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Association of types of diabetes and insulin dependency on birth outcomes

World Journal of Clinical Cases 2022年第7期10卷 2147-2158页

作者： Pamela K Xaverius Steven W Howard Deborah Kiel jerry e thurman ethan Wankum Catherine Carter Clairy Fang Romi Carriere Department of epidemiology and Biostatistics Saint Louis UniversitySt.LouisMO 63104United States Department of Health Management and Policy Saint Louis UniversitySt.LouisMO 63104United States Department of endocrinology Diabetes and MetabolismSSM HealthSt.CharlesMO 63303United States Division of epidemiology Institute for Health and EquityMedical College of WisconsinMilwaukeeWI 53226United States Department of epidemiology Fielding School of Public HealthUniversity of CaliforniaLos AngelesCA 90095United States Population Health Sciences Institute Centre for Ageing and VitalityNewcastle UniversityNewcastle upon TyneEngland NE45PLUnited Kingdom

BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy *** To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes *** Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant *** included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm *** and multivariate logistic regression assessed differences in outcomes by diabetes *** Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic *** with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic *** Diabetes is associated with the poor birth *** management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes.

关键词： epidemiology Pregnancy Health care delivery Birth outcomes Gestational diabetes Insulin

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IDS-INT:Intrusion detection system using transformer-based transfer learning for imbalanced network traffic

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Digital Communications and Networks 2024年第1期10卷 190-204页

作者： Farhan Ullah Shamsher Ullah Gautam Srivastava jerry Chun-Wei Lin School of Software Northwestern Polytechnical UniversityXian710072ShaanxiChina Knowledge Unit of Systems and Technology University of Management and TechnologySialkot 51040Pakistan Department of Math and Computer Science Brandon UniversityBrandonMB R7A 6A9Canada Department of Computer Science and Math Lebanese American UniversityBeirut1102Lebanon Western Norway University of Applied Sciences BergenNorway Research Centre for Interneural Computing China Medical UniversityTaichungTaiwanChina

A network intrusion detection system is critical for cyber security against llegitimate *** terms of feature perspectives,network traffic may include a variety of elements such as attack reference,attack type,a subcategory of attack,host information,malicious scripts,*** terms of network perspectives,network traffic may contain an imbalanced number of harmful attacks when compared to normal *** is challenging to identify a specific attack due to complex features and data imbalance *** address these issues,this paper proposes an Intrusion Detection System using transformer-based transfer learning for Imbalanced Network Traffic(IDS-INT).IDS-INT uses transformer-based transfer learning to learn feature interactions in both network feature representation and imbalanced ***,detailed information about each type of attack is gathered from network interaction descriptions,which include network nodes,attack type,reference,host information,***,the transformer-based transfer learning approach is developed to learn detailed feature representation using their semantic ***,the Synthetic Minority Oversampling Technique(SMOTe)is implemented to balance abnormal traffic and detect minority ***,the Convolution Neural Network(CNN)model is designed to extract deep features from the balanced network ***,the hybrid approach of the CNN-Long Short-Term Memory(CNN-LSTM)model is developed to detect different types of attacks from the deep *** experiments are conducted to test the proposed approach using three standard datasets,i.e.,UNsWNB15,CIC-IDS2017,and *** explainable AI approach is implemented to interpret the proposed method and develop a trustable model.

关键词： Network intrusion detection Transfer learning Features extraction Imbalance data explainable AI Cybersecurity

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Anti-N-methyl-D-aspartate receptor-associated encephalitis: A review of clinicopathologic hallmarks and multimodal imaging manifestations

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World Journal of Radiology 2024年第1期16卷 1-8页

作者： Bryce David Beutler Alastair e Moody jerry Mathew Thomas Benjamin Phillip Sugar Mark B Ulanja Daniel Antwi-Amoabeng Lucas Anthony Tsikitas Department of Radiology University of Southern CaliforniaKeck School of MedicineLos AngelesCA 90033United States Department of Anesthesiology University of UtahSalt Lake CityUT 84132United States Department of Internal Medicine Christus Ochsner St.Patrick HospitalLake CharlesLA 70601United States

