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Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Plant performance and morphofunctional differentiation in response to edaphic variation in Iberian columbines: cues for range distribution?

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Journal of Plant Ecology 2014年第4期7卷 403-412页

作者： jesús M.Bastida Pedro J.Rey Julio M.Alcántara Departamento de Biología Animal Biología Vegetal y EcologíaUniversidad de JaénParaje Las Lagunillas s/n.E-23071 JaénSpain

Aims Experimental studies of the response to environmental variation of closely related taxa are needed to understand the mechanisms underly-ing phenotypic divergence,habitat segregation and range span within a radiating *** explored the magnitude of phenotypic differenti-ation and adaptive plasticity in relation to edaphic variation and its sig-nificance for habitat segregation and range span in Iberian *** We performed a common garden experiment varying soil type(cal-careous ***)and depth(rocky-shallow ***)with two pairs of widespread and narrowly distributed subspecies of Iberian columbines:Aquilegia vulgaris(*** and nevadensis)and Aquilegia pyrenaica(*** and cazorlensis).We com-pared tolerance to edaphic variation,trait differentiation and adaptive plasticity of 10 morpho-functional traits between species and distri-bution ***,we obtained estimates of the competitive environment faced by each taxon in two to four populations per *** Findingsresults partially support hypotheses of higher competitive ability and tolerance to edaphic variation in widespread than in narrow endemic *** the species level,the widely distributed taxon was the most tolerant to edaphic *** species,no consistent pattern emerged since the population from the most widespread subspecies was the most tolerant in *** but not in *** were differentiated in many traits at species and range ***,the pattern of differentiation does not fully support the hypothesis of higher specialization and stress toler-ance in narrow *** plasticity was generally low,the results support the hypothesis of adaptive plasticity in widespread but not in restricted taxa at least at species *** differences(adaptive plasticity and competitive ability among others)may have contributed to phenotypic divergence and edaphic niche segregation,as well as to differen

关键词： Aquilegia habitat differentiation phenotypic divergence phenotypic plasticity endemism

Women in visual neural regeneration research

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Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia s.Rex David J.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National science Foundation(NsF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Ascorbic acid and prunasin,two candidate biomarkers for endodormancy release in almond flower buds identified by a nontargeted metabolomic study

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Horticulture Research 2020年第1期7卷 117-129页

作者： jesús Guillamón Guillamón Ángela sánchez Prudencio JoséEnrique Yuste Federico Dicenta Raquel sánchez-Pérez Department of Plant Breeding.CEBAs-CsIC Campus Universitario de Espinardo30100 EspinardoSpain Metabolomics Platform of CEBAs-CsIC Campus Universitario de Espinardo30100 EspinardoSpain

Temperate fruit trees belonging to Prunus species have the ability to suspend(induce dormancy)and resume growth periodically in response to environmental and seasonal *** release requires the long-term accumulation of *** accumulation of cultivar-specific chill requirements,plants enter the state of ecodormancy,which means the ability to grow has been restored,depending on the fulfilment of heat *** many different metabolic pathways are implicated in endodormancy release,we have performed a metabolomic analysis,using the ultra-high-performance liquid chromatography–quadrupole time-of-flying(UPLC–QToF)*** assayed flower buds in different stages of endodormancy in four almond cultivars with different flowering times:the extra-early Desmayo Largueta,the late Antoñeta,the extra-late Penta,and the ultra-late *** orthogonal projection to latent-structure discriminant-analysis model was created to observe differences between endodormant and ecodormant flower *** metabolites showing the most significant variation were searched against the Metlin,HMDB,and KEGG libraries,which allowed us to identify 87 *** metabolites were subsequently assigned to specific pathways,such as abscisic acid biosynthesis,phenylpropanoid biosynthesis,and D-sorbitol metabolism,among *** two metabolites that exhibited the most significant variations in all the cultivars studied with fold changes of up to 6.49 were ascorbic acid and *** the first time,these two metabolites have been proposed as potential biomarkers for endodormancy release in *** the high synteny present between the Rosaceae species,these results could be extrapolated to other important crops like peach,plum,cherry,or apricot,among others.

关键词： metabolism release crops

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.V.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA Vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

comLocal adaptation to distinct elevational cores contributes to current elevational divergence of two Aquilegia vulgaris subspecies

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Journal of Plant Ecology 2015年第3期8卷 273-283页

作者： jesús M.Bastida Pedro J.Rey Julio M.Alcántara Departamento de Biología Animal Biología Vegetal y EcologíaUniversidad de JaénJaén E-23071Spain

Aims Phenotypic plasticity and local adaptation of populations at their distributional limits are crucial to understand species colonization and persistence in novel or marginal environments,as well as spe-cies divergence and niche width *** assess the contri-bution of these processes to shape current elevational limits and determine elevational phenotypic divergence between two subspe-cies of Aquilegia vulgaris(*** and nevadensis).Methods We conducted sowing and transplant experiments considering four elevations throughout the current elevational range of *** in southern Iberian *** were designed to explore,on the one hand,local adaptation through three components of performance(germination,survival and growth)and,on the other hand,the phenotypic differentiation and/or plasticity associated to local *** populations per subspecies(three from the elevational core and one from the elevational boundary)were used as seed *** of local adaptation and phenotypic differentiation are examined in the context of the‘centre-periphery’*** Findings Central populations of both subspecies performed better at their local elevations while marginal populations were maladapted,confirming the hypothesis and contributing to explain the current elevational segregation of these *** of glandular pubescence and germination timing seem to be related to local adaptation,through phenotypic differentiation between subspe-cies or *** widespread *** showed signals of adaptive plasticity in the timing of germination while it was not the case in the endemic ***.

