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Review of source-monitoring processes in obsessive-compulsive disorder

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World Journal of Psychiatry 2020年第2期10卷 12-20页

作者： Layla Lavalle jerome Brunelin Remy Bation Marine Mondino French National Institute of Health and Medical Research U1028 Centre National de la Recherche Scientifique UMR5292Lyon Neuroscience Research CenterLyon 69000France Lyon University 69000France Centre Hospitalier le Vinatier Batiment 416Bron 69678France Psychiatric Unit Wertheimer Neurologic HospitalBron 69500France

Obsessive-compulsive disorder(OCD)is a severe mental illness characterized by persistent,intrusive and distressing obsessions and/or *** symptoms have been conceptualized as resulting from a failure in sourcemonitoring processes,suggesting that patients with OCD fail to distinguish actions they perform from those they just imagine *** this study,we aimed to provide an updated and exhaustive review of the literature examining the relationship between source-monitoring and OCD.A systematic search in the literature through January 2019 allowed us to identify 13 relevant publications investigating source-monitoring abilities in patients with OCD or participants with subclinical compulsive *** of the retrieved studies did not report any source-monitoring deficits in clinical and subclinical subjects compared with healthy ***,most of the studies reported that patients with OCD and subclinical subjects displayed reduced confidence in source-monitoring judgments or global cognitive confidence compared to *** present review highlighted some methodological and statistical ***,further studies are needed to explore source monitoring with regard to the subcategories of OCD symptoms(i.e.,symmetryordering,contamination-washing,hoarding,aggressive obsession-checking,sexual-religious thoughts)and to clarify the relationship between sourcemonitoring subtypes(i.e.,reality or internal source-monitoring)and confidence in these populations.

关键词： Reality-monitoring Source-monitoring Obsessive-compulsive disorder Subclinical compulsive symptoms

Medium-term clinical efficacy and safety of single incision and modified trans-obturator mid-urethral slings for female stress urinary incontinence

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Gynecology and Obstetrics Clinical Medicine 2022年第2期2卷 57-62页

作者： jerome Melon Paivi k.karjalainen Claire McGannon Joseph k.Lee Anna Rosamilia Pelvic Floor Unit Monash Medical CentreMelbourneVICAustralia Central Finland Central Hospital JyvaskylaFinland Department of Obstetrics and Gynaecology Monash Medical CentreMelbourneVICAustralia University of New South Wales KensingtonNSWAustralia Cabrini Hospital Malvern MelbourneVICAustralia

Aims:To evaluate the medium term efficacy and safety of Altis and Solyx single incision slings(SIS)compared with tension-free vaginal tape(TVT)Abbrevo trans-obturator *** hypothesize that both SIS show little difference in efficacy and safety and perform similarly to TVT ***:We conducted an ambispective comparative cohort study of women with stress urinary incontinence who received a SIS in comparison to matched TVT Abbrevo subjects from a concurrent randomized controlled trial(RCT).Subjects were identified retrospectively,and prospectively invited for examination and questionnaires>12 months *** included intrinsic sphincter deficiency,previous sling surgery,and *** outcome was subjective cure[negative response to International Consultation Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-UI SF)question 6,leakage during coughing/activity].Secondary outcomes include objective cure(negative cough stress test),functional outcomes,and adverse ***:Between 2012 and 2018,a total of 113 women received one of two SIS surgeries;Solyx(n=50)followed by the Altis(n=63);104 were available for final efficacy *** follow-up was 21.7(Altis),46.0(Solyx),and 29.0(Abbrevo)*** characteristics were comparable between the *** was no significant differences in the subjective or objective cure rates between the groups,and no differences in functional outcomes such as patient global impression of improvement,and post-operative ICIQ-UI SF *** was a low rate of mesh related complications and no differences seen between the ***:Despite being an underpowered study,Altis and Solyx SIS have favourable efficacy and safety profiles which are comparable to an established trans-obturator mid-urethral slings(MUS).

