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World Journal of Critical Care Medicine 2021年第5期10卷 163-169页

作者： R Ponampalam jeremy Zhenwen Pong Xiang-Yi Wong Department of Emergency Medicine Singapore General HospitalSingapore 169608Singapore Duke-NUs Medical school National University of SingaporeSingapore 169857Singapore

Disasters resulting in mass casualty incidents can rapidly overwhelm the Emergency Department(ED).To address critical manpower needs in the ED’s disaster response,medical student involvement has been ***-National University of singapore Medical school is in proximity to singapore General Hospital and represents an untapped manpower *** appropriate training and integration into ED disaster workflows,medical students can be leveraged upon as qualified *** review provides a snapshot of the conceptualization and setting up of the Disaster Volunteer Corps-a programme where medical students were recruited to receive regular training and assessment from emergency physicians on disaster response principles to fulfil specific roles during a crisis,while working as part of a team under *** discuss overall strategy and benefits to stakeholders,emphasizing the close symbiotic relationship between academia and healthcare services.

关键词： Disaster medicine Disaster response Medical students Volunteers Medical education

Extent and predictors of grade upgrading and downgrading in an Australian cohort according to the new prostate cancer grade groupings

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Asian Journal of Urology 2019年第4期6卷 321-329页

作者： Kerri Beckmann Michael O’Callaghan Andrew Vincent Penelope Cohen Martin Borg David Roder sue Evans jeremy Millar Kim Moretti Cancer Research Institute School of Health SciencesUniversity of South AustraliaAdelaideAustralia school of Cancer and Pharmaceutical sciences King’s College LondonLondonUK Flinders Medical Centre Urology UnitAdelaideAustralia school of Medicine University of AdelaideAdelaideAustralia sA Pathology Health SAAdelaideSouth AustraliaAustralia Genesis Care University of AdelaideAdelaideAustralia Department of Epidemiology and Preventive Medicine Monash UniversityMelbourneAustralia

Object:To determine the extent and impact of upgrading and downgrading among men who underwent radical prostatectomy(RP)according to new grade groupings and to identify predictors of upgrading from biopsy grade Group Ⅰ and Ⅱ,and downgrading to grade Group I,in a community ***:study participants included 2279 men with non-metastatic prostate cancer diagnosed 2006-2015 who underwent prostatectomy,from the multi-institutional south Australia Prostate Cancer Clinical Outcomes Collaborative *** of up-or down-grading was assessed by comparing biopsy and prostatectomy grade *** of biochemical recurrence(BCR)with upgrading was assessed using multivariable competing risk *** logistic regression was used to identify pre-treatment predictors of upgrading from grade Groups Ⅰ and Ⅱ,and risk group reclassification among men with low risk ***:Upgrading occurred in 35%of cases,while downgrading occurred in 13%of *** percent with grade Group I disease were upgraded following *** from grade Group I was associated with greater risk of BCR compared with concordant grading(Hazard ratio:3.1,95%confidence interval:1.7-6.0).Older age,higher prostate-specific antigen levels(PsA),fewer biopsy cores,higher number of positive cores and more recent diagnosis predicted upgrading from grade Group Ⅰ,while higher PsA and clinical stage predicted upgrading from grade Group Ⅱ.No clinical risk factors for reclassification were ***:Biopsy sampling errors may play an important role in upgrading from grade Group *** clinical assessment of grade is needed to encourage greater uptake of active surveillance.

关键词： Prostate cancer Grade misclassification Biopsy Radical prostatectomy Pathology

Climate change,air pollution,and allergic respiratory diseases:a call to action for health professionals

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Chinese Medical Journal 2020年第13期133卷 1552-1560页

作者： shi-Zhou Deng Bin BJalaludin Josep MAnto jeremy JHess Cun-Rui Huang school of Public Health Sun Yat-sen UniversityGuangzhouGuangdong 510080China shanghai Key Laboratory of Meteorology and Health Shanghai Meteorological ServiceShanghai 200030China school of Public Health and Community Medicine University of New South WalesSydneyAustralia IsGIobal Centre for Research in Environmental Epidemiology(CREAL)BarcelonaSpain IMIM(Hospital del Mar Research Institute) BarcelonaSpain CIBER Epidemiologla y salud Publica(CIBEREsP) BarcelonaSpain Universitat Pompeu Fabra(UPF) BarcelonaSpain Departments of Emergency Medicine Environmental and Occupational Health Sciencesand Global HealthSchools of Medicine and Public HealthUniversity of WashingtonSeattleWAUSA school of Public Health Zhengzhou UniversityZhengzhouHenan 450001China shanghai Typhoon Institute China Meteorological AdministrationShanghai 200030China

