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Open Journal of Preventive Medicine 2023年第5期13卷 183-197页

作者： Moussiliou Paraïso cyriaque comlan Degbey Yasmine Bakary Ozavino colette Azandjeme charles Sossa-jerome Regional Institute of Public Health University of Abomey-Calavi Abomey-Calavi Benin

Background: Food safety is an integral part of food security. It refers to the protection of the food supply against risks of microbial, chemical and physical origin at every stage of the food chain. The study aimed to investigate the sanitary quality of meals served in the canteens and vicinity of the Lagoon Mother and child University Hospital centre (cHU-MEL) and National Hospital and University centre Hubert Koutoukou Maga (cNHU-HKM) of cotonou. Methods: It was a cross-sectional with a data collection period from 16 March to 22 April 2021. There were 32 vendors surveyed and 40 meals sampled for microbiological examination. We collected data on the vendors’ socio-demographic characteristics, working environment, health status, knowledge and food hygiene practices. Results: About 83% of the meals contained pathogenic microorganisms. All meals had a temperature from 4°c to 60°c called the “danger zone”. The level of knowledge about food hygiene was low in 65.7% of the vendors. About 47% had poor personal and clothing hygiene, food storage and service practices. conclusion: These results show that the meals sold in the cHU-MEL and cNHU-HKM could present a health risk for the consumer. There is a need for improvement of the sanitary quality of the meals delivered in the canteens and vicinity of these hospitals.

关键词： Sanitary Quality Meals canteens cHU-MEL cNHU-HKM Benin

Fatty acid desaturation by stearoyl-coA desaturase-1 controls regulatory T cell differentiation and autoimmunity

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cellular & Molecular Immunology 2023年第6期20卷 666-679页

作者： Elien Grajchen Melanie Loix Paulien Baeten Beatriz F.côrte-Real Ibrahim Hamad Sam Vanherle Mansour Haidar Jonas Dehairs Jelle Y.Broos James M.Ntambi Robert Zimmermann Rolf Breinbauer Piet Stinissen Niels Hellings Sanne G.S.Verberk Gijs Kooij Martin Giera Johannes V.Swinnen Bieke Broux Markus Kleinewietfeld jerome J.A.Hendriks Jeroen F.J.Bogie Department of Immunology and Infection Biomedical Research InstituteHasselt UniversityDiepenbeekBelgium University MS center Hasselt PeltBelgium Neuro-Immune connections and Repair Lab Department of Immunology and InfectionBiomedical Research InstituteHasselt UniversityDiepenbeekBelgium VIB Laboratory of Translational Immunomodulation VIB Center for Inflammation ResearchHasselt UniversityDiepenbeekBelgium Department of Oncology Laboratory of Lipid Metabolism and CancerLKI–Leuven Cancer InstituteKU Leuven-University of LeuvenLeuvenBelgium Department of Molecular cell Biology and Immunology Amsterdam University Medical CenterVrije Universiteit AmsterdamAmsterdam NeuroscienceMS Center AmsterdamAmsterdamThe Netherlands center for Proteomics and Metabolomics Leiden University Medical CenterLeidenThe Netherlands Department of Biochemistry Department of Nutritional SciencesUniversity of Wisconsin-MadisonMadisonUSA Institute of Molecular Biosciences University of GrazGrazAustria BioTechMed-Graz GrazAustria Institute of Organic chemistry Graz University of TechnologyGrazAustria cardiovascular Research Institute Maastricht Department of Internal MedicineMaastricht UniversityMaastrichtThe Netherlands

The imbalance between pathogenic and protective T cell subsets is a cardinal feature of autoimmune disorders such as multiple sclerosis(MS).Emerging evidence indicates that endogenous and dietary-induced changes in fatty acid metabolism have a major impact on both T cell fate and *** date,however,the molecular mechanisms that underlie the impact of fatty acid metabolism on T cell physiology and autoimmunity remain poorly ***,we report that stearoyl-coA desaturase-1(ScD1),an enzyme essential for the desaturation of fatty acids and highly regulated by dietary factors,acts as an endogenous brake on regulatory T-cell(Treg)differentiation and augments autoimmunity in an animal model of MS in a T cell-dependent *** by RNA sequencing and lipidomics analysis,we found that the absence of Scd1 in T cells promotes the hydrolysis of triglycerides and phosphatidylcholine through adipose triglyceride lipase(ATGL).ATGL-dependent release of docosahexaenoic acid enhanced Treg differentiation by activating the nuclear receptor peroxisome proliferator-activated receptor *** findings identify fatty acid desaturation by ScD1 as an essential determinant of Treg differentiation and autoimmunity,with potentially broad implications for the development of novel therapeutic strategies and dietary interventions for autoimmune disorders such as MS.