关键词： Efficacy Mini-sling Safety Single incision sling Stress urinary incontinence

Assessing Community Health Interventions in Reducing Infant and Child Mortality in the Southeastern Benin

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Nonlinear increase,invisibility,and sign inversion of a localized fs-laser-induced refractive index change in crystals and glasses

Open Journal of Preventive Medicine（预防医学期刊） 2024年第1期

作者： Charles Sossa jerome Daouda Gbadamassi Lamidhi Salami Colette Azandjeme Clémence Metonnou Moussiliou N. Paraiso

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Light(Science & Applications) 2020年第1期9卷 1398-1409页

作者： jerome Lapointe Jean-Philippe Berube Yannick Ledemi Albert Dupont Vincent Fortin Younes Messaddeq Real Vallee Centre d’Optique Photonique et Laser2375 Rue de la TerrasseUniversite LavalG1V 0A6 QuebecQCCanada

Multiphoton absorption via ultrafast laser focusing is the only technology that allows a three-dimensional structural modification of transparent ***,the magnitude of the refractive index change is rather limited,preventing the technology from being a tool of choice for the manufacture of compact photonic integrated *** propose to address this issue by employing a femtosecond-laser-induced electronic band-gap shift(FLIBGS),which has an exponential impact on the refractive index change for propagating wavelengths approaching the material electronic resonance,as predicted by the kramers–kronig *** by theoretical calculations,based on a modified Sellmeier equation,the Tauc law,and waveguide bend loss calculations,we experimentally show that several applications could take advantage of this ***,we demonstrate waveguide bends down to a submillimeter radius,which is of great interest for higher-density integration of fs-laser-written quantum and photonic *** also demonstrate that the refractive index contrast can be switched from negative to positive,allowing direct waveguide inscription in ***,the effect of the FLIBGS can compensate for the fs-laser-induced negative refractive index change,resulting in a zero refractive index change at specific wavelengths,paving the way for new invisibility applications.

关键词： waveguide millimeter refractive

Assessment of left-ventricular diastolic function in pediatric intensive-care patients:a review of parameters and indications compared with those for adults

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World Journal of Pediatrics 2021年第1期17卷 21-30页

作者： Morgan Recher Astrid Botte jerome Soquet Jean-Benoit Baudelet François Godart Stephane Leteurtre ULR 2694-METRICS:évaluation des Technologies de santéet des Pratiques Médicales Univ.LilleCHU Lille59000 LilleFrance Réanimation et Surveillance Continue Pédiatriques Hopital Jeanne de FlandreCHU de Lille59037 Lille CedexFrance Pediatric and Neonatal Intensive Care Unit CHU Bordeaux33076 BordeauxFrance Cardiac Surgery Unit CHU Lille59000 LilleFrance Congenital and Pediatric Cardiology Unit CHU Lille59000 LilleFrance

Background The incidence of diastolic heart failure has increased over *** evaluation of left-ventricular diastolic func-tion is complex,ongoing,and remains poorly performed in pediatric intensive-care *** study aimed to review the literature and to provide an update on the evaluation of left-ventricular diastolic function in adults and children in intensive *** sources We searched data from PubMed/***-two studies were *** pragmatic questions were identified:(1)What is the physiopathology of diastolic dysfunction?(2)Which tools are required to evaluate diastolic func-tion?(3)What are the echocardiographic criteria needed to evaluate diastolic function?(4)When should diastolic function be evaluated in pediatric intensive care?Results Early diastole allows characterization of relaxation,whereas compliance assessments and filling pressures are evalu-ated during late *** evolution of diastolic function differs between adults and *** in adults,decreased compliance occurs at the same time as delayed relaxation in *** function can be evaluated by Doppler *** echocardiographic criteria for ventricular relaxation include the E wave,E/A wave ratio,and isovolumic relaxation *** compliance can be assessed by the E/e'wave ratio,atrial volume,and Ap wave duration during pulmonary vein *** adult intensive-care patients,the E/e'ratio can be used as an index of tolerance for volume expan-sion in septic patients and to adjust the inotropic *** Clinical studies would allow some of these parameters to be validated for use in children in intensive care.

