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Review and synthesis of the effects of climate change on amphibians

Integrative Zoology 2013年第2期8卷 145-161页

作者： Yiming LI jeremy m.cohen Jason R.ROHR Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Department of Integrative Biology University of South FloridaTampaFLUSA

Considerable progress has been made in understanding the responses of amphibians to climate change,with successful research carried out on climate change-associated shifts in amphibian phenology,elevational distributions and amphibian-parasite *** review and synthesize the literature on this topic,emphasizing acutely lethal,sublethal,indirect and positive effects of climate change on amphibians,and major research *** instance,evidence is lacking on poleward shifts in amphibian distributions and on changes in body sizes and morphologies of amphibians in response to climate *** have limited information on amphibian thermal tolerances,thermal preferences,dehydration breaths,opportunity costs of water conserving behaviors and actual temperature and moisture ranges amphibians *** when much of this information is available,there remains little evidence that climate change is acutely lethal to *** suggests that if climate change is contributing to declines,it might be through effects that are not acutely lethal,indirect,or both,but evidence in support of this suggestion is *** fact,evidence that climate change is directly contributing to amphibian declines is weak,partly because researchers have not often ruled out alternative hypotheses,such as chytrid fungus or climate-fungus ***,we recommend that amphibian-climate research shift from primarily inductive,correlational approach as to studies that evaluate alternative hypotheses for *** additional rigor will require interdisciplinary collaborations,estimates of costs and benefits of climate change to amphibian fitness and populations,and the integration of correlative field studies,experiments on‘model’amphibian species,and mathematical and functional,physiological models.

关键词： amphibian decline Batrachochytrium dendrobatidis breeding date climate-linked epidemic hypothesis global warming

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motion of charged particles in bright squeezed vacuum

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Light(Science & Applications) 2024年第2期13卷 347-353页

作者： matan Even Tzur Oren cohen Solid State Institute and Physics Department Technion-Israel Institute of TechnologyHaifa3200003Israel

The motion of laser-driven electrons quivers with an average energy termed pondermotive *** explore electron dynamics driven by bright squeezed vacuum(BSV),finding that BSV induces width oscillations,akin to electron quivering in laser light,with an equivalent ponderomotive *** identify closed and open trajectories of the electronic width that are associated with high harmonic generation and above-threshold ionization,respectively,similarly to trajectories of the electron position when its motion is driven by coherent *** the case of bound electrons,the width oscillations may lead to ionization with noisy sub-cycle *** results are foundational for strong-field and free-electron quantum optics,as they shed light on ionization,high harmonic generation,and nonlinear Compton scattering in BSV.

关键词： structure vacuum ionization

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Improvements in energy saving and thermal comfort for electric vehicles in summer through coupled electrochromic and radiative cooling smart windows

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Building Simulation 2024年第8期17卷 1231-1251页

作者： Zhoujie Duan Shuangdui Wu Hongli Sun Borong Lin Pei Ding Tao Cui jeremy To Xi Zhang College of Architectureand Environment Sichuan UniversityChengdu610065China Department of Building Science Tsinghua UniversityBejing 100084China KeyLaboratoryofEco Planning&Green Building MinistryofEducationTsinghua UniversityBeijing100084China State Key Laboratory of Hydraulics and mountain River Engineering Sichuan UniversityChengdu 610065China School of Emergencymanagement Xihua UniversityChengdu 610039China Department of PSVD Mercedes-benz Group China Ltd.Beijing 100102China

