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The formulation for cancer prevention &therapy

Advances in Biological Chemistry 2013年第3期3卷 356-387页

作者： jerry T. Thornthwaite Hare R. Shah Pasupati Shah William C. Peeples Henry Respess Cancer Research Institute of South Florida Palmetto Bay USA

Our natural product research over nine years has been to discover effective over-the-counter-supplements, designed to facilitate classical treatments in fighting disease, specifically cancer. These supplements are important in antiangiogenic, immune and antioxidant defense systems. The components include Acetyl l-Carnitine (AlC), Alpha lipoic Acid (AlA), Coenzyme Q10 (CoQ10), Curcumin with Piperine, Genistein, lentinan, N-Acetylcysteine (NAC), Resveratrol, selenium, Vitamin B Complex, Vitamin C, Vitamin E and zinc. These supplement components are supported for human cancer by over 15,000 references in the scientific literature withover of these being published clinical trials, not including zinc and the vitamins. These chemical defined components from natural origins have demonstrated, either individually or collectively, to have antioxidant, anti-angiogenesis, and immune stimulation properties. Furthermore, the direct cancer cell cytotoxicity for Curcumin, Genistein and NAC have been shown. Some of the antiangiogenesis components that affect the majority if not all pathways of angiogenesis, such as Curcumin, Genistein and NAC, actually stimulate the in vivo production of natural antiangiogenic compounds that include Angiostatin, Endostatin and Thrombospotin 1. All of the components play a role in serving as either water or lipid soluble (able to cross the blood-brain barrier) antioxidants. Curcumin, Genistein, Resveratrol, lentinan, NAC, zinc, selenium and vitamins B and C all stimulate the immune system. Except for AlC and CoQ10, the other components show anti-inflammatory activity. AlC, Resveratrol along with the B and C vitamins are helpful in treating fatigue. The components that help protect the brain and promote nerve regeneration include AlA, CoQ10, Resveratrol, NAC, selenium, zinc and the B and C vitamins. In conclusion, effective prevention and treatment for diseases such as cancer, heart disease and immune deficiency will require multiple compounds.

关键词： Cancer Prevention Formulation

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l波段和S波段脉冲雷达的功率模块新产品

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电源世界 2007年第11期 71-73,59页

作者： jerry Chang Microsemi Corporation Power Products Group Santa ClaraCalifornia

针对脉冲雷达应用,Microsemi公司PPG集团推出了系列化的l波段和S波段功率模块(PSM)。这些功率模块可输出2～3倍于当今市场上单个晶体功率管所能输出的功率,其设计采用了易于使用的"即插即用"概念,用户能够直接将其植入系统而不需进行更... 详细信息

针对脉冲雷达应用,Microsemi公司PPG集团推出了系列化的l波段和S波段功率模块(PSM)。这些功率模块可输出2～3倍于当今市场上单个晶体功率管所能输出的功率,其设计采用了易于使用的"即插即用"概念,用户能够直接将其植入系统而不需进行更多的阻抗匹配设计。更高的输出功率和更高的效率,加上"即插即用"的特点能够极大地简化用户系统设计的复杂性,缩短设计周期,功放部分的尽寸缩小50%以上,并且极大地提高了用户产品的开机合格率。

关键词：即插即用阻抗匹配设计开机合格率

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Host Factors Alter Effects of Angiopoietin-like Protein 8 on Glucose Homeostasis in Diabetic Mice

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Journal of Diabetes Mellitus 2016年第4期6卷 277-290页

作者： Sichen liu Emily M. Smith Timothy H. King lindsey Glenn Michelle Trevino So Hyun Park Yui Machida Ciriaco Villaflor Wojciech Grzesik Margaret A. Morris Yumi Imai jerry l. Nadler Eastern Virginia Medical School Department of Internal Medicine Strelitz Diabetes Center Norfolk VA USA Department of Internal Medicine Fraternal Order of Eagles Diabetes Research Center The University of Iowa Carver College of Medicine Iowa City IA USA

