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Validating cone-beam computed tomography for peri-implant bone morphometric analysis

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Bone Research 2014年第2期2卷 103-109页

作者： Yan Huang jeroen Van Dessel maarten Depypere mostafa EzEldeen Alexandru Andrei Iliescu Emanuela Dos Santos Ivo Lambrichts Xin Liang Reinhilde Jacobs OmFS ImPATH Research Group Department of Imaging & Pathology Faculty of Medicine University of Leuven and Oral & Maxillofacial SurgeryUniversity Hospitals Leuven Leuven Belgium State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University ESAT/PSI Medical Image Computing KU Leuven Leuven Belgium Faculty of Dentistry UMF Craiova Romania School of Dentistry Pontifical Catholic University of Paraná Curitiba Brazil Biomedical Research Institute Hasselt University Diepenbeek Belgium School of Stomatology Dalian Medical University Dalian China

Cone-beam computed tomography （CBCT） has been recently used to analyse trabecular bone structure around dental implants. To validate the use of CBCT for three-dimensional （3D） peri-implant trabecular bone morphometry by comparing it to two-dimensional （2D） histology, 36 alveolar bone samples （with implants n=27 vs. without implants n=9） from six mongrel dogs, were scanned ex vivo using a high-resolution （80 ~m） CBCT. After scanning, all samples were decalcified and then sectioned into thin histological sections （-6 jim） to obtain high contrast 2D images. By using CTAn imaging software, bone morphometric parameters including trabecular number （Tb.N）, thickness （***）, separation （***） and bone volume fraction （BV/TV） were examined on both CBCT and corresponding histological images. Higher *** and ***, lower BV/TV and Tb.N were found on CBCT images （P〈0.001）. Both measurements on the peri-implant trabecular bone structure showed moderate to high correlation （r=0.65-0.85）. The Bland-Altman plots showed strongest agreement for *** followed by ***, Tb.N and BV/TV, regardless of the presence of implants. The current findings support the assumption that peri-implant trabecular bone structures based on high-resolution CBCT measurements are representative for the underlying histological bone characteristics, indicating a potential clinical diagnostic use of CBCT-based peri-implant bone morphometric characterisation.

关键词： bone CBCT

LC–UV/mS quality analytics of paediatricartemether formulations

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Journal of Pharmaceutical Analysis 2014年第1期4卷 37-52页

作者： Kirsten Vandercruyssen matthias D’Hondt Valentijn Vergote Herwig jansen Christian Burvenich Bart De Spiegeleer Drug Quality and Registration (DruQuaR) group Faculty of Pharmaceutical Sciences Ghent University Dafra Pharma International Slachthuisstraat 30/7 Department of Physiology and Biometrics Faculty of Veterinary Medicine Ghent University

A highly selective and stability-indicating HPLC-method, combined with appropriate sample preparation steps, is developed for β-artemether assay and profiling of related impurities, including possible degradants, in a complex powder for oral suspension. Following HPLC conditions allowed the required selectivity： a Prevail organic acid （OA） column （250 mm＆#215;4.6 mm, 5μm）, flow rate set at 1.5 mL/min combined with a linear gradient （where A ？ 25 mm phosphate buffer （pH 2.5）, and B ？ acetonitrile） from 30% to 75% B in a runtime of 60 min. Quantitative UV-detection was performed at 210 nm. Acetonitrile was applied as extraction solvent for sample preparation. Using acetonitrile-water mixtures as extraction solvent, a compartmental behaviour by a non-solving excipient-bound fraction and an artemether-solubilising free fraction of solvent was demonstrated, making a mobile phase based extraction not a good choice. method validation showed that the developed HPLC-method is considered to be suitable for its intended regulatory stability-quality characterisation of β-artemether paediatric formulations. Furthermore, LC-mS on references as well as on stability samples was performed allowing identity confirmation of the β-artemether related impurities. mS-fragmentation scheme of β-artemether and its related substances is proposed, explaining the m/z values of the in-source fragments obtained.