关键词： Iberian Aquilegia local adaptation phenotypic plasticity centre-periphery hypothesis elevational divergence germination timing

Carbide derived carbon electrode with natural graphite addition in magnesium electrolyte based cell for supercapacitor enhancements

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Journal of Energy Chemistry 2015年第3期24卷 264-270页

作者： Ramasamy Chandrasekaran jesús Palma Marc Anderson Electrochemical Processes Unit Instituto IMDEA Energ?a3 Avda.Ramón de la SagraParque Tecnologico de Móstoles

Herein,we have presented a supercapacitor based on carbide derived carbon（CDC） electrode with natural graphite（NG） *** capacitor was analyzed at 22°C by cyclic voltammetry,galvanostatic charge-discharge and impedance techniques using a 0.5 mol/L of magnesium（II）bis（trifluoro methanesulfonyl） imide（Mg TFsI） in ethylene carbonate-propylene carbonate（EC ：PC = 1 ：1,v/v） as *** results conclude that the CDC cell enhancements have been proven by the composite electrode（5%–30% NG to CDC） especially on the cell efficiency and voltage i.e.,the CDC cell around 2.5 V limit was *** obtainable specific capacitance,real power and energy density are 15 F g-1,1.2 k W kg-1and 15 Wh kg-1,respectively.

关键词： supercapacitor carbide derived carbon magnesium imide organic electrolyte natural graphite

Virtual Conductance Based Cascade Voltage Controller for VsCs in Islanded Operation Mode

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Journal of Modern Power systems and Clean Energy 2022年第6期10卷 1704-1713页

作者： Francisco jesús Matas-Díaz Manuel Barragán-Villarejo Juan Carlos Olives-Camps Juan Manuel Mauricio JoséMaría Maza-Ortega Department of Elec‐trical Engineering Universidad de SevillaSeville 41092Spain

Voltage source converters have become the main enabler for the integration of distributed energy resources in *** the case of islanded operation,these devices normally set the amplitude and frequency of the network voltage by means of a cascade controller composed of an outer voltage control loop and an inner current control *** strategies to compute the gains of both control loops have been proposed in the literature in order to obtain a fast and decoupled response of the voltages at the point of common *** paper proposes an alternative and simple methodology based on the introduction of a virtual conductance in the classic cascade *** strategy allows to design each control loop independently,obtaining a closed-loop response of a first-order *** this way,the gains of each control loop are easily derived from the parameters of the LC coupling filter and the desired closed-loop time ***,a state observer is included in the controller to estimate the inductor current of the LC filter in order to reduce the number of required measurements.A laboratory testbed is used to validate and compare the proposed *** experimental results demonstrate the effectiveness of the proposal both in steady-state and transient regimes.

关键词： Voltage source converter microgrid cascade controller virtual conductance

Using fuzzy-AHP and parametric technique to assess soil fertility status in Northeast of Iran

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Journal of Mountain science 2020年第4期17卷 931-948页

作者： Ali KEsHAVARZI Henry Oppong TUFFOUR Ali BAGHERZADEH Leo Paapa TATTRAH Vinod KUMAR Amin GHOLIZADEH jesús RODRIGO-COMINO Laboratory of Remote sensing and GIs Department of Soil ScienceUniversity of TehranKaraj 31587-77871Iran Department of Mining Engineering Hacettepe University06800 BeytepeAnkaraTurkey Department of Crop and soil sciences Kwame Nkrumah University of Science and TechnologyKumasi 00233Ghana Department of Agriculture Islamic Azad UniversityMashhad BranchP.O.Box:91735-413Mashhad 91735-413Iran Department of Computer science Kumasi Technical UniversityKumasi 00233Ghana Government Degree College Ramban-182144 Jammu and KashmirIndia Physical Geography Trier University54286 TrierGermany soil Erosion and Degradation Research Group.Department of Geography Valencia UniversityBlasco Ibànez2846010 ValenciaSpain

A good understanding of the levels and distribution patterns of soil properties and/or quality indicators is a prerequisite for developing sustainable agricultural land management programs. Traditional assessments of these parameters of soil fertility status are somewhat costly, in both economics and time aspects. Different modelling techniques have been proposed as a useful tool for determination of soil quality indicators and development of soil fertility maps, but to what extent these results are reliable remains under-quantified in many regions worldwide. To address this uncertainty, Fuzzy-Analytical Hierarchy Process(Fuzzy-AHP) and Parametric analyses were conducted to ascertain the soil fertility status of a semiarid region in the Northeast of Iran for some selected crops: alfalfa, corn silage, potato, sugar beet, tomato and wheat. The Fuzzy-AHP and Parametric techniques using soil suitability indices were estimated for each crop and each soil delineation was achieved by Ordinary Kriging. The Technique for Order of Preference by similarity to Ideal solution(TOPsIs) was used as a compensatory method to allow tradeoffs among the selected criteria. Our results demonstrated that from the Fuzzy-AHP analysis, the soil fertility indices ranged from moderate to high for production of alfalfa;from low to high for production of corn silage and sugar beet;moderate to high for production of potato and tomato;and from low to moderate for production of wheat. However, the parametric analysis showed soil fertility classes ranging from very low to high for production of all the selected crops. High correlations were also observed between soil fertility indices predicted by both models. similarly, the capacities of both models to predict soil fertility status for production of the selected crops were also highly correlated. The preference for the cultivation of the selected crops based on the Fuzzy-AHP analysis was sugar beet > corn silage > wheat > alfalfa > tomato > potato.

关键词： soil fertility Agricultural land management Parametric model Geographic information systems Analytic Hierarchy Process