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Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation

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World Journal of Gastroenterology 2020年第34期26卷 5101-5117页

作者： David Fernández-Ramos Fernando Lopitz-Otsoa Laura Delacruz-Villar Jon Bilbao Martina Pagano Laura Mosca Maider Bizkarguenaga Marina serrano-Macia Mikel Azkargorta Marta Iruarrizaga-Lejarreta jesús sot Darya Tsvirkun sebastiaan Martijn van Liempd Felix M Goni Cristina Alonso María Luz Martínez-Chantar Felix Elortza Liat Hayardeny shelly C Lu JoséM Mato Precision Medicine and Metabolism Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160BizkaiaSpain CIBERehd-Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas Madrid 28029Spain Department of Precision Medicine University of Campania"Luigi Vanvitelli"Naples 80138Italy Liver Disease Laboratory Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Proteomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain OWL Metabolomics Derio 48160Spain Instituto Biofisika(UPV/EHU CSIC)Leioa 48940SpainDepartamento de Bioquímica y Biología MolecularUniversidad del País VascoLeioa 48940Spain Pre-clinical and Chemistry Manufacturing and ControlsGalmed PharmaceuticalsTel Aviv 6578317Israel Metabolomics Platform Centro de Investigación Cooperativa en Biociencias(CIC bioGUNE)Derio 48160Spain Division of Digestive and Liver Diseases Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Arachidyl amido cholanoic acid(Aramchol)is a potent downregulator of hepatic stearoyl-CoA desaturase 1(sCD1)protein expression that reduces liver triglycerides and fibrosis in animal models of *** a phase IIb clinical trial in patients with nonalcoholic steatohepatitis(NAsH),52 wk of treatment with Aramchol reduced blood levels of glycated hemoglobin A1c,an indicator of glycemic *** To assess lipid and glucose metabolism in mouse hepatocytes and in a NAsH mouse model[induced with a 0.1%methionine and choline deficient diet(0.1MCD)]after treatment with *** Isolated primary mouse hepatocytes were incubated with 20μmol/L Aramchol or vehicle for 48 ***,analyses were performed including Western blot,proteomics by mass spectrometry,and fluxomic analysis with 13C-uniformly labeled *** the in vivo part of the study,male C57BL/6J mice were randomly fed a control or 0.1MCD for 4 wk and received 1 or 5 mg/kg/d Aramchol or vehicle by intragastric gavage for the last 2 *** metabolomics were assessed using ultra-high-performance liquid chromatography-time of flight-Ms for the determination of glucose metabolism-related *** Combination of proteomics and Western blot analyses showed increased AMPK activity while the activity of nutrient sensor mTORC1 was decreased by Aramchol in *** translated into changes in the content of their downstream targets including proteins involved in fatty acid(FA)synthesis and oxidation[PACCα/β(s79),sCD1,CPT1A/B,HADHA,and HADHB],oxidative phosphorylation(NDUFA9,NDUFB11,NDUFs1,NDUFV1,ETFDH,and UQCRC2),tricarboxylic acid(TCA)cycle(MDH2,sUCLA2,and sUCLG2),and ribosome(P-p70s6K[T389]and P-s6[s235/s236]).Flux experiments with 13Cuniformely labeled glucose showed that TCA cycle cataplerosis was reduced by Aramchol in hepatocytes,as indicated by the increase in the number of rounds that malate remained in the TCA ***,liver metabolomic analysis showed

关键词： Nonalcoholic fatty liver disease steatohepatitis Methionine and choline deficient diet Tricarboxylic acid cycle Hemoglobin A1c stearoyl-CoA desaturase 1

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基于响应目标的特大型冷却塔优选组合方案

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哈尔滨工业大学学报 2018年第6期50卷 40-46页

作者：孙捷王浩柯世堂南京航空航天大学土木工程系南京210016

现有冷却塔群组合形式选型主要基于荷载干扰因子来考虑,这一做法难以真实反映冷却塔群结构的受力特征.为研究基于静风响应目标的四塔组合优选方案及特大型冷却塔在不同四塔组合下的综合受力性能,本文以在建世界最高冷却塔(220 m)为工程... 详细信息

