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Characteristics of clear cell renal cell carcinoma metastases to the thyroid gland: A systematic review

World Journal of Clinical Cases 2019年第21期7卷 3474-3485页

作者： Karam Khaddour Nadiia Marernych Wendy L Ward jerry liu Theodora Pappa Department of Medicine at Rosalind Franklin University of Medicine and Science ChicagoIL 60050United States Northwestern Medicine McHenry ChicagoIL 60050United States Advocate Medical Group Oncology Crystal LakeIL 60014United States

BACKGROUND Thyroid gland is an uncommon site for metastases from clear cell renal cell carcinoma(CCRCC)and literature is *** to the variable and often long lag time before development of metastases in patients with CCRCC,thyroid nodules may be misdiagnosed initially as *** systematic review aims at a better understanding of the nature of these *** A bibliographic search was performed using PubMed(1990-2019),key words being“renal cell carcinoma,thyroid,kidney cancer,clear cell.”147 cases were *** patient’s characteristics assessed were:age,sex,stage,size of metastases,lag time,diagnostic modality,initial symptoms,treatment and outcome in last documented follow *** logistic regression,Spearman’s rho and ANOVA were used to identify differences between the existing *** The mean age(±SD)was 64±(10)years in males and 64(±11)in *** mean lag time to diagnosis of thyroid metastases was 8.7(±6.3)*** distribution of the patients was 46.3%male,52.4%*** was a weak correlation between lag time and size of metastases,not statistically *** of metastases was significantly higher in symptomatic patients(6.06±3.51 cm)compared to those with painless mass(4.6±0.29 cm)and asymptomatic ones(3.93±1.99 cm)(P=0.03).Fine Needle Aspiration was diagnostic in 29.4%of cases,47.1%were non *** patients(80.3%)underwent thyroid *** 1 year follow up,55.6%of patients operated were alive versus 35.3%who did not have surgery,though this was not statistically significant(P=0.1).CONCLUSION A larger size of thyroid metastasis was more likely to present with symptomatology.A high index of suspicion is warranted when evaluating thyroid nodules in CCRCC *** was no significant difference in outcome between patients who underwent surgery and those who did *** the wider use of immune check-point inhibitors and tyrosine kinase inhibitors in metastatic CCRCC,surgery may eventually be

关键词： Clear cell renal cell carcinoma Thyroid Metastases Thyroidectomy

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Regulation of hepatic micro RNA expression by hepatocyte nuclear factor 4 alpha

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World Journal of Hepatology 2017年第4期9卷 191-208页

作者： Hong Lu Xiaohong Lei jerry liu Curtis Klaassen Department of Pharmacology SUNY Upstate Medical University Department of Medicine University of Kansas Medical Center

AIMTo uncover the role of hepatocyte nuclear factor 4 alpha (HNF4α) in regulating hepatic expression of microRNAs. METHODSMicroarray and real-time PCR were used to determine hepatic expression of microRNAs in young-adult mice lacking Hnf4α expression in liver (Hnf4α-LivKO). Integrative genomics viewer software was used to analyze the public chromatin immunoprecipitation-sequencing datasets for DNA-binding of HNF4α, RNA polymerase-II, and histone modifications to loci of microRNAs in mouse liver and human hepatoma cells. Dual-luciferase reporter assay was conducted to determine effects of HNF4α on the promoters of mouse and human microRNAs as well as effects of microRNAs on the untranslated regions (3’UTR) of two genes in human hepatoma cells. RESULTSMicroarray data indicated that most microRNAs remained unaltered by Hnf4α deficiency in Hnf4α-LivKO mice. However, certain liver-predominant microRNAs were down-regulated similarly in young-adult male and female Hnf4α-LivKO mice. The down-regulation of miR-101, miR-192, miR-193a, miR-194, miR-215, miR-802, and miR-122 as well as induction of miR-34 and miR-29 in male Hnf4α-LivKO mice were confirmed by real-time PCR. Analysis of public chromatin immunoprecipitation-sequencing data indicates that HNF4α directly binds to the promoters of miR-101, miR-122, miR-194-2/miR-192 and miR-193, which is associated with histone marks of active transcription. Luciferase reporter assay showed that HNF4α markedly activated the promoters of mouse and human miR-101b/miR-101-2 and the miR-194/miR-192 cluster. Additionally, miR-192 and miR-194 significantly decreased activities of luciferase reporters for the 3’UTR of histone H3F3 and chromodomain helicase DNA binding protein 1 (CHD1), respectively, suggesting that miR-192 and miR-194 might be important in chromosome remodeling through directly targeting H3F3 and CHD1. CONCLUSIONHNF4α is essential for hepatic basal expression of a group of liver-enriched microRNAs, including miR-101, miR-19