Rising emissions of greenhouse gases in the atmosphere have warmed the planet substantially and are also accompanied by poor air *** increased prevalence of allergic airway disease worldwide can be partially attributed to those global environmental *** change and air pollution pose adverse impacts on respiratory allergies,and that the mechanisms are complex and *** weather conditions,such as extreme temperatures,can act directly on the respiratory tract to induce allergic respiratory *** and floods can alter the production and distribution of aeroallergens while wildfires and dust storms increase air pollution,and therefore indirectly enhance health *** of particulate matter and ozone in the air have been projected to increase with climate warming and air stagnation,and the rising temperatures and CO2 increase pollen,molds,and spores,which escalate the risk of allergic respiratory *** synergistic effects of extreme heat and aeroallergens intensify the toxic effect of air pollutants,which in turn augment the allergenicity of *** the Earth’s climate change,migration of humans and plants shift the living environments and allergens of susceptible *** residents are exposed to multiple factors while children are sensitive to environmental *** climate change may pose many unexpected and persistent effects on allergic respiratory diseases,health professionals should advocate for effective mitigation and adaptation strategies to minimize its respiratory health effects.

关键词： Respiratory allergy Climate change Air pollution Extreme weather events Aeroallergen

Time trend and characteristics of prostate cancer diagnosed in Hong Kong(China)in the past two decades

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Asian Journal of Andrology 2019年第1期21卷 104-106页

作者： Ho-Fai Wong Chi-Hang Yee jeremy YC Teoh samson Ys Chan Peter KF Chiu Ho-Yuen Cheung simon sM Hou Chi Fai Ng s H.Ho Urology Centre Department of SurgeryThe Chinese University of Hong KongHong KongChina

Dear Editor, Prostate cancer is an important disease worldwide)In 2015 it was the third most common cancer diagnosed in male in Hong Kong (China) and the incidence of prostate cancer has been rising in the past 15 years. Meanwhile,with increasing public awareness,health education, presentation,and detection of prostate cancer maybe ***, we would like to review how the epidemiology of prostate cancer in Hong Kong (China)had changed in the past two decades.

关键词： prostate cancer Time trend

乙腈/碳酸氢钠溶液混合物电嫁接叔丁氧羟基-乙二胺

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电化学 2017年第2期23卷 130-140页

作者： Hisham Hamzah Guy Denuault Philip Bartlett Aleksandra Pinczewska jeremy Kilburn 南安普顿大学化学系英国南安普顿S0171AL 伦敦大学玛丽女王学院生物与化学科学学院英国伦敦E14NS 阿伯丁大学国王学院英国阿伯丁AB243FX

碳电极表面的伯胺电嫁接被广泛地应用于电极表面改性.本文通过比较发现,在比例为4:1的乙腈和0.1mol·L^(-1) 碳酸氢钠溶液混合物中,玻碳电极表面嫁接上叔丁氧羟基-乙二胺的效率比在单纯的乙腈中显著提高.有碳氢酸钠存在时,循环伏安测得... 详细信息

碳电极表面的伯胺电嫁接被广泛地应用于电极表面改性.本文通过比较发现,在比例为4:1的乙腈和0.1mol·L^(-1) 碳酸氢钠溶液混合物中,玻碳电极表面嫁接上叔丁氧羟基-乙二胺的效率比在单纯的乙腈中显著提高.有碳氢酸钠存在时,循环伏安测得电极的初始电流增大,表明电极表面胺嫁接层的形成更快速,从而使得电极表面更容易钝化,导致乙二胺-叔丁氧羟基膜层更严重地阻碍[Fe(CN)_6]^(3-)的反应.通过去除叔丁氧羟基保护层,在蒽醌-2-羧酸上接自由胺,可获得较高的蒽醌表面覆盖度.采用简单动力学模型模拟了电嫁接反应,结果表明,模拟得到的循环伏安曲线与实验测得的循环伏安曲线相一致.对比在单纯乙腈和乙腈/碳酸氢钠溶液混合物中模型拟合得到的参数值可知,胺自由基与碳表面的反应和在均相溶液中的反应相互竞争,更有利于乙腈与碳氢酸钠的表面反应.

