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Molecular Biology of the Gene 5th ed.

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Life on the Cusp of Ruins

2004年

作者： James D. Watson Tania A. Baker stephen P. Bell Alexander Gann Michael levine Richard Losick

ISBN: (纸本)9780805346350

Every student package automatically includes a CD-ROM and access to a website containing tutorials, molecular models, and *** long-awaited Fifth Edition of James D. Watson's classic text, Molecular Biology of the Gene, has been thoroughly revised and is published to coincide with the 50th anniversary of Watson and Crick's paper on the structure of the DNA double- *** being completely updated, the new edition retains the distinctive character of earlier editions that made it the most widely used book in molecular biology. Twenty-one concise chapters, co-authored by five highly respected molecular biologists, provide current, authoritative coverage of a fast-changing discipline. The completely new art is printed in full colour for the first *** into four parts, the first (Genetics and Chemistry) begins with an overview of molecular biology, placing the discipline in historical context and introducing the basic chemical concepts that underpin our description of molecular biology today. The second part (Central Dogma) forms the heart of the book, describing in detail the basic mechanisms of molecular biology. The third part of the book (Regulation) deals with how gene expression is regulated - from the examination of basic mechanisms that regulate gene expression in bacterial and eukaryotic systems, to a description of how regulation of gene expression lies at the heart of the process of development. Recent findings from sequencing whole genomes of several animals have revealed that they all share essentially the same genes. The last chapter in the regulation section looks at how changes in gene regulation can account for how different animals can be made from the same genes. The final part of the book (Methods) deals with the techniques and methods used in molecular biology.[Contents]I. CHEMIsTRY AND GENETICs.1. The Mendelian View of the World.2. Nucleic Acids Convey Genetic Information.3. The Importance of Weak Chemical Interactions.4. The Impo

关键词： Molecular biology.

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Beijing Review 2012年第26期55卷 48-48页

作者： Jonathan levine

More than a few of my students at Tsinghua University were per- plexed by my decision to spend this Labor-Day holiday-（May I） vacationing in shanxi Province. At the heart of China＇s coal belt, the province is an es... 详细信息

关键词：生命风口废墟中国经济清华大学中心地带组成部分山西省

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食物回收等级制度帮助处理剩余食物（英文）

英语画刊(高中版) 2024年第1期 12-14页

作者： Daisy Chung Ally J.levine Clare Trainor

每天,世界各个角落都会丢弃大量的剩余食物,比如吃不完的饭菜、发霉的面包和不能吃的果皮果核等。这不仅造成食物浪费,还会导致环境问题日益严重。Humans grow and waste food at a staggering(令人吃惊的)*** devote half the earth’s...

每天,世界各个角落都会丢弃大量的剩余食物,比如吃不完的饭菜、发霉的面包和不能吃的果皮果核等。这不仅造成食物浪费,还会导致环境问题日益严重。Humans grow and waste food at a staggering(令人吃惊的)*** devote half the earth’s habitable land to food production,while ultimately tossing one-third of that food.

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肺炎链球菌耐药性和血清型分布及隐匿性耐药克隆株的研究

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中华儿科杂志 2000年第7期38卷 424-427页

作者：俞桑洁王槿芳李洁李艳王雪莲 Whitney CG levine Os Dowell sF 杨永弘北京市儿科研究所微生物免疫室 100045 美国疾病控制中心

目的　了解儿童肺炎链球菌携带者耐药菌株的流行情况 ,比较携带者菌株血清型与肺炎链球菌结合疫苗血清型的符合率 ,寻找单个患儿同时携带敏感和耐药菌株的可能性。方法　 (1)对1997年 11月～ 12月在北京儿童医院普通门诊登记的 3个月～ ... 详细信息

