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优良的药物黏附性可改善银屑病严重程度

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 59-59页

作者： Carroll C.L. Feldman s.R. camacho F.T. Balkrishnan R. 党倩丽 Univ. of Texas Hlth. sciences Center RAS-E331 1200 Herman Pressler Houston TX 77 025 United States

Background: Patients are commonly nonadherent to medication regimens. In derm atology, there has been little study of the effect of nonadherence on outcomes. Objectives: To test the association between adherence behaviour and changes in s everity of psoriasis. Methods: Twenty-four subjects with psoriasis were enroll ed in an 8- week, left/right, controlled trial of salicylic acid plus topical t acrolimus ointment vs. salicylic acid plus placebo. subjects were given salicyli c acid to apply to all lesions. The salicylic acid was supplied in a bottle with a medication event monitoring system cap in order to assess adherence to the sa licylic acid. The primary outcome for this study was the relationship between th e change in the disease severity (change in sum score of erythema, scale and thi ckness scores for a target plaque) and medication adherence. Results: The mean i nitial disease severity was 5- 8 on a nine-point sum score scale. For the top ical tacrolimus-treated side, a decrease in adherence rate of 10% was associ ated with a 1- point increase in severity (P side, adherence was not significantly correlated with changes in severity. Conc lusions: Nonadherence may have a significant role in altering clinical trial dat a, skewing it towards ineffectiveness. Improved outcomes in psoriasis may be ach ievable through interventions that improve patients’adherence to treatment.

关键词：银屑病黏附性药物监测黏附作用安慰剂皮肤病学局部应用数据显示

快速培养法对结核病诊断的评价:拉丁美洲的一个多中心研究

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国际结核病与肺部疾病杂志 2006年第3期1卷 101-106页

作者： J.A.Robledo G.I.Mejía N.Morcillo L.Chacón M.camacho J.Luna J.Zurita A.Bodon M.Velasco J.C.Palomino A.Martin F. Portaels 张宗德 Unidad de Bacteriología y Micobacterias Corporación para investigaciones Biológicas-CIBMedellínAntioquiaDepartamento de MedicinaUniversidad Pontificia BolivarianaMedellínAntioquiaColombia Laboratorio Regional de Referencia de Micobacterias Hospital CetrángoloBuenos AiresBuenos AiresArgentina Departamento de Micobacterias Centra Nacional de Diagnóstico y ReferenciaMinisterio de SaludManaguaNicaragua Institute Nacional de Laboratories de salud (INLAsA) La PazBolivia Escuela Nacional de Ciencias Biológicas Instituto Politecnico NacionalMexicoDFMexico Laboratorio de Microbiología y Tuberculosis Hospital VozandesQuitoEcuador sección de Micobacterias Instituto de Salud Pública de ChileSantiago de ChileChile Institute of Tropical Medicine AntwerpBelgium

地点:拉丁美洲的结核病(TB)诊断实验室。目的:薄层琼脂(thin-layer agar,TLA)和罗氏培养(Lowenstein-Jensen,LJ)对结核病诊断的对比评价。设计:6个实验室Ⅱ期前瞻性研究。临床诊断的TB病人样本包括痰标本和肺外结核的标本。呼吸道标本用... 详细信息

地点:拉丁美洲的结核病(TB)诊断实验室。目的:薄层琼脂(thin-layer agar,TLA)和罗氏培养(Lowenstein-Jensen,LJ)对结核病诊断的对比评价。设计:6个实验室Ⅱ期前瞻性研究。临床诊断的TB病人样本包括痰标本和肺外结核的标本。呼吸道标本用NaOH／NALC去污;根据推荐的操作程序对所有标本进行离心,萋尼氏法进行抗酸菌(AFB)染色,用LJ和TLA法培养检查。计算两种培养基的敏感度和似然比、生长检测时间和污染率。结果:总共研究了1118份临床标本。所有AFB阳性标本培养后均检出结核分枝杆菌,AFB阴性标本中,LJ检出率为3．2％,TLA为4．4％。TLA和LJ的敏感性分别为92．6％(95％CI:87．9-95．9)和84．7％(95％CI:78．8-89．0)。阳性和阴性LR相似。TLA和LJ的污染率分别为5．1％和3．0％。TLA和LJ对培养阳性的检出平均时间分别为11．5天(95％CI: 9．3-15．0)和30．5天(95％CI:26．9-39．0)(P<0．0001)。结论:参加研究实验室的不同特点、疾病流行情况和标本处理的不同并不影响TLA和LJ的总体效果,建议不同实验室使用这种方法,因它具有可靠性和可行性。

