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Windows IT Pro Magazine（国际中文版） 2008年第4期 63-65页

作者： jeremy l.smith 肖欣(译)

在购买补丁管理软件之前，评估一下补丁服务是否更适合你们的情况。同样，中小企业在恶意软件防护、防垃圾邮件、备份／恢复以及一致性扫描等管理服务方面都可以进行类似的评估。

关键词：安全管理中小企业服务备份/恢复管理软件软件防护垃圾邮件一致性

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脑缺血与缺血耐受

国际脑血管病杂志 2006年第3期14卷 190+195-196页

作者： Daniel Zemke jeremy l.smith Mathew J.Reeves Arshad Majid 孙明徐超 Fromthe Department of Neurology and Ophthalmology Michigan State UniversityEastLansingMI48824USA Neuroscience Program Michigan State UniversityEastLan-singMI48824USA Department of Epidemiology Michigan State UniversityEast LansingMI48824USA 北京市神经外科研究所

在美国,卒中是死亡的第三大原因和成人致残的首要原因。本文概述了卒中后导致细胞死亡的通路,并对目前有关缺血耐受现象的文献加以总结。缺血耐受是一种内源性神经保护机制,通过这一机制保护神经元免受卒中期间和卒中后出现的脑缺血有... 详细信息

在美国,卒中是死亡的第三大原因和成人致残的首要原因。本文概述了卒中后导致细胞死亡的通路,并对目前有关缺血耐受现象的文献加以总结。缺血耐受是一种内源性神经保护机制,通过这一机制保护神经元免受卒中期间和卒中后出现的脑缺血有害效应。深入了解卒中后导致细胞死亡的过程和诸如缺血耐受之类的内源性神经保护机制,有助于为这种破坏性神经疾病找到新的治疗策略。

关键词：卒中缺血耐受预处理

Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger Schmidt jeremy l.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III jeremy l.Barth Rodney J.Schlosser Thomas S.Edwards Timothy l.smith Zachary M.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pld change 2.69).Reactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pluding Il-4 and Il-13 signaling,Il-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of Il-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

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Comment on: Effect of intubation in patients with functional epiphora after endoscopic dacryocystorhinostomy

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1576-1576页

作者： Mansooreh Jamshidian-Tehrani Hossein Ghahvehchian Christopher J Compton jeremy D Clark Nicole l West Mohsen Bahmani Kashkouli Department of Ophthalmology Eye Research CenterThe Five Senses Health InstituteRassoul Akram HospitalIran University of Medical SciencesTehran ***Iran Department of Ophthalmology and Visual Sciences University of Louisville School of MedicineLouisville 40202KentuckyUSA

Dear Editor,We read with interest the article by Han et al[1]in which they retrospectively assessed the effect of bicanalicular intubation for functional epiphora after a failed endoscopic dacryocystorhinostomy(DCR).They confirmed the post-DCR“functional obstruction”based on fluorescein dye disappearance(FDDT)and irrigation test[1].

关键词： intubation assessed endoscopic

Metal to insulator transition for conducting polymers in plasmonic nanogaps

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light(Science & Applications) 2024年第1期13卷 23-32页

作者： Yuling Xiong Rohit Chikkaraddy Charlie Readman Shu Hu Kunli Xiong Jialong Peng Qianqi lin jeremy J.Baumberg NanoPhotonics Centre Cavendish LaboratoryDepartment of PhysicsUniversity of CambridgeCambridgeCB30HEUK School of Physics&Astronomy University of BirminghamEdgbastonBirminghamUK College of Advanced Interdisciplinary Studies and Hunan Provincial Key laboratory of Novel Nano-Optoelectronic Information Materials and Devices National University of Defense TechnologyChangshaChina Hybrid Materials for Opto-Electronics Group Department of Molecules and MaterialsMESA+Institute for NanotechnologyMolecules Center and Center for Brain-Inspired Nano SystemsFaculty of Science and TechnologyUniversity of TwenteEnschedeNetherlands