关键词： Paediatric formulations Sample preparation Polar embedded organicacid column Artemisinin trioxanederivatives Related impurities anddegradation compounds mS-fragmentation

On the Temperature Dependent Excitation and Reflection Spectra of Ln3Al5O12:Ce3+Ceramics (Ln = Y, Lu) for White LEDs

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materials Sciences and Applications 2014年第14期5卷 1074-1078页

作者： Thomas jansen Thomas Jüstel Department of Chemical Engineering Münster University of Applied Sciences Steinfurt Germany

Yttrium aluminum garnet (YAG) and Lutetium aluminum garnet (LuAG) doped with Ce3+ are widely applied phosphor powders or ceramics for the conversion of blue into green to yellow light in the rapidly expanding market of white light emitting high power LEDs. Surprisingly, the temperature dependent reflection and excitation spectra of these well-established materials have not been investigated until today. In this work, we report the temperature dependence of the reflection and excitation spectra of Ce3+ doped YAG and LuAG in the temperature range from 300 to 800 K.

关键词： Temperature-Dependent Reflection Excitation Spectra Garnet Phosphor Ceramics Thermal Population

The Association of Night Shift Work with the Development of Breast Cancer in Women

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Open Journal of Epidemiology 2015年第1期5卷 14-21页

作者： P. I. J. moukangoe m. S. jansen van Rensburg Independent Consultants Johannesburg South Africa

Breast cancer is a serious public health concern in South Africa and globally. It is estimated that one in seven South Africans will develop cancer in their lifetime. According to a case-controlled study, 80% of cancer cases are thought to be due to external, non-inherited factors, which could potentially have been prevented. The objectives of the current case-control study were: 1) to determine the relationship between night shift work and the development of breast cancer;2) to explore the relationship between night shift work and other types of cancer;3) to explore any difference between night shift work and breast cancer, and night shift work and other types of cancer. A total of 106 research participants were selected using non-probability, convenience sampling methods and interviewed using a structured questionnaire. Seventy-two (68%) of the women who were interviewed were black, while 32% (n = 35) were white. Of the 106 research participants, 82% (n = 87) had a history of being employed, while 18% (n = 19) had never been employed. Analysed data showed that 29% (n = 31) of the women had a history of working night shift. Of the 31 research participants who reported having worked night shift, 90% (n = 28) had actually done rotating shift work, rather than regular night shift work. The odds ratio of working night shift was found to be 1.24 (OR = 1.24, p = 0.615) higher in breast cancer research participants compared to research participants diagnosed with other types of cancer—odds ratio of 0.80 (p = 0.610). For rotational work, the OR was 1.445, indicating a higher risk than for shift work. It is recommended that the relationship between working night shift and breast cancer risk be explored further through cross-sectional and cohort studies.

关键词： Breast Cancer Cancer Night Shift Rotating Shift Regular Night Shift Parity Genetic Predisposition

Binding Ability of Corn Cobs Hemicellulose toward Cadmium

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American Journal of Analytical Chemistry 2013年第7期4卷 86-93页

作者： muchlisyam Urip Harahap jansen Silalahi Zul Alfian Department of Chemistry Faculty of Mathematics and Natural Sciences University of North Sumatera Medan Indonesia Faculty of Pharmacy University of North Sumatera Medan Indonesia

