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RegCM3对东亚环流和中国气候模拟能力的检验

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热带气象学报 2007年第5期23卷 444-452页

作者：张冬峰欧阳里程高学杰赵宗慈 PAL jeremy s GIORGI Filippo 中国科学院大气物理研究所广州国际专业气象台国家气候中心 The Abdus salamInternational Centre for Theoretical Physics 34100 TriesteItaly

使用RegCM3区域气候模式,嵌套ERA40再分析资料,对东亚地区进行了15年（1987～2001年）时间长度的数值积分试验,分析了模式对东亚平均环流及中国地区气温和降水的模拟。结果表明,模式对东亚平均环流的特征和中国地区降水、地面气温的年... 详细信息

使用RegCM3区域气候模式,嵌套ERA40再分析资料,对东亚地区进行了15年（1987～2001年）时间长度的数值积分试验,分析了模式对东亚平均环流及中国地区气温和降水的模拟。结果表明,模式对东亚平均环流的特征和中国地区降水、地面气温的年、季地理分布和季节变化特征均具有一定的模拟能力,对气温和降水年际变率的模拟也较好。此外模式模拟在测站稀少地区,可以提供局地如降水分布更可靠的信息。模式对气温的模拟存在1-3℃的系统性冷偏差;对中国地区降水地理分布的模拟也存在一定偏差,如对年平均降水的模拟中,降水最大值位置与观测有一定差距,特别是对冬季降水中心的模拟存在较大偏差。模式模拟的夏季降水,在中国北方地区总体偏大100-200 mm,南方总体偏小100-200 mm。模式对地面气温的模拟效果好于降水。

关键词：区域气候模式气候模拟检验东亚地区中国

Genome-Wide sequencing of 41 Rice （Oryza sativa L.） Mutated Lines Reveals Diverse Mutations Induced by Fast-Neutron Irradiation

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Molecular Plant 2016年第7期9卷 1078-1081页

作者： Li, Guotian Chern, Mawsheng Jain, Rashmi Martin, Joel A. schackwitz, Wendy s. Jiang, Liangrong Vega-sanchez, Miguel E. Lipzen, Anna M. Barry, Kerrie W. schmutz, jeremy Ronald, Pamela C. Univ Calif Davis Dept Plant Pathol Davis CA 95616 USA Univ Calif Davis Genome Ctr Davis CA 95616 USA Lawrence Berkeley Natl Lab Feedstocks Div Joint BioEnergy Inst Berkeley CA 94720 USA Us DOE Joint Genome Inst Walnut Creek CA 94598 USA Xiamen Univ Sch Life Sci Xiamen 361102 Peoples R China HudsonAlpha Inst Biotechnol Huntsville AL 35806 USA Monsanto Co Chesterfield Village Campus Chesterfield MO 63017 USA

Fast-neutron （FN） irradiation has been used to create mutagen- ized collections of many plant species （Bolon et al., 2014）, FN- induced mutagenesis has clear advantages： it is an efficient means of saturating the genome, and it does not involve time- consuming plant transformation or tissue culture. In rice, most mutant collections, although highly valuable, were generated us- ing either T-DNA insertion or transposon tagging approaches that often induce mutations unlinked to the insertion and complicating analysis （Wang et al., 2013）. Another disadvantage of some of these collections is that they were created in rice varieties that are photoperiod-sensitive and often have long generation times.

关键词： mutagenesis genome valuable

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儿童脓毒症

英国医学杂志中文版 2017年第4期20卷 205-219页

作者： Adrian Plunkett jeremy Tong 林瑶杜忠东 Birmingham Children's Hospital Birmingham UK University Hospitals of Leicester NHs Trust Leicester UK 首都儿科研究所附属儿童医院首都医科大学附属北京儿童医院

脓毒症（sepsis）是一种由感染导致的全身炎症反应综合征。其特征在于泛化的促炎症瀑布反应，由此可能导致广泛的组织损伤，依据严重程度不同，包括一系列临床谱：严重脓毒症、脓毒性休克，以及多脏器衰竭。脓毒症是全球儿童发病和死亡... 详细信息

脓毒症（sepsis）是一种由感染导致的全身炎症反应综合征。其特征在于泛化的促炎症瀑布反应，由此可能导致广泛的组织损伤，依据严重程度不同，包括一系列临床谱：严重脓毒症、脓毒性休克，以及多脏器衰竭。脓毒症是全球儿童发病和死亡的主要原因。