关键词： Liver Hepatocyte nuclear factor 4 alpha Knockout Mice Human miR-122 miR-192 miR-194 miR-101 miR-802

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Effect of a high strength chemical industry wastewater on microbial community dynamics and mesophilic methane generation

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Journal of Environmental Sciences 2014年第4期26卷 875-884页

作者： Harish Venkatakrishnan Youming Tan Maszenan bin Abdul Majid Santosh Pathak Antonius Yudi Sendjaja Dongzhe Li jerry Jian Lin liu Yan Zhou Wun Jern Ng School of Civil and Environmental Engineering Nanyang Technological University Advanced Environmental Biotechnology Center Nanyang Environment and Water Research Institute Nanyang Technological University School of Public Health Shanghai Jiaotong University Nanyang Environment and Water Research Institute Nanyang Technological University Sembcorp Industries Ltd.

A high strength chemical industry wastewater was assessed for its impact on anaerobic microbial com- munity dynamics and consequently mesophilic methane generation. Cumulative methane production was 251 mL/g total chemical oxygen demand removed at standard temperature and pressure at the end of 30 days experimental period with a highest recorded methane percentage of 80.6% of total biogas volume. Volatile fatty acids （VFAs） analysis revealed that acetic acid was the major intermediate VFAs produced with propionic acid accumulating over the experimental period. Quantitative analysis of microbial communities in the test and control groups with quantitative real time polymerase chain reaction highlighted that in the test group, Eubacteria （96.3%） was dominant in comparison with methanogens （3.7%）. The latter were dominated by Methanomicrobiales and Methanobacteriales while in test groups increased over the experimental period, reaching a maximum on day 30. Denaturing gradient gel electrophoresis profile was performed, targeting the 16S rRNA gene of Eubacteria and Archaea, with the DNA samples extracted at 3 different time points from the test groups. A phylogenetic tree was constructed for the sequences using the neighborhood joining method. The analysis revealed that the presence of organisms resembling Syntrophomonadaceae could have contributed to increased production of acetic and propionic acid intermediates while decrease of organisms resembling Pelotomaculum sp. could have most likely contributed to accumulation of propionic acid. This study suggested that the degradation of organic components within the high strength industrial wastewater is closely linked with the activity of certain niche microbial communities within eubacteria and methanogens.

关键词： biochemical methane potential biogas community dynamics denaturing gradient gel electrophoresis industrial chemical wastewater quantitative real-time PCR

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高速全晶圆薄膜厚度均匀图像在CMP工艺快速评定中的应用(英文)

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电子工业专用设备 2004年第9期33卷 78-82页

作者： jerry liu ADE Corp.1525 McCandless Dr.Milpitas.CA.USA

应用高速度、高点密度熏覆盖全晶圆的薄膜检测仪得到的膜厚均匀图像来对CMP工艺进行快速评定。高点密度、全晶圆的膜厚均匀图像能即时显现出CMP工艺中的非对称性膜厚均匀问题并为根源分析和工艺改进提供快速反馈。对一些用常规的稀疏抽... 详细信息

应用高速度、高点密度熏覆盖全晶圆的薄膜检测仪得到的膜厚均匀图像来对CMP工艺进行快速评定。高点密度、全晶圆的膜厚均匀图像能即时显现出CMP工艺中的非对称性膜厚均匀问题并为根源分析和工艺改进提供快速反馈。对一些用常规的稀疏抽样点薄膜测量方法难以检测到但常见的CMP工艺中导致非对称性膜厚均匀问题熏例如垫片异常熏抛光机头安装不当熏空白晶圆nanotopography等进行比较分析和探讨。

