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T cells from induced and spontaneous models of sLE recognize a common T cell epitope on β2-glycoprotein Ⅰ

Cellular & Molecular Immunology 2019年第8期16卷 685-693页

作者： David salem Rebecca subang Masataka Kuwana jerrold s.levine Joyce Rauch Division of Rheumatology Department of MedicineResearch Institute of the McGill University Health CentreMontrealQCCanada Department of Allergy and Rheumatology Nippon Medical SchoolGraduate School of MedicineTokyoJapan section of Nephrology Department of MedicineUniversity of Illinois at ChicagoChicagoILUSA section of Nephrology Department of MedicineJesse Brown Veterans Affairs Medical CenterChicago IL USA

systemic lupus erythematosus is a prototypic model for B-cell epitope spread in *** to numerous molecularly distinct self-antigens emerge in a sequential manner over several years,leading to disease *** the earliest autoantibodies to appear are those targeting phospholipid-binding proteins,particularlyβ2-glycoprotein Ⅰ.Notably,mice immunized with β2-glycoprotein Ⅰ and lipopolysaccharide develop a strong T cell response to β2-glycoprotein Ⅰ that is associated with autoantibody production and renal disease,similar to that seen in human *** we hypothesized that mice with murine systemic lupus erythematosus,whether induced or spontaneous,should have T cells that recognizeβ2-glycoprotein *** evaluated the response of splenic T cells from mice with induced(C57BL/6 and C3H/HeN)and spontaneous(MRL/lpr)systemic lupus erythematosus to peptides spanning the entire sequence of humanβ*** found that mice with induced and spontaneous systemic lupus erythematosus recognize a common T cell epitope(peptide 31;LYRDTAVFECLPQHAMFG)in domain Ⅲ ofβ2-glycoprotein I.β2GPI-reactive CD4^(+)T cells from the two models differed primarily in cytokine production:T cells from mice with induced sLE expressed IFN-γ,while T cells from MRL/lpr mice expressed both IL-17 and IFN-γ,indicating that IL-17-expressing T cells are not necessary for generating aβ2GPI-reactive T cell *** data suggest that the generation of aβ2-glycoprotein Ireactive T cell response is shared by both induced and spontaneous models of systemic lupus erythematosus and that this T cell response may mediate epitope spread to autoantibodies in both models.

关键词： β2-glycoprotein I T cells systemic lupus erythematosus autoantibodies MHC class II haplotypes

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sino-U.s. partnerships in research, education, and patient care：The experience of the University of Pittsburgh and UPMC

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science China(Life sciences) 2017年第10期60卷 1150-1156页

作者： s.levine Margaret C.McDonald Charles E.Bogosta University of Pittsburgh schools of the Health sciences Pittsburgh PA 15261 USA University of Pittsburgh Medical Center (UPMC) Pittsburgh PA 15219 USA

In 2011, the University of Pittsburgh school of Medicine(UPsOM) and Tsinghua University formed a partnership to further the education of Tsinghua medical students. These students come to UPsOM as visiting research scholars for two years of their eight-year MD curriculum. During this time, the students, who have completed four years at Tsinghua, work full-time in medical school laboratories and research programs of their choice, essentially functioning as graduate students. In their first two months in Pittsburgh, the scholars have a one-week orientation to biomedical research, followed by two-week rotations in four labs selected on the basis of the scholars' scientific interests, after which they choose one of these labs for the remainder of the two *** labs may be in basic science departments, basic science divisions of clinical departments, or specialized centers that focus on approaches like simulation and modeling. The Tsinghua students also have a brief exposure to clinical medicine. UPsOM has also formed a similar partnership with Central south University Xiangya school of Medicine in Changsha, Hunan Province. The Xiangya students come to UPsOM for two years of research training after their sixth year and, thus, unlike the Tsinghua students,have already completed their clinical rotations. UPsOM faculty members have also paved the way for UPMC(University of Pittsburgh Medical Center), UPsOM's clinical partner, to engage with clinical centers in China. Major relationships involving advisory, training, managerial, and/or equity roles exist with Xiangya International Medical Center, KingMED Diagnostics, First Chengmei Medical Industry Group, and Macare Women's Hospital. Both UPsOM and UPMC are actively exploring other clinical and academic opportunities in China.

关键词： medical education research training partnership

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Principles for Code Choice in the ForeignLanguage Classroom： A Focus on Grammaring （Ⅱ）

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基础教育外语教学研究 2014年第11期 19-28页

作者： Glenn s.levine

(上接第10期)***,grammaring and L1 useOne of the arguably central functions of communication in the L2 classroom is explicit communication about language *** of the studies that have examined functions of the L1 in the classroom found communication about grammar to be a common,unmarked context for L1 *** the literature dealing with how adult learners develop grammatical knowledge of the L2,there has been some disagreement about the relative importance of implicit *** learning of grammatical forms and patterns (see *** 2005),but there is overall agreement that explicit learning is important.