关键词：儿童脓毒症炎症反应综合征医学研究

Dependence of interface energetics and kinetics on catalyst loading in a photoelectrochemical system

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Nano Research 2019年第9期12卷 2378-2384页

作者： Yumin He srin ivas Vanka Tianyue Gao Da He jeremy Espano Yanyan Zhao Qi Dong Chaochao Lang Yongjie Wang Thomas W. Hamann Zetian Mi Dunwei Wang Department of Chemistry Merkert Chemistry CenterBoston College2609 Beacon StreetChestnut HillMassachusetts 02467USA Department of Electrical Engineering and Computer science University of Michigan1301 Beal AvenueAnn ArborMichigan 48109USA Department of Chemistry Michigan State UniversityEast LansingMichigan 48824USA Department of Electrical and Computer Engineering McGill University3480 University StreetMontrealQuebecH3A 0E9Canada

solar hydrogen production by the photoelectrochemical method promises a means to store solar *** it is generally understood that the process is highly sensitive to the nature of the interface between the semiconductor and the electrolyte,a detailed understanding of this interface is still *** instance,few prior studies have established a clear relationship between the interface energetics and the catalyst loading *** we aim to study this relationship on a prototypical si-based photoelectrochemical *** types of interfaces were examined,one with GaN nanowires as a protection layer and one *** was found that when GaN was present,higher Pt loading (> 0.1 μg/cm2) led to not only better water reduction (and,hence,hydrogen evolution) kinetics but also more favorable interface energetics for greater *** the absence of the protection layer,by stark contrast,increased Pt loading exhibited no measurable influence on the interface energetics,and the main difference was observed only in the hydrogen evolution *** study sheds new light on the importance of interface engineering for further improvement of photoelectrochemical systems,especially concerning the role of catalysts and protection layers.

关键词： photoelectrochemistry water splitt ing si hydroge n evolutio n catalyst nano wires

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作为医学人文教育核心的历史学

广西民族大学学报（哲学社会科学版） 2018年第2期40卷 114-128页

作者： [美]David s. Jones [美]jeremy A. Greene [美]Jacalyn Duffin [美]John Harley Warner 方芗(译) 美国哈佛大学历史系约翰斯·霍普金斯大学皇后大学耶鲁大学医学史系中山大学社会学与人类学学院广东广州510275

尝试从不同的角度讨论史学对于医学核心能力在知识、论证和操作上所发挥的作用。史学对于了解疾病的成因(如非还原论机制需要计算疾病长期以来的变化量)、疗效(如为什么医生认为他们的治疗方案有效,还有就是他们在不同时期的评估方式的... 详细信息

尝试从不同的角度讨论史学对于医学核心能力在知识、论证和操作上所发挥的作用。史学对于了解疾病的成因(如非还原论机制需要计算疾病长期以来的变化量)、疗效(如为什么医生认为他们的治疗方案有效,还有就是他们在不同时期的评估方式的变化)有核心贡献。同时有助于了解医学知识和实际操作在不同的社会、经济和政治背景中的偶然性。这些都是医生作为诊断者和治疗者需要知道的。因此史学恰恰能被纳入医学教育中最为盛行的核心技能的培养。

关键词：医学史医学教育医学人文

Beyond the Western Horizon in Educational Research: Toward a Deeper Dialogue About Our Interdependent Futures

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ECNU Review of Education 2020年第1期3卷 3-19页

作者： Iveta silova jeremy Rappleye Yun You Arizona state University Kyoto University East China Normal University

Despite awareness that simple dichotomies are cul-de-sacs for our research imagination,these academic standoffs continue to shape cultural space and research *** of the most salient,if conflicting,currents in educational research gaining momentum over the past decade have been what Mignolo(2011)has usefully termed“Rewesternization”and“Dewesternization.”The former indicates an array of projects,both theoretical and empirical,that seek to expand the scope and depth of the modern Western paradigm,in particular liberal truths and neoliberal *** examples include the Western-led expansion of international large-scale learning assessments,the apparent triumph of Knowledge Capital Theory,and the shaping of the sustainable Development Goals toward liberal(and often neoliberal)policies long preferred in Anglo-American policy circles.

