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Associations between Avocado intake and Lower Rates of incident Type 2 Diabetes in US Adults with Hispanic/Latino Ancestry

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Journal of Diabetes Mellitus 2023年第2期13卷 116-129页

作者： Alexis C. Wood Mackenzie K. Senn jerome i. rotter USDA/ARS Children’s Nutrition Research Center Baylor College of Medicine Houston USA The institute for Translational Genomics and Population Sciences Department of Pediatrics The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Torrance USA

Background/Purpose: Hispanic/Latinos in the US are at increased risk for type 2 diabetes (T2D). Data suggest that avocado intake is associated with better glycemic control, but whether this translates to protection from T2D has not been studied. The goal of the current analyses was to examine whether consuming avocados at baseline is associated with lower incident T2D over a six-year period, compared to not consuming avocados at baseline. Subjects/Methods: Using data from a large population of US adults with Hispanic ancestry, without known or unknown T2D at baseline (N = 6159), participants were classified as avocado consumers (N = 983) or non-consumers (N = 5176) based on the mean of two 24-hour dietary recalls. Cox proportional hazard models estimated the association of avocado consumption with incident T2D (N = 656 cases) over a six-year follow-up period, in the population as a whole, and separately in those with normoglycemia vs. prediabetes at baseline. A set of three sequential models were run: the first controlling only for sociodemographic factors (“minimally adjusted” models), the second for these and health behaviors (“fully adjusted” models), and a third for both sets of covariates and also body mass index (BMi;“fully adjusted + BMi” models). Results: in the population as a whole, avocado intake at baseline was associated with reduced incident T2D in both the minimally adjusted (hazard ratio [HR] (±95% confidence intervals [Cis]): 0.70 (0.52 - 0.94), P = 0.04) and the fully adjusted models (HR: 0.72 (0.54 - 0.97), P = 0.03). This association was observed in both those with prediabetes and with normoglycemia at baseline, but only reached significance in those with prediabetes (minimally adjusted model: HR: 0.68 (0.48 - 0.97), P = 0.03;fully adjusted model: HR: 0.69 (0.48 - 0.98), P = 0.04), not in those with normoglycemia (minimally adjusted model: HR: 0.86 (0.45 - 1.65), P = 0.65;fully adjusted model: HR: 0.80 (0.41 - 1.55), P = 0.50). in models which ad

关键词： Avocado Diet Type 2 Diabetes Dysglycemia Monounsaturated Fats

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维持人类遗传病频率的原因是什么?

世界科学 1989年第6期 43-43,46页

作者： jerome i.rotter 范宗理

进化生物学家们很容易认识到,传染病是两个种间,即寄主和病原菌之间斗争结果的反映.可是,是什么魔力影响着避免遗传病基因的自然选择.使人类遭受遗传病之害呢?从不断增加的病例看,遗传病的基因频率,似乎是由补偿效益所维持的.

关键词：人类遗传病糖尿病患者镰状细胞性贫血杂合子发病率犹太人希伯莱人结核病肌营养障碍基因携带者北欧欧洲

Differentially expressed genes in adipocytokine signaling pathway of adipose tissue in pregnancy

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Journal of Diabetes Mellitus 2013年第2期3卷 86-95页

作者： Dotun Ogunyemi Jun Xu Arnold M. Mahesan Steve Rad Eric Kim Jacqueline Yano Carolyn Alexander jerome i. rotter Y.-D. ida Chen Department of Endocrinology Cedars-Sinai Medical Center Los Angeles USA Department of Medical Education David Geffen School of Medicine at UCLA Los Angeles USA Department of Medical Genetics Cedars-Sinai Medical Center Los Angeles USA Department of Obstetrics and Gynecology Cedars-Sinai Medical Center Los Angeles USA

Objective: To profile the differential gene expression of the KEGG Adipocytokine Signaling pathway in omental compared to subcutaneous tissue in normal pregnancy. Study Design: Subjects included 14 nonobese, normal glucose tolerant, healthy pregnant women. Matched omental and subcutaneous tissue were obtained at elective cesarean delivery. Gene expression was evaluated using microarray and validated by RT-PCR. Differential gene expression was defined as ≥1.5 fold increase at p ix genes were significantly downregulated with two upregulated genes in omental tissue. Downregulation of Adiponectin and insulin Receptor substrate, key genes mediating insulin sensitivity, were observed with borderline upregulation of GLUT-1. There were downregulations of CD36 and acyl-CoA Synthetase Long-chain Family Member 1which are genes involved in fatty acid uptake and activation. There was a novel expression of Carnitine palmitoyltransferase 1C. Conclusion: Differential gene expression of Adipocytokine Signaling Pathway in omental relative to subcutaneous adipose tissue in normal pregnancy suggests a pattern of insulin resistance, hyperlipidemia, and inflammation.