Recovery of functional beta cell mass offers a biological cure for type 1 diabetes. However, beta cell mass is difficult to regain once lost since the proliferation rate of beta cells after youth is very low. Angiopoietin like-protein 8 (ANGPTl8), a peptide that has a role in the regulation of lipoprotein lipase activity, was reported to increase beta cell proliferation in mice in 2013. Subsequent studies of human ANGPTl8 for short term (3 to 8 days) in non-diabetic mice showed little or no increase in beta cell proliferation. Here, we examined the effect of ANGPTl8 on glucose homeostasis in models that have not been examined previously. We expressed mouse ANGPTl8 using adenovirus in 2 mouse models of diabetes (streptozotocin and Non-Obese Diabetic (NOD) mice) over 2 weeks. Also, we tested ANGPTl8 in NOD mice deficient in leukocyte 12-lipoxygenase (12lO), an enzyme that contributes to insulitis and loss of beta cell function in NOD, in an effort to determine whether 12lO deficiency alters the response to ANGPTl8. Adenovirus-mediated expression of ANGPTl8 lowered blood glucose levels in streptozotocin treated mice without an increase in beta cell proliferation or serum insulin concentration. While ANGPTl8 did not reverse hyperglycemia in overtly hyperglycemic NOD mice or alter glucose homeostasis of non-diabetic NOD mice, ANGPTl8 reduced blood glucose levels in 12lOKO NOD mice. However, the lower glucose levels in 12lOKO NOD were not associated with higher serum insulin levels or beta cell proliferation. In summary, while mouse ANGPTl8 does not increase beta cell proliferation in NOD mice or streptozotocin treated mice in agreement with studies in non-diabetic mice, it lowers blood glucose levels in multiple low-dose streptozotocin induced diabetes and 12lO deficiency indicating that host factors influence the impact of ANGPTl8 on glucose homeostasis.

关键词： Angiopoietin-like Protein 8 Type 1 Diabetes NOD 12-lipoxygenase Beta Cells Glucose Homeostasis

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心房纤颤时心室起搏使心室律规整对心排血量的影响

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中国心脏起搏与心电生理杂志 1988年第1期 35-36页

作者：胡大一 Robert J.Hariman Jose l Gallestegui KarenJ.Beckman jerry l Bauman. 北京医科大学第一医院心内科伊利诺大学医学院心内科伊利诺大学医学院心内科伊利诺大学医学院心内科伊利诺大学医学院心内科伊利诺大学医学院心内科伊利诺大学医学院心内科

心房纤颤时,以适当频率刺激心室起搏,可使心室律规整。为了评价心室律规则化对血流动力学的影响,本组用9只麻醉的狗研究了心房纤颤时及VVI型心室起搏后心排血量、主动脉压和肺动脉压的变化。当心室起搏频率为房颤时心室率+5～10次/min时... 详细信息

心房纤颤时,以适当频率刺激心室起搏,可使心室律规整。为了评价心室律规则化对血流动力学的影响,本组用9只麻醉的狗研究了心房纤颤时及VVI型心室起搏后心排血量、主动脉压和肺动脉压的变化。当心室起搏频率为房颤时心室率+5～10次/min时,心排血量增加4.1～15.8%(P<0.05,0.01).

关键词：心室起搏房颤心房纤颤心律失常心室率心排血量

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牛脑Ca^(2+)/CaM依赖性蛋白激酶Ⅱ的纯化和鉴定

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生物化学杂志 1991年第4期7卷 407-413页

作者：张光毅赵昇皓 Rajendra K.Sharma jerry H.Wang 徐州医学院生化教研室徐州221002 加拿大卡尔加里大学医学生化系

通过一系列层析法,首次从牛脑纯化得到胶凝电泳匀一的Ca^(2+)/CaM PKⅡ。凝胶过滤法测定全酶分子量为550kD,SDS-PAGE法测定亚基分子量为55kD,推测牛脑Ca^(2+)/CaM PK Ⅱ由十个相同的亚基组成。该酶活性绝对依赖于Ca^(2+)和CaM,以63kD PD... 详细信息

通过一系列层析法,首次从牛脑纯化得到胶凝电泳匀一的Ca^(2+)/CaM PKⅡ。凝胶过滤法测定全酶分子量为550kD,SDS-PAGE法测定亚基分子量为55kD,推测牛脑Ca^(2+)/CaM PK Ⅱ由十个相同的亚基组成。该酶活性绝对依赖于Ca^(2+)和CaM,以63kD PDE同工酶为底物,其AC_(50)分别为0.85μmol/l和0.18μmol/l;以酪蛋白为底物,其AC_(50)分别为0.22μmol/l和0.06μmol/l。牛脑Ca^(2+)/CaM PK Ⅱ旣能催化63kD PDE同工酶等多种蛋白或酶磷酸化,又能进行自身磷酸化。该酶催化63kD PDE同工酶最大磷酸参入量为1mol/mol亚基。磷酸化型63kD PDE同工酶的Ca^(2+)的AC_(50)高于非磷酸化型。

