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Control of tendon cell fate in the embryonic limb: A molecular perspective

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BIOCELL 2023年第3期47卷 465-471页

作者： jessICA CRIsTINA MARÍN-LLERA CARLOs AMAURY JIMÉNEZ-CÁRDENAs jesÚs CHIMAL-MONROY Departamento de Medicina Genómica y Toxicología Ambiental Instituto de Investigaciones BiomédicasUniversidad Nacional Autónoma de México Ciudad UniversitariaApartado Postal 70228MéxicoDF 04510México

The molecular cascade underlying tendon formation starts when progenitor cells begin to express the scleraxis(scx)*** knockout mice develop some but not all tendons,suggesting that additional factors are necessary for tendon commitment,maintenance,and *** transcription factors,such as Mohawk(Mkx)or early growth response(Egr),maintain scx expression and extracellular matrix formation during *** inhibition of wingless and int-related protein signaling is necessary and sufficient to induce the expression of *** the commitment of tenogenic lineage occurs,transforming growth factor-beta(TGFβ)induces the scx gene expression,becoming involved in the maintenance of tendon cell *** this point of view,we discussed two phases of the tenogenic process during limb development:dependent and independent of mechanical ***,we highlight the importance of understanding embryonic tendon development to improve therapeutic strategies in regenerative medicines for tendons.

关键词： Tendon differentiation Tenocyte scleraxis Mohawk Early growth response Tendon development WNT TGFβ

Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?

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World Journal of Gastroenterology 2016年第10期22卷 2869-2874页

作者： Diego García-Compeán José Alberto González-González Fernando Javier Lavalle-González Emmanuel Irineo González-Moreno jesús Zacarías Villarreal-Pérez Héctor jesús Maldonado-Garza Gastroenterology service and Department of Internal Medicine University Hospital "Dr. José E. González" and Medical SchoolUniversidad Autónoma de Nuevo León Endocrinology service and Department of Internal Medicine University Hospital "Dr. José E. González" and Medical SchoolUniversidad Autónoma de Nuevo León

Diabetes mellitus(DM) that occurs because of chronic liver disease(CLD) is known as hepatogenous diabetes(HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus(HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease.

关键词： Hepatogenous diabetes Diabetes mellitus Outcomes Therapy Hepatitis C virus Chronic liver disease

Liquid biopsy for gastric cancer:Techniques,applications,and future directions

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World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina Díaz del Arco M jesús Fernández Aceñero Luis Ortega Medina Department of surgical Pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain Department of Legal Medicine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free DNA Circulating tumor DNA Molecular

A mild, configurable, flexible CoNi-LDH（v）/Zn battery based on H-vacancy-induced reversible Zn2+ intercalation

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Journal of Energy Chemistry 2025年第1期100卷 498-508页

作者： Xinyue Cheng Dingsheng Wu Hao Gao Qingqing Wang Pengfei Lv sam s.Yoon Qufu Wei Key Laboratory of Eco-textiles Ministry of Education Jiangnan University school of Mechanical Engineering Korea University

Flexible Zn-based batteries have attracted increasing research interest as essential components of wearable energy storage ***,the advancement of flexible aqueous Zn-based batteries based on Co-Ni layered double hydroxide （CoNi-LDH） as the cathode material is hampered by their poor cycling stability and the corrosiveness of alkaline ***,CoNi-LDH nanosheets enriched with H vacancies (CoNi-LDH（v）) were constructed on a flexible carbon cloth （CC） substrate via electrochemical deposition and *** Zn-based battery comprising CoNi-LDH（v）@CC as the cathode exhibited highly reversible conversion reactions and stable operation in 3 M ZnsO4electrolyte （pH=4）.The battery delivered an excellent specific capacity (225 mA h g-1,0.26 mA h cm-2),acceptable cycling stability（53.9%,900 cycles）,and high discharging *** abundant H vacancies served as active sites for the reversible intercalation of Zn2+and the extravasation of NO3-generated channels and space for Zn2+transport and storage,together enabling an excellent Zn2+storage ***,a sandwich-structured solid-state CoNi-LDH（v）@CC//Zn@CC battery was fabricated and was found to exhibit a noteworthy electrochemical performance and mechanical *** a proof of concept,the unencapsulated battery powered a digital watch under various deformation conditions and operated stably for 80 ***,the flexible battery displayed outstanding customizability,maintaining an open-circuit voltage of 1.42 V even after being cut *** proposed engineering strategy contributes to the realization of textiles with truly wearable energy-storage devices.

关键词： CoNi/Zn battery H vacancies Mild aqueous electrolyte Tailorable battery Wearable energy storage device

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNs)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Tree encroachment into savannas alters soil microbiological and chemical properties facilitating forest expansion

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Journal of Forestry Research 2016年第5期27卷 1047-1054页

作者： Davi rodrigo Rossatto Everlon Cid Rigobelo Departamento de Biologia Faculdade de Ciencias Agrairias e veterinàrias Univ. Estadual Paulista UNESP Via de Acesso Prof. Paulo Donatto Castellane S/N Vila IndustrialJaboticabal - SP 14884-900 Brazil Departamento de Producao Vegetal Faculdade de Ciencias Agrairias e Veterinarias Univ. Estadual Paulista UNESP Viade Acesso Prof. Paulo Donatto Castellane S/N VilaIndustrial Jaboticabal - SP 14884-900 Brazil