关键词： Adipose Tissue Pregnancy Adipocytokine Pathway insulin Resistance

Associations between Avocado intake and Lower Rates of incident Type 2 Diabetes in US Adults with Hispanic/Latino Ancestry

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Journal of Diabetes Mellitus（糖尿病） 2023年第2期

作者： Alexis C.Wood Mackenzie K.Senn jerome i.rotter

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来到牛津

疯狂英语（新悦读） 2024年第5期 40-42,75页

作者： jerome K.jerome 不详

We left Streatley early the next morn⁃*** were going to Culham,and we wanted to spend the night *** Streatley and Wallingford the river is not very *** from Cleeve,there is quite a long piece of the river which has no *** people are pleased about this because it makes everything much easier,but i quite like locks,myself.i remember that George and i nearly had an accident in a lock once...

关键词： quite has remember

Retinoblastoma: The Situation in Burkina Faso over Ten Years

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Open Journal of Ophthalmology 2024年第3期14卷 175-195页

作者： Amadou Ouattara Anicet Corneille Beremwidougou Paté Sankara Mariam Traore Dolo Tierinyê Armand Meda Windinmanégdé Pierre Djiguimde Rolande Kabore Chantal Gabrielle Bouda Gertrude Augustine Meda Hien jerome Sanou Jean Wenceslas Diallo Ahgbatouhabeba Zabsonre Ahnoux Ophthalmology Department Regional University Hospital of Ouahigouya Ouahigouya Burkina Faso Regional University Hospital of Ouahigouya Ouahigouya Burkina Faso National Center for the Fight against Blindness Ouagadougou Burkina Faso University Hospital of Sour Sanou Bobo-Dioulasso Burkina Faso Nouna District Hospital Nouna Burkina Faso University Hospital of Bogodogo Ouagadougou Burkina Faso University Hospital of Yalgado Ouedraogo Ouagadougou Burkina Faso

Context: in Burkina Faso, there is only one retinoblastoma treatment center located in the capital. Nowadays, the treatment of retinoblastoma has benefited from the contribution of scientific progress. Objective: The aim was to take stock of the situation of retinoblastoma in the pediatric oncology department from January 1, 2010 to December 31, 2019. Materials and Methods: This was a descriptive cross-sectional study with retrospective data collection over a 10-year period, based on records of patients admitted to pediatric oncology department of CHU-YO. Data were analysed using CS Pro version 7.2 software. Categorical variables were compared using Pearsons Chi-square test at the 5% significance level. Overall survival was estimated using the Kaplan-Meier method. Operational definitions were used for lost to follow-up, consultation and diagnosis delays. Results: We collected a total of 204 cases in 10 years, i.e. an annual average of 20.4 cases/year. The mean age at diagnosis was 37.5 months for unilateral cases and 26.4 months for bilateral cases. Male predominance was noted, with a sex ratio of 1.31. The majority of patients came from disadvantaged backgrounds (72% farming fathers and 91% housewives). Clinically, leukocoria and exophthalmos were the main presenting features. The average time to consultation was long (8.73 months) and unilateral localization was predominantly unilateral at 77%. in terms of treatment, 102 patients were eligible for curative treatment and 80 for palliative treatment. The prognosis was poor, with 41% death and numerous cases of lost to follow-up (18%). Overall survival was estimated at 32%. The factor associated with the lethality of retiniblastoma was the extension of the tumor to other organs. Conclusion: Recognition of the early clinical signs of retinoblastoma can anticipate the occurrence of this cancer. Health professionals should be encouraged to perform the Buckner test every time they come into contact with children aged 0 t

关键词： Retinoblastoma Prognosis Pediatric Oncology CHU-YO Burkina Faso

Spatial distribution of Vespa velutina individuals hunting at domestic honeybee hives： heterogeneity at a local scale

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insect Science 2014年第6期21卷 765-774页

作者： Karine Monceau Olivier Bonnard jerome Moreau Denis Thiery iNRA UMR1065 Sante et Agroecologie du Vignoble F-33883 Villenave d'Omon iSVV UMR1065 Sante et Agroecologie du Vignoble Bordeaux Sciences Agro Universite de Bordeaux F-33883 Villenave d'Omon Equipe Ecologie Evolutive UMR 6282 Biogeosciences 6 Bd Gabriel Universite de Bourgogne F-21000 Dijon France

