combustion systems

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Particuology 2017年第6期15卷 31-41页

作者： jesper Aronsson David Pallares Anders Lyngfelt Division of Energy Technology Department of Energy and Environment Chalmers University of Technology SE-41296 Gothenburg Sweden

This work investigates the scale-up of chemical looping combustion （CLC）, a next-generation technology for carbon capture and storage, to the industrial scale. The study focused on the bottom bed of the unit, which was considered to be the critical region during scale-up due to the large solids inventory in this zone combined with relatively inefficient gas-solids contact. Two CLC reactors of vastly different sizes （bench and utility scale） were studied to discern their difference related to scale-up via a one-dimensional model. This model considered kinetics that varied with the degree of oxidation and population distribution of the oxygen carriers, the mixing of which accounts for both convective and dispersive transport. The model was validated against bench scale data, and was used to evaluate the performance of a 1000 MWth CLC fuel reactor using either syngas or methane as fuels. Sensitivity analyses were also carried out with this model to determine the effects of several parameters on fuel conversion, including solids circulation, oxygen carrier reactivity, bed height, and maximum bubble size. The results show that the mass transfer of gas from bubbles to the emulsion phase represents a significant limiting factor for fuel conversion in the bottom bed of a utility scale fuel reactor.

关键词： Chemical looping combustion Semi-empirical modeling Fluidization Up scaling

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