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Microdebrider complications in sinus surgery:Analysis of the openFDA database

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World Journal of Otorhinolaryngology-Head and Neck surgery 2023年第4期9卷 328-332页

作者： Elias s.saba Jacob Hoerter jeremy Chang David W.Chou Chris Xiao Jacob G.Eide Rijul s.Kshirsagar James N.Palmer Nithin D.Adappa Department of Head and Neck surgery Kaiser Permanente Oakland Medical CenterOaklandCaliforniaUSA Department of Otorhinolaryngology‐Headand Neck surgery Perelman School of MedicineUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA Department of Otolaryngology‐Head and Neck surgery Mount Sinai Medical CenterNew YorkNew YorkUSA Department of Otorhinolaryngology‐Head and Neck surgery University of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:Functional endoscopic sinus surgery is a commonly performed otolaryngologic procedure that often uses the microdebrider device for tissue *** the ubiquitous nature of the instrument,we sought to better define the patterns of device failure using the postmarket surveillance openFDA ***:The openFDA database was queried for all microdebrider‐related adverse events from January 1,2000 to November 1,*** information on the nature of device failure and any associated patient injury was *** not directly related to device failure were excluded from the ***:A total of 641 events were included in the *** most common device failure was overheating(n=348,54.3%),followed by material separation(n=173,27%),and inconsistent device activation(n=52,8.1%).Of the reported events,the vast majority did not result in patient harm(n=579,90.3%).On review of the remaining cases,only 24 events(3.7%)resulted in true harm to the patient,defined as a temporary or permanent injury or>30 min of additional anesthesia *** these cases,the need to reschedule surgical cases(n=5,0.8%),retained foreign body(n=5,0.8%),and thermal tissue injury(n=3,0.5%)were the most *** patients suffered an injury due to surgeon error unrelated to device malfunction(n=5,0.8%).Conclusions:Microdebrider device failures are extremely *** they do occur,less than 10%result in patient *** cases of patient harm related to microdebrider failure,preoperative testing of the device before use could prevent many of the reported malfunctions.

关键词： device failure microdebrider openFDA outcomes sinus

20世纪美国土壤学家对中国土壤地理学的贡献

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土壤通报 2010年第6期41卷 1491-1498页

作者：龚子同王志刚 jeremy Landon Darilek 黄标张甘霖中国科学院南京土壤研究所江苏南京210008 中国科学院研究生院北京100039

中美土壤学家之间有着长期的友好合作。对现代中国土壤地理学、乃至整个土壤学的建立和发展起过重要作用的美国土壤学家,按年代大致可以分成两组:第一组是20世纪早期(主要是30年代)的***,***,***和***;第二组是改革开放(1978年)以后的**... 详细信息

中美土壤学家之间有着长期的友好合作。对现代中国土壤地理学、乃至整个土壤学的建立和发展起过重要作用的美国土壤学家,按年代大致可以分成两组:第一组是20世纪早期(主要是30年代)的***,***,***和***;第二组是改革开放(1978年)以后的***,***,***和***。

关键词：历史土壤学土壤系统分类

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给教授发电邮的“门道”

新东方英语（中英文版） 2009年第6期 50-53页

作者： Lynn F.Jacobs jeremy s.Hyman 阿诺

教授们在赶办公电子化的潮流，这意味着，除了一对一的单独辅导，教授们越来越喜欢通过电子邮件和学生交流。以下是你在点击“发送”按钮前要注意的一些事情。

关键词：发电办公电子化学生交流电子邮件

Transurethral resection of prostate for acute urinary retention is linked to shorter survival in younger men

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Asian Journal of Andrology 2019年第5期21卷 468-472页

作者： jeremy Yuen-Chun Teoh Chi-Kwok Chan Maggie Haitian Wang Chi-Ho Leung Eddie shu-Yin Chan Peter Ka-Fung Chiu Chi-Hang Yee Hon-Ming Wong simon see-Ming Hou Chi-Fai Ng s.H.Ho Urology Centre Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Division of Biostatistics JC School of Public Health and Primary CareThe Chinese University of Hong KongHong KongChina Division of Urology Department of SurgeryNorth District HospitalHong KongChina Division of Urology Department of SurgeryAlice Ho Miu Ling Nethersole HospitalHong KongChina