Since its recent introduction into Europe, the yellow-legged hornet, Vespa velutina, has become a major predator of the domestic honeybee, Apis mellifera, but little is known about its hunting behavior. We studied V. velutina hunting behavior by a capture- mark-recapture procedure in an experimental apiary. A total of 360 hornets were captured and tagged, and we determined：（i） the number of hornets visiting the apiary and the changes in time, （ii） the average number of individual visits per half-day and the time elapsed between consecutive recaptures, and （iii） the individual and global distribution of the hornets in the apiary. More than 50% of the marked hornets were recaptured at least once, this increased to 74% in considering the first marked individuals. We estimated 350 hornets visiting the patch daily with at least 1 visit per half-day. The number of marked hornets decreased over time while the number of unmarked ones increased, suggesting a turnover of individuals. The reduction of the delay between consecutive visits indicates that hornets became more efficient over time. Most of the hornets （88%） were recaptured in front of different hives but, overall, the global distribution was aggregative. Hornets were mainly recaptured in front of 1 hive which was neither the smallest nor the biggest colony, suggesting that the major cue used by hornets is not the amount of food. We hypothesize that the defensive behavior of the honeybee colony could explain our results which may be promising to further studies.

关键词： Apis mellifera capture-mark-recapture learning predation Vespidae yellow-legged hornet

Behavioral syndrome in a native and an invasive hymenoptera species

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insect Science 2015年第4期22卷 541-548页

作者： Karine Monceau jerome Moreau Juliette Poidatz Olivier Bonnard Denis Thiery iNRA UMR 1065 Sante et Agroecologie du Vignoble F-33883 Villenave d'Omon France iSVV UMR 1065 Sante et Agroecologie du Vignoble Bordeaux Sciences Agro Universite de Bordeaux F-33883 Villenave d'Omon France Universite de Bourgogne UMR CNRS 6282 Biogeosciences 6 bd Gabriel 21000 Dijon France

Recent studies have focused on the role of behavior in biological invasions. individuals may differ consistently in time for several behavioral traits （personality） which covary （behavioral syndrome） resulting in different behavioral types, some of them favoring invasion. Social hymenopterans have a strong potential to be invaders and their success depends primarily on the foundresses＇ ability to found viable colonies. They are expected to be active, explorative and bold for optimally establishing their nest. in Europe, 2 homet species coexist： the native Vespa crabro and the invasive Vespa velutina. These 2 species may compete for nesting sites and we suggest that the initial success of V. velutina has been favored by its behavior in outperforming V. crabro for the traits involved in nest initiation. Here, we （i） defined the personality of V. crabro and V：. velutina, （ii） tested for the existence of behavioral syndrome in these species, and （iii） compared their performances using an open-field test. Our results show that V. crabro foundresses behave consistently but not V. velutina; this lack of consistency being mainly due to reduced variance among individuals. This result questions the possibility of detecting consistent behavioral differences in species having recently undergone a strong bottleneck. Both species exhibit the same correlations between activity, boldness and exploration and V. velutina clearly outperforms 14. crabro for all traits. Our results suggest that activity, boldness, and exploration are implicated in both hornet nest initiation and invasion process which contributed to explain why social hymenopterans are so successful at colonization.

关键词： animal personality biological invasion invasion syndrome Vespa crabro Vespa velutina Vespidae

Targeting mRNA translation aberrations:A novel approach for therapy in chronic lymphocytic leukemia

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Cancer Communications 2023年第12期43卷 1373-1376页

作者： Vanessa Klapp jerome Paggetti Anne Largeot Etienne Moussay Tumor Stroma interactions Department of Cancer Research Luxembourg Institute of Health Luxembourg Luxembourg Faculty of Science Technology and Medicine University of Luxembourg Esch-sur-Alzette Luxembourg

1 mRNA TRANSLATiON iS AFFECTED iN CHRONiC LYMPHOCYTiC LEUKEMiA(CLL)AT VARiOUS LEVELS mRNA translation dynamics enable tight regulation of protein expression and rapid stress adaptation;however,its contribution to oncogenesis is overlooked compared to genetic and epigenetic *** in mRNA translation are a common feature of cancer and are established as a therapeutic *** is growing evidence of dysregulated protein synthesis in CLL.

关键词： lymphocytic leukemia translation