现有冷却塔群组合形式选型主要基于荷载干扰因子来考虑,这一做法难以真实反映冷却塔群结构的受力特征.为研究基于静风响应目标的四塔组合优选方案及特大型冷却塔在不同四塔组合下的综合受力性能,本文以在建世界最高冷却塔(220 m)为工程背景,分别对串列、矩形、菱形、L形和斜L型5种典型四塔组合冷却塔群共320个工况进行了同步刚体测压风洞试验.获取了5种四塔组合形式下各工况冷却塔表面风压分布模式,并基于有限元方法建立了"塔筒-支柱-环基"一体化仿真计算模型,分别对不同组合形式、来流风向角和塔群相对位置工况进行了三维非对称风荷载作用下的特大型冷却塔静风响应分析,探讨了7种典型响应目标下四塔干扰作用对特大型冷却塔风致位移响应及内力响应影响规律.在此基础上,综合对比研究了不同静风响应指标的影响程度与分布规律.最终,基于静风响应目标综合定性地给出了四塔组合形式的优选方案,其中的串列组合布置方案抗风性能最优,菱形、斜L形、矩形和L形组合抗风性能依次递减.

关键词：特大型冷却塔典型四塔组合风洞试验风致响应优选方案

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Acute aortic dissection:utilizing imaging modalities to improve detection

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Journal of Geriatric Cardiology 2005年第1期2卷 59-60页

作者： Pairoj Rerkpattanapipat Bangkok Heart Institute 2 soi soonvijai 1 New Petchaburi RoadBangkok 10320Thailand

Acute aortic dissection is a serious condition in elderly patients and may become fatal rapidly if left undiagnosed and untreated. As pointed out by Welch et al1chest radiography is a screening test for this condition... 详细信息

关键词： dissection modalities radiography screening utilizing aorta detecting chest untreated assessed

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Microclimatic Experimentation Applied to Insulating Horizontal Coverage in Mexicali, Mexico

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Journal of Environmental science and Engineering(A) 2013年第9期2卷 561-568页

作者： Zalia Haro-Rincon Nestor santillfin-sot1 Rafael Garcia-Cueto sara Ojeda-Benltez AlejandroLambert-Arista Institute of Engineering Autonomous University of Baja California Mexicali 21280 Mexico Faculty of Engineering Autonomous University of Baja California Mexicali 21280 Mexico

The thermal response of hedges alters the urban climate, resulting in energy and comfort affectations that impact city dwellers, so the aim of this study is to analyze the energy fluxes of urban horizontal coverage, especially expanded polystyrene waterproofed with elastomeric paint in the city of Mexicali, Baja California, located northwest of Mexico. The experiment was realized on summer of 2011 and 2012 by using four components radiometric sensor, eddy covariance equipment, which was possible to analyze the behavior and intensities of heat fluxes using the model Q＊ = QE ＋ QG ＋ QH ＋ QF ＋ QD. The results show that in both campaigns the sensible heat flux exceeds the net radiation, in 2011 the net radiation was 31.41 W/mE and sensible heat flux of 74.9 W/m2, in 2012 resulted 43.46 W/m2 and 87.32 W/mE, respectively. This additional heat flux is attributed to the thermal influence of the air conditioning units, which changes the energy balance model to Q＊ = QH ＋ QF ＋ QD. With the results arise the need for experimentation on a larger scale in which it is possible to model the flow in housing development. The knowledge of the energy balance model will help to propose materials that minimize the thermal impact to the city of Mexicali.

关键词： Energy fluxes coating insulating coverage thermal impact urban climatology.

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Determination of Enantiomeric Composition of substituted Tetrahydroisoquinolines Based on Derivatization with Menthyl Chloroformate

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American Journal of Analytical Chemistry 2013年第3期4卷 125-133页

作者： Jan Prech Václav Matousek JiriVáclavik Jan Pechacek Kamila syslova Petr sot Jakub Januscak Beáta Vilhanová Marek Kuzma Jaromir Toman Petr Kacer Department of Organic Technology Institute of Chemical TechnologyPragueCzech Republic Laboratory of Molecular structure Characterization Institute of MicrobiologyAcademy of Sciences of the Czech RepublicPragueCzech Republic

A method for the analysis of the optical purity of a series of chiral substituted tetrahydroisoquinolines (THIQs) was developed. The method is based on pre-column derivatization of the analytes with the derivatization reagent (–)-(1R)-menthyl chloroformate. The derivatization reaction selectively gives diastereomeric carbamates that are resolvable on an achiral non-polar GC column. The developed technique covers variously substituted THIQs, which differ significantly in volatility, steric and electronic properties. In all cases, the resolution factors (R) exceeded the value of 1.5. The method represents a robust way of analysis of mixtures of THIQs, which are often present in various matrixes such as body fluids, tissues and reaction mixtures.