关键词： Regulatory T cells Autoimmunity Fatty acid metabolism Stearoyl-coA desaturase-1 Multiple sclerosis

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AN/APG-67多功能雷达性能鉴定

现代雷达 1989年第6期11卷 1-16页

作者： Robert L.Nevin jerome c.Hill 杨楠黄淪中

概述 AN/APG-67多功能雷达是一种采用现代技术的相参数字式火控雷达,它是为诺斯罗普公司F-20“虎鲨”式飞机研制的。从1983年初开始对这种雷达进行了飞行试验和鉴定。本报告提出了鉴定的主要结论。 AN/APG-67雷达能够帮助F-20飞机完成... 详细信息

概述 AN/APG-67多功能雷达是一种采用现代技术的相参数字式火控雷达,它是为诺斯罗普公司F-20“虎鲨”式飞机研制的。从1983年初开始对这种雷达进行了飞行试验和鉴定。本报告提出了鉴定的主要结论。 AN/APG-67雷达能够帮助F-20飞机完成空对空和空对地任务。空对空搜索和跟踪工作方式具有上视、下视和边扫描边跟踪方式,以及人工或自动截获转入单目标跟踪的能力。在完成空对地任务时,雷达能对地面和海面动目标进行探测和跟踪,并且有真波束和多卜勒锐化地图测绘和空对地测距功能。

关键词：火控雷达多功能雷达机载雷达

cyberMax ValueMax c5 200+ MMX,HiQ 6x86MX PowerStation,NEc PowerMate Professional,Tri-Star StarStationⅡ——cyrix M2挑战300MHz PentiumⅡ

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电子与电脑 1997年第11期4卷 40-41页

作者： Marty jerome 唐宏

随着cyrix首次推出大家期待已久的M2处理器,市场上涌现出的大量新cPU使用户做出购买决定变得很困难。与此同时,Intel公司也将其Pentium Ⅱ处理器的主频提升到300MHz。这些新产品的陆续问世的确令人困惑,但我们对四种新系统进行预览后发... 详细信息

随着cyrix首次推出大家期待已久的M2处理器,市场上涌现出的大量新cPU使用户做出购买决定变得很困难。与此同时,Intel公司也将其Pentium Ⅱ处理器的主频提升到300MHz。这些新产品的陆续问世的确令人困惑,但我们对四种新系统进行预览后发现,Windows NT的能力在这些系统中比以前得到了更充分的发挥。低标价 cyrix这种最新版处理器芯片的正式名称为6x86MX,有两种型号:200MHz和233MHz,它们主要针对Pentium Ⅱ。

关键词：微处理器 M2 PentiumⅡ

Left Ventricular Diastolic Dysfunction and Silent Myocardial Ischemia amongst Asymptomatic Type 2 Diabetic Patients in Two Referral Hospitals in cameroon

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World Journal of cardiovascular Diseases 2022年第7期12卷 374-381页

作者： Joshua Njimbuc Walinjom jerome Boombhi Martine Etoa collins chenwi Ambe Emerentia Eho Alain Menanga Samuel Kingue Faculty of Medicine and Biomedical Sciences (FMBS) University of Yaoundé I Yaoundé Cameroon Medical and cardiology Unit General Hospital Yaoundé Yaoundé Cameroon central Hospital Yaoundé Yaoundé Cameroon Mvangan District Hospital Mvangan Cameroon

Background: cardiovascular events, the leading cause of death among diabetic patients, are usually under-diagnosed due to subclinical presentation. Methods: We conducted a cross-sectional study from March-2019 to September-2020, in two reference hospitals in Yaoundé, cameroon, to assess the prevalence of asymptomatic Left Ventricular Diastolic Dysfunction (LVDD) and Silent Myocardial Infarction (SMI) and potentially associated factors. Results: Out of 95 participants (mean age ± SD: 43 ± 7 years;M/F sex-ratio 1.6), 22 (23.1%;95% cI: 15.8% - 32.6%) had LVDD and fewer (n = 13, 13.6%;95% cI: 8.2% - 22.0%) had SMI, p = 0.86. Though not statistically significant, patients with ≥5 years diabetes duration, as well as patients with HbA1c ≥ 7.5% had two-fold increased risk of LVDD (p = 0.22 and p = 0.15 respectively). LVDD was significantly higher in patients with SMI (29% vs 6.3%, p conclusion: The significant presence of asymptomatic cardiovascular manifestations in this population entails mandatory preventive screening, especially, in patients with long standing diabetes and poor glycemic control, to allow timely detection and management.

