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Bio-Design and manufacturing 2019年第3期2卷 145-152页

作者： Ivo Radice jeroen H.m.Bergmann Department of Engineering Science Old Road Campus Research BuildingInstitute of Biomedical EngineeringUniversity of OxfordHeadingtonOxfordUK

Gripping devices help patients carry out everyday tasks and increase their ***,there seems to be a lack of bionic gripping technologies that can fully adapt to any possible shape,as the use of artificial fingers and predetermined grip settings limits the operating *** development of a more agile device,which is operated by a simple control paradigm,could greatly benefit *** electrorheological(ER)fluid system should be able to adapt to the shape of an object and then hold that *** aim of this study was to explore if a conceptual prototype of an ER system could hold a geometric shape when it is activated.A test rig was constructed with a moving part(set in different silicone oils)that could be displaced using a *** particles were dispersed in the silicone oils,and a field with a voltage of 4 kV mm?1 was generated to activate the *** results show that the developed system can support an increased force when activated and hold a simple geometric position without any noticeable *** outcome provides an initial proof of concept for a possible new(gravity-assisted)gripping approach using smart fluids,which could be developed with materials that are biocompatible and widely available.

关键词： Smart materials Prosthetics Exoskeleton Grasping manipulation Assistive technologies

较大直肠腺瘤中经肛门内镜显微手术与内镜下黏膜切除术的随机对照试验(TREND研究)

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英国医学杂志中文版 2018年第11期21卷 676-676页

作者： Renee m Barendse Gijsbert D musters Eelco J R de Graaf Frank J C van den Broek Esther C J Consten Pascal G Doornebosch James C Hardwick Ignace H J T de Hingh Chrisiaan Hoft jeroen m jansen A W marc van milligen de Wit George P van der Schelling Erik J Schoon matthijs P Schwartz Bas L A m Weusten marcel G Dijkgraaf Paul Fockens Willem A Bemelman Evelien Dekker TREND研究小组李佳宁(译) 吴东(校) 不详北京协和医院消化科

摘要目的非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EmR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEm)同样有效,但EmR可能更具成本效益且相对安全。本试验旨在对比摘除较... 详细信息

摘要目的非随机研究表明内镜下黏膜切除术(endoscopic mucosal resection,EmR)在切除直肠较大腺瘤时与经肛门内镜显微手术(transanal endoscopic microsurgery,TEm)同样有效,但EmR可能更具成本效益且相对安全。本试验旨在对比摘除较大直肠腺瘤时EmR与TEm的临床结局与成本效益。

关键词：随机对照试验显微手术切除术内镜黏膜肛门肠腺成本效益

Parameter Ecology for Feedback Vertex Set

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Tsinghua Science and Technology 2014年第4期19卷 387-409页

作者： Bart m.P.jansen Venkatesh Raman martin Vatshelle the Department of Informatics University of Bergen 5005 Bergen Norway the Institute of mathematical Sciences Chennai India

This paper deals with the FEEDBACK VERTEX SET problem on undirected graphs, which asks for the existence of a vertex set of bounded size that intersects all cycles. Due it is theoretical and practical importance,the problem has been the subject of intensive study. motivated by the parameter ecology program we attempt to classify the parameterized and kernelization complexity of FEEDBACK VERTEX SET for a wide range of *** survey known results and present several new complexity classifications. For example, we prove that FEEDBACK VERTEX SET is fixed-parameter tractable parameterized by the vertex-deletion distance to a chordal graph. We also prove that the problem admits a polynomial kernel when parameterized by the vertex-deletion distance to a pseudo forest, a graph in which every connected component has at most one cycle. In contrast, we prove that a slightly smaller parameterization does not allow for a polynomial kernel unless NP coNP=poly and the polynomial-time hierarchy collapses.

关键词： feedback vertex set parameterized complexity parameter ecology program structural parameterizations kernelization

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FRAmE STORE

现代装饰 2014年第7期 106-111页

作者： jaspar jansen jeroen Dellensen 姜敏华 i29 interiorar chitects

全球顶尖店面设计杂志FRAmE与阿姆斯特丹FOAm摄影博物馆携手,在一栋具有历史意义的Felix meritis大楼内带来一次极富创造力的设计碰撞。项目位于阿姆斯特丹Keizersgracht324号,一个创新性平台由此开启。在这里,未来将举办更多由FRAmE杂... 详细信息

全球顶尖店面设计杂志FRAmE与阿姆斯特丹FOAm摄影博物馆携手,在一栋具有历史意义的Felix meritis大楼内带来一次极富创造力的设计碰撞。项目位于阿姆斯特丹Keizersgracht324号,一个创新性平台由此开启。在这里,未来将举办更多由FRAmE杂志与FOAm博物馆联手组织的一系列活动和展览,同时,FRAmE还规划了两个零售空间,由荷兰空间建筑事务所i29 interior architects进行设计。