It is largely unknown whether lower urinary tract symptoms(LUTs)or acute retention of urine(AROU)is linked to shorter life expectancy in *** conducted a multicenter,retrospective database analysis of patients undergoing transurethral resection of prostate(TURP)to study their *** Cox regression analysis and Kaplan-Meier analysis with stratification to age and indication of TURP were *** further performed an age-and sex-matched survival analysis with the general population using data from the Census and statistics Department of the Hong Kong special Administrative Region(Hong Kong,China).From January 2002 to December 2012,3496 patients undergoing TURP were included in our study,with 1764 patients in the LUTs group and 1732 patients in the AROU *** age,ischemic heart disease,cerebrovascular accident,and AROU were risk factors of *** ageds(adjusted hazard ratio[HR]:1.52,95%confidence interval[Cl]:1.11-2.09,P=0.010)and 70-80 years(adjusted HR:1.39,95%Cl:1.15-1.70,P-0.001)in the AROU group had worse survival than those in the LUTs group,but such difference was not demonstrated in patients aged>80 *** to the general population,younger patients in the LUTs group appeared to have better survival(s,P=0.091;70-80 years,P=0.011),but younger patients in the AROU group had worse survival(s,P=0.021;70-80 years,P=0.003).For patients aged>80 years,survival was similar with the general population in both the LUTs and AROU *** conclusion,AROU at young age was associated with mortality,while early detection and management of LUTs may improve survival.

关键词： acute retention of urine lower urinary tract symptoms mortality transurethral resection of prostate

In-vivo evaluation of molybdenum as bioabsorbable stent candidate

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Bioactive Materials 2022年第8期7卷 262-271页

作者： Malgorzata sikora-Jasinska Lea M.Morath Maria P.Kwesiga Margaret E.Plank Alexia L.Nelson Alexander A.Oliver Martin L.Bocks Roger J.Guillory II jeremy Goldman Department of Biomedical Engineering Michigan Technological UniversityUSA Department of Biomedical Engineering and Physiology Mayo Clinic Graduate School of Biomedical SciencesUSA Case Western Reserve University school of Medicine UH Rainbow Babies&Children’s HospitalClevelandOHUSA

Biodegradable stents have tremendous theoretical potential as an alternative to bare metal stents and drug-eluting stents for the treatment of obstructive coronary artery *** bioresorbable or biodegradable scaffold material needs to possess optimal mechanical properties and uniform degradation behavior that avoids local and systemic ***,molybdenum(Mo)has been investigated as a potential novel biodegradable material for this *** its proven moderate degradation rate and excellent mechanical properties,Mo may represent an ideal source material for clinical cardiac and vascular *** present study was performed to evaluate the mechanical performance of metallic Mo in vitro and the biodegradation properties in *** results demonstrated favorable mechanical behavior and a uniform degradation profile as desired for a new generation ultra-thin degradable endovascular stent ***,Mo implants in mouse arteries avoided the typical cellular response that contributes to *** was minimal neointimal hyperplasia over 6 months,an absence of excessive smooth muscle cell(sMC)proliferation or inflammation near the implant,and avoidance of significant harm to regenerating endothelial cells(EC).Qualitative inspection of kidney sections showed a potentially pathological remodeling of kidney Bowman’s capsule and glomeruli,indicative of impaired filtering function and development of kidney disease,although quantifications of these morphological changes were not statistically ***,the results suggest that the products of Mo corrosion may exert beneficial or inert effects on the activities of inflammatory and arterial cells,while exerting potentially toxic effects in the kidneys that warrant further investigation.