关键词：电嫁接叔丁氧羟基-乙二胺胺氧化玻碳电极表面修饰

A Life Cycle Comparison of Remote, Deployed Expeditionary Waste Management scenarios

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Journal of Environmental Protection 2021年第2期12卷 141-159页

作者： David Chester Chandrani Mukherjee jeremy slagley Eric Mbonimpa Thomas Hornstein Department of systems Engineering and Management Air Force Institute of Technology Wpafb OH USA

The current barrier to acquisition and utilization of viable waste-to-energy (WTE) technologies at remote or deployed expeditionary sites requires high capital and operation & maintenance costs. The impacts to environment and human health of differing expeditionary waste management strategies were compared using the Life Cycle Assessment software simaPro 8.0. Emissions of individual waste management scenarios were compiled from peer-reviewed literature, converted to values compatible with simaPro’s waste scenario inputs, and the calculated impacts compared using simaPro’s pre-loaded methodologies. These calculated impacts and the economic impacts confirm that open-air burning of waste is not only dangerous to humans and the environment, but is also not cost-effective. Considering the economic effects and the mitigated human and environmental health impacts, WTE technologies may be a viable waste management strategy for the future.

关键词： Life Cycle Assessment (LCA) Municipal solid Waste (MsW) Incineration sanitary Landfill Open Burn Pits

Resident accuracy in locating the common femoral vein in normal weight vs. obese patients

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Open Journal of Clinical Diagnostics 2013年第3期3卷 105-108页

作者： Leigh Patterson jeremy J. Bennett Kori Brewer Department of Emergency Medicine East Carolina University Greenville USA

Objectives: Ultrasound guidance increases the success of internal jugular central venous catheter (CVC) placement. The common femoral vein (CFV) is considered an easier site and physicians frequently place CFV CVCs using anatomical landmark guidance. No research has demonstrated the effect of patient weight on placement of a femoral CVC. The authors hypothesized that resident physicians could determine by anatomical landmarks the insertion site of a femoral CVC in normal and overweight adults. Methods: Investigators consented adult patients in the Emergency Department to serve as study models. Patients were grouped by BMI: Normal (BMI (BMI > 25). PGYI-III Emergency Medicine residents who volunteered to participate were included. Residents inspected and palpated the inguinal regions on a patient and marked the patient’s skin directly over the CFV. A faculty member assessed success using a 10 MHz linear probe (sonosite Micro Maxx) centered over the mark. The attempt was successful if the mark was directly over the CFV and unsuccessful if distal, lateral, or medial to the CFV. Results: Nineteen residents (6 PGYI, 7 PGY II, and 6 PGYIII) assessed 17 patients. There were 43 attempts on Normal patients and 57 attempts on Overweight patients. The success rate on Normal patients was 74% and on Overweight patients was 42% (p = 0.0021). Conclusion: Residents were more successful in correctly identifying the CFV by anatomical landmarks in Normal patients. Training year had no effect on success. Ultrasound guidance may increase the success rate of placing a femoral CVC in patients with BMI > 25.

关键词： Ultrasound Central Venous Access Obesity

Transitions of the Understanding and Definition of Primary Glaucoma

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Chinese Medical Journal 2018年第23期131卷 2852-2859页

作者： si-An Liu Zhen-Ni Zhao Nan-Nan sun Ying Han jeremy Chen Zhi-Gang Fan Department of Glaucoma State Key Laboratory of OphthalmologyZhongshan Ophthalmic CenterSun Yat-Sen UniversityGuangzhouGuangdong 510060China Department of Ophthalmology UCSF Medical CenterUniversity of California at San FranciscoSan Francisco 94010USA