关键词：建筑装饰室内装饰装饰材料环保材料

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Delivery of micro RNAs by plant virus-based nanoparticles to functionally alter the osteogenic differentiation of human mesenchymal stem cells

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Chinese Chemical Letters 2023年第1期34卷 215-220页

作者： Fei Xue jeroen J.L.m.Cornelissen Quan Yuan Shuqin Cao State Key Laboratory of Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Department of molecules&materials MESA+Institute for NanotechnologyUniversity of TwenteEnschede AE 7500the Netherlands

micro RNA-26a(miR-26a)has been verified to promote osteogenic differentiation of mesenchymal stem cells in recent *** main obstacles to its application in bone regeneration are instability in the physiological environment and low efficiency of cellular membrane *** overcome these problems,we constructed a novel plant virus gene delivery system based on Cowpea chlorotic mottle virus(CCmV).By encapsulating miR-26a with purified capsid protein(CP)dimers derived from CCmV,CPmiR-26a(CP26a)virus-like particles(VLPs)were ***26a retained a structure similar to the native CCmV and protected miR-26a from digestion with its exterior ***,CP26a featured similar cellular uptake efficiency,osteogenesis promotion ability,and better biocompatibility compared with Lipofectamine2000-miR-26a(lipo26a),which indicated a promising prospect for CCmV as a novel gene delivery system.

关键词： VLPs Cowpea chlorotic mottle virus Gene delivery microRNAs Osteogenesis

The efficacy and effectiveness of machine learning for weaning in mechanically ventilated patients at the intensive care unit: a systematic review

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Bio-Design and manufacturing 2019年第1期2卷 31-40页

作者： man Ting Kwong Glen Wright Colopy Anika m.Weber Ari Ercole jeroen H.m.Bergmann Department of Engineering Science University of OxfordParks Road. Oxford OXI 3PJ. UK snap40 Inc.125 Princess Street Edinburgh EH2 4AD UK CRUK/mRC Oxford Institute for Radiation Oncology.Roosevelt Drive Oxford OX3 7DQ. UK Division of Anaesthesia Addenbrooke's Hospital University of Cambridge Hills Road Cambridge CB2 0QQ. UK

Weani ng from mechanical ventilation in the in tensive care unit (ICU) is a complex clinical problem and relevant for future organ engineering. Prolonged mechanical ventilation (mV) leads to a range of medical complications that increases length of stay and costs as well as contributes to morbidity and even mortality and long-term quality of life. The need to reduce mV is both clinical and economical. Artificial intelligence or machine learning (mL) methods are promising opportunities to positively influence patient outcomes. mL methods have been proposed to enhance clinical decisions processes by using the large amount of digital information generated in the ICU setting. There is a particular interest in empirical methods (such as mL) to improve management of "difficult-to-wean" patients, due to the associated costs and adverse events associated with this population. A systematic literature search was performed using the OVID, IEEEXplore, Pubmed, and Web of Science databases. All publications that included (1) the application of mL to weaning from mV in the ICU and (2) a clinical outcome measurement were reviewed. A checklist to assess the study quality of medical mL publications was modified to suit the critical assessment of mL in mV weaning literature. The systematic search identified nine studies that used mL for weaning management from mV in critical care. The weaning management application areas included (1) prediction of successful spontaneous breathing trials (SBTs),(2) prediction of successful extubation,(3) prediction of arterial blood gases, and (4) ventilator setting and oxygenation-adjustment advisory systems. Seven of the nine studies scored seven out of eight on the quality index. The remaining two of the nine studies scored one out of eight on the quality index. This scoring may, in part, be explained by the publications' focus on technical novelty, and therefore focusing on issues most important to a technical audience, instead of issues most impor

关键词： Artificial intelligence Patient-centred medicine Clinical trial Critical care Data science

Accuracy of sedimentgraph modeling from topography map scale and DEm mesh size

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International Soil and Water Conservation Research 2019年第2期7卷 138-149页

作者： Seyed Hamidreza Sadeghi mostafa moradi Dashtpagerdi Hamidreza moradi Rekabdarkoolai jeroen m.Schoorl Department of Watershed management Engineering Faculty of Natural ResourcesTarbiat Modares UniversityNoor 46417-76489MazandaranIran Department of Environmental Sciences Soil Geography and landscapeWageningen University and ResearchPO Box 47 6700AA WageningenThe Netherlands