Abstract Forests have been expanding over typical savanna sites for the past 3000 years in the Neotropics. such invasion can produce a series of environmental modifications on typical savanna; however, it remains unclear how modifications in soil properties, caused by the encroachment of woody species, facilitate the expansion of forest ecosystems under dystrophic conditions. Here we examined chemical and microbiological changes associ- ated with tree encroachment in oxisols of a Neotropical savanna at Assis Ecological station, southeastern Brazil. We predicted that tree encroachment caused by typical forest species would cause significant changes in the chemical and microbiological properties of savanna soils. soils were sampled at Assis Ecological station, from savanna sites differing in tree encroachment （typical, dense and forested savanna） caused by decades of fire exclusion. We analysed vegetation leaf area index and leaf litter volume deposited in the studied plots and chemical （pH,organic matter, P, K, Ca, Mg, A1, NO3-, NH4＋） and microbiological （microbial C biomass and dehydrogenase activity） properties of soils under distinct encroachment conditions. Most soil chemical properties did not change along the tree encroachment gradient; however, total P, soil organic matter, soil microbial C and dehydrogenase activity increased from typical savanna to forested savanna. The changes in soil organic matter and dehydrogenase activity were correlated with the values of leaf area index and litter volume along the encroachment gradient. Our results demonstrate that forest species can increase carbon and phosphorus supplies in tropical savanna soils.

关键词： Dystrophic Encroachment - Forest - Litter Microbiological activity

Is the Export-led Growth Hypothesis Enough to Account for China's Growth?

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China & World Economy 2010年第4期18卷 34-51页

作者： María jesús Herrerias Vicente Orts Department of Economics and lnstitut of International Economics Universitat Jaume I Department of Economics Universitat Jaume I

One of the missing pieces preventing us from understanding recent Chinese economic development is the role played by openness and capital accumulation in this process. The question is whether the sharp economic＇ growth that the Chinese economy has experienced is another case of export-led growth due to the open-door policy or whether, on the contrary, this growth has been caused by high domestic savings and investment rates （and the consequent capital accumulation）. To answer this question, we employed an empirical framework of the cointegrated vector autoregressive model. The empirical results show that both investment （in physieal capital and R＆D） and exports, as well as the exchange rate policy, are relevant factors in explaining China＇s long-run economic growth over the past 4 decades.

关键词： investment labor productivity openness output

CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture

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World Journal of stem Cells 2015年第2期7卷 470-476页

作者： María álvarez-Viejo Yolanda Menéndez-Menéndez jesús Otero-Hernández Unidad de Trasplantes Terapia Celulary Medicina RegenerativaAvenida de Roma s/nHospital Universitario Central de Asturias

Mesenchymal stem cells, due to their characteristics are ideal candidates for cellular therapy. Currently, in culture these cells are defined by their adherence to plastic, specific surface antigen expression and multipotent differentiation potential. However, the in vivo identification of mesenchymal stem cells, before culture, is not so well established. Pre-culture identification markers would ensure higher purity than that obtained with selection based on adherence to plastic. Up until now, CD271 has been described as the most specific marker for the characterization andpurification of human bone marrow mesenchymal stem cells. This marker has been shown to be specifically expressed by these cells. Thus, CD271 has been proposed as a versatile marker to selectively isolated and expand multipotent mesenchymal stem cells with both immunosuppressive and lymphohematopoietic engraftment-promoting properties. This review focuses on this marker, specifically on identification of mesenchymal stem cells from different tissues. Literature revision suggests that CD271 should not be defined as a universal marker to identify mesenchymal stem cells before culture from different sources. In the case of bone marrow or adipose tissue, CD271 could be considered a quite suitable marker; however this marker seems to be inadequate for the isolation of mesenchymal stem cells from other tissues such as umbilical cord blood or wharton's jelly among others.

关键词： Mesenchymal stem cells CD271 Lowaffinitynerve growth factor receptor p75 Bone marrow

On water security, sustainability, and the water-food-energy-climate nexus

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Frontiers of Environmental science & Engineering 2013年第5期7卷 626-639页

作者： Michael Bruce BECK rodrigo VILLARROEL WALKER Wamell school of Forestry and Natural Resources University of Georgia Athens GA 30602-2152 USA

The role of water security in sustainable development and in the nexus of water, food, energy and climate interactions is examined from the starting point of the definition of water security offered by Grey and sadoff. Much about the notion of security has to do with the presumption of scarcity in the resources required to meet human needs. The treatment of scarcity in mainstream economics is in turn examined, therefore, in relation to how each of us as individuals reconciles means with ends, a procedure at the core of the idea of sustainable development. According to the Grey-sadoff definition, attaining water security amounts to achieving basic, single- sector water development as a precursor of more general, self-sustaining, multi-sectoral development. This is con- sistent with the way in which water is treated as ＂first among equals＂, i.e. privileged, in thinking about what is key in achieving security around the nexus of water, food, energy and climate. Cities, of course, are locations where demands for these multiple resource-energy flows are increasingly being generated. The paper discusses two important facets of security, i.e., diversity of access to resources and services （such as sanitation） and resilience in the behavior of coupled human-built-natural systems. Eight quasi-operational principles, by which to gauge nexus security with respect to city buildings and infrastructure, are developed.

关键词： cities as forces for good diversity energy and nutrient recovery green economy infrastructure failure,resilience