Anti-N-methyl-D-aspartate receptor-associated encephalitis(NMDARe)is a rare immune-mediated neuroinflammatory condition characterized by the rapid onset of neuropsychiatric symptoms and autonomic *** mechanism of pathogenesis remains incompletely understood,but is thought to be related to antibodies targeting the GluN1 subunit of the NMDA receptor with resultant downstream dysregulation of dopaminergic *** adults are most frequently affected;the median age at diagnosis is 21 *** is a strong female predilection with a female sex predominance of 4:*** often develops as a paraneoplastic process and is most commonly associated with ovarian ***,NMDARe has also been described in patients with small cell lung cancer,clear cell renal carcinoma,and other benign and malignant *** is based on correlation of the clinical presentation,electro-encephalography,laboratory studies,and *** tomography,positron emission tomography,and magnetic resonance imaging are essential to identify an underlying tumor,exclude clinicopathologic mimics,and predict the likelihood of long-term functional *** imaging may be of value for prognostication and to assess the response to *** may involve high-dose corticosteroids,intravenous immunoglobulin,and plasma ***,we review the hallmark clinicopathologic features and imaging findings of this rare but potentially devastating condition and summarize diagnostic criteria,treatment regimens,and proposed pathogenetic mechanisms.

关键词： Anti-N-methyl-D-aspartate receptor-associated encephalitis Autoimmune encephalitis encephalitis Ovarian teratoma Paraneoplastic syndrome Teratoma

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The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches

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Oncology Research 2024年第9期32卷 1407-1422页

作者： ROSSANA RONCATO jerry POLeSeL FeDeRICA TOSI eLeNA PeRUZZI eRIKA BRUGUGNOLI CLAUDIA LAURIA PANTANO MARIA FURFARO FILIPPO DI GIROLAMO ALeSSANDRO NANI ARIANNA PANI NOeMI MILAN eLeNA De MATTIA ANDReA SARTORe-BIANCHI eRIKA CeCCHIN experimental and Clinical Pharmacology Unit Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Medicine(DMeD) University of UdineUdine33100Italy Unit of Cancer epidemiology Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Oncology and Hemato-Oncology Universitàdegli Studi di MilanoMilan20122Italy Department of Hematology Oncologyand Molecular MedicineGrande Ospedale Metropolitano NiguardaMilan20122Italy Oncology Pharmacy Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino AmadoriMeldola47014Italy Pharmacy Unit Fondazione IRCCS Istituto Tumori di MilanoMilan20122Italy Department of Pharmacy Ca’Foncello Treviso Regional HospitalPiazzale Ospedale 1Treviso31100Italy Department of Medical Surgical and Health Sciences University of TriesteTrieste34127Italy Hospital Pharmacy Cattinara HospitalAzienda Sanitaria Universitaria Giuliano IsontinaTrieste34148Italy Department of Oncology and Onco-Hematology Postgraduate School of Clinical Pharmacology and ToxicologyUniversity of MilanMilan20122Italy

Objectives:Treatment of metastatic colorectal cancer(mCRC)includes resection of liver metastases(LM),however,no validated biomarker identifies patients most likely to benefit from this *** meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC(i.e.,RAS,BRAF,SMAD4,PIK3CA)as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM ***:A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM,stratified according to RAS,BRAF,PIK3CA,and SMAD4 mutational *** ratios(HRs)from multivariate analyses were pooled in the meta-analysis and various adjustment strategies for confounding factors were *** search was conducted in numerous databases,including MeDLINe(PubMed),embase,Cumulative Index to Nursing and Allied Health Literature(CINAHL)(eBSCO host),and WHO Global Index Medicus,through March 18th,***-analyses,editorials,letters to the editor,case reports,studies on other primary cancers,studies with primary metastatic sites other than the liver,studies lacking specific oncological outcome variables or genetic data,non-english language studies,and studies omitting residual disease data from liver metastasectomy were *** remaining 47 studies were summarized in a descriptive table which outlines the key characteristics of each study and final results were graphically ***:RAS mutation status was negatively associated with overall survival(OS)(HR,1.68;95%CI,1.54–1.84)and recurrence free survival(RFS)(HR,1.46;95%CI,1.33–1.61).A negative association was also found for BRAF regarding OS(HR,2.64;95%CI,2.15–3.24)and RFS(HR,1.89;95%CI,1.32–2.73)and SMAD4 regarding OS(HR,1.93;95%CI,1.56–2.38)and RFS(HR,1.95;95%CI,1.31–2.91).For PIK3CA only three studies were eligible and no significant associati