关键词：钙调素蛋白激酶牛脑提纯鉴定

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Spatial variation of carbon dioxide fluxes in corn and soybean fields

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Agricultural Sciences（农业科学） 2012年第8期

作者： jerry l. Hatfield Timothy B. Parkin

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C-Reactive Protein as a Triage Test in Guiding Who Should Get a Confirmatory Test for Pulmonary Tuberculosis Diagnosis among Adults: A Case-Control Proof-of-Concept Study from Urban Tanzania

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Journal of Tuberculosis Research 2022年第1期10卷 28-44页

作者： Evarist Chiweka Thomas Maroa Hosiana Temba Joseph Ponera Sharifa Athumani lujeko Kamwela Mohamed Sasamalo Rastard Naftari Mirambi Tito Francis Mhimbira jerry Hella Ifakara Health Institute Dar es Salaam Tanzania Nelson Mandela African Institution of Science and Technology Arusha Tanzania

Background: The current screening tools for tuberculosis (TB) are inadequate resulting in insufficient TB case detection and continued community transmission of TB. As the world is geared into finding missing TB cases, new strategies are called for to aid in rapid identification of TB cases. This study aimed to evaluate the role C-reactive protein (CRP) in triaging patients to get a definitive test for active pulmonary TB diagnosis in urban Tanzania. Methods: A case-control study was conducted among pulmonary TB (PTB) patients and contacts without active PTB. The diagnosis of PTB was performed using GeneXpert MTB/RIF assay and culture. Blood was collected from cases and controls for measuring CRP levels during recruitment. We compared socio-demographic characteristics, clinical and laboratory parameters obtained during recruitment and performed diagnostic accuracy analyses for CRP. Results: Out of all 193 study participants who were involved in final analysis, 147 (76.2%) were males. Pulmonary TB cases had significantly lower median BMI than controls (median 17.4 kg/m2 [IQR: 15.8 - 19.2 kg/m2] vs., 24.9 kg/m2 [IQR: 22.1 - 28.5 kg/m2), p l difference in prevalence of HIV between PTB cases and controls i.e., 13.33% vs., 11.7%, p = 0.48. CRP was significantly higher in PTB cases vs., controls (median 67.8 mg/l, [IQR: 36.5 - 116.9 mg/l] vs., 1.55 mg/l, [IQR: 0.59 - 6.0 mg/l], p = 0.003). Furthermore, CRP at cut-off ≥10 mg/l was associated with best combination of sensitivity, specificity and area under the curve of 89.9%, 95% CI: 82.2 - 95.0, 80.9%, CI: 71.4 - 88.2 and 0.85, 95% CI: 0.80 - 0.90 respectively. A multivariate logistic regression model adjusted for fever, night sweats and body mass index showed that CRP above 10 mg/l was significantly associated with PTB, aOR 5.2, 95% CI 1.2 - 22.8. Conclusions: CRP at cut-off ≥10 mg/l can be used to screen pulmonary TB. These findings can be used

关键词： C-Reactive Protein Pulmonary Tuberculosis Screening Temeke Tanzania

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loss of GSNOR1 Function leads to Compromised Auxin Signaling and Polar Auxin Transport

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Molecular Plant 2015年第9期8卷 1350-1365页

作者： Ya-Fei Shi Da-li Wang Chao Wang Angela Hendrickson Culler Molly A. Kreiser Jayanti Suresh jerry D. Cohen Jianwei Pan Barbara Baker Jian-Zhong liu College of Chemistry and life Sciences Zhejiang Normal University Jinhua Zhejiang 321004 China Department of Plant and Microbial Biology University of California Berkeley Berkeley CA 94720 USA Department of Horticultural Science Microbial and Plant Genomics Institute University of Minnesota Saint Paul MN 55108 USA These authors contributed equally to this article.