关键词： Biodegradable stent Molybdenum Biocompatibility Degradation

Hybrid multi-chip assembly of optical communication engines by in situ 3D nanolithography

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Light(science & Applications) 2020年第1期9卷 1340-1350页

作者： Matthias Blaicher Muhammad Rodlin Billah Juned Kemal Tobias Hoose Pablo Marin-Palomo Andreas Hofmann Yasar Kutuvantavida Clemens Kieninger Philipp-Immanuel Dietrich Matthias Lauermann stefan Wolf Ute Troppenz Martin Moehrle Florian Merget sebastian skacel jeremy Witzens sebastian Randel Wolfgang Freude Christian Koos Institute of Photonics and Quantum Electronics(IPQ) Karlsruhe Institute of Technology(KIT)Engesserstraße 576131 KarlsruheGermany Institute for Microstructure Technology(IMT) KITHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Institute for Automation and Applied Informatics(IAI) KITHermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany Vanguard Automation GmbH Gablonzer StraBe 1076185 KarlsruheGermany Fraunhofer Institute for Telecommunications Heinrich Hertz Institute(HHI)Einsteinufer 3710587 BerlinGermany Institute of Integrated Photonics(IPH) RWTH AachenSommerfeldstraße 18/2452074 AachenGermany

Three-dimensional(3D)nano-printing of freeform optical waveguides,also referred to as photonic wire bonding,allows for efficient coupling between photonic chips and can greatly simplify optical system *** a key advantage,the shape and the trajectory of photonic wire bonds can be adapted to the mode-field profiles and the positions of the chips,thereby offering an attractive alternative to conventional optical assembly techniques that rely on technically complex and costly high-precision ***,while the fundamental advantages of the photonic wire bonding concept have been shown in proof-of-concept experiments,it has so far been unclear whether the technique can also be leveraged for practically relevant use cases with stringent reproducibility and reliability *** this paper,we demonstrate optical communication engines that rely on photonic wire bonding for connecting arrays of silicon photonic modulators to InP lasers and single-mode *** a first experiment,we show an eight-channel transmitter offering an aggregate line rate of 448 Gbit/s by low-complexity intensity modulation.A second experiment is dedicated to a four-channel coherent transmitter,operating at a net data rate of 732.7 Gbit/s-a record for coherent silicon photonic transmitters with co-packaged *** dedicated test chips,we further demonstrate automated mass production of photonic wire bonds with insertion losses of(0.7±0.15)dB,and we show their resilience in environmental-stability tests and at high optical *** results might form the basis for simplified assembly of advanced photonic multi-chip systems that combine the distinct advantages of different integration platforms.

关键词： communication lithography bonding

Identification of neuron selective androgen receptor inhibitors

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World Journal of Biological Chemistry 2017年第2期8卷 138-150页

作者： Maya Otto-Duessel Ben Yi Tew steven Vonderfecht Roger Moore jeremy O Jones Department of Cancer Biology Beckman Research Institute City of Hope National Medical Center Division of Comparative Medicine Beck-man Research Institute City of Hope National Medical Center Department of Molecular Immunology Beckman Research Institute City of Hope National Medical Center

AIM To identify neuron-selective androgen receptor(AR) signaling inhibitors, which could be useful in the treatment of spinal and bulbar muscular atrophy(sBMA), or Kennedy's disease, a neuromuscular disorder in which deterioration of motor neurons leads to progressive muscle weakness. METHODs Cell lines representing prostate, kidney, neuron, adipose, and muscle tissue were developed that stably expressed the CFP-AR-YFP FRET reporter. We used these cells to screen a library of small molecules for cell typeselective AR inhibitors. secondary screening in luciferase assays was used to identify the best cell-type specific AR inhibitors. The mechanism of action of a neuronselective AR inhibitor was examined in vitro using luciferase reporter assays, immunofluorescence microscopy, and immunoprecipitations. Rats were treated with the most potent compound and tissue-selective AR inhibition was examined using RT-q PCR of AR-regulated genes and *** We identified the thiazole class of antibiotics as com-pounds able to inhibit AR signaling in a neuronal cell line but not a muscle cell line. One of these antibiotics, thiostrepton is able to inhibit the activity of both wild type and polyglutamine expanded AR in neuronal GT1-7 cells with nanomolar potency. The thiazole antibiotics are known to inhibit FOXM1 activity and accordingly, a novel FOXM1 inhibitor FDI-6 also inhibited AR activity in a neuron-selective fashion. The selective inhibition of AR is likely indirect as the varied structures of these compounds would not suggest that they are competitive antagonists. Indeed, we found that FOXM1 expression correlates with cell-type selectivity, FOXM1 co-localizes with AR in the nucleus, and that sh RNA-mediated knock down of FOXM1 reduces AR activity and thiostrepton sensitivity in a neuronal cell line. Thiostrepton treatment reduces FOXM1 levels and the nuclear localization of beta-catenin, a known co-activator of both FOXM1 and AR, and reduces the associa