In hot climates,the large amount of cooling load in electric vehicle(EV)results in a lot of battery energy consumption,leading the decrease of driving *** the widespread application of windows in EV,the electrochromic glass(EC)shows great prospect in lowering the cooling ***,researches on the application of EC in EV lack the consideration of both passive cooling measures and passenger comfort,which limits the further application of *** this paper,we proposed an idea combining the novel techniques of both electrochromism and radiative *** fluid dynamics(CFD)is modeled to simulate the application of electrochromic and radiative cooling coupled smart windows in hot parking conditions,exploring the improvement effect of the window on the thermal environment,comfort and energy saving of the *** results indicate that,under the intense sunlight with an outdoor temperature of 33℃,activating the air conditioning to maintain an average interior temperature of 26℃,the coupled windows reduced the cooling capacity of the air conditioning by 762 W compared to regular windows,which can further increase the range of ***,compared to simple electrochromic fully colored glass,the integration of radiative cooling technology can lower the window surface temperature by up to 10.7℃.moreover,compared to regular windows,the coupled windows lowered the standard effective temperature(SET*)for passengers by approximately 7℃,significantly improving *** research findings are expected to provide guidance for optimizing window design and enhancing the performance of EV.

关键词： electrochromism radiative cooling smart windowel ectric vehicle cabin thermal comfort energy saving

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聆听回声,感知历史:音乐离散者的挑战

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音乐探索 2024年第3期 132-144页

作者：朱达·m.科恩程瑜瑶(译) 不详新加坡国立大学中文系中山大学中文系浙江大学城市学院人文学院

本文为麦科勒姆、赫伯特主编的《历史音乐人类学的理论与方法》的第四章。本文的主题离散的范式强烈地唤起了身份认同,这超越了民族主义的学术局限,并能够与后现代理论结构巧妙兼容。对人类学家、政治学家、历史学家和文化理论家来说,... 详细信息

本文为麦科勒姆、赫伯特主编的《历史音乐人类学的理论与方法》的第四章。本文的主题离散的范式强烈地唤起了身份认同,这超越了民族主义的学术局限,并能够与后现代理论结构巧妙兼容。对人类学家、政治学家、历史学家和文化理论家来说,离散一直着散发无尽魅力,有助于理解迁徙和离散问题,也为探索人们如何保持多点在场观念提供了出发点。作者通过关注离散理论的两个代表群体——犹太及美籍非裔移民群体——之间的音乐交流,探讨离散话语所涉及的历史、音乐和离散族群的挑战等一些意义和内涵。

关键词：《历史音乐人类学的理论与方法》离散与音乐身份认同族群与音乐

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Inorganic arsenic： A non-genotoxic carcinogen

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Journal of Environmental Sciences 2016年第11期28卷 28-37页

作者： Samuel m.cohen Aparajita Chowdhury Lora L.Arnold Department of Pathology and microbiology University of Nebraska Medical Center Omaha NE 68198-3135 USA.

Inorganic arsenic induces a variety of toxicities including cancer. The mode of action for cancer and non-cancer effects involves the metabolic generation of trivalent arsenicals and their reaction with sulfhydryl groups within critical proteins in various cell types which leads to the biological response. In epithelial cells, the response is cell death with consequent regenerative proliferation. If this continues for a long period of time, it can result in an increased risk of cancer. Arsenicals do not react with DNA. There is evidence for indirect genotoxicity in various in vitro and in vivo systems, but these involve exposures at cytotoxic concentrations and are not the basis for cancer development. The resulting markers of genotoxicity could readily be due to the cytotoxicity rather than an effect on the DNA itself. Evidence for genotoxicity in humans has involved detection of chromosomal aberrations, sister chromatid exchanges in lymphocytes and micronucleus formation in lymphocytes, buccal mucosal cells, and exfoliated urothelial cells in the urine. Numerous difficulties have been identified in the interpretation of such results, including inadequate assessment of exposure to arsenic, measurement of micronuclei, and potential confounding factors such as tobacco exposure, folate deficiency, and others. Overall, the data strongly supports a non-linear dose response for the effects of inorganic arsenic. In various in vitro and in vivo models and in human epidemiology studies there appears to be a threshold for biological responses, including cancer.