关键词：基础教育英语学习学习方法阅读知识

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The oxidative DNA damage response： A review of research undertaken with Tsinghua and Xiangya students at the University of Pittsburgh

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science China(Life sciences) 2017年第10期60卷 1077-1080页

作者： s.levine Luxi sun Rong Tan Ying Gao Lu Yang Hao Chen Yaqun Teng Li Lan UPMC Hillman Cancer Center Pittsburgh PA 15213 USA Department of Microbiology and Molecular Genetics University of Pittsburgh School of Medicine Pittsburgh PA 15219 USA school of Medicine Tsinghua University Beijing 100084 China Xiangya Hospital Central South University Changsha 410008 China

Endogenous stress and exogenous toxicants(chemicals and UV light) alter genetic information either directly or indirectly through the production of reactive oxygen species(ROs), thereby driving genomic instability in cells and promoting tumorigenesis. All living cells try to faithfully preserve and transmit their genomic information from one generation to the next using DNA repair mechanisms to repair oxidative DNA damage to prevent cancer or premature aging. Oxidative DNA damage comprises a mixture of DNA lesions including base damage, DNA single strand breaks(ssBs), and DNA double strand breaks(DsBs). This review summarizes some of the studies on DNA damage response at a defined genome locus that are performed by students from the Tsinghua University school of Medicine and the school of Medicine of Central south University(Xiangya Hospital) at the University of Pittsburgh school of Medicine. A summary of their work highlights the continuous contribution of the students to a particular research program and exemplifies the achievements of this China-U.s. collaborative training program.

关键词： DNA damage chromatin telomere DNA repair

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Primary and secondary prevention of colorectal cancer: An evidence- based review

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Family Medicine and Community Health 2017年第1期5卷 78-84页

作者： sandra J.Gonzalez Maria C.Mejia de Grubb Robert s.levine Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA

Colorectal cancer (CRC) is a common cancer that affects one in three men and one in four women worldwide. Late-stage detection is associated with significantly lower 5-year survival rates. Although it is well established that CRC mortality rates have decreased in the past several decades, adoption of routine screening continues to lag behind screening for other common cancers such as cervical and breast cancer. The decrease in overall rates has been attributed, in part, to improved primary and secondary prevention efforts, including smoking prevention and cessation programs, nutritional counseling, and the use of evidence-based screening protocols, as well as access to better treatment. Despite the increased screening rates, it is estimated that at least one-third of eligible people do not receive appropriate screening. The objective of this review is to describe the current epidemiology of CRC and to demonstrate effective primary and secondary prevention strategies for the primary care provider.

关键词： Colorectal cancer adenocarcinoma modifiable risk factors primary prevention secondary prevention primary care

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smoking,depression,and hospital costs of respiratory cancers:Examining race and sex variation

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Family Medicine and Community Health 2017年第1期5卷 29-42页

作者： Baqar A.Husaini Robert s.levine Phillip Lammers Pam Hull Meggan Novotny Majaz Moonis Tennessee state University NashvilleTNUSA Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Meharry Medical College NashvilleTNUSA Division of Epidemiology Vanderbilt UniversityNashvilleTNUSA Counseling Psychology Tennessee State UniversityNashvilleTNUSA Department of Medicine-Neurology University of Massachusetts Medical SchoolWorcesterMAUSA

Objective:To investigate the effect of smoking and depression on hospital costs for lung cancer(LC).Methods:We extracted data on depression,smoking history,demographics,and hospital charges for patients with respiratory cancers(ICD-9 codes 161-163,165)from the 2008 Tennessee Hospital Discharge Data *** sample(n=6665)was mostly white(86%)and male(57%).Age-adjusted rates were developed in accordance with Centers for Disease Control and Prevention methods,and hospital costs were compared for patients with LC with versus without depression and a smoking ***:Three findings(Ps higher among blacks than among whites,and higher among men than among women;(2)while 66%of LC patients smoked(more men than women without racial variation),24%had depression(more females and whites were depressed);(3)the LC hospital cost was 54%higher than the non-LC hospital cost,and this cost doubled for patients with LC with depression and smoking versus those without such ***:While LC is more prevalent among blacks and men,depression is higher among female and white *** depression with higher costs existed among LC patients,our find-ings point to(1)the possibility of cost savings by diagnosing and treating depression among LC patients,and(2)implementation of proven smoking cessation programs to reduce LC morbidity and hospital costs.

关键词： smoking depression lung cancer race sex

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Depression and race affect hospitalization costs of heart failure patients

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Family Medicine and Community Health 2015年第2期3卷 39-47页

作者： Baqar A.Husaini Robert s.levine Meggan L.Novotny Van A.Cain Uchechukwu K.A.sampson Majaz Moonis Center for Prevention Research Tennessee State UniversityNashvilleTNUSA Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Vanderbilt University Medical Center NashvilleTNUSA Department of Neurology Memorial HospitalWorcesterMAUSA