关键词： Androgen receptor selective androgen receptor modulator spinal and bulbar muscular atrophy Kennedy’s disease

“缪斯之助力?”:约翰·弗洛里奥和威廉·莎士比亚的文艺复兴（英文）

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戏剧艺术 2016年第5期 20-28页

作者：杰瑞米.李斯特威尼斯东方大学

本文研究的核心是约翰·弗洛里奥,探讨杰出的语言学家以及蒙田作品译者约翰·弗洛里奥在莎士比亚全集创作过程中曾被低估的重大作用。虽然约翰·弗洛里奥对于相关专家而言并不陌生,但他是伊丽莎白和雅各宾时代的思想与文艺版图中的次要... 详细信息

本文研究的核心是约翰·弗洛里奥,探讨杰出的语言学家以及蒙田作品译者约翰·弗洛里奥在莎士比亚全集创作过程中曾被低估的重大作用。虽然约翰·弗洛里奥对于相关专家而言并不陌生,但他是伊丽莎白和雅各宾时代的思想与文艺版图中的次要人物。根据兰伯特·塔希纳里2009年的作品《约翰·弗洛里奥:名为莎士比亚之人》为依据,本文作者认真研究了弗洛里奥的生平和作品,探讨了英国威斯敏斯特大学的学者索尔·弗兰普顿的观点,该学者在2013年7月和8月发表在伦敦《卫报》上的两篇专题文章中指出,约翰·弗洛里奥是1623年莎士比亚全集(《第一对开本》)的主编,并且可以对莎士比亚原著进行"审查"、"修改"、"补充"。作为《第一对开本》出版的主要推动者本·琼森是弗洛里奥的密友和崇拜者,在自己的一本《狐狸》的献词中称弗洛里奥是"缪斯之助力"。本文作者分析了塔希纳里的理论,并论断弗洛里奥不仅仅是编辑、"诗人的‘缪斯之助力’",而且就是化名莎士比亚的作者本人,以"莎士比亚"为笔名。塔希纳里的作品现已翻译成法语版《化名为"莎士比亚"的约翰·弗洛里奥》,在法国媒体领域引发了激烈的争论。

关键词：莎士比亚编辑弗洛里奥琼森作者身份意大利

Point-of-care testing in the diagnosis of gastrointestinal cancers: Current technology and future directions

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World Journal of Gastroenterology 2015年第14期21卷 4111-4120页

作者： jeremy R Huddy Melody Z Ni sheraz R Markar George B Hanna Department of surgery and Cancer Imperial College LondonSt Mary’s Hospital

Point-of-care(POC) tests enable rapid results and are well established in medical *** advances in analytical techniques have led to a new generation of POC devices that will alter gastrointestinal diagnostic *** review aims to identify current and newtechnologies for the POC diagnosis of gastrointestinal cancer.A structured search of the Embase and Medline databases was *** reporting diagnostic tests for gastrointestinal cancer available as a POC device or containing a description of feasibility for POC application were *** recovered were heterogeneous and therefore results are presented as a narrative *** diagnostic methods were identified(fecal occult blood, fecal proteins, volatile organic compounds, pyruvate kinase isoenzyme type M2, tumour markers and DNA analysis).Fecal occult blood testing has a reported sensitivity of 66%-85% and specificity greater than 95%.The others are at a range of development and clinical *** devices have a proven role in the diagnosis of gastrointestinal *** to their implementation exist and the transition from experimental to clinical medicine is currently *** technologies demonstrate potential to provide accurate POC tests and an ability to diagnose gastrointestinal cancer at an early stage with improved clinical outcome and survival.

关键词： Colorectal cancer Cancer-diagnosis Gastric cancer