关键词： Asymptomatic cardiovascular Manifestations Left ventricular Diastolic Dysfunction Silent Myocardial Ischemia Type 2 Diabetes cameroon

45kWcO_2激光器大面积cSiB+NiMoco合金化研究

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金属热处理 2000年第1期25卷 11-15页

作者：钟敏霖刘文今清华大学机械系激光加工研究中心北京100084

用45kWcO2激光器在Xc38碳钢上激光合金化获得了表面光洁、无氧化和无裂纹缺陷的大面积合金化层。合金化区的微观组织由马氏体、残留奥氏体和多元共晶所组成,其硬度为61～65HRc。保护气体对于激光合金化结果有明显的影响。与氩气和氮气... 详细信息

用45kWcO2激光器在Xc38碳钢上激光合金化获得了表面光洁、无氧化和无裂纹缺陷的大面积合金化层。合金化区的微观组织由马氏体、残留奥氏体和多元共晶所组成,其硬度为61～65HRc。保护气体对于激光合金化结果有明显的影响。与氩气和氮气保护比较,氦气保护能产生最好的表面光洁度、最细化的微观组织(二次臂间距SAD,Ar∶N2∶He=1∶1∶06)、最高的冷却速率(Ar∶N2∶He=1∶11∶4)、最高的表面硬度(HV02,Ar∶N2∶He=1∶114∶115)、最多的合金元素溶解率(Ar∶N2∶He=1∶11∶15)。这些结果可以用3种气体的物理特性之间差别来很好解释。

关键词：大面积激光合金化激光器保护气体微观组织

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子宫内膜局部的瘦素信号传导系统及其调控

生殖与避孕 2008年第2期28卷 74-79页

作者：张跃辉吴效科曲军卫王勇侯丽辉 Erkkola Risto Strauss jerome 匡海学黑龙江中医药大学附属第一医院妇产科哈尔滨150040 南京大学医学院南京210009 芬兰图尔库大学中心医院妇产科美国弗吉尼亚邦联大学医学院黑龙江中医药大学哈尔滨150040

目的:探讨瘦素及瘦素信号传导系统中各关键信号蛋白在子宫内膜的表达及其调控。方法:健康雌性***-m+/+Leprdb小鼠(实验组)和其同窝出生的雌性野生型c57BL/6J小鼠(对照组)各10只,于16周龄的动情间期进行瘦素刺激实验,用免疫组化法检测瘦... 详细信息

目的:探讨瘦素及瘦素信号传导系统中各关键信号蛋白在子宫内膜的表达及其调控。方法:健康雌性***-m+/+Leprdb小鼠(实验组)和其同窝出生的雌性野生型c57BL/6J小鼠(对照组)各10只,于16周龄的动情间期进行瘦素刺激实验,用免疫组化法检测瘦素及瘦素信号传导系统中各关键信号蛋白在子宫内膜的表达情况。结果:①16周龄时与对照组比,实验组较其体重增加约1倍(Pc)和胰岛素水平增加2-3倍(P<0.01);子宫重量及E2、P、FSH、LH水平显著下降(P<0.05)。阴道涂片发现对照组均出现正常的动情周期,而实验组则始终处于动情间期。②免疫组化研究显示,瘦素信号传导系统的各关键信号蛋白在对照组子宫内膜间质中均有表达,但在子宫瘦素受体缺失组则JAK2为阴性表达,stat3的磷酸化过程也受阻。结论:①瘦素对子宫内膜存在影响。②体内瘦素受体缺失引起机体的高糖脂血症导致了子宫的脂质化,同时子宫局部的瘦素信号传导缺失,均可能参与生殖功能障碍。

关键词：子宫瘦素瘦素受体信号传导

Impact of time to diagnosis on the occurrence of cardiogenic shock in MIS‑c post‑cOVID-19 infection

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World Journal of Pediatrics 2023年第6期19卷 595-604页

作者： Said Bichali Mathilde Bonnet Marie‑Emilie Lampin Jean‑Benoit Baudelet Heloise Reumaux Olivia Domanski Thameur Rakza Alexandre Delarue Morgan Recher jerome Soquet Francois Dubos Stephane Leteurtre Ali Houeijeh Francois Godart Pediatric cardiology Univ.LilleCHU Lille2 Avenue Oscar Lambret59000 LilleFrance Pediatric Intensive care Univ.LilleCHU Lille59000 LilleFrance ULR 2694‑Metrics:Evaluation des Technologies de Sante et des Pratiques Medicales Univ.Lille59000 LilleFrance Pediatric Rhumatology Univ.LilleCHU Lille59000 LilleFrance cardiac Surgery Univ.LilleCHU Lille59000 LilleFrance Pediatric Emergency Univ.LilleCHU Lille59000 LilleFrance