关键词： Arsenic Cancer Genotoxicity Cytotoxicity Regeneration Cell proliferation

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基于TROPOmI NO_(2)、CO及HCHO重构数据的近地面O_(3)浓度估算研究

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遥感学报 2024年第9期28卷 2348-2361页

作者：陈小娟秦凯 cohen Jason 何秦中国矿业大学环境与测绘学院徐州221116

以TROPOmI大气成分产品为代表的卫星遥感数据在近地面臭氧(O_(3))浓度估算中表现出很好的潜力。由于云及反演算法局限性等原因,TROPOmI的大气成分产品存在一定的数据缺失,使得基于此的近地面O_(3)浓度估算数据覆盖度较低。为此,本文采... 详细信息

以TROPOmI大气成分产品为代表的卫星遥感数据在近地面臭氧(O_(3))浓度估算中表现出很好的潜力。由于云及反演算法局限性等原因,TROPOmI的大气成分产品存在一定的数据缺失,使得基于此的近地面O_(3)浓度估算数据覆盖度较低。为此,本文采用经验正交函数分解插值法(DINEOF)对TROPOmI NO_(2)、CO、HCHO原始数据产品进行缺失像元重构,并基于重构数据产品采用极限梯度提升算法(XGBoost)估算了中国大陆地区2019年—2021年高覆盖度的日最大8 h平均O_(3)浓度(mDA8 O_(3))。对比研究了DINEOF方法对TROPOmI NO_(2)、CO、HCHO原始数据产品的缺失像元进行重构后再建模估算O_(3)的方法(方案1),使用TROPOmI NO_(2)、CO、HCHO原始数据产品并对其缺失像元赋空值并输入其他特征变量来建模估算O_(3)的方法(方案2),有TROPOmI NO_(2)、CO、HCHO原始数据产品的建模结果和无TROPOmI NO_(2)、CO、HCHO原始数据产品,只有其他特征变量的建模结果相结合的方法(方案3),均可提升O_(3)模型估算结果的覆盖度。实验表明:方案1的结果最好,其十折交叉验证R^(2)=0.86,RmSE=15.86μg/m^(3),模型精度和方案2基本一致且高于方案3,在重构区域的模型精度最高(训练集R^(2)=0.82,RmSE=15.57μg/m^(3)),且当重构区域出现O_(3)重污染时(浓度大于160μg/m^(3)),能明显改善模型高值低估现象,结果的空间分布更合理。方案1估算的2019年—2021年近地面mDA8 O_(3)的平均覆盖度从33.6%提升到97.2%,使用TROPOmI NO_(2)、CO、HCHO重构数据产品建模估算O_(3)可提升模型性能和模型结果的覆盖度。

关键词：遥感近地面O_(3) TROPOmI DINEOF XGBoost 数据重构

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Scalable orthogonal delay-division multiplexed OEO artificial neural network trained for TI-ADC equalization

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Photonics Research 2024年第1期12卷 85-105页

作者： ANDREA ZAZZI ARKA DIPTA DAS LUKAS HüSSEN RENATO NEGRA jeremy WITZENS Institute of Integrated Photonics RWTH Aachen University52074 AachenGermany Chair of High-Frequency Electronics RWTH Aachen University52074 AachenGermany

We propose a new signaling scheme for on-chip optical-electrical-optical artificial neural networks that utilizes orthogonal delay-division multiplexing and pilot-tone-based self-homodyne *** scheme offers a more efficient scaling of the optical power budget with increasing network *** simulations,based on220 nm silicon-on-insulator silicon photonics technology,suggest that the network can support 31×31 neurons,with 961 links and freely programmable weights,using a single 500 m W optical comb and a signal-to-noise ratio of 21.3 d B per ***,it features a low sensitivity to temperature fluctuations,ensuring that it can be operated outside of a laboratory *** demonstrate the network’s effectiveness in nonlinear equalization tasks by training it to equalize a time-interleaved analog-to-digital converter(ADC)architecture,achieving an effective number of bits over 4 over the entire 75 GHz ADC *** anticipate that this network architecture will enable broadband and low latency nonlinear signal processing in practical settings such as ultra-broadband data converters and real-time control systems.