Non-Starch Polysaccahride (NSP) is an agricultural byproduct containing of cellulose, hemicelluloses, and lignin. Hemicellulose has a hydroxyl functional group and carboxylic function on the monomer hemicellulose used as a binding ability for cadmium ion and hence as a pharmaceutical active ingredient to prevent cadmium toxicity. The purpose of this study is to isolate and evaluate hemicelluloses from corn cobs as a binding ability toward cadmium ion. The study is conducted by isolating the corn cobs in such way using 0.2 m NaOH, characterization of hemicellulose from corn cobs produced by Infra Red Spectrofotometry. Binding ability of corn cobs hemicellulose (CCH) was done in 3 ways. The first, it was by titrimetric with cadmium 3 mg/cm3 as a titrant and indicator of 0.05 N NaOH. The second, it was by in vitro test at pH 2 as a comparison to use pectin. The third, the in vivo test was conducted in 3 variations of treatment covering CCH 10 mg, 100 mcg of cadmium for 10 weeks. Assay of cadmium was conducted using atomic absorption spectrophotometry with flame at a wavelength of 228.8 nm. The research result showed that the highest yield of hemicellulose (12.04%) was obtained from delignication with 0.03 m NaOH in 60% ethanol and 3% H2O2, hemicellulose isolation with 500 cm3 of 0.2 m NaOH, and precipitation with 1:4 ratio of 10% acetic acid in 95% ethanol. Characteristics of CCH on infrared vibration methods provide vibrational hemicellulose in the region of 1820-1600 cm-1. It meant that the functional group carbonyl was present, and the vibration widened near 3400-2400 cm-1. It indicated that there was the functional group vibration region of hydroxyl. It also meant that there was carboxylic group and finger print at 1500-500 cm-1. Test results of the titrimetric holding ability showed that CCH was binding 100 mg of cadmium (46.17 ± 0.9256) mg or 46.17%. Binding ability test results at pH 2 showed that 300 mg of CCH yield was binding 30 mg cadmium of (26.68 ± 0.1490)

关键词： Corn Cobs Hemicellulose Cadmium Solution Binding Ability In Vitro In Vivo

One-Year Outcomes of Women Started on Antiretroviral Therapy during Pregnancy before and after the Implementation of Option B+ in malawi: A Retrospective Chart Review from Three Facilities

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World Journal of AIDS 2014年第3期4卷 332-337页

作者： Alfred A. Kamuyango Lisa R. Hirschhorn Wenjia Wang Perry jansen Risa m. Hoffman Department of Global Health and Social medicine Harvard Medical School Boston USA Department of medicine and Division of Infectious Diseases David Geffen School of Medicine University of California Los Angeles USA Department of Pathology College of Medicine University of Malawi Blantyre Malawi Department of Statistics University of California Los Angeles USA Hope medical Centre Lilongwe Malawi

Objective: To compare one-year outcomes of women started on antiretroviral therapy (ART) during?pregnancy in the pre-Option B+ era to those in the Option B+ era. methods: A retrospective chart review was performed at three sites in malawi. Women were included in the “pre-Option B+” cohort if they started ART during pregnancy for a CD4 count 3?or WHO 3/4 condition and in the “Option B+” cohort if they started ART during pregnancy regardless of CD4 count or clinical stage. One-year outcomes were compared using Fisher’s exact and ANOVA F-tests. Results: A higher proportion of women in the pre-Option B+ cohort started ART at WHO stage 3/4 (11.9% versus 1.1%, P mens (5.9% versus 0%, P = 0.002), or died in the first year after starting treatment (3.9% versus 0.5%, P = 0.05). While more women in the Option B+ cohort had poor adherence or defaulted, these differences were not significant. Conclusions: At our study sites, the transition to Option B+ has been associated with ART initiation in women with less advanced HIV infection, improved medication tolerability, and lower mortality. Further research is needed to better understand outcomes of Option B+.

关键词： Antiretroviral Therapy Pregnancy Option B+ Prevention of mother-to-Child Transmission

Evolution of the Internet AS-level topology:From nodes and edges to components

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Chinese Physics B 2018年第12期27卷 200-210页

作者： Xiao Liu Jinfa Wang Wei Jing Hai Zhao College of Computer Science and Engineering Northeastern University School of Biosciences Durham University School of Information Engineering Shenyang University

Studying the topology of infrastructure communication networks(e.g., the Internet) has become a means to understand and develop complex systems. Therefore, investigating the evolution of Internet network topology might elucidate disciplines governing the dynamic process of complex systems. It may also contribute to a more intelligent communication network framework based on its autonomous behavior. In this paper, the Internet Autonomous Systems(ASes) topology from 1998 to 2013 was studied by deconstructing and analysing topological entities on three different scales(i.e., nodes,edges and 3 network components: single-edge component m1, binary component m2 and triangle component m3). The results indicate that: a) 95% of the Internet edges are internal edges(as opposed to external and boundary edges); b) the Internet network consists mainly of internal components, particularly m2 internal components; c) in most cases, a node initially connects with multiple nodes to form an m2 component to take part in the network; d) the Internet network evolves to lower entropy. Furthermore, we find that, as a complex system, the evolution of the Internet exhibits a behavioral series,which is similar to the biological phenomena concerned with the study on metabolism and replication. To the best of our knowledge, this is the first study of the evolution of the Internet network through analysis of dynamic features of its nodes,edges and components, and therefore our study represents an innovative approach to the subject.