Objective:In previous decades,glaucoma has been primarily attributed to elevated intraocular pressure (IOP),but this has gradually been replaced by the development of optic neuropathy as the central concept of glaucoma in developed ***,there still remain strong controversies in the definition of glaucoma in *** this current review,we are going to discuss these controversies and elaborate on the historical transitions of the definition of glaucoma both in China and developed ***,we will briefly describe the "ocular-cranial pressure gradient"theory and discuss the relationship between glaucoma and degenerative diseases of the central nervous system (CNs)in order to show the complex pathogenesis of glaucoma and the importance for the modification to the definition of glaucoma. Data sources:We performed a comprehensive search in both PubMed and sinoMed using the following keywords:(a)"primary glaucoma"and "guideline,"(b)"ocular-cranial pressure gradient,"and (c)"glaucoma,""Alzheimer's disease,"and "Parkinson's disease." The literature search included the related articles with no restrictions on publication date. study selection:The primary references were Chinese and English articles including (a)original guidelines and expert consensuses of primary glaucoma,(b)reviews focusing on the differences between various versions of these guidelines and consensuses,and (c)papers about ocular-cranial pressure gradient theory and the relationship between glaucoma and CNs degenerative diseases. Results:The definitions and classifications of both primary open-angle glaucoma and primary angle-closure glaucoma differ between Chinese glaucoma consensuses and international primary glaucoma *** definitions and classifications put more emphasis on the IOP,while international guidelines put more emphasis on the presence of optic *** ocular-cranial pressure gradient theory and the research on the relationship between glaucoma an

关键词： Central Nervous system Degenerative Disease Intraocular Pressure Ocular-Cranial Pressure Gradient Optic Neuropathy Primary Glaucoma

Internal Iliac Pseudoaneurysm Rupture Attributed to Perforated Hartmann’s Pouch Diagnosed on CT

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Open Journal of Radiology 2012年第2期2卷 52-54页

作者： jeremy R. Camden Laura R. Carucci Department of Radiology Virginia Commonwealth University Richmond USA

Rupture is a rare but disastrous complication of an arterial aneurysm. Intraabdominal abscess in association with iliac artery aneurysm is uncommon but can predispose to aneurysm rupture. We report the Computed Tomography (CT) findings of an internal iliac artery pseudoaneurysm formed by a pelvic abscess attributed to the perforation of the patient’s Hartmann’s pouch. Rupture of the pseudoaneurysm resulted in the patient’s death.

关键词： Iliac Artery Pseudoaneurysm Hartmann’s Pouch Rupture Computed Tomography

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癌症的免疫治疗和细胞治疗（英文）

中国药理学与毒理学杂志 2016年第2期30卷 87-94页

作者： jeremy COPP 谢伟东张朝杰 Jon BERGLIN Theragene Pharmaceuticals Inc.11555 Sorrento Valley RoadSuite ASan DiegoCAUSA 92121 Lindan Biotech Ltd.4-1250 Waverly StreetWinnipegMBCanada 东莞中山大学研究院广东东莞523000

最近,癌症免疫治疗作为可行性的新治疗法而得到广泛青睐。免疫治疗主要分为2种类型,即被动免疫治疗和主动免疫治疗。被动免疫治疗包括单克隆抗体和(或)抗体-药物偶联物治疗;主动免疫治疗包括癌症疫苗和嵌合抗原受体T细胞(CAR-T)治疗。... 详细信息

最近,癌症免疫治疗作为可行性的新治疗法而得到广泛青睐。免疫治疗主要分为2种类型,即被动免疫治疗和主动免疫治疗。被动免疫治疗包括单克隆抗体和(或)抗体-药物偶联物治疗;主动免疫治疗包括癌症疫苗和嵌合抗原受体T细胞(CAR-T)治疗。癌症疫苗是利用患者自身的细胞作为抗原递呈细胞,识别特异性的肿瘤抗原。CAR-T治疗是利用遗传工程改造的患者的T细胞,通过嵌合抗原受体识别肿瘤抗原。最近一些成功的案例,包括美国FDA批准的癌症免疫疗法,让各大制药公司对癌症免疫治疗研究报以强烈兴趣,如使用抗免疫检查点抑制剂单克隆抗体治疗肿瘤和针对前列腺癌的Provenge癌症疫苗,以及治疗复发或难治性急性淋巴细胞白血病的具有突破性的CAR-T免疫治疗。本综述讨论了目前肿瘤免疫学领域的最新进展以及未来的发展方向。

关键词：癌症免疫治疗被动免疫治疗主动免疫治疗癌症疫苗嵌合抗原受体T细胞(CAR-T)