Objective:Depression and anxiety are frequently observed in heart failure(HF)patients;however,the effect of such factors on hospitalization costs of HF patients,and whether such costs vary by race and gender remain poorly *** analysis delineated the preva-lence of depression/anxiety among HF patients and estimated the effect of race and gender on hospitalization ***:We examined the 2008 files of the Tennessee Hospital Discharge Data system(HDDs)on patients(≥20 years of age)with a primary diagnosis of HF(ICD-9 codes 402,404,and 428)along with demographic data,depression/anxiety diagnoses,hospital costs,and *** the HF sample(n=16,889)53%were female and 23%were *** and gender differences in hospital costs were evaluated for the following three groups:(1)HF patients with depression/anxiety(HF+D);(2)HF-only patients without depression/anxiety(HFO);and(3)HF patients with other mental diagnoses(HF+M).Results:HF was significantly(ps compared to whites,and higher among males than *** 25%of HF patients had depression/anxiety(more whites and females were depressed).HF patients averaged more than 3 comorbidities(blacks had a greater number of comorbidities and hospitalization cost for the year).Costs were higher among HF+D patients compared to HFO *** HF+D patients,costs were higher for black males compared with white *** cost patterns prevailed largely because of higher comorbidities that required more re-admissions and longer hospital ***:Race and depression/anxiety are associated with increased hospitalization costs of HF *** higher costs among blacks reflect the higher burden of comorbidities,such as hypertension and diabetes,which calls for widespread dissemination,adoption,and implementation of proven interventions for the control of these comorbidities.

关键词： Hospitalization costs heart failure race gender depression

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Principles for Code Choice in the Foreign Language Classroom： A Focus on Grammaring （I）

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基础教育外语教学研究 2014年第10期 29-33页

作者： Glenn s. levine

The social and cultural 'turn' in language education of recent years has helped move language teaching and curriculum design away from many of the more rigid dogmas of earlier generations,but the issue of the roles of the learners' first language (L1) in language pedagogy and classroom interaction is far from *** follow a strict 'exclusive target language' pedagogy,while others 'resort to' the use of the L1 for a variety of purposes (see ACTFL 2008).Underlying thesecompeting views is the perspective of the L1 as an impediment to second language learning.

关键词：英语学习学习方法阅读知识阅读材料

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Rural congestive heart failure mortality among Us elderly, 1999-2013: Identifying counties with promising outcomes and opportunities for implementation research

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Family Medicine and Community Health 2015年第2期3卷 27-38页

作者： Maria C.Mejia de Grubb Robert s.levine Barbara Kilbourne Baqar A.Husaini Tyler skelton Lisa Gittner Michael A.Langston George E.Rust Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Department of sociology Tennessee State UniversityNashvilleTennesseeUSA Center for PreventionResearch Tennessee State University College of AgricultureNashvilleTennesseeUSA Department of Political science Texas Tech UniversityLubbockTXUSA Department of Electrical Engineering and Computer science University of TennesseeKnoxvilleTennesseeUSA Department of Family Medicine National Center for Primary CareMorehouse School of MedicineAtlantaGeorgiaUSA

Objective:Describe modern trends in congestive heart failure(CHF)among elderly(>65 years of age)in the United states,to identify potentially successful rural *** CHF mortality using multiple-(MCOD)versus underlying-(UCOD)cause of death ***:*** for Disease Control and Prevention mortality files(WONDER internet site).Results:Using MCOD data,overall mortality rates/100,000 population(and 95%confidence intervals)for CHF among persons>65 years of age(1999-2013)were 482.0(481.2-482.8)for large central and large fringe metropolitan(LCLF)counties,549.6(548.6-550.7)in small and medium metropolitan(sM)counties,and 652.6(650.9-654.0)in micropolitan and non-core,non-metropolitan(MNCNM)*** positive deviance NCNM counties(collectively including 198,581 residents>65 years of age)had an overall CHF rate of 300.9(275.0-326.9)in *** was significantly lower than the LCLF rate for 2013(482.0[481.2-482.8]),and rep-resented a reduction of 47%since *** CHF occurrence as estimated with MCOD was 3.4-fold higher than that obtained with ***:These data illustrate underestimation of CHF by UCOD data and the importance of correct death *** CHF mortality rates are higher than urban rates,but some positive deviance counties demonstrate that this is not *** research is needed to understand the relative contribution of research innovation,medical care,and public health to rural-urban disparities and the relative success of positive deviance counties.

关键词： Congestive heart failure elderly mortality rural

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Consistency Conditions for Cone-Beam CT Data Acquired with a straight-Line source Trajectory

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Tsinghua science and Technology 2010年第1期15卷 56-61页

作者： levine Margo s sIDKY Emil Y Department of Radiology University of Chicago5841 S.Maryland Ave.ChicagoIL 60637USA

A consistency condition is developed for computed tomography （CT） projection data acquired from a straight-line X-ray source trajectory. The condition states that integrals of normalized projection data along detector lines parallel to the X-ray path must be equal. The projection data is required to be untruncated only along the detector lines parallel to the X-ray path, a less restrictive requirement compared to Fourier conditions that necessitate completely untruncated data. The condition is implemented numerically on simple image functions, a discretization error bound is estimated, and detection of motion inconsistencies is demonstrated. The results show that the consistency condition may be used to quantitatively compare the quality of projection data sets obtained from different scans of the same image object.

关键词： data redundancy John's equation consistency conditions

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