Conjugated polymers are promising material candidates for many future applications in flexible displays, organic circuits, and sensors. Their performance is strongly affected by their structural conformation including both electrical and optical anisotropy. Particularly for thin layers or close to crucial interfaces, there are few methods to track their organization and functional behaviors. Here we present a platform based on plasmonic nanogaps that can assess the chemical structure and orientation of conjugated polymers down to sub-10 nm thickness using light. We focus on a representative conjugated polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), of varying thickness (2-20 nm) while it undergoes redox in situ. This allows dynamic switching of the plasmonic gap spacer through a metal-insulator transition. Both dark-field (DF) and surface-enhanced Raman scattering (SERS) spectra track the optical anisotropy and orientation of polymer chains close to a metallic interface. Moreover, we demonstrate how this influences both optical and redox switching for nanothick PEDOT devices.

关键词： transition insulator conjugated

Kernel-based Consensus Clustering for Ontology-embedded Document Repository of Power Substations

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CSEE Journal of Power and Energy Systems 2017年第2期3卷 212-221页

作者： long Yan Wenhu Tang Q.H.Wu jeremy Simon smith Department of Electrical Engineering and Electronic The University of LiverpoolLiverpoolL693GJU.K. School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China

This paper presents a novel consensus clustering(CC)approach for a document repository concerning power substations(PSD)and contributes to the intangible asset management of power systems.A domain ontology model,i.e.,substation ontology(SONT),is applied to modify the traditional vector space model(VSM)for document representation,which is concerned with the semantic relationship between terms.A new document representation is generated using a term mutual information matrix with the aid of *** addition,compared with two other novel CC algorithms,i.e.,non-negative matrix factorisation-based CC(NNMF-CC)and information theory-based CC(INT-CC),weighted partition via kernel-based CC algorithm(WPK-CC)is utilised to solve the CC issue for ***,genetic algorithms(GA)were applied to WPK-CC for PSD,as there are limitations in the original WPK-CC for document ***,selected mechanisms in each GA’s procedure are compared and improved,resulting in comprehensive parameter settings for the PSD *** simulation studies have been designed,in which the results are evaluated by purity validation method and show that the SONT-based document representation and improved WPK-CC,via modified GA,significantly improve the performance of the PSD CC.

关键词： power system asset management document clustering consensus clustering ontology kernel method GA

Placental accommodations for transport and metabolism during intra-uterine crowding in pigs

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Journal of Animal Science and Biotechnology 2015年第2期6卷 163-176页

作者： Jeffrey l Vallet Anthony K Mc Neel jeremy R Miles Bradley A Freking U.S. Department of Agriculture Agricultural Research Service U.S. Meat Animal Research CenterState Spur 18D Clay Center NE 68933 USA

litter size and birth weights are limited by uterine capacity, defined as the ability of the uterus to maintain the appropriate development of some number of conceptuses. Uterine capacity is the result of the combined effects of uterine, placental and embryo/fetal function. The number of living conceptuses that the uterus is capable of supporting is greater during early gestation compared to later gestation. Plots of log fetal weight versus log placental weight also indicate that fetal weights are less sensitive to reduced placental weight （and therefore reduced intrauterine space） in early gestation compared to late gestation. However, even in late gestation, mechanisms still exist that maintain fetal growth when the size of the placenta is reduced. One such mechanism is likely to be improved development of the folded placental-epithelial/maternal-epithelial bilayer. Fold depth, and therefore the maternal fetal interactive surface, increases as gestation advances and is greater in placenta from smal fetuses. On the fetal side of the placenta, the epithelial bilayer is embedded in stromal tissue. Glycosaminoglycans are major components of stroma, including hyaluronan and heparan sulfate. Hyaluronidases and heparanases are present within placental tissues, and likely play roles in modification of stromal components to facilitate fold development. Glycosaminoglycans are polymers of forms of glucose （glucosamine, glucuronic acid, iduronic acid） suggesting that glycosaminoglycan synthesis may compete with the glucose needs of the developing fetus. Pig conceptuses are fructogenic, such that a substantial portion of glucose transferred from mother to fetus is converted to fructose. Fructose is an intermediate product in the synthesis of glucosamine from glucose, and glucosamine is linked to regulation of trophoblast cell proliferation through regulation of mTOR. These findings suggest a link between glucose, fructose, glucosamine synthesis, GAG production, and placental m