Background In multisystem inflammatory syndrome in children(MIS-c),diagnostic delay could be associated with *** study aims to measure the time to diagnosis in MIS-c,assess its impact on the occurrence of cardiogenic shock,and specify its *** A single-center prospective cohort observational study was conducted between May 2020 and July 2022 at a tertiary care *** meeting the World Health Organization MIS-c criteria were included.A long time to diagnosis was defined as six days or *** on time to diagnosis were collected by two independent *** primary outcome was the occurrence of cardiogenic *** regression and receiver operating characteristic curve analysis were used for outcomes,and a cox proportional hazards model was used for *** Totally 60 children were assessed for inclusion,and 31 were finally analyzed[52%males,median age 8.8(5.7-10.7)years].The median time to diagnosis was 5.3(4.2-6.2)*** univariable analysis,age above the median,time to diagnosis,high c-reactive protein,and high N-terminal pro-B-type natriuretic peptide(NT-proBNP)were associated with cardiogenic shock[odds ratio(OR)6.13(1.02-36.9),2.79(1.15-6.74),2.08(1.05-4.12),and 1.70(1.04-2.78),respectively].In multivariable analysis,time to diagnosis≥6 days was associated with cardiogenic shock[adjusted OR(aOR)21.2(1.98-227)].Time to diagnosis≥6 days had a sensitivity of 89% and a specificity of 77% in predicting cardiogenic shock;the addition of age>8 years and NT-proBNP at diagnosis≥11,254 ng/L increased the specificity to 91%.Independent determinants of short time to diagnosis were agece to tertiary care hospital[aHR 0.27(0.08-0.92)],and the late period of the cOVID-19 pandemic[aHR 2.48(1.05-5.85)].conclusions Time to diagnosis≥6 days was independently associated with cardiogenic shock in *** diagnosis and treatment are crucial to avoid the use of inotropes and

关键词： cOVID-19 Delay in diagnosis Heart failure MIS-c SARS-coV-2

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热成象的数字模拟

红外技术 1984年第3期 63-65页

作者： jerome N. Deutschman 陶勇

在热成象系统的分析中,时常需要对微分辐射率((（?）Wλ)/(（?）T))进行积分。由于适当的工作,验证了波长限λ1和λ2之间积分的级数解。当然不是完整形式的解,但该级数容易借助于使用小型计算机得到数值解。该级数的求导借普朗克黑体辐... 详细信息

在热成象系统的分析中,时常需要对微分辐射率((（?）Wλ)/(（?）T))进行积分。由于适当的工作,验证了波长限λ1和λ2之间积分的级数解。当然不是完整形式的解,但该级数容易借助于使用小型计算机得到数值解。该级数的求导借普朗克黑体辐射定律开始:式中,Wλ是辐射率并且是波长的函数,c1和c2是第一和第二辐射常数,T是绝对温度。得到Wλ对T的偏导数的简单形式:

关键词：方程波长辐射率级数解积分积分学代入上微分上限

Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments

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Horticulture Research 2016年第1期3卷 1-11页

作者： Mahendra Dia Todd c Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla jerome Bernier Benito Juarez Department of Horticultural Science North Carolina State UniversityRaleigh27695-7609NCUSA Plants for Human Health Institute North Carolina Research Campus NCSUKannapolis28081NCUSA clemson University Coastal Research and Education CenterCharleston29414SCUSA Georgia county Extension SW DistrictCordele31015GAUSA Department of Horticulture University of GeorgiaAthens30602GAUSA North Florida REc University of FloridaQuincy32351-5677FLUSA Department of Horticulture Science Texas A&M UniversityCollege Station77845TXUSA USDA-ARS Lane74555OKUSA Monsanto/Seminis Veg.Seeds Woodland95695CAUSA Sakata Seed America Inc.1833 Dunlap Pl.Woodland95776CAUSA

Lycopene is a naturally occurring red carotenoid compound that is found in *** has antioxidant *** content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits *** objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest *** was tested in a subset of 10 *** were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE *** were strong effects of environment as well as G×E interaction on watermelon quality *** the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart *** developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality *** chart will assist in choosing parents for improvement of watermelon *** http://***/cucurbit/wmelon/***.

关键词： stability. sugar stability