关键词： complex system Internet AS-level topology evolution network component

Value of a comprehensive geriatric assessment for predicting one-year outcomes in patients undergoing transcatheter aortic valve implantation: results from the CGA-TAVI multicentre registry

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Journal of Geriatric Cardiology 2019年第6期16卷 468-477页

作者： martijn S.van mourik Nathalie van der Velde Giulio mannarino marie-Pierre Thibodeau Jean-Bernard masson Gennaro Santoro Jan Baan Sofie jansen Jana Kurucova martin Thoenes Cornelia Deutsch ANDreas W.Schoenenberger ANDrea Ungar Peter Bramlage m marije Vis Department of Cardiology Amsterdam UMC University of Amsterdam Department of Internal medicine Section of Geriatric Medicine Amsterdam UMC University of Amsterdam Geriatric Intensive Care Unit Department of Geriatrics and Medicine Careggi Hospital and University of Florence Centre Hospitalier de l’Université de montréal Edwards Lifesciences Edwards Lifesciences Nyon Switzerland Institute for Pharmacology und Preventive medicine Department of Geriatrics Inselspital Bern University Hospital University of Bern Switzerland

Background In a three-month report from the CGA-TAVI registry, we found the multidimensional Prognostic Index (mPI) and Short Physical Performance Battery (SPPB) to be of value for predicting short-term outcomes in elderly patients undergoing transcatheter aortic valve implantation (TAVI). In the present analysis, we examined the association of these tools with outcomes up to one year post-TAVI. methods CGA-TAVI is an international, observational registry of geriatric patients undergoing TAVI. Patients were assessed using the mPI and SPPB. Efficacy of baseline values and any postoperative change for predicting outcome were established using logistic regression. Kaplan- meier analysis was carried out for each comprehensive geriatric assessment tool, with survival stratified by risk category. Results One year after TAVI, 14.1% of patients deceased, while 17.4% met the combined endpoint of death and/or non-fatal stroke, and 37.7% the combined endpoint of death and/or hospitalisation and/or non-fatal stroke. A high-risk mPI score was associated with an increased risk of all-cause mortality (aOR = 36.13, 95% CI: 2.77–470.78, P = 0.006) and death and/or non-fatal stroke (aOR = 10.10, 95% CI: 1.48–68.75, P = 0.018). No significant associations were found between a high-risk SPPB score and mortality or two main combined endpoints. In contrast to a worsening SPPB, an aggravating mPI score at three months post-TAVI was associated with an increased risk of death and/or non-fatal stoke at one year (aOR = 95.16, 95% CI: 3.41–2657.01). Conclusions The mPI showed value for predicting the likelihood of death and a combination of death and/or non-fatal stroke by one year after TAVI in elderly patients.

关键词： Comprehensive geriatric assessment multidimensional prognostic index Short physical performance battery Silver code Transcatheter aortic valve implantation

Is there a role for surgery in stage ⅢA-N2 non-small cell lung cancer?

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中国肺癌杂志 2008年第5期11卷 615-621页

作者： Paul E.VAN SCHIL michèle DE WAELE jeroen m.HENDRIKS Patrick R.LAUWERS Department of Thoracic and Vascular Surgery University of Antwerp

The role of surgery in stage ⅢA-N2 non-small cell lung cancer(NSCLC) remains *** important prognostic factors are mediastinal downstaging and complete surgical *** restaging techniques exist to evaluate response after induction therapy and these are subdivided into non-invasive,invasive and alternative or minimally invasive *** contrast to imaging or functional studies,remediastinoscopy provides pathological evidence of response after induction *** techn...

关键词： Lung neoplasms Neoplasm staging Induction therapy mediastinoseopy Postoperative Intraoperative comphations