关键词：薄膜检测设备 CMP 全晶圆膜厚均匀图像膜厚非均匀性

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突尼斯的橄榄油之旅

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中国食品 2010年第23期 72-79页

作者：青藤 jerry liu

本期我们为读者设计一条别样的旅行路线——突尼斯橄榄油之旅。之所以以＂橄榄油＂为主题,是因为突尼斯素来有＂橄榄王国＂的美誉,橄榄树几乎遍布了突尼斯。突尼斯位于非洲北部、地中海南岸,具有悠久的橄榄树种植历史。橄榄文化经历了... 详细信息

本期我们为读者设计一条别样的旅行路线——突尼斯橄榄油之旅。之所以以＂橄榄油＂为主题,是因为突尼斯素来有＂橄榄王国＂的美誉,橄榄树几乎遍布了突尼斯。突尼斯位于非洲北部、地中海南岸,具有悠久的橄榄树种植历史。橄榄文化经历了突尼斯的文化繁荣,在突尼斯的文化与经济方面占据了显著的地位。突尼斯从北到南,都布满了橄榄树。

关键词：突尼斯橄榄油橄榄树种植历史地中海文化

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橄榄油,摩洛哥的绿色黄金

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中国食品 2010年第23期 80-83页

作者：青藤 jerry liu

摩洛哥王国（Royaume du Maroc）位于非洲西北端的阿拉伯马格里布地区,东、南部与阿尔及利亚接壤,南部为摩实际占领的西撒哈拉地区,再往南是毛里塔尼亚,西濒大西洋,北临地中海,北隔直布罗陀海峡与西班牙相望。1月平均气温12℃,7月22℃-2... 详细信息

摩洛哥王国（Royaume du Maroc）位于非洲西北端的阿拉伯马格里布地区,东、南部与阿尔及利亚接壤,南部为摩实际占领的西撒哈拉地区,再往南是毛里塔尼亚,西濒大西洋,北临地中海,北隔直布罗陀海峡与西班牙相望。1月平均气温12℃,7月22℃-28℃。

关键词：橄榄油摩洛哥饮食文化美食学

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感受阿布鲁佐的绿色

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中国食品 2010年第23期 84-87页

作者：青藤 jerry liu

从意大利罗马市到阿布鲁佐大区（意大利语：Abruzzo）途中你会看到群山环抱,层峦叠嶂,正值深秋,各种植被的色彩错落有致,风光无限,给你带来休闲好心情。突然间有人惊呼,原来是看到雪山了!蓝蓝的天,白云飘,晴朗的天空下,雪山远远的矗立着... 详细信息

从意大利罗马市到阿布鲁佐大区（意大利语：Abruzzo）途中你会看到群山环抱,层峦叠嶂,正值深秋,各种植被的色彩错落有致,风光无限,给你带来休闲好心情。突然间有人惊呼,原来是看到雪山了!蓝蓝的天,白云飘,晴朗的天空下,雪山远远的矗立着,周边却仍是在一片绿色,暖洋洋的,并没有丝毫冰天雪地的感觉,令人惊叹大自然的奇妙!

关键词：阿布鲁佐意大利风景名胜文化传统

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涨跌停制度变革、股票流动性与资本市场表现

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金融研究 2024年第3期 113-131页

作者：赵家悦卢锐柳建华 jerry Cao 中山大学商学院广东深圳518107 中山大学管理学院/现代会计与账务研究中心广东广州510275 中山大学岭南学院广东广州510275 香港恒生大学商学院中国香港999077

完善的资本市场基础制度,是建设高质量资本市场的根本保障。本文以创业板放宽涨跌幅限制至20%作为准自然实验,细致研究涨跌停制度变革的政策效应。首先,我们意外地发现,放宽涨跌幅限制后,触及10%涨跌幅的样本比例反而明显减少,且股价受... 详细信息