目的　了解儿童肺炎链球菌携带者耐药菌株的流行情况 ,比较携带者菌株血清型与肺炎链球菌结合疫苗血清型的符合率 ,寻找单个患儿同时携带敏感和耐药菌株的可能性。方法　 (1)对1997年 11月～ 12月在北京儿童医院普通门诊登记的 3个月～ 5岁儿童进行问卷调查 ;(2 )采集鼻咽拭子和尿标本 ,培养、分离和鉴定肺炎链球菌 ,并测定尿标本中的抗生素活性 ;(3)根据NCCLs方法使用微量稀释法测定肺炎链球菌对青霉素、头孢呋新、头孢噻肟、复方新诺明、红霉素和氯霉素的敏感性 ;(4 )从最初发现的青霉素、红霉素敏感株中寻找“隐匿性耐药克隆株”。结果　 (1) 5 0 2例受试儿童中 ,分离出 190株肺炎链球菌 ,携带率为 37.8% (190 / 5 0 2 ) ,对青霉素的敏感率为 91.1% ;(2 )只有33 .9%的菌株血清型与建议使用的肺炎链球菌结合疫苗血清型相符 ;(3) 4 2例含青霉素和红霉素敏感菌株鼻咽拭子中发现 6株 (14% )“隐匿性耐药克隆株”。结论　在携带者中 ,肺炎链球菌对 β 内酰胺类耐药还不常见 ,但对红霉素和复方新诺明耐药却非常严重 ;建议使用的结合疫苗血清型不能覆盖大部分携带菌株 ;耐药菌株的小部分隐匿在敏感菌株中。

关键词：肺炎链球菌儿童抗药性克隆抗生素

Caloric restriction mimetics enhance anticancer immunosurveillance

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Caloric restriction mimetics enhance anticancer immunosurvei...

The effect of exposure to normbaric hypoxia on the body weight in rats

第十一届全国免疫学学术大会

作者： Pol J Pietrocola F Vacchelli E Rao s Enot DP Baracco EE Levesque s Castoldi F Jacquelot N Yamazaki T senovilla L Marino G Aranda F Durand s sica V Chery A Lachkar s sigl V Bloy N Buque A Falzoni s Ryffel B Apetoh L Di Virgilio F Madeo F Maiuri MC Zitvogel L levine B Penninger JM Kroemer G

Caloric restriction mimetics(CRMs)are compounds that mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins,thus triggering *** CRMs have been identified including hy...

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青海医学院学报 2005年第3期26卷 153-155页

作者： Yi Lina Keishi Kubo Ge Rili Benjamin levine Tony Babb Frist Department of Internal Medicine Shinshu University School of Medicine Japan Research Center for High Altitude Medicine Qinghai Medical College China the Institute for Exercise and Environmental Medicine Southwest Medical Center of Dallas USA.

为了确定大鼠的体重是否在标准气压缺氧环境下会减轻,本实验将12只5周龄Wis-tar大鼠移高至海拔2260m并使之持续暴露于含10%O2的低氧小低压舱内(相当于在海拔5000m)20日。在基线每5日测一次体重。由于标准气压缺氧环境可影响血循环功能,... 详细信息

为了确定大鼠的体重是否在标准气压缺氧环境下会减轻,本实验将12只5周龄Wis-tar大鼠移高至海拔2260m并使之持续暴露于含10%O2的低氧小低压舱内(相当于在海拔5000m)20日。在基线每5日测一次体重。由于标准气压缺氧环境可影响血循环功能,所以在大鼠移入高原前后20天,分别对其肺动脉压和血红蛋白浓度进行了测定。基线处体重为(222.4±20.7)g,而与基线处相比。大鼠体重在移高5、10、15和20天后明显下降,分别下降了(4.88±sD)%、(7.67土sD)%、(11.05±sD)%和(11.9±sD)%,差异显著(P<0.05)。基线处大鼠的平均肺动脉压为(21.3±2.5)mmHg,低氧暴露20天后肺动脉压明显增高[(45.3±5.8)mmHg,P<0.001]。血红蛋白浓度在基线处的平均值为(14.5±3.2)g/L,而在低氧暴露20天后明显增加[(22.6±5.4)g/L,P<0.001]。该结果显示,模拟高海拔可使大鼠体重明显下降,这与先前报道的人体试验结果相似。结果也进一步说明,标准气压下持续的低氧环境对肺动脉压和血红蛋白浓度可产生实质性影响。