关键词： network delay artificial

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mode of action for inorganic arsenic toxicity and carcinogenesis

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Chinese Science Bulletin 2014年第11期59卷 1078-1082页

作者： Puttappa R.Dodmane Lora L.Arnold Samuel m.cohen Department of Pathology and microbiology University of Nebraska Medical Center983135 Nebraska Medical Center

Inorganic arsenic(iAs) at high doses is a known human carcinogen, inducing tumors of the skin,urinary bladder, and lung. It is also associated with noncancer toxicities. An understanding of the mode of action(mOA) for arsenic-induced effects is needed to develop a scientifically-based risk assessment. To determine an mOA for iAs induced toxicities, it is necessary to understand the metabolism, kinetics, cell transport, and interaction with specific proteins of iAs. Based on in vitro investigations using animal and human cells, studies from animal models,and clinical and epidemiological studies, we have proposed an mOA involving formation of sufficient levels of reactive trivalent metabolites which interact with critical free sulfhydryl groups, leading to cytotoxicity and regenerative cell proliferation. There is a strong correlation between in vitro cytotoxicity([0.1 lmol/L trivalent arsenicals) and the no effect levels in rodents [approximately 1 ppm(1 ppm = 1 mg/L) of water or diet]. In epithelial target tissues, the cytotoxic effects of iAs result in chronic precursor lesions which have the potential for an increased risk of developing cancer. In non-epithelial tissues, noncancer toxicities such as hypertension and atherosclerosis develop. This mOA implies a non-linear, threshold dose–response relationship for both non-cancer and cancer end points of exposure to iAs.

关键词：体外细胞毒性致癌作用无机砷诱导效应会计准则氧化锌避雷器上皮组织动脉粥样硬化

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multivariate relationships between microstructure evolution and strengthening mechanisms in laser powder bed fusion of Al-mn-Sc alloy:towards improved fatigue performance

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Light(Advanced manufacturing) 2024年第1期5卷 3-18页

作者： Huaping Tang Chaofeng Gao Shiheng Zhang Xiaojing Xiong Sheng Cao Xiaopeng Wu Yunjie Bi jeremy Heng Rao Institute of Advanced Additive manufacturing Ji Hua LaboratoryFoshanGuangdong528200China Department of mechanical Engineering College of EngineeringShantou UniversityShantouGuangdong515063China School of materials Science and Engineering Northeastern UniversityShenyang 110819China

The effects of direct aging treatment(at 300°C for 5 hours)on selective laser melted(SLmed)Al-4.5mn-1.5mg-0.9Sc-0.2Zr alloy were investigated in this work,with the microstructure,fatigue behaviors,and fracture characteristics examined to determine the primary cause of fatigue crack *** results revealed that the microstructure of the investigated alloy comprised fine equiaxed and columnar *** aging treatment,a significant number of nano-scaled Al3(Sc,Zr)precipitates were dispersed within the grains,leading to a substantial increase in *** yield strength improved from 431 mPa to 568 mPa,representing an increase of more than 32%,while the fatigue strength improved from 180 mPa to 220 mPa after aging ***,the fracture toughness decreased significantly from 25.1 mPa·√m to 12.3 mPa·√*** results of the fatigue fracture characteristics indicate that the mn-rich phase and the formation of defects such as pores and poor powder fusion are the sources of fatigue *** direct aging treatment can significantly increase the yield strength,decrease the rate of fatigue crack propagation,and thus improve the fatigue performance,it deteriorates the fracture toughness,and thus shortens the fatigue life of the alloy as well.

关键词： Selective laser melting Al-mn-Sc alloys High-cycle fatigue

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Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III jeremy L.Barth Rodney J.Schlosser Thomas S.Edwards Timothy L.Smith Zachary m.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pme functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pmation regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of IL-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

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