完善的资本市场基础制度,是建设高质量资本市场的根本保障。本文以创业板放宽涨跌幅限制至20%作为准自然实验,细致研究涨跌停制度变革的政策效应。首先,我们意外地发现,放宽涨跌幅限制后,触及10%涨跌幅的样本比例反而明显减少,且股价受到冲击后的表现也更加平稳。然后,我们考察股票流动性这一底层核心要素发现,实施涨跌停制度变革后,股票流动性显著提升:具体而言,每亿元成交量所引发的股价冲击幅度下降了大约0.73个百分点,相当于在同等规模的市场成交下,股票价格所受到的冲击减小了近五分之一。机制分析表明,涨跌停制度变革能够有效减少投资者的“羊群行为”,且有助于抑制过度投机,继而改善股票流动性。最后,对政策效果进行拓展性分析发现,涨跌停制度变革提高了市场定价效率,但并不会提升市场风险,从而回应了投资者对于该政策可能加剧市场风险的关切。本文的研究结果证实了涨跌停制度变革的适当性与必要性,表明这一变革符合我国发展高质量资本市场的长期目标,并为进一步深化资本市场改革提供了经验证据。

关键词：涨跌停制度变革股票流动性投资者行为市场定价效率流动性风险

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Estimating the effects of meteorology on PM_(2.5) reduction during the 2008 Summer Olympic Games in Beijing, China

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Frontiers of Environmental Science & Engineering 2011年第3期5卷 331-341页

作者： liu YANG Ye WU jerry M.DAVIS Jiming HAO School of Environment Tsinghua UniversityBeijing 100084China Office of Air Quality Planning and Standards Health and Environmental Impacts DivisionUS Environmental Protection AgencyRaleighNC 27513USA

Particulate pollution was a critical challenge to the promise of good air quality during the 2008 Beijing Olympic Games,which took place from August 8th to *** ensure good air quality for the Games,several temporary emission control measures were implemented in Beijing and surrounding *** particulate matter concentration decreased significantly during the Olympic period;however,it is difficult to distinguish the effectiveness of those control measures since meteorology also affects ambient PM_(2.5) *** this work,a multiple linear regression model based on continuous field monitoring at a roadside site was conducted to evaluate the effects of meteorology and emission control measures on the reduction of PM_(2.5) during the 2008 Olympic *** hourly data set was divided into two time periods,the no control period,June 22nd to July 4th,and the control period,July 28th to August *** response variable was PM_(2.5) and the meteorology covariates used in the model were hourly temperature,dew point temperature,wind speed and *** direction was not a significant predictor of PM_(2.5) levels in either the control or the no control *** the meteorologically-based regression coefficients from the two time periods,meteorology was found to contribute to at least a 16%reduction in PM_(2.5) levels in the roadside microenvironment;while the pollution control measures contributed to at least a 43%reduction in PM_(2.5) levels.

关键词： meteorology emission control measures Beijing Olympic Games PM_(2.5) linear statistical models

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Research and application of wireless sensor network technology in power transmission and distribution system

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Intelligent and Converged Networks 2020年第2期1卷 199-220页

作者： Jianming liu Ziyan Zhao jerry Ji Miaolong Hu “Smart Grid Technology and Equipment”Expert Committee Industry Development and Promotion Center of the Ministry of Industry and Information TechnologyBeijing 100846China State Grid I&T Branch Beijing 100761China Huawei Technologies Co. Ltd.Shenzhen 518129China Wins Wireless Network Technology Co. Ltd.Jiaxing 314036China

Power is an important part of the energy industry,relating to national economy and people’s livelihood,and it is of great significance to ensure the security and stability in operation of power transmission and distribution *** on Wireless Sensor Network technology(WSN)and combined with the monitoring and operating requirements of power transmission and distribution system,this paper puts forward an application system for monitoring,inspection,security,and interactive service of layered power transmission and distribution ***,this paper demonstrates the system verification projects in Wuxi,Jiangsu Province and Lianxiangyuan Community in Beijing,which have been widely used nationwide.

关键词： Wireless Sensor Network(WSN) smart grid power system power transmission power distribution monitoring system

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