关键词： Metastasectomy Liver metastases RAS BRAF SMAD4 PIK3CA Colorectal

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液相飞行时间质谱(LC/MSD TOF)和液相色谱/离子阱质谱(LC/MSD Trap)测定色拉蔬菜中的氯烟碱类杀虫剂

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环境化学 2005年第3期24卷 349-354页

作者： Imma Ferrer eMichael thurman jerry Zweigenbaum Pesticide Residue Research Group University of Almeria04120AlmeriaSpainPesticide Residue Research GroupUniversity of Almeria04120AlmeriaSpainAgilent TechnologiesInc.2850 Centerville RoadWilmingtonDE198081610

本工作考察了液相色谱/飞行时间质谱检测器(LC/MSDTOF)和液相/离子阱质谱检测器(LC/MSDTrap)联用技术分析一些氯烟碱类杀虫剂的可行性.杀虫剂包括:啶虫咪(acetamiprid),吡虫啉(imidacloprid)和噻虫啉(thiacloprid).色拉蔬菜有四种:番茄... 详细信息

本工作考察了液相色谱/飞行时间质谱检测器(LC/MSDTOF)和液相/离子阱质谱检测器(LC/MSDTrap)联用技术分析一些氯烟碱类杀虫剂的可行性.杀虫剂包括:啶虫咪(acetamiprid),吡虫啉(imidacloprid)和噻虫啉(thiacloprid).色拉蔬菜有四种:番茄、辣椒、莴苣和黄瓜.本文介绍的内容包括三种氯烟碱类杀虫剂的LC/MSDTOF和LC/MSDTrap质谱,TOF获得的实验分子式和四种蔬菜基质中氯烟碱类杀虫剂的MS/MS碎片离子.同时也将详细介绍样品制备程序以及色拉蔬菜中杀虫剂的回收、最低检测限(MDL)的质谱质量、线性,使用TOF和Trap对纯溶剂和四种蔬菜提取物中杀虫剂的定量分析.给出了来自市场的实际色拉蔬菜样品中杀虫剂的分析结果.

关键词：液相飞行时间质谱液相色谱离子阱质谱色拉蔬菜氯烟碱类杀虫剂质量标准

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液相色谱/离子阱质谱和飞行时间质谱分析橄榄油中的特丁津除草剂

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环境化学 2005年第6期 106-109页

作者： Imma Ferrer,Michael thurman,jerry Zweigenbaum University of Almeria 04120 Almeria Spai University of Almeria 04120 Almeria Spai Agilent Technologies Inc.2850 Centerville Road Wilmington De 19808-1610 USA

本文摘要介绍了液相色谱/离子阱质谱和液相/飞行时间质谱对橄榄油中特丁津的定性定量分析.详细介绍了样品处理,包括液液萃取和以氨基硅胶为基质分散的固相萃取法.样品的净化采用Florisil硅土小柱,用乙腈洗脱溶质.液相色谱/离子阱质谱的M... 详细信息

本文摘要介绍了液相色谱/离子阱质谱和液相/飞行时间质谱对橄榄油中特丁津的定性定量分析.详细介绍了样品处理,包括液液萃取和以氨基硅胶为基质分散的固相萃取法.样品的净化采用Florisil硅土小柱,用乙腈洗脱溶质.液相色谱/离子阱质谱的MS/MS模式采集特征离子m/z174.而利用液相/飞行时间质谱进行精确质量数分析(\[M+H\]+,m/z230),同时得到碎片的精确质量数和特征同位素分布.对于飞行时间质谱测得的质量精度小于ppm.此方法具有高灵敏度、线性好及精度高的优点.液相/离子阱质谱和飞行时间质谱可以作为橄榄油中特丁津的常规方法.