关键词： Diastole Echocardiography Heart failure Intensive-care unit Pediatric

Intramolecular (4+3) cycloadditions of nitrogen-tethered epoxy enosilanes for the synthesis of heteropolycycles

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Chinese Chemical Letters 2019年第8期30卷 1523-1526页

作者： Jiayun He Shuk Mei Lam jerome PLNg Wing-Tak Wong Pauline Chiu State key Laboratory of Synthetic Chemistry Department of ChemistryThe University of Hong KongHong KongChina Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHong KongChina

Furans bearing epoxy enolsilane units via a tether that incorporates a nitrogen heteroatom,undergo intramolecular(4+3)cycloadditions to generate bis-heteroatomic polycyclic adducts having piperidine moieties in their *** cycloadducts,ultimately derived from furfural,a renewal chemical feedstock,are obtained with up to 4:1 dr and with ee retained from the epoxide.

关键词： Heterocycles (4+3)cycloaddition Furan Intramolecular Epoxides Piperidine Polycyclic compounds

New insights into diet breadth of polyphagous and oligophagous aphids on two Arabidopsis ecotypes

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Insect Science 2019年第4期26卷 753-769页

作者： Christopher Wattier Amelie Turbant Lisa Sargos-Vallade jerome Pelloux Christine Rusterucci Anas Cherqui CRRBM (Centre de Ressources Regionales en Biologie Moleculaire) Universite de Picardie Jules Verne Amiens Cedex France EA 3900 BIOPI (Biologie des Plantes et Innovation) Universite de Picardie Jules Verne Amiens Cedex France FRE CNRS 3498 EDYSAN (Ecologie et Dynamique des Systemes Anthropises) University de Picardie Jules Verne Amiens Cedex France

We investigated whether plant ecotype might affect aphid performance and behavioi. The probing behaviors of the polyphagous aphid Myzus persicae and the oligophagous aphid Brevicoryne brassicae on two ecotypes of Arabidopsis thaliana, WS and Col-0 were recorded using the direct current electrical penetration graph method (DC-EPG). Myzus persicae displayed a significant preference for the WS ecotype but was not greatly disturbed on Col-0, while B. brassicae discriminated between the two A. thaliana ecotypes, feeding less on WS than on Col-0. A Principal Component Analysis of aphid probing behavior data recorded on Col-0 and WS ecotypes showed that the one of M. persicae was positively correlated with the phloem ingestion phases while the one of B. brassicae was more related to nonfeeding phase. The survival of the aphid species was followed during early larval stages on the two ecotypes and a significantly higher mortality was observed of B. brassicae neonates compared to M. persicae. Both reared on WS. Moreover, transcriptomic analysis of non infested plant leaves from both ecotypes was monitored and underlined constitutive differences between Col-0 and WS gene expression that might explain the different aphid behaviors. Among a unigene set comprising 39 042 sequences for A. thaliana, 6% were differently expressed affecting, for example, the secondary metabolites and cell wall pathways: two third upregulated in WS and one third upregulated in Col-0. Thus, the "ecotype” variable should be taken into account when setting up a plant-insect experimental research.

关键词： Arabidopsis thaliana Brevicoryne brassicae ecotypes EPG microarray Myzus persicae

Response of soil mite abundance and diversity to a monospecific timber Tectona grandis plantation in Ivory Coast

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Current Zoology 2013年第5期59卷 633-643页

作者： Julien kouadio N'DRI Henri Marc ANDRE Jan LAGERLOEF jerome Ebagnerin TONDOH Thierry HANCE UFR des Sciences de la Nature/Centre de Recherche en Ecologie Universit6 d'Ab0bo-Adjam6 02 BP 801 Abidjan 02 C6te d'Ivoire Mus6e royal de l'Afrique centrale Leuvensesteenweg 13 B-3080 Tervuren Belgium Swedish University of Agricultural Sciences (SLU) Dept. of Ecology EO.Box 7044 SE-750 07 Uppsala Sweden CIAT-TSBF Institut d'Economie Rurale CRRA de Sotuba Laboratoire Sol-Eau-Plante c/o Icraf Sahel BPE 5118 Bamako Mali Universite Catholique de Louvain Biodiversity Research Center Earth and Life Institute Place Croix du Sud 4 B-1348 Lou-vain-la-Neuve Belgium