Cross talk between phytohormones, nitric oxide （NO）, and auxin has been implicated in the control of plant growth and development. Two recent reports indicate that NO promoted auxin signaling but inhibited auxin transport probably through S-nitrosylation. However, genetic evidence for the effect of S-nitrosylation on auxin physiology has been lacking. In this study, we used a genetic approach to understand the broader role of S-nitrosylation in auxin physiology in Arabidopsis. We compared auxin signaling and transport in Col-0 and gsnorl-3, a loss-of-function GSNOR1 mutant defective in protein de-nitrosylation. Our results showed that auxin signaling was impaired in the gsnorl-3 mutant as revealed by significantly reduced DR5-GUS/ DR5-GFP accumulation and compromised degradation of AXR3NT-GUS, a useful reporter in interrogating auxin-mediated degradation of Aux/IAA by auxin receptors. In addition, polar auxin transport was compro- mised in gsnorl-3, which was correlated with universally reduced levels of PIN or GFP-PIN proteins in the roots of the mutant in a manner independent of transcription and 26S proteasome degradation. Our results suggest that S-nitrosylation and GSNORl-mediated de-nitrosylation contribute to auxin physiology, and impaired auxin signaling and compromised auxin transport are responsible for the auxin-related morpho- logical phenotypes displayed by the gsnorl-3 mutant.

关键词： phytohormone cross talk S-nitrosoglutathione reductase (GSNOR) S-nitrosylation auxin signaling,auxin transport Arabidopsis

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结膜广泛鳞状细胞癌切除术前局部应用丝裂霉素C化学减小法

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美国医学会眼科杂志（中文版） 2005年第3期17卷 166-169页

作者： Carol l. Shields Hakan Demirci Brian P. Marr Arman Masheyekhi Miguel Materin jerry A. Shields 郑邦和（译）

局部丝裂霉素C（MMC）对表层或侵人性结膜鳞状细胞癌（SCC）的治疗有效。在大多数情况下，化学疗法制剂以局部眼药水形式直接滴于病眼表面，每日4次。药物一般持续3或4周，在此时其肿瘤常完全退化。

关键词：结膜鳞状细胞癌丝裂霉素C 局部应用化学疗法癌切除术前眼表面眼药水

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哇巴因刺激肺慢适应感受器(英文)

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生理学报 2005年第6期57卷 689-695页

作者： Edward WINNER 张静文 Mary PROCTOR 於峻路易斯维尔大学内科学系与生理系

钠钾泵抑制剂——哇巴因能引起气道内慢适应感受器异相发放,表现为冲动在正常时的吸气相发放,呼气相终止转变为在呼气相发放,吸气相终止。我们推测异相发放由过度兴奋所致,如果假设正确,那么降低气道压力从而减少对感受器刺激,将能防止... 详细信息

钠钾泵抑制剂——哇巴因能引起气道内慢适应感受器异相发放,表现为冲动在正常时的吸气相发放,呼气相终止转变为在呼气相发放,吸气相终止。我们推测异相发放由过度兴奋所致,如果假设正确,那么降低气道压力从而减少对感受器刺激,将能防止异相发放。本工作在麻醉、开胸、机械通气(在呼气末附加3 cm水柱的正压)的家兔中记录颈迷走神经中慢适应感受器的单位放电,向感受野注射微量哇巴因(1 μmol／l,20 μ1),可观察到感受器活动发生变化。感受器放电经历紧张性发放、异相发放、以及不规则发放三个时期,随后放电终止,进入静息状态。在紧张期,感受器呈持续发放,冲动频率随肺部通气变化的波动幅度明显减小。在异相发放期,感受器活动出现突然发放(呼气相)与终止(吸气相),其冲动快速转换于高频发放和静止之间。此时,若撤除呼气末正压而减少气道内压力,感受器活动恢复正常,即冲动频率于气管压峰值时为最高,在呼气相减少或终止。在不规则期,感受器通常处于静止状态,时而出现突发高频冲动,且与呼吸周期无关。可以设想:在吸气相,感受器受到牵拉,引起钠、钙等阳离子内流,产生感受器电位。正常时,由于激活钠泵, 将钠离子泵出细胞,使感受器电位回复。当钠泵受到抑制后,钠外流受阻,感受器电位加大。在异相发放期,肺充气时牵拉感受器,进一步增加感受器电位,当它超越了产生动作电位的活动范围后,则感受器因过度去极化而失去兴奋性。

关键词：迷走神经肺反射机械感受器传入神经

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