关键词：标准气压缺氧环境体重减轻摄食肺动脉压

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一种自动化高精度相位测量系统

宇航计测技术 1984年第S1期 122-126页

作者： s.stein D.Glaze J.levine J.Gray D.Hilliard D.Howe 乔石琼

一种采用了多种已有技术、具有多种特点的全自动测量系统已研制成功。这个系统为双混频时差技术的扩展而保持了它的重要特点:间歇时间为零,能进行相位差绝对测量,精度很高,能测量频率相同的振荡器并根据使用人选择的时间进行测量。对某... 详细信息

一种采用了多种已有技术、具有多种特点的全自动测量系统已研制成功。这个系统为双混频时差技术的扩展而保持了它的重要特点:间歇时间为零,能进行相位差绝对测量,精度很高,能测量频率相同的振荡器并根据使用人选择的时间进行测量。对某一套设计参数来说,理论分辨度为0。2ps,测量噪声为2ps(有效值)并可在所选时间的0.1s内进行测量。由于增加了定标器以消除过去实验中发生的周期模糊(CyCle ambiguify),双混频时差技术得到了发展。在这方面,系统的功能相当于一个分频器加上钟,对设备中被测的每一个器件的恒定相位延迟进行贮存。自动化是以ANsI/IEEE—583(CAMAC)接口标准为基础的。每个测量通道包括一个混频器,过零检波器、定标器和时间间隔计数器。一个两倍宽度的标准卡马克(CAMAC)组件中安装有四个通道。这个组件安装在一个标准的CAMAC箱内,备有控制器以便与多种计算机以及与任何IEEE—488兼容的装置相对接。现有两个系统已工作数月,一个系统每天工作24小时,从NBs时标的15个钟取得数据,另一个系统在实验室的短期实验中使用。

关键词：振荡器定标器电子设备混频器时间间隔计数器相位测量相移测量电量测量时差测量相位差混频技术综合器

Waldenstrm巨球蛋白血症中的周围神经病变

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 50-51页

作者： levine T. Pestronk A. Florence J. 谢琰臣 Box 8111 Neurology 660 South Euclid Avenue St. Louis MO 63110 United States Dr.

Objective: We sought to determine the prevalence, clinical features, and laboratory characteristics of polyneuropathies in Waldenstr m’s macroglobulinaemia (WM), a malignant bone marrow disorder with lymphocytes that produce monoclonal IgM. Methods: We prospectively studied 119 patients with WM and 58 controls. Medical history was taken, and neurological examinations, electrodiagnostic tests, and serum studies were performed by different examiners who were blinded to results except the diagnosis of WM. Results: Polyneuropathy symptoms, including discomfort and sensory loss in the legs, occurred more frequently (p s with WM (47% ) than in controls (9% ). Patients with WM had 35% lower quantitative vibration scores, and more frequent pin loss (3.4 times) and gait disorders (5.5 times) than controls (all ps with IgM binding to sulphatide (5% of WM) had sensory axon loss; those with IgM binding to myelin associated glycoprotein (MAG) (4% of WM) had sensorimotor axon loss and demyelination. Patients with WM with IgM binding to sulphatide (psevere sensory axon loss than other patients with WM. Demyelination occurred in 4% of patients with WM with no IgM binding to MAG. Age related reductions in vibration sense and sural sNAP amplitudes were similar (～ 30% ) in WM and controls. Conclusions: Peripheral nerve symptoms and signs occur more frequently in patients with WM than controls, involve sensory modalities, and are often associated with gait disorders. IgM binding to MAG or sulphatide is associated with a further increase in the frequency and severity of peripheral nerve involvement. Age related changes, similar to those in controls, add to the degree of reduced nerve function in patients with WM.

关键词：巨球蛋白血症周围神经神经病变 IgM 患者血蛋白异常硫脂 Waldenstr

踏着先辈的足迹前行——记“读习近平总书记给国际友人亲属复信有感座谈会”

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国际人才交流 2021年第11期 9-13页

作者： [美]马克·力文不详

2005年来中国后,我有幸见到了几名年长的国际友人,他们曾在中国抗日战争以及中华人民共和国成立的过程中作出贡献。遗憾的是,当时已仅有极少数国际友人仍在世上。但好在我仍有机会见到这些国际友人们的中国配偶、子女,甚至是第三代。

关键词：国际友人第三代抗日战争习近平总书记足迹亲属座谈会