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Cell-free DNA liquid biopsy for early detection of gastrointestinal cancers:A systematic review

World Journal of Gastrointestinal Oncology 2021年第11期13卷 1799-1812页

作者： Isabelle Uhe Monika Elisabeth Hagen Frederic Ris jeremy meyer Christian Toso Jonathan Douissard Abdominal Surgery Division Geneva University HospitalsGeneva 1211Switzerland

BACKGROUND Gastrointestinal tumors are among the most common cancer types,and early detection is paramount to improve their ***-free DNA(cfDNA)liquid biopsy raises significant hopes for non-invasive early *** To describe current applications of this technology for gastrointestinal cancer detection and *** A systematic review of the literature was performed across the PubMed *** reporting the use of cfDNA liquid biopsy in the screening or diagnosis of gastrointestinal cancers were included in the *** A total of 263 articles were screened for eligibility,of which 13 articles were *** investigated colorectal cancer(5 studies),pancreatic cancer(2 studies),hepatocellular carcinoma(3 studies),and multi-cancer detection(3 studies),including gastric,oesophageal,or bile duct cancer,representing a total of 4824 *** sensitivities ranged from 71% to 100%,and specificities ranged from 67.4% to 100%.Pre-cancerous lesions detection was less performant with a sensitivity of 16.9% and a 100% specificity in one *** study using a large biobank demonstrated a 94.9% sensitivity in detecting cancer up to 4 years before clinical symptoms,with a 61% accuracy in tissue-of-origin *** cfDNA liquid biopsy seems capable of detecting gastrointestinal cancers at an early stage of development in a non-invasive and repeatable manner and screening simultaneously for multiple cancer types in a single blood *** trials in clinically relevant settings are required to determine the exact place of this technology in gastrointestinal cancer screening and diagnosis strategies.

关键词： Cell-free DNA Tumor DNA Liquid biopsy Next-generation sequencing Cancer genomics Pancreatic cancer Colorectal cancer Hepatocellular carcinoma Multicancer detection Cancer screening Public health Precision oncology

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Lateral lymph node dissection for low rectal cancer: Is it necessary?

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World Journal of Gastroenterology 2019年第31期25卷 4294-4299页

作者： Niki Christou jeremy meyer Christian Toso Frédéric Ris Nicolas Christian Buchs Service de Chirurgie Digestive Endocrinienne et GénéraleCHU de LimogesLimoges Cedex 87042France Division of Digestive Surgery University Hospitals of GenevaGenève 1211Switzerland Unit of Surgical Research University of GenevaGenève 1206Switzerland

Rectal cancer constitutes a major public health *** mesorectal excision has remained the gold standard treatment for mid and low rectal tumors since its introduction in the late *** of all lymph nodes located in the mesorectum has indeed improved pathological and oncological ***,when cancer spreads to the lateral lymph nodes(located along the iliac and obturator arteries)Western and Japanese practices *** the Western guidelines consider this condition as an advanced form of the disease and use neoadjuvant radiochemotherapy liberally,the Japanese guidelines define it as a local disease and proceed to lateral lymph node dissection with or without neoadjuvant ***,we review the current literature regarding both therapeutic strategies,with the aim of contributing to potential improvements in treatment and outcome for patients with low and mid rectal cancer.

关键词： Total mesorectum excision Mesorectal resection Lateral node metastasis Extended lymphadenectomy

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Risk of colorectal cancer in patients with diverticular disease

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World Journal of Clinical Oncology 2018年第6期9卷 119-122页

作者： jeremy meyer Nicolas Christian Buchs Frédéric Ris Division of Digestive Surgery University Hospitals of Geneva

Colorectal cancer constitutes an important burden on the healthcare system. Screening at-risk populations to reduce colorectal cancer-related morbidity and mortality has become part of good clinical practice. However, recommendations regarding subgroups of patients with diverticular disease are subject to controversy. Herein, we review the most recent literature regarding the prevalence of colorectal cancer in patients with diverticular disease, diverticulitis and uncomplicated diverticulitis. The recent literature does not identify diverticular disease as a long-term risk factor for colorectal cancer. However, the risk of colorectal cancer is increased in the short-term period after hospitalization related to diverticular disease. According to a recent systematic review and meta-analysis, the prevalence of colorectal cancer is 1.6% in patients with acute diverticulitis who underwent colonoscopy. The risk of having colorectal cancer after an episode of acute diverticulitis is 44-fold higher than that of an age-and gender-adjusted reference population. Despite lower among patients with uncomplicated episode, the risk of colorectal cancer remains 40-fold higher in that subpopulation than that in the reference population. To conclude, the recent literature describes an increased risk of colorectal cancer among patients with acute diverticulitis compared to the reference population. Colonoscopy is therefore recommended in patients with diverticulitis to exclude colorectal cancer.