关键词： Tetrahydroisoquinolines Enantiomeric Composition Derivatization Menthyl Chloroformate Gas Chromatography

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澳门生态一区和二区水鸟谱系多样性的季节变化

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四川动物 2020年第2期39卷 130-138页

作者：丁志锋陈述植诗雅谭金庆梁健超冯永军广东省生物资源应用研究所广东省动物保护与资源利用重点实验室广东省野生动物保护与利用公共实验室广州510260 澳门特别行政区市政署园林绿化厅自然护理处中国澳门澳门特别行政区市政署园林绿化厅自然保护研究处中国澳门

季节变化是鸟类群落的重要特征之一,其引起的环境变化决定着鸟类群落构建过程中不同驱动因子的作用力。因此,了解鸟类群落结构的季节变化,对于全面认识生物群落结构具有重要意义,尤其利用谱系多样性来探讨鸟类的季节性变化和推断群落聚... 详细信息

季节变化是鸟类群落的重要特征之一,其引起的环境变化决定着鸟类群落构建过程中不同驱动因子的作用力。因此,了解鸟类群落结构的季节变化,对于全面认识生物群落结构具有重要意义,尤其利用谱系多样性来探讨鸟类的季节性变化和推断群落聚集规律越来越受到关注。2018年1—12月,采用样线法对澳门生态一区和二区2块湿地进行逐月调查,记录水鸟的物种丰富度和多度,并分析水鸟谱系多样性的季节动态。结果显示,1)共记录水鸟37种,隶属于6目9科,目、科、种中数量最多的依次为:鸻形目Charadriiformes物种数为15种,鹭科Ardeidae物种数为11种,白鹭Egretta garzetta多度为540只。2)生态一区和二区水鸟的物种丰富度在冬季最高,其次为秋季;生态一区和二区的物种多度分别在秋季和冬季最高;谱系多样性和平均成对谱系距离的季节变化规律与物种丰富度的相似。3)生态一区和二区的鸟类群落分别在春、秋、冬季和秋季趋向于谱系发散,而在其他时间大多呈现出谱系聚集。谱系发散可能表明了种间竞争在群落构建中作用更大,而谱系聚集则表明了环境过滤对繁殖季水鸟群落构建具有重要作用。结果表明,湿地水鸟群落的驱动因子存在季节变化,考虑这些变化是全面认识群落结构的前提。

关键词：澳门水鸟谱系多样性环境过滤

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Water Quality Monitoring and Cadmium Contamination in the sediments of Mae Tao stream,Mae sot District,Tak Province,Thailand

Water Quality Monitoring and Cadmium Contamination in the Se...

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作者： P.Weeraprapan C.Phalaraksh s.Chantara M.Kawashima Environmental science Program Faculty of ScienceChiang Mai University Department of Biology Faculty of ScienceChiang Mai University Department of Chemistry Faculty of ScienceChiang Mai University

some lands and streams at Mae sot District,Tak Province,Thailand are polluted by cadmium(Cd) which leach from the zinc *** objectives of present study were to evaluate physico-chemical parameters of Mae Tao stream and Cd concentration in the *** water and sediment samples were collected from the upstream and downstream of Mae Tao stream from April 2011 to February *** downstream sites are affected by the water from the zinc ***-chemical parameters such as Temperature,Water Velocity,p H,Electrical Conductivity,Total Dissolved solid,Dissolved Oxygen,Nutrients(Nitrate,Ammonium and Orthophosphate),suspended solids,Alkalinity and Total Hardness were *** from the parameters,Mae Tao stream was classified to Type III of the surface Water Quality standard of Thailand for agriculture at all sampling *** concentrations in the sediments were measured in the range of 0.84-7.86 mg *** the sediments of polluted sites,Cd concentrations exceeded the European maximum permissible level of 3.0 mg kg for Agricultural *** is important to continue to monitor the physico-chemical parameters and the cadmium concentrations in the sediments,and the bio-assessment should be begun around the stream.

关键词： Water quality cadmium sediment monitoring Mae Tao stream

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