关键词：结核分枝杆菌分离结核病诊断

1例与反复表面轻伤有关的半圆形脂肪萎缩新病例及文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 18-18页

作者： Gómez-Espejo C Pérez-Bernal A camacho-Martnez F 刘芯 Department of Dermatology Virgen Macarena Hospital Avenida Dr. Fedriani s/n 41009-Seville Spain

We present a new case of semicircular lipoatrophy whose lesions disappeared after 2 months of avoiding a repeated trauma in that area. It seems that this is the only associated aetiological factor, and this entity is perhaps a consequence of certain postural habits. The repeated microtraumas would damage the fatty tissue giving rise to the histopathological findings described, which are compatible with traumatic panniculitis. In conclusion, repeated microtraumas may be the aetiological factor in these cutaneous lesions. Other data in favour of this hyp othesis are the disappearance of the lesions after avoiding the mechanical traum a, the fact that there were other affected people at work, and that this factor has also been identified in the majority of cases reported previously.

关键词：脂肪萎缩文献回顾新病例组织病理学改变脂膜炎脂肪组织机械性损伤

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAs detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht s.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.s. Acharya C. Adam Bourdarios L. Adamczyk s.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.s. Ahmed s. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy s. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali s. Ali s.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei s.P. Amor Dos santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders s.Y. Andrean A. Andreazza s. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal s.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin s. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai s. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos s. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten s. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay s. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-s. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAs Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAs Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAs *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAs JET QUARK GLUON TAGGING

垂柳和银合欢叶提取物对羔羊瘤胃发酵、尿嘌呤衍生物排出量及微生物蛋白合成的影响

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饲料博览 2014年第6期24卷 53-53页

作者： Hernandez P salem A Z M López s sun X Z Rojo R camacho L M Elghandour M M Y Gonzalez-Ronquillo M

试验选择Katahdin×Pelibuey杂交羊(体重24±0.3 kg)16只来研究垂柳(sB)和银合欢(LL)叶提取物对瘤胃pH、总不饱和脂肪酸和单不饱和脂肪酸(VFA)、NH3-N浓度、尿嘌呤衍生物(PD)的排泄量和微生物蛋白合成的影响。饲喂含有CP 219 g·kg-1和N... 详细信息

试验选择Katahdin×Pelibuey杂交羊(体重24±0.3 kg)16只来研究垂柳(sB)和银合欢(LL)叶提取物对瘤胃pH、总不饱和脂肪酸和单不饱和脂肪酸(VFA)、NH3-N浓度、尿嘌呤衍生物(PD)的排泄量和微生物蛋白合成的影响。饲喂含有CP 219 g·kg-1和NDF 141 g·kg-1的全混合日粮(TMR)。试验分为4个处理:对照组(不添加提取物),sB(sB 30 ml·d-1),LL(LL 30 ml·d-1),sBLL(sB 30 ml·d-1+LL 30 ml·d-1)。每天早上饲喂前口服给药。在试验22 d(P1)、43 d(P2)和63 d(P3)进行测量。sBLL组的瘤胃pH上升(P=0.014),sB组下降。与对照组相比,sBLL组醋酸与丙酸的比升高(P=0.042)。各处理和试验期对瘤胃NH3-N浓度无显著影响。处理组的原虫数无显著影响(P=0.489),但与P1、P2相比,P3阶段的原虫数降低(PsBLL组相比,sB和LL组的尿酸浓度显著提高(P0.05)。研究发现,在63 d时垂柳和银合欢提取物或两者1:1混合对瘤胃发酵、尿嘌呤排出量及微生物蛋白合成影响较小。

关键词：尿嘌呤衍生物叶提取物蛋白合成银合欢微生物瘤胃发酵垂柳单不饱和脂肪酸

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发育不良性pointillist痣

世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 25-25页

作者： Moreno-Ramirez D Ferrandiz L Rios-Martin J.J camacho F.M 李晓莉 Department of Dermatology Pigmented Lesion and Teledermatology Clinic University Hospital Virgen Macarena Avenida Dr Fedriani S/N 41073 Seville Spain.Dr

Background: Three cases of pointillist nevus,which is a distinctive clinical type of benign melanocytic nevus with variegated pigment, have been described in the literature to date. Observations: A 24-year-old man presented with an acquired melanocytic lesion composed of multiple tiny pigmented dots. Dermoscopy revealed multiple brown globules on a reddish skin-colored background, and histologic examination demonstrated architectural disorder with cytologic atypia. Conclusion: To the best of our knowledge, we report a case of dysplastic pointillist nevus.