This study aims to assess the impact of monospecific Tectona grandis forest plantation on the soil mite abundance and diversity. To achieve these objectives, two sites situated in Ivory Coast were investigated. The first, a primary forest was characterized by a very weak human activities whereas the second, a teak plantation was characterized by a high disturbance performed during the planting. After extracting, sorted and description, 116 mite species were described in the two sites. Mite densities were lower in teak plantation and also higher in the litter and decreased to the depth in both sites. Species richness re- corded in teak plantation （52 species） was significantly lower compared to primary forest （98 species）. The same trend was ob- served for Oribatida but not for Gamasida. The lower Oribatida （5 vs. 17） and higher Oribatida （24 vs. 41） were recorded respec- tively in teak plantation and primary forest. Mite Shannon index and evenness were significantly different between sites. High Jaccard index values and the appearance of exclusive species in both habitats showed that the sites are very distinct. Total number of species recorded corresponded to 58%-63% of the total number of species estimated by ACE and Chao 1＆2 estimators, indi- cating that the sampling effort was not sufficient. Mite abundance and diversity varied depending on the characteristics of habi- tats. Chemical element （Corn, Ctot, Ntot, and SOM） values were lower in teak plantation （disturbed habitat） and significantly dif- ferent to primary forest in the topsoil. Apart from litter height, soil depth, pH and C/N ratio, others variables were strongly corre- lated to mite abundance and diversity [Current Zoology 59 （5）： 633-643, 2013].

关键词： Soil mite Teak plantation Diversity and community structure Disturbance.

Physiological and druggable skipping of immunoglobulin variable exons in plasma cells

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Cellular & Molecular Immunology 2019年第10期16卷 810-819页

作者： Mohamad Omar Ashi Nivine Srour Jean-Marie Lambert Anne Marchalot Ophelie Martin Sandrine Le Noir Eric Pinaud Maria Victoria Ayala Christophe Sirac jerome Sauliere jerome Moreaux Michel Cogne Laurent Delpy Unite Mixte de Recherche Centre National de la Recherche Scientifique 7276 INSERM U1262-Controle de la Reponse Immune B et LymphoproliferationsUniversitede LimogesLimogesFrance Institute of Human Genetics CNRS-UM UMR9002Department of Biological HaematologyCHU MontpellierUniversity of MontpellierUFR MedecineMontpellierFrance Institut Universitaire de France Universitede LimogesLimogesFrance Present address:Lady Davis Institute for Medical Research McGill University3755 Cote Ste-Catherine RoadMontrealQC H3T 1E2Canada

The error-prone V(D)J recombination process generates considerable amounts of nonproductive immunoglobulin(Ig)*** recently demonstrated that aberrant Ig chains lacking variable(V)domains can be produced after nonsense-associated altered splicing(NAS)***,the expression of these truncated Ig polypeptides heightens endoplasmic reticulum stress and shortens plasma cell(PC)*** questions remain regarding the molecular mechanisms underlying this new truncated Ig exclusion(TIE-)checkpoint and its restriction to the ultimate stage of B-cell *** address these issues,we evaluated the extent of NAS of Ig pre-mRNAs using an Ig heavy chain(IgH)knock-in model that allows for uncoupling of V exon skipping from TIE-induced *** found high levels of V exon skipping in PCs compared with B cells,and this skipping was correlated with a biallelic boost in IgH transcription during PC *** analysis further revealed that the skipped V exon turned into a ***,we showed that hypertranscription of Ig genes facilitated V exon skipping upon passive administration of splice-switching antisense oligonucleotides(ASOs).Thus,V exon skipping is coupled to transcription and increases as PC differentiation proceeds,likely explaining the late occurrence of the TIE-checkpoint and opening new avenues for ASO-mediated strategies in PC disorders.

关键词： Immunoglobulin Exon skipping Plasma cells Antisense Oligonucleotides Nonsense-associated altered splicing