The evaluation of scale effects on modeling performance of sedimentgraphs as the ultimate outputs of the hydrological simulation is vital for adaptive watershed *** present study therefore analyzed effectability of simulated sedimentgraphs components in association with different topographic maps with various vector *** whole procedure was materialized to select the critical scale and cell size for the Galazchai Watershed,*** this end,the stormwise sedimentgraphs were modeled for 23 recorded events using the Clark's Instantaneous Unit Hydrograph (IUH) model stemmed for developing Instantaneous Unit Sedimentgraphs (IUSGs) incorporated with dimensionless sediment concentTation distribution (DSCD) based on the vector scales of 1∶25000,1∶50000,1∶100000 and 1∶250000 and cell sizes of 5,10,20 30,50,100 and 200 *** 644 direct sedimentgraphs (DSGs) were then evaluated based on Relative Errors (REs) for sediment volume,peak sediment,time to peak,base time and the Coefficient of Efficiency (CE).The results confirmed that REs for peak sediment,time to peak and CE were sensitive to cell *** results further verified that the cell sizes of 5,20,30,50 and 100 m were critical cell sizes in viewpoint of time to *** addition,the vector scales of 1∶50000 with cell size of 50 m,and 1∶100000 with cell sizes of 5 and 10 m were critical vector scales and cell sizes based on RmSE evaluation *** is concluded from the current research that the accuracy of simulation of sedimentgraph was influenced by map scales and mesh sizes.

关键词： multiscale modeling Sedimentgraph variability Spatial Resolution Watershed simulation

Spatio-temporal Variability of Soil Water at Three Seasonal Floodplain Sites: A Case Study in Tarim Basin,Northwest China

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Chinese Geographical Science 2014年第6期24卷 647-657页

作者： Sven GRASHEY-jansen martin KUBA Bernd CYFFKA müt HALIK Tayierjiang AISHAN Institute of Geography University of Augsburg Augsburg 86135Germany Applied Physical Geography Catholic University of Eichstaett-Ingolstadt Eichstaett 85072Germany Key Laboratory of Oasis Ecology College of Resources and Environmental ScienceXinjiang University

The floodplain -egetation of the Tarim River in Northwest China is strongly influenced by irrigated agriculture. The abstrac- tion of river water disturbs; the natural dynamics of the floodplain ecosystem. The human impact on the hydrological system by bank dams and the irrigation of cotton plantings have caused adverse changes of the Tarim River and its floodplains, so the current stocks of the typical Tugai vegetation show significant signs of degradation. Field studies of soils and statistical analysis of soil moisture data have shown that the vitality of the Tugai vegetation is primarily determined by its position to the riverbank and the groundwater. There exist complex interactions between soil hydrological conditions and the vitality of the vegetation. But the availability of water is not only influenced by the groundwater level and seasonal flood events. The spatial distribution of stocks at different states of vitality seems also to be decisively influenced by physical soil properties. Our results show that the water supply of plant communities is strongly in- fluenced by the soil texture. Spatial differences of soil moisture and corresponding soil water tensions may be the decisive factors for the zonafion of vegetation. Physical soil properties control the water retention and rising of capillary water from deeper soil layers and the phreatic zone and may supply the root systems of the phreatophytic vegetation with water. Keywords： soil moisture;soil texture; soil water tensions; Tarim River; water retention

关键词： soil moisture soil texture soil water tensions Tarim River water retention

Evaluation of large language models for the classification of medical device software

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Bio-Design and manufacturing 2024年第5期7卷 819-822页

作者： Yu Han Aaron Ceross Florence Bourgeois Paulo Savaget jeroen H.m.Bergmann Department of Engineering Science University of OxfordOld Road CampusOxford OX37QDUK Harvard-mIT Center for Regulatory Science Harvard Medical SchoolBostonMAUSA Computational Health Informatics Program(CHIP) Boston Children’s HospitalBostonMAUSA Department of Technology and Innovation The University of Southern DenmarkOdenseDenmark

Amidst the rapidly expanding integration of large language models(LLms)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

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OFFICE 05

现代装饰 2015年第4期 108-111页

作者： Jaspar jansen jeroen Dellensen Ewout Huibers 姜敏华 i29 interior architects

继荷兰i29空间建筑设计事务所与VmX建筑事务所为Combiwerk公司成功设计工作室之后,双方再度联袂合作,为位于荷兰阿姆斯特丹的媒体代理公司mediaXplain创造了一个全新的办公项目,将建筑与室内设计进行了完美的无缝连接。项目地处阿姆斯... 详细信息

继荷兰i29空间建筑设计事务所与VmX建筑事务所为Combiwerk公司成功设计工作室之后,双方再度联袂合作,为位于荷兰阿姆斯特丹的媒体代理公司mediaXplain创造了一个全新的办公项目,将建筑与室内设计进行了完美的无缝连接。项目地处阿姆斯特丹老港口,是一栋工业建筑,风格上可以兼容大胆的内部装饰。

关键词：建筑设计事务所设计工作室全开放式媒体代理无缝连接室内设计工作区 OFFICE 建筑立面内部装饰