关键词：飞行时间质谱橄榄油离子阱质谱特丁津家得便质量数特征离子分子离子峰液相色谱液体色谱离子流同位素分布除草剂除莠剂

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液相色谱/离子阱质谱和飞行时间质谱分析橄榄油中的特丁津除草剂

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环境化学 2005年第6期24卷 735-738页

作者： Imma Ferrer Michael thurman jerry Zweigenbaum University of Almeria 04120 AlmeriaSpai University of Almeria04120 AlmeriaSpai Agilent TechnologiesInc.2850 Centerville Road WilmingtonDE 19808-1610 USA

关键词：飞行时间质谱离子阱质谱液相色谱橄榄油质谱分析除草剂定性定量分析样品处理质量精度固相萃取法

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Less common etiologies of exocrine pancreatic insufficiency

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World Journal of Gastroenterology 2017年第39期23卷 7059-7076页

作者： Vikesh K Singh Mark e Haupt David e Geller jerry A Hall Pedro M Quintana Diez Division of Gastroenterology Johns Hopkins University School of MedicineBaltimoreMD 21287United States Medical Affairs AbbVie Inc.North ChicagoIL 60064United States Cystic Fibrosis Clinical Development AbbVie Inc.North ChicagoIL 60064United States CReON^(█) Clinical Development AbbVie Inc.North ChicagoIL 60064United States CReON^(█) Development AbbVie Inc.North ChicagoIL 60064United States

exocrine pancreatic insufficiency(ePI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of ePI, other causes of ePI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with ePI and examines the role of pancreatic enzyme replacement therapy(PeRT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop ePI(66%-92%). ePI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have ePI. ePI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. ePI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PeRT use for these conditions, recommendations for or against PeRT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between ePI and medical conditions beyond those with proven mechanisms, and examine the potential role for PeRT.

关键词： Celiac disease Inflammatory bowel disease exocrine pancreatic insufficiency Malabsorption epidemiology Pancreas Pancreatic cancer Secretion/absorption Surgery

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effective rural electrification via optimal network: Optimal path-finding in highly anisotropic search space using multiplier-accelerated A* algorithm

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能源与人工智能(英文) 2022年第1期7卷 1-17页

作者： jerry CFLi Daniel Zimmerle Peter MYoung Colorado State University United States

United Nations’7th Sustainable Development Goal envisions the availability of modern energy for everyone by *** the progress has been satisfactory in the last few years,further rural electrification is increasingly *** current mainstream approach of electrifying villages individually is becoming cost-ineffective due to uncertainties in both resource availability and energy demand for small,difficult-to-reach,residences.A networked rural electrification model,i.e.a cost-optimized network connecting villages and generation facilities,could improve resources utilization,reliability and ***,determining optimal paths with common search algorithms is extremely inefficient due to complex topographic features of rural *** work develops and applies an artificial intelligence search method to efficiently route inter-village power connections in the common rural electrification situation where substantial topological variations *** method is evolved from the canonical A**** compare favorably with optimal A*results,at significantly reduced computational ***,users can adaptively trade-off between computation speed and optimality and hence quickly evaluate sites and configurations at reasonable accuracy,which is impossible with classical methods.

关键词： A*routing Optimal path finding System optimization Rural electrification Sustainable development goals SDG7 energy utilization

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LC/TOF MS分子特征数据库检索方法进行食品中600种农药的自动筛选

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食品安全质量检测学报 2010年第3期1卷 140-148页

作者： e.Michael thurman Imma Ferrer jerry A.Zweigenbaum Pesticide Residue Research Group University of AlmeriaSpain Agilent Technologies Inc.WilmingtonUSA

通过液相色谱/飞行时间质谱在正离子模式下全扫描精确质谱测定,建立了分子特征(MF)算法进行数据库检索的方法用于筛选食品提取物中600种农药及其降解产物。数据库检索将实际化合物检测和鉴定中得到的离子的精确质量数收集起来,并且将它... 详细信息

通过液相色谱/飞行时间质谱在正离子模式下全扫描精确质谱测定,建立了分子特征(MF)算法进行数据库检索的方法用于筛选食品提取物中600种农药及其降解产物。数据库检索将实际化合物检测和鉴定中得到的离子的精确质量数收集起来,并且将它们与数据库中化合物的单一同位素的准确质量数进行比较。筛选标准包括:±5 ppm精确质量窗口;±0.2分钟保留时间窗口;最小峰面积计数1000(信噪比约为10:1)。检出限和保留时间是由600种化合物中的100种来确定,其中34%的化合物的检出限小于0.01mg/kg,95%的化合物的检出限小于0.5 mg/kg。与需要几小时到几天的手工方法相比,分子特征算法的优势在于它可以在几分钟内灵敏快速地筛选几百种化合物。

关键词：数据库检出限数据库系统化合物农药化学污染物碎片离子正离子阳离子分子特征婴儿食品质量数检索方法同位素峰马拉硫磷样品筛分子式 MS TOF

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