关键词： Glycosaminoglycans Nutrient transport Placenta

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Glucosamine supplementation during late gestation alters placental development and increases litter size

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Journal of Animal Science and Biotechnology 2018年第1期9卷 135-144页

作者： Jeffrey l.Vallet jeremy R.Miles Bradley A.Freking Shane Meyer USDA ARS U.S. Meat Animal Research Center (USMARQ P.O. Box 166 Clay Center NE Nebraska 68933 USA Plymouth Ag Group Diller NE Nebraska 68342 USA

Background： During late gestation the placental epithelial interface becomes highly folded, which involves changes in stromal hyaluronan. Hyaluronan is composed of glucoronate and N-acetyl-glucosamine. We hypothesized that supplementing gestating dams with glucosamine during this time would support placental folded-epithelial-bilayer development and increase litter size. In Exp. 1, gilts were unilaterally hysterectomizedovariectomized（UHO）. UHO gilts were mated and then supplemented daily with 10 g glucosamine（n = 16） or glucose（control, n = 17） from d 85 of gestation until slaughter（d 105）. At slaughter, the number of live fetuses was recorded and each live fetus and its placenta was weighed. Uterine wall samples adjacent to the largest and smallest fetuses within each litter were processed for histology. In Exp. 2, pregnant sows in a commercial sow farm were supplemented with either 10 g glucosamine or glucose daily from d 85 of gestation to farrowing. Total piglets born and born alive were recorded for each litter. In Exp. 3, the same commercial farm and same protocol were used except that the dose of glucosamine and glucose was doubled to 20 g/***： In Exp. 1, the number of live fetuses tended to be greater in glucosamine-treated UHO gilts（P = 0.098）.Placental morphometry indicated that the width of the folded bilayer was greater（P = 0.05） in glucosamine-treated gilts. In Exp. 2, litter size did not differ between glucosamine-and glucose-treated sows. However in Exp. 3, the increased dose of glucosamine resulted in a significant treatment by parity interaction（P ≤ 0.01）, in which total piglets born and born alive were greater in glucosamine treated sows of later parity（5 and 6）.Conclusions： These results indicated that glucosamine supplementation increased the width of the folds of the placental bilayer and increased litter size in later parity, intact pregnant commercial sows.

关键词： Fructose Glucosamine Hyaluronan Swine Uterine capacity

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Spin-preserving chiral photonic crystal mirror

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light(Science & Applications) 2020年第1期9卷 1787-1798页

作者： Behrooz Semnani jeremy Flannery Rubayet Al Maruf Michal Bajcsy Institute for Quantum Computing(IQC) University of WaterlooWaterloo N2L3G1 ONCanada Department of Electrical&Computer Engineering University of WaterlooWaterloo N2L3G1 ONCanada Department of Physics and Astronomy University of WaterlooWaterloo N2L3G1 ONCanada

Chirality refers to a geometric phenomenon in which objects are not superimposable on their mirror *** made of nanoscale chiral elements can exhibit chiroptical effects,such as dichroism for left-and right-handed circularly polarized light,which makes these structures highly suitable for applications ranging from quantum information processing and quantum optics to circular dichroism spectroscopy and molecular *** the same time,strong chiroptical effects have been challenging to achieve even in synthetic optical media,and chiroptical effects for light with normal incidence have been speculated to be prohibited in thin,lossless quasi-two-dimensional ***,we report an experimental realization of a giant chiroptical effect in a thin monolithic photonic crystal *** conventional mirrors,our mirror selectively reflects only one spin state of light while preserving its handedness,with a near-unity level of circular *** operational principle of the photonic crystal mirror relies on guided-mode resonance(GMR)with a simultaneous excitation of leaky transverse electric(TE-like)and transverse magnetic(TM-like)Bloch modes in the photonic crystal *** modes are not reliant on the suppression of radiative losses through long-range destructive interference,and even small areas of the photonic crystal exhibit robust circular *** its simplicity,the mirror strongly outperforms earlier reported structures and,contrary to a prevailing notion,demonstrates that near-unity reflectivity contrast for opposite helicities is achievable in a quasi-two-dimensional structure.

关键词： mirror crystal circular