关键词：不良性 pointillist 黑色素细胞组织学检查色素斑皮色

Detection of Mycoplasmas in Patients with Amyotrophic Lateral sclerosis

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Advances in Microbiology 2014年第11期4卷 712-719页

作者： Constantino Gil Alma Aurora sánchez González Isidro Lecona León Antonio Rivera Rayo santellán Olea Lilia Cedillo Centro de Investigaciones en Ciencias Microbiológicas Instituto de Ciencias Benemérita Universidad Autónoma de Puebla Edificio 103J Ciudad Universitaria Col. San Manuel Puebla Pue México Escuela de Biología Benemérita Universidad Autónoma de Puebla Edificio 112A Ciudad Universitaria Col. San Manuel Puebla Pue México servicio de Neurología Centro Médico Nacional Manuel ávila Camacho IMSS Puebla México

Amyotrophic Lateral sclerosis (ALs) is a progressive degenerative disease of the motor neurons and the cause is unknown. Diverse factors such as genetic defects, nutritional deficiencies, head trauma, environmental toxin, autoimmune responses and viral and bacterial infections are involved. Mycoplasmas have been implicated as causal agents of different illnesses in human. The purpose of this study was to investigate the presence of mycoplasmas in the bloodstream of patients with ALs. Patients with ALs and healthy individuals were included in the study. A blood sample was taken in tubes with or without anticoagulant. Mycoplasmas were detected by culture or direct PCR, and the presence of antibodies IgM and IgG against LAMPs of these microorganisms by Western blot. Cultures for aerobic facultative bacteria were also done. Blood samples from 13 patients and 44 healthy individuals were screened. All blood cultures for non-fermentative mycoplasmas and aerobic facultative bacteria were negative. Cultures for fermentative mycoplasmas were considered positive after identification of mycoplasmal DNA by PCR. Mycoplasma sp. was detected by culture or direct PCR in 6/13 (46%) patients and in 4/44 (9%) of healthy individuals. M. fermentans was detected by PCR using specific primers in six patients and in two healthy individuals. IgM against LAMPs of M. fermentans were detected in 6/13 (46%) blood samples from patients and in 13/44 (30%) from healthy individuals, while. IgG was detected in 4/13 (31%) patients and in 3/44 (7%) healthy individuals. The results of this study show that mycoplasmas cause a systemic infection and could play a role in the origin or progression of the ALs.

关键词： Amyotrophic Lateral sclerosis Mycoplasmas Immune Response

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Ofuji丘疹样红皮病发展为T细胞淋巴瘤

世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 24-24页

作者： Martnez-Barranca M.L. Mu.ńoz-Pé rez M.A. Garca-Morales I. F.camacho 李晓莉冯义国 Departamento Dermatologa Hosp. Universitario Virgen Macarena Avda. Dr. Fedriani s/n 41009 Sevilla Spain

Ofuji papuloerythroderma is an uncommon entity of unknown aetiology, characterized by a pruritic eruption of widespread, red-brown, flat papules that leads to spare skin folds. A number of cases have been described associated with tumour pathology, mainly cutaneous T-cell lymphomas. We report a new case of Ofuji papuloerythroderma evolving to cutaneous T-cell lymphoma in an 85-year-old woman who had been previously diagnosed with papuloerythroderma 7 years previously.

关键词： T细胞淋巴瘤红皮病 Ofuji 新病例红棕色

Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul sahin Jeong Yun shim Maureen stewart Gonzalo Vazquez-camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de sonora Ciudad ObregónMexico Instituto Mexicano del seguro social HermosilloMexico Instituto Mexicano del seguro social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del seguro social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United states, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA study and provide a risk factor comparison between women in the U.s. and those in Mexico based on a sample of 765 patients (364 in the U.s. and 401 in Mexico). Compared to women in Mexico, U.s. women had significantly (p s. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.s. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational study Breast Cancer Hispanics Mexico United states