关键词： Diverticulosis Diverticulitis Colonoscopy Screening Tumor Risk factor

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Role of near-infrared fluorescence in colorectal surgery

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World Journal of Gastroenterology 2021年第31期27卷 5189-5200页

作者： Elodie Zocola jeremy meyer Niki Christou Emilie Liot Christian Toso Nicolas Christian Buchs Frederic Ris Medical School University of GenevaGenève 1205Switzerland Division of Digestive Surgery University Hospitals of GenevaGenève 1205Switzerland Service de Chirurgie Digestive Endocrinienne et GénéraleCHU de LimogesLimoges Cedex 87025France

Near-infrared fluorescence(NIRF)is a technique of augmented reality that,when applied in the operating theatre,allows the colorectal surgeon to visualize and assess bowel vascularization,to identify lymph nodes draini... 详细信息

关键词： Fluorescence Enhanced reality Anastomotic leak Ureter Anastomosis

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Reducing anastomotic leak in colorectal surgery: The old dogmas and the new challenges

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World Journal of Gastroenterology 2019年第34期25卷 5017-5025页

作者： jeremy meyer Surennaidoo Naiken Niki Christou Emilie Liot Christian Toso Nicolas Christian Buchs Frédéric Ris Division of Digestive Surgery University Hospitals of Geneva

Anastomotic leak(AL)constitutes a significant issue in colorectal surgery,and its incidence has remained stable over the last *** use of intra-abdominal drain or the use of mechanical bowel preparation alone have been proven to be useless in preventing AL and should be *** role or oral antibiotics preparation regimens should be clarified and compared to other routes of administration,such as the intravenous route or *** parallel,preoperative antibiotherapy should aim at targeting collagenase-inducing pathogens,as identified by the microbiome *** can be further reduced by fluorescence angiography,which leads to significant intraoperative changes in surgical *** of fluorescence angiography should be *** made in AL comprehension and prevention might probably allow reducing the rate of diverting stoma and conduct to a revision of its indications.

关键词： Anastomotic leakage Rectal surgery Colic surgery Prevention Surgical site infection Anastomosis Complication

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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang Roger Schmidt jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

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Scalable orthogonal delay-division multiplexed OEO artificial neural network trained for TI-ADC equalization

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Photonics Research 2024年第1期12卷 85-105页

作者： ANDREA ZAZZI ARKA DIPTA DAS LUKAS HüSSEN RENATO NEGRA jeremy WITZENS Institute of Integrated Photonics RWTH Aachen University52074 AachenGermany Chair of High-Frequency Electronics RWTH Aachen University52074 AachenGermany

We propose a new signaling scheme for on-chip optical-electrical-optical artificial neural networks that utilizes orthogonal delay-division multiplexing and pilot-tone-based self-homodyne *** scheme offers a more efficient scaling of the optical power budget with increasing network *** simulations,based on220 nm silicon-on-insulator silicon photonics technology,suggest that the network can support 31×31 neurons,with 961 links and freely programmable weights,using a single 500 m W optical comb and a signal-to-noise ratio of 21.3 d B per ***,it features a low sensitivity to temperature fluctuations,ensuring that it can be operated outside of a laboratory *** demonstrate the network’s effectiveness in nonlinear equalization tasks by training it to equalize a time-interleaved analog-to-digital converter(ADC)architecture,achieving an effective number of bits over 4 over the entire 75 GHz ADC *** anticipate that this network architecture will enable broadband and low latency nonlinear signal processing in practical settings such as ultra-broadband data converters and real-time control systems.

关键词： network delay artificial

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Changes of tropical cyclone size in three oceanic basins of the northern hemisphere from 2001 to 2021

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Frontiers of Earth Science 2024年第2期18卷 312-323页

作者： Banglin ZHANG jeremy Cheuk-Hin LEUNG Shengyuan LIU Jianjun XU Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction CMAGuangzhou 510640China College of Atmospheric Science Lanzhou UniversityLanzhou 730020China College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088China CMA-GDOU Joint Laboratory for Marine Meteorology&South China Sea Institute of Marine Meteorology Guangdong Ocean UniversityZhanjiang 524088China

In this study the changes of tropical cyclone(TC)size from 2001 to 2021 are analyzed based on linear and quadratic curve fittings of the National Hurricane Center(NHC)/Joint Typhoon Warning Center(JTWC)best track data,based on the radius of maximum wind(RMW)and the average radius of 34-kt wind(AR34),in three oceanic basins of the North Atlantic(NATL),the Western North Pacific(WPAC)and the Eastern North Pacific(EPAC).The computations are done separately for two categories of tropical cyclones:tropical storms(TS)and hurricanes(HT).Size changes of landfalling and non-landfalling TCs are also *** show that there is a great inter-basin variability among the changes in TC *** conclusions include:1)overall,the inner cores of TSs have become larger in all three basins,with the increasing tendencies being significant in the NATL and WAPC,while those of HTs mostly get smaller or remain similar;2)meanwhile,comparatively large inter-basin differences are observed for the TC outer core sizes,and the sizes of landfalling TCs;3)particularly,a significant decrease in landfalling HT outer core size is observed over the EPAC;4)in contrast,significant increases in landfalling TS inner core size are found over the NATL and *** presented analysis results could benefit future research about TC forecasts,storm surge studies,and the cyclone climate and its changes.