关键词： spite Deep Beyond

P2X7 receptor signaling during adult hippocampal neurogenesis

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Neural Regeneration Research 2019年第10期14卷 1684-1694页

作者： Hannah C. Leeson Tailoi Chan-Ling Michael D. Lovelace jeremy C. Brownlie Ben J. Gu Michael W. Weible II Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia Griffith Institute for Drug Discovery Griffith UniversityBrisbaneQueenslandAustralia Discipline of Anatomy and Histology School of Medical ScienceThe University of SydneySydneyNew South WalesAustralia Bosch Institute The University of SydneySydneyNew South WalesAustralia Applied Neurosciences Program Peter Duncan Neurosciences Research UnitSt. Vincent’s Centre for Applied Medical ResearchSydneyNew South WalesAustralia Faculty of Medicine St. Vincent’s Clinical SchoolUniversity of New South Wales SydneySydneyNew South WalesAustralia school of Environment and science Griffith UniversityBrisbaneQueenslandAustralia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoriaAustralia

Neurogenesis is a persistent and essential feature of the adult mammalian *** neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new *** of hippocampal neurogenesis is complex and multifaceted,and numerous signaling pathways converge to modulate cell proliferation,apoptosis,and clearance of cellular debris,as well as synaptic integration of newborn immature *** expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored.P2X7 receptors are exceptionally versatile:in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation.P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication,and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form,which induce apoptotic cell death through cytosolic ion ***,as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis,as well as during some disease *** how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative *** review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus,and neural stem and progenitor cells.

关键词： P2X7 P2X7R adult neurogenesis neural stem cells neural progenitor cells hippocampus sGZ calcium signaling purinergic signaling

High-performance carbon fiber/gold/copper composite wires for lightweight electrical cables

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Journal of Materials science & Technology 2020年第7期42卷 46-53页

作者： Thang Q.Tran jeremy Kong Yoong Lee Amutha Chinnappan Nguyen Huu Loc Long T.Tran Dongxiao Ji W.A.D.M.Jayathilaka Vishnu Vijay Kumar seeram Ramakrishna Department of Mechanical Engineering National University of Singapore9 Engineering Drive 1EA-07-05Singapore 117575Singapore Faculty of Mechanical Engineering Ho Chi Minh City University of TechnologyVNUHCM268 Ly Thuong KietDistrict 10Ho Chi Minh City 740400Viet Nam

In this study,we synthesized high-performance Carbon Fiber/Gold/Copper(CF/Au/Cu)composite wires by using a 2-step deposition method via sputtering and *** Au was sputtered on PANbased CFs as a pre-treatment,the wettability and surface reactivity of the CFs were improved,resulting in a homogeneous deposition of Cu on their *** different Cu electrodeposition time,the resulting CF/Au/Cu composite wires could possess a high strength of up to 3.27 GPa(~10 times stronger than copper wires)while their electrical conductivity could be as high as 4.4×10^5 s/cm(~75%of that for copper).More importantly,since the composite wires were lightweight(up to 70%lower than Cu mass density),they are a promising candidate to substitute conventional heavy metal wires in the future electrical applications.

关键词： Carbon fiber Copper composite wires strength Electrical properties

Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

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Journal of Pharmaceutical Analysis 2018年第6期8卷 407-412页

作者： Jayesh A.Dhanani suzanne L.Parker Jeffrey Lipman steven C.Wallis jeremy Cohen John Fraser Adrian Barnett Michelle Chew Jason A.Roberts Burns Trauma and Critical Care Research Centre The University of Queensland UQ Centre for Clinical Research Department of Intensive Care Medicine Royal Brisbane & Women's Hospital Faculty of Health Queensland University of Technology Critical Care Research Group The University of Queensland Institute of Health and Biomedical Innovation & school of Public Health and social Work Queensland University of Technology Department of Anaesthesiology and Intensive Care and Department of Medical and Health Sciences Link?ping University school of Pharmacy The University of Queensland Department of Pharmacy Royal Brisbane & Women's Hospital

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. Comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/mL and flow rate of 1.0μL/min had the best recovery. A concentration of 5.0μg/mL and flow rate of 1.0μL/min yielded maximal recovery for vancomycin. Large molecular size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. Low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations.

关键词： Microdialysis Combination antibiotic therapy Relative recovery rate Pharmacokinetics Anti-infectives Protein binding