关键词： tropical cyclone storm size frequency intensity duration

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Combinatorial Optimization of Physics Parameterization Schemes for Typhoon Simulation Based on a Simple Genetic Algorithm(SGA)

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Journal of Meteorological Research 2024年第1期38卷 10-26页

作者： Zebin LU Jianjun XU Zhiqiang CHEN Jinyi YANG jeremy Cheuk-Hin LEUNG Daosheng XU Banglin ZHANG China Meteorological Administration–Guangdong Ocean University Joint Laboratory for Marine Meteorology South China Sea Institute of Marine MeteorologyGuangdong Ocean UniversityZhanjiang 524088 College of Ocean and Meteorology Guangdong Ocean UniversityZhanjiang 524088 Guangzhou Institute of Tropical and Marine Meteorology/Guangdong Provincial Key Laboratory of Regional Numerical Weather Prediction China Meteorological AdministrationGuangzhou 510640 Shenzhen Institute of Guangdong Ocean University Shenzhen 518120 College of Atmospheric Science Lanzhou UniversityLanzhou 730000

Each physical process in a numerical weather prediction(NWP)system may have many different parameterization *** studies have shown that the performance of different physical parameterization schemes varies with the weather situation to be ***,it is necessary to select a suitable combination of physical parameterization schemes according to the variation of weather ***,it is rather difficult to identify an optimal combination among millions of possible parameterization scheme *** study applied a simple genetic algorithm(SGA)to optimizing the combination of parameterization schemes in NWP models for typhoon *** feasibility of SGA was verified with the simulation of Typhoon Mujigae(2015)by using the Weather Research and Forecasting(WRF)model and Typhoon Higos(2020)by using the Coupled Ocean–Atmosphere–Wave–Sediment Transport(COAWST)modeling *** results show that SGA can efficiently obtain the optimal combination of *** Typhoon Mujigae(2015),the optimal combination can be found from the 1,304,576 possible combinations by running only 488 *** results can be obtained for Typhoon Higos(2020).Compared to the default combination proposed by the COAWST model system,the optimal combination scheme significantly improves the simulation of typhoon track and *** study provides a feasible way to search for the optimal combinations of physical parameterization schemes in WRF and COAWST for more accurate typhoon *** can help provide references for future development of NWP models,and for analyzing the coordination and adaptability of different physical process parameterization schemes under specific weather backgrounds.

关键词： simple genetic algorithm(SGA) combinatorial optimization typhoon forecast numerical weather prediction(NWP)

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Free-electron crystals for enhanced X-ray radiation

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Light(Science & Applications) 2024年第7期13卷 1299-1309页

作者： Lee Wei Wesley Wong Xihang Shi Aviv Karnieli jeremy Lim Suraj Kumar Sergio Carbajo Ido Kaminer Liang Jie Wong School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore. Solid State Institute and Faculty of Electrical and Computer Engineering Technion–Israel Institute of TechnologyHaifa 3200003Israel. School of Electrical Engineering Fleischman Faculty of EngineeringTel Aviv UniversityTel Aviv 69978Israel Department of Applied Physics Stanford UniversityStanfordCA 94305USA. Science Mathematics and TechnologySingapore University of Technology and Design8 Somapah RoadSingapore 487372Singapore. Electrical and Computer Engineering Department UCLA420 WestwoodLos AngelesCA 90095USA. Physics and Astronomy Department UCLA475 Portola PlazaLos AngelesCA 90095USA. SLAC National Accelerator Laboratory Stanford University2575 Sand Hill RoadMenlo ParkCA 94025USA

Bremsstrahlung—the spontaneous emission of broadband radiation from free electrons that are deflected by atomic nuclei—contributes to the majority of X-rays emitted from X-ray tubes and used in applications ranging from medical imaging to semiconductor chip ***,we show that the bremsstrahlung intensity can be enhanced significantly—by more than three orders of magnitude—through shaping the electron wavefunction to periodically overlap with atoms in crystalline ***,we show how to shape the bremsstrahlung X-ray emission pattern into arbitrary angular emission profiles for purposes such as unidirectionality and ***,we find that these enhancements and shaped emission profiles cannot be attributed solely to the spatial overlap between the electron probability distribution and the atomic centers,as predicted by the paraxial and nonrecoil theory for free electron light *** work highlights an unprecedented regime of free electron light emission where electron waveshaping provides multi-dimensional control over practical radiation processes like *** results pave the way towards greater versatility in table-top X-ray sources and improved fundamental understanding of quantum electron-light interactions.

